Computational Discovery Of Phenotype Related Biochemical Processes For Engineering

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Computational Discovery of Phenotype Related Biochemical Processes for Engineering

Author : Andrea M. Rocha
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (778 download)

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Book Synopsis Computational Discovery of Phenotype Related Biochemical Processes for Engineering by : Andrea M. Rocha

Download or read book Computational Discovery of Phenotype Related Biochemical Processes for Engineering written by Andrea M. Rocha and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Application of bioengineering technologies for enhanced biological hydrogen production is a promising approach that may play a vital role in sustainable energy. Due to the ability of several naturally occurring microorganisms to generate hydrogen through varying metabolic processes, biological hydrogen has become an attractive alternative energy and fuel source. One area of particular interest is the production of biological hydrogen in organically-rich engineered systems, such as those associated with waste treatment. Despite the potential for high energy yields, hydrogen yields generated by bacteria in waste systems are often limited due to a focus on microbial utilization of organic material towards cellular growth rather than production of biogas. To address this concern and to improve upon current technological applications, metabolic engineering approaches may be applied to known hydrogen producing organisms. However, to successfully modify metabolic pathways, full understanding of metabolic networks involved in expression of microbial traits in hydrogen producing organisms is necessary. Because microbial communities associated with hydrogen production are capable of exhibiting a number of phenotypes, attempts to apply metabolic engineering concepts have been restricted due to limited information regarding complex metabolic processes and regulatory networks involved in expression of microbial traits associated with biohydrogen production. To bridge this gap, this dissertation focuses on identification of phenotype-related biochemical processes within sets of phenotype-expressing organisms. Specifically, through co-development and application of evolutionary genome-scale phenotype-centric comparative network analysis tools, metabolic and cellular components related to three phenotypes (i.e., dark fermentative, hydrogen production and acid tolerance) were identified.

Genotype to Phenotype

Author : J. J. Goodship
Publisher : Garland Science
ISBN 13 : 1135322929
Total Pages : 247 pages
Book Rating : 4.1/5 (353 download)

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Book Synopsis Genotype to Phenotype by : J. J. Goodship

Download or read book Genotype to Phenotype written by J. J. Goodship and published by Garland Science. This book was released on 2003-12-16 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new edition builds on the success of the first by reviewing the increased understanding of the mechanisms of gene action in humans, focusing particularly on those derived from the study of genetic diseases. It deals mainly with the fundamental aspects of gene arrangement and expression rather than mutation. As well as updating and revising material from the first edition, it covers methods of exploring gene function and contains a range of chapters on specific systems which raise issues of special interest such as imprinting or homologous genes within clusters.

Evolution of Translational Omics

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309224187
Total Pages : 354 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Evolution of Translational Omics by : Institute of Medicine

Download or read book Evolution of Translational Omics written by Institute of Medicine and published by National Academies Press. This book was released on 2012-09-13 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.

XIV Mediterranean Conference on Medical and Biological Engineering and Computing 2016

Author : Efthyvoulos Kyriacou
Publisher : Springer
ISBN 13 : 3319327038
Total Pages : 1384 pages
Book Rating : 4.3/5 (193 download)

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Book Synopsis XIV Mediterranean Conference on Medical and Biological Engineering and Computing 2016 by : Efthyvoulos Kyriacou

Download or read book XIV Mediterranean Conference on Medical and Biological Engineering and Computing 2016 written by Efthyvoulos Kyriacou and published by Springer. This book was released on 2016-03-31 with total page 1384 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents the proceedings of Medicon 2016, held in Paphos, Cyprus. Medicon 2016 is the XIV in the series of regional meetings of the International Federation of Medical and Biological Engineering (IFMBE) in the Mediterranean. The goal of Medicon 2016 is to provide updated information on the state of the art on Medical and Biological Engineering and Computing under the main theme “Systems Medicine for the Delivery of Better Healthcare Services”. Medical and Biological Engineering and Computing cover complementary disciplines that hold great promise for the advancement of research and development in complex medical and biological systems. Research and development in these areas are impacting the science and technology by advancing fundamental concepts in translational medicine, by helping us understand human physiology and function at multiple levels, by improving tools and techniques for the detection, prevention and treatment of disease. Medicon 2016 provides a common platform for the cross fertilization of ideas, and to help shape knowledge and scientific achievements by bridging complementary disciplines into an interactive and attractive forum under the special theme of the conference that is Systems Medicine for the Delivery of Better Healthcare Services. The programme consists of some 290 invited and submitted papers on new developments around the Conference theme, presented in 3 plenary sessions, 29 parallel scientific sessions and 12 special sessions.

