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Conditionally Toxic Proteins
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Book Synopsis Conditionally Toxic Proteins by : Catherine H. Schein
Download or read book Conditionally Toxic Proteins written by Catherine H. Schein and published by CRC Press. This book was released on 2023-10-12 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human health depends upon access to high-quality proteins for our diet and pharmaceutical use. This book deals with the nature of toxicity as it applies to proteins in food and drugs. Many proteins, such as glutens and allergens, are valuable food sources but toxic for sensitized individuals. Even proteins produced in the human body can become toxic through mutation or aggregation. For example, Alzheimer's and Huntington's disease are characterized by plaques in the brain of insoluble protein aggregations. Paradoxically, even toxins produced by the most pathogenic microorganisms, such as Botox, have found use in the clinic and industry. This book discusses how many proteins, including interferons and cytokines, can be valuable therapeutics, while still associated with autoimmune diseases, such as psoriasis or lupus erythematosus. Key Features: Shows why gluten proteins are different from all others and how this can account for symptoms throughout the body in those with celiac disease Illustrates that "multiple allergy syndrome" is not only real and related to similar allergens in extremely different plants Discusses the difficulties in using human proteins and cytokines as therapeutics Presents examples of how protein aggregates are vital to many physiological processes but also characterize renal and neurological syndromes Shows examples of protein toxins that have medical and industrial uses Related Titles Almeida, P. Proteins: Concepts in Biochemistry (ISBN 978-0-8153-4502-2) Williamson, M. How Proteins Work (ISBN 978-0-8153-4446-9) Lopata, A. L., ed. Food Allergy: Molecular and Clinical Practice (ISBN 978-0-3677-8199-6) Wegrzyn, R. D. & A. S. Rudolph, eds. Alzheimer’s Disease: Targets of New Clinical Diagnostic and Therapeutic Strategies (ISBN 978-1-4398-2708-6)
Book Synopsis Conditionally Toxic Proteins by : Catherine H. Schein
Download or read book Conditionally Toxic Proteins written by Catherine H. Schein and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Human health depends upon access to high-quality proteins for our diet and pharmaceutical use. This book deals with the nature of toxicity as it applies to proteins in food and drugs. Many proteins, such as glutens and allergens, are valuable food sources but toxic for sensitized individuals. Even proteins produced in the human body can become toxic through mutation or aggregation. For example, Alzheimer and Huntington disease are characterized by plaques in the brain of insoluble protein aggregations. Paradoxically, even toxins produced by the most pathogenic microorganisms, such as Botox, have found use in the clinic and industry. This book discusses how many proteins, including interferons and cytokines, can be valuable therapeutics, and associated with autoimmune diseases, such as psoriasis or lupus erythematosus"--
Book Synopsis Bacterial Protein Toxins by : K. Aktories
Download or read book Bacterial Protein Toxins written by K. Aktories and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 713 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years remarkable progress has been accomplished with respect to our knowledge about bacterial protein toxins. This refers especially to structural aspects of protein toxins but also holds true for genetics, molecular biology and biochemical mechanisms underlying the action of toxins. This volume covers the very current and exciting aspects of up-to-date bacterial toxicology and comprehensively reviews the most important bacterial protein toxins such as the intracellular acting toxins which exhibit enzyme activity, as well as those toxins that interact with cell plasma membranes by damaging the membranes (pore formation) or stimulating cell receptors (superantigens). This is the most current reference work on these important bacterial protein toxins, which are presented from the point of view of different disciplines such as pharmacology, microbiology, cell biology and protein chemistry.
Book Synopsis Evolutionary Biology by : Pierre Pontarotti
Download or read book Evolutionary Biology written by Pierre Pontarotti and published by Springer. This book was released on 2016-09-20 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents selected contributions to the 19th Evolutionary Biology Meeting, which took place in September 2015 in Marseille. It consists of 22 chapters, which are grouped in four sections: · Convergent Evolution · Evolution of Complex Traits · Concepts · Methods The annual Evolutionary Biology Meetings in Marseille serve to gather leading evolutionary biologists and other scientists using evolutionary biology concepts, e.g for medical research, to promote the exchange of ideas and to encourage interdisciplinary collaborations. Offering an up-to-date overview of recent findings in the field of evolutionary biology, this book is an invaluable source of information for scientists, teachers and advanced students.