Catalyzing Inquiry at the Interface of Computing and Biology

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 030909612X
Total Pages : 469 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Catalyzing Inquiry at the Interface of Computing and Biology by : National Research Council

Download or read book Catalyzing Inquiry at the Interface of Computing and Biology written by National Research Council and published by National Academies Press. This book was released on 2006-01-01 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in computer science and technology and in biology over the last several years have opened up the possibility for computing to help answer fundamental questions in biology and for biology to help with new approaches to computing. Making the most of the research opportunities at the interface of computing and biology requires the active participation of people from both fields. While past attempts have been made in this direction, circumstances today appear to be much more favorable for progress. To help take advantage of these opportunities, this study was requested of the NRC by the National Science Foundation, the Department of Defense, the National Institutes of Health, and the Department of Energy. The report provides the basis for establishing cross-disciplinary collaboration between biology and computing including an analysis of potential impediments and strategies for overcoming them. The report also presents a wealth of examples that should encourage students in the biological sciences to look for ways to enable them to be more effective users of computing in their studies.

Multimodal Brain Image Analysis and Mathematical Foundations of Computational Anatomy

Author : Dajiang Zhu
Publisher : Springer Nature
ISBN 13 : 3030332268
Total Pages : 230 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Multimodal Brain Image Analysis and Mathematical Foundations of Computational Anatomy by : Dajiang Zhu

Download or read book Multimodal Brain Image Analysis and Mathematical Foundations of Computational Anatomy written by Dajiang Zhu and published by Springer Nature. This book was released on 2019-10-10 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed joint proceedings of the 4th International Workshop on Multimodal Brain Image Analysis, MBAI 2019, and the 7th International Workshop on Mathematical Foundations of Computational Anatomy, MFCA 2019, held in conjunction with the 22nd International Conference on Medical Imaging and Computer-Assisted Intervention, MICCAI 2019, in Shenzhen, China, in October 2019. The 16 full papers presented at MBAI 2019 and the 7 full papers presented at MFCA 2019 were carefully reviewed and selected. The MBAI papers intend to move forward the state of the art in multimodal brain image analysis, in terms of analysis methodologies, algorithms, software systems, validation approaches, benchmark datasets, neuroscience, and clinical applications. The MFCA papers are devoted to statistical and geometrical methods for modeling the variability of biological shapes. The goal is to foster the interactions between the mathematical community around shapes and the MICCAI community around computational anatomy applications.

Reverse Chemical Genetics

Author : Hisashi Koga
Publisher : Methods in Molecular Biology
ISBN 13 :
Total Pages : 292 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Reverse Chemical Genetics by : Hisashi Koga

Download or read book Reverse Chemical Genetics written by Hisashi Koga and published by Methods in Molecular Biology. This book was released on 2009-09-24 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book orchestrates the differential fields of technology in order to create a new era of the study of reverse chemical genetics. It introduces fundamental resources as well as the modification of these resources by recent molecular technologies.

Algorithms in Computational Molecular Biology

Author : Mourad Elloumi
Publisher : John Wiley & Sons
ISBN 13 : 1118101987
Total Pages : 1027 pages
Book Rating : 4.1/5 (181 download)

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Book Synopsis Algorithms in Computational Molecular Biology by : Mourad Elloumi

Download or read book Algorithms in Computational Molecular Biology written by Mourad Elloumi and published by John Wiley & Sons. This book was released on 2011-04-04 with total page 1027 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book represents the most comprehensive and up-to-date collection of information on the topic of computational molecular biology. Bringing the most recent research into the forefront of discussion, Algorithms in Computational Molecular Biology studies the most important and useful algorithms currently being used in the field, and provides related problems. It also succeeds where other titles have failed, in offering a wide range of information from the introductory fundamentals right up to the latest, most advanced levels of study.

The Science and Applications of Synthetic and Systems Biology

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309219396
Total Pages : 570 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis The Science and Applications of Synthetic and Systems Biology by : Institute of Medicine

Download or read book The Science and Applications of Synthetic and Systems Biology written by Institute of Medicine and published by National Academies Press. This book was released on 2011-12-30 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.

Bioinformatics and Biomarker Discovery

Author : Francisco Azuaje
Publisher : John Wiley & Sons
ISBN 13 : 111996430X
Total Pages : 206 pages
Book Rating : 4.1/5 (199 download)

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Book Synopsis Bioinformatics and Biomarker Discovery by : Francisco Azuaje

Download or read book Bioinformatics and Biomarker Discovery written by Francisco Azuaje and published by John Wiley & Sons. This book was released on 2011-08-24 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is designed to introduce biologists, clinicians and computational researchers to fundamental data analysis principles, techniques and tools for supporting the discovery of biomarkers and the implementation of diagnostic/prognostic systems. The focus of the book is on how fundamental statistical and data mining approaches can support biomarker discovery and evaluation, emphasising applications based on different types of "omic" data. The book also discusses design factors, requirements and techniques for disease screening, diagnostic and prognostic applications. Readers are provided with the knowledge needed to assess the requirements, computational approaches and outputs in disease biomarker research. Commentaries from guest experts are also included, containing detailed discussions of methodologies and applications based on specific types of "omic" data, as well as their integration. Covers the main range of data sources currently used for biomarker discovery Covers the main range of data sources currently used for biomarker discovery Puts emphasis on concepts, design principles and methodologies that can be extended or tailored to more specific applications Offers principles and methods for assessing the bioinformatic/biostatistic limitations, strengths and challenges in biomarker discovery studies Discusses systems biology approaches and applications Includes expert chapter commentaries to further discuss relevance of techniques, summarize biological/clinical implications and provide alternative interpretations

Bioinformatics and Biomedical Engineering

Author : Ignacio Rojas
Publisher : Springer
ISBN 13 : 3319787233
Total Pages : 571 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Bioinformatics and Biomedical Engineering by : Ignacio Rojas

Download or read book Bioinformatics and Biomedical Engineering written by Ignacio Rojas and published by Springer. This book was released on 2018-04-19 with total page 571 pages. Available in PDF, EPUB and Kindle. Book excerpt: This two-volume set LNBI 10813 and LNBI 10814 constitutes the proceedings of the 6th International Work-Conference on Bioinformatics and Biomedical Engineering, IWBBIO 2018, held in Granada, Spain, in April 2018.The 88 regular papers presented were carefully reviewed and selected from 273 submissions. The scope of the conference spans the following areas: bioinformatics for healthcare and diseases; bioinformatics tools to integrate omics dataset and address biological question; challenges and advances in measurement and self-parametrization of complex biological systems; computational genomics; computational proteomics; computational systems for modelling biological processes; drug delivery system design aided by mathematical modelling and experiments; generation, management and biological insights from big data; high-throughput bioinformatic tools for medical genomics; next generation sequencing and sequence analysis; interpretable models in biomedicine and bioinformatics; little-big data. Reducing the complexity and facing uncertainty of highly underdetermined phenotype prediction problems; biomedical engineering; biomedical image analysis; biomedical signal analysis; challenges in smart and wearable sensor design for mobile health; and healthcare and diseases.

Systems Genetics

Author : Florian Markowetz
Publisher : Cambridge University Press
ISBN 13 : 131638098X
Total Pages : 287 pages
Book Rating : 4.3/5 (163 download)

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Book Synopsis Systems Genetics by : Florian Markowetz

Download or read book Systems Genetics written by Florian Markowetz and published by Cambridge University Press. This book was released on 2015-07-02 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: Whereas genetic studies have traditionally focused on explaining heritance of single traits and their phenotypes, recent technological advances have made it possible to comprehensively dissect the genetic architecture of complex traits and quantify how genes interact to shape phenotypes. This exciting new area has been termed systems genetics and is born out of a synthesis of multiple fields, integrating a range of approaches and exploiting our increased ability to obtain quantitative and detailed measurements on a broad spectrum of phenotypes. Gathering the contributions of leading scientists, both computational and experimental, this book shows how experimental perturbations can help us to understand the link between genotype and phenotype. A snapshot of current research activity and state-of-the-art approaches to systems genetics are provided, including work from model organisms such as Saccharomyces cerevisiae and Drosophila melanogaster, as well as from human studies.