Book Synopsis Conditional Mutagenesis: An Approach to Disease Models by : Robert Feil
Download or read book Conditional Mutagenesis: An Approach to Disease Models written by Robert Feil and published by Springer Science & Business Media. This book was released on 2007-02-01 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, leading experts provide timely and comprehensive information on methods for conditional mutagenesis in the mouse and their application to model human physiology and pathophysiology. The book illustrates how sophisticated genetic manipulations of the mouse genome are employed to model human diseases and to identify underlying molecular mechanisms. In addition, it considers the development of new drugs to treat human diseases.
Download or read book Plasmids written by Marcelo E. Tolmasky and published by John Wiley & Sons. This book was released on 2020-07-24 with total page 720 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explore the remarkable discoveries in the rapidly expanding field of plasmid biology Plasmids are integral to biological research as models for innumerable mechanisms of living cells, as tools for creating the most diverse therapies, and as crucial helpers for understanding the dissemination of microbial populations. Their role in virulence and antibiotic resistance, together with the generalization of "omics" disciplines, has recently ignited a new wave of interest in plasmids. This comprehensive book contains a series of expertly written chapters focused on plasmid biology, mechanistic details of plasmid function, and the increased utilization of plasmids in biotechnology and pharmacology that has occurred in the past decade. Plasmids: Biology and Impact in Biotechnology and Discovery serves as an invaluable reference for researchers in the wide range of fields and disciplines that utilize plasmids and can also be used as a textbook for upper-level undergraduate and graduate courses in biotechnology and molecular biology.
Book Synopsis Encyclopedia of Microbiology by : Thomas M. Schmidt
Download or read book Encyclopedia of Microbiology written by Thomas M. Schmidt and published by Academic Press. This book was released on 2019-09-11 with total page 3248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of Microbiology, Fourth Edition, Five Volume Set gathers both basic and applied dimensions in this dynamic field that includes virtually all environments on Earth. This range attracts a growing number of cross-disciplinary studies, which the encyclopedia makes available to readers from diverse educational backgrounds. The new edition builds on the solid foundation established in earlier versions, adding new material that reflects recent advances in the field. New focus areas include `Animal and Plant Microbiomes’ and ‘Global Impact of Microbes`. The thematic organization of the work allows users to focus on specific areas, e.g., for didactical purposes, while also browsing for topics in different areas. Offers an up-to-date and authoritative resource that covers the entire field of microbiology, from basic principles, to applied technologies Provides an organic overview that is useful to academic teachers and scientists from different backgrounds Includes chapters that are enriched with figures and graphs, and that can be easily consulted in isolation to find fundamental definitions and concepts
Book Synopsis Conditional Control of Protein Function by : Lystranne Alysia Maynard
Download or read book Conditional Control of Protein Function written by Lystranne Alysia Maynard and published by . This book was released on 2006 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Parkinson's Disease by : Richard Nass
Download or read book Parkinson's Disease written by Richard Nass and published by Elsevier. This book was released on 2011-04-28 with total page 687 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parkinson's disease is the second most prevalent neurodegenerative disease and is characterized by the irreversible loss of dopamine neurons. Despite its high prevalence in society and many decades of research, the origin of the pathogenesis and the molecular determinants involved in the disorder has remained elusive. Confounding this issue is the lack of experimental models that completely recapitulate the disease state. The identification of a number of genes thought to play a role in the cell death, and development of both toxin and genetic models to explore the function of the genes both in unaffected and diseased cells are now providing new insights into the molecular basis of the neurodegeneration, as well as therapeutic approaches. In this reference, we will describe the advances and the advantages that various invertebrates, cell culture, rodents, and mammals provide in the identification of the molecular components and mechanisms involved in the cell death, and outline the opportunities that these systems provide in drug discovery. - Comprehensive and critical assessment of the utility of various model systems to identify the molecular components and pathways involved in Parkinson's disease - Describes the power of toxin and genetic models to identify novel therapeutic targets and compounds that can be used in PD - Current overviews of current status of PD research and discovery from bench-to-bedside - Provides novel insights and views on where the future of PD research may lead - Provides a powerful teaching tool and template to explore the utility of model systems to identify molecular pathways, molecular targets, and therapeutics that are applicable to a variety of neurological diseases
Download or read book Bt Resistance written by Mario Soberon and published by CABI. This book was released on 2015-04-24 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bacillus thuringiensis (Bt) bacteria use Cry proteins to kill their insect larval hosts. The expression of certain Cry toxins in transgenic crops has been widely used to achieve efficient control of insect pests. This book describes the use of Bt crops and the emerging problem of resistance, recent progress in understanding the mechanism of action of Bt toxins, different resistance mechanisms and strategies to cope with resistance in the field. It describes resistant insects found in the field in different countries, particularly in the developing world, and ways to counter resistance such as gene stalking, refuges, modified toxins and gene discovery of novel toxins with different mode of action.
Book Synopsis Advances in Malaria Research by : Deepak Gaur
Download or read book Advances in Malaria Research written by Deepak Gaur and published by John Wiley & Sons. This book was released on 2016-11-30 with total page 615 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thoroughly reviews our current understanding of malarial biology Explores the subject with insights from post-genomic technologies Looks broadly at the disease, vectors of infection, and treatment and prevention strategies A timely publication with chapters written by global researchers leaders
Book Synopsis Emerging Roles for Hippocampal Adult Neural Stem Cells in Memory by : Aaron R. Friedman
Download or read book Emerging Roles for Hippocampal Adult Neural Stem Cells in Memory written by Aaron R. Friedman and published by Biota Publishing. This book was released on 2013-12-01 with total page 41 pages. Available in PDF, EPUB and Kindle. Book excerpt: Approximately 50 years ago, newly generated neurons were discovered in the adult hippocampus of the rat brain. This discovery contradicted a key principle in mammalian developmental neurobiology—that all the neurons of the brain are made during early development—and led to intensive study to find out how new neurons are generated and how the process of neurogenesis is regulated. Since then, a unique population of adult neural stem cells has been identified, and many of the molecular pathways that control their self-renewal, proliferation, and cell fate have been elucidated. However, the presence of new neurons in the adult brain also poses intriguing functional questions that have, as yet, gone largely unanswered. Why is adult neurogenesis restricted to select brain regions? What functional benefit do these new cells confer? Indeed, the field of adult neurogenesis offers a unique opportunity to study naïve neurons as they mature, form connections with existing neural networks, and begin to participate in information processing. We review the basics of adult NSC biology and the maturation of newborn neurons. In particular, we focus on new neurons in the hippocampus, and how they contribute to function in this key memory-forming structure of the brain.
Book Synopsis The Comprehensive Sourcebook of Bacterial Protein Toxins by : Joseph E. Alouf
Download or read book The Comprehensive Sourcebook of Bacterial Protein Toxins written by Joseph E. Alouf and published by Elsevier. This book was released on 2005-12-20 with total page 1072 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the major achievements and discoveries relevant to bacterial protein toxins since the turn of the new century illustrated by the discovery of more than fifty novel toxins (many of them identified through genome screening). The establishment of the three-dimensional crystal structure of more than 20 toxins during the same period offers deeper knowledge of structure-activity relationships and provides a framework to understand how toxins recognize receptors, penetrate membranes and interact with and modify intracellular substrates. - Edited by two of the most highly regarded experts in the field from the Institut Pasteur, France - 14 brand new chapters dedicated to coverage of historical and general aspects of toxinology - Includes the major toxins of both basic and clinical interest are described in depth - Details applied aspects of toxins such as therapy, vaccinology, and toolkits in cell biology - Evolutionary and functional aspects of bacterial toxins evaluated and summarized - Toxin applications in cell biology presented - Therapy (cancer therapy, dystonias) discussed - Vaccines (native and genetically engineered vaccines) featured - Toxins discussed as biological weapons, comprising chapters on anthrax, diphtheria, ricin etc.
Book Synopsis Biology of Negative Strand RNA Viruses: The Power of Reverse Genetics by : Yoshihiro Kawaoka
Download or read book Biology of Negative Strand RNA Viruses: The Power of Reverse Genetics written by Yoshihiro Kawaoka and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Negative-strand RNA viruses, so named because of the polarity of their genomic RNA to mRNA, include important human and non-human pathogens. This volume covers major advances in reverse genetics techniques over the past decade, state-of-the-art basic science and the clinical implications of experimental findings. This should rekindle interest in negative-strand RNA viruses among readers, including those in other disciplines, leading to further progress in understanding these important viruses and in developing effective measures of control.
Download or read book Immunotoxins written by Arthur E. Frankel and published by Springer Science & Business Media. This book was released on 1988-05-31 with total page 606 pages. Available in PDF, EPUB and Kindle. Book excerpt: Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good indepth reviews of cancer topics, and published symposium lectures are often the best overviews available. Un fortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes which aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up-to-date, easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion. First, by dividing the oncology literature into specific subdivisions such as lung cancer, genitourinary cancer, pediatric oncology, etc. Second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.
Book Synopsis The Role of Protein and Amino Acids in Sustaining and Enhancing Performance by : Institute of Medicine
Download or read book The Role of Protein and Amino Acids in Sustaining and Enhancing Performance written by Institute of Medicine and published by National Academies Press. This book was released on 1999-09-15 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is a commonly held belief that athletes, particularly body builders, have greater requirements for dietary protein than sedentary individuals. However, the evidence in support of this contention is controversial. This book is the latest in a series of publications designed to inform both civilian and military scientists and personnel about issues related to nutrition and military service. Among the many other stressors they experience, soldiers face unique nutritional demands during combat. Of particular concern is the role that dietary protein might play in controlling muscle mass and strength, response to injury and infection, and cognitive performance. The first part of the book contains the committee's summary of the workshop, responses to the Army's questions, conclusions, and recommendations. The remainder of the book contains papers contributed by speakers at the workshop on such topics as, the effects of aging and hormones on regulation of muscle mass and function, alterations in protein metabolism due to the stress of injury or infection, the role of individual amino acids, the components of proteins, as neurotransmitters, hormones, and modulators of various physiological processes, and the efficacy and safety considerations associated with dietary supplements aimed at enhancing performance.
Book Synopsis The Chemistry of Food by : Jan Velisek
Download or read book The Chemistry of Food written by Jan Velisek and published by John Wiley & Sons. This book was released on 2020-07-29 with total page 1204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Wiley's landmark food chemistry textbook that provides an all-in-one reference book, revised and updated The revised second edition of The Chemistry of Food provides a comprehensive overview of important compounds constituting of food and raw materials for food production. The authors highlight food’s structural features, chemical reactions, organoleptic properties, nutritional, and toxicological importance. The updated second edition reflects the thousands of new scientific papers concerning food chemistry and related disciplines that have been published since 2012. Recent discoveries deal with existing as well as new food constituents, their origin, reactivity, degradation, reactions with other compounds, organoleptic, biological, and other important properties. The second edition extends and supplements the current knowledge and presents new facts about chemistry, legislation, nutrition, and food safety. The main chapters of the book explore the chemical structure of substances and subchapters examine the properties or uses. This important resource: • Offers in a single volume an updated text dealing with food chemistry • Contains complete and fully up-to-date information on food chemistry, from structural features to applications • Features several visual aids including reaction schemes, diagrams and tables, and nearly 2,000 chemical structures • Written by internationally recognized authors on food chemistry Written for upper-level students, lecturers, researchers and the food industry, the revised second edition of The Chemistry of Food is a quick reference for almost anything food-related as pertains to its chemical properties and applications.