XIII Mediterranean Conference on Medical and Biological Engineering and Computing 2013

Author : Laura M. Roa Romero
Publisher : Springer Science & Business Media
ISBN 13 : 3319008463
Total Pages : 1978 pages
Book Rating : 4.3/5 (19 download)

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Book Synopsis XIII Mediterranean Conference on Medical and Biological Engineering and Computing 2013 by : Laura M. Roa Romero

Download or read book XIII Mediterranean Conference on Medical and Biological Engineering and Computing 2013 written by Laura M. Roa Romero and published by Springer Science & Business Media. This book was released on 2013-10-01 with total page 1978 pages. Available in PDF, EPUB and Kindle. Book excerpt: The general theme of MEDICON 2013 is "Research and Development of Technology for Sustainable Healthcare". This decade is being characterized by the appearance and use of emergent technologies under development. This situation has produced a tremendous impact on Medicine and Biology from which it is expected an unparalleled evolution in these disciplines towards novel concept and practices. The consequence will be a significant improvement in health care and well-fare, i.e. the shift from a reactive medicine to a preventive medicine. This shift implies that the citizen will play an important role in the healthcare delivery process, what requires a comprehensive and personalized assistance. In this context, society will meet emerging media, incorporated to all objects, capable of providing a seamless, adaptive, anticipatory, unobtrusive and pervasive assistance. The challenge will be to remove current barriers related to the lack of knowledge required to produce new opportunities for all the society, while new paradigms are created for this inclusive society to be socially and economically sustainable, and respectful with the environment. In this way, these proceedings focus on the convergence of biomedical engineering topics ranging from formalized theory through experimental science and technological development to practical clinical applications.

10th International Conference on Practical Applications of Computational Biology & Bioinformatics

Author : Mohd Saberi Mohamad
Publisher : Springer
ISBN 13 : 3319401262
Total Pages : 217 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis 10th International Conference on Practical Applications of Computational Biology & Bioinformatics by : Mohd Saberi Mohamad

Download or read book 10th International Conference on Practical Applications of Computational Biology & Bioinformatics written by Mohd Saberi Mohamad and published by Springer. This book was released on 2016-05-31 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological and biomedical research are increasingly driven by experimental techniques that challenge our ability to analyse, process and extract meaningful knowledge from the underlying data. The impressive capabilities of next generation sequencing technologies, together with novel and ever evolving distinct types of omics data technologies, have put an increasingly complex set of challenges for the growing fields of Bioinformatics and Computational Biology. The analysis of the datasets produced and their integration call for new algorithms and approaches from fields such as Databases, Statistics, Data Mining, Machine Learning, Optimization, Computer Science and Artificial Intelligence. Clearly, Biology is more and more a science of information requiring tools from the computational sciences. In the last few years, we have seen the surge of a new generation of interdisciplinary scientists that have a strong background in the biological and computational sciences. In this context, the interaction of researchers from different scientific fields is, more than ever, of foremost importance boosting the research efforts in the field and contributing to the education of a new generation of Bioinformatics scientists. PACBB‘16 hopes to contribute to this effort promoting this fruitful interaction. PACBB'16 technical program included 21 papers spanning many different sub-fields in Bioinformatics and Computational Biology. Therefore, the conference will certainly promote the interaction of scientists from diverse research groups and with a distinct background (computer scientists, mathematicians, biologists). The scientific content will certainly be challenging and will promote the improvement of the work being developed by each of the participants.

Proceedings of The International Conference on Inter Disciplinary Research in Engineering and Technology 2015

Author : Kokula Krishna Hari Kunasekaran
Publisher : Association of Scientists, Developers and Faculties (ASDF)
ISBN 13 : 8192974251
Total Pages : 273 pages
Book Rating : 4.1/5 (929 download)

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Book Synopsis Proceedings of The International Conference on Inter Disciplinary Research in Engineering and Technology 2015 by : Kokula Krishna Hari Kunasekaran

Download or read book Proceedings of The International Conference on Inter Disciplinary Research in Engineering and Technology 2015 written by Kokula Krishna Hari Kunasekaran and published by Association of Scientists, Developers and Faculties (ASDF). This book was released on 2015-04-30 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Welcome to the International Conference on Inter Disciplinary Research in Engineering and Technology (ICIDRET) 2015 in DSIIDC, Government of NCT, New Delhi, India, Asia on 29 – 30 April, 2015. If this is your first time to New Delhi, you need to look on more objects which you could never forget in your lifetime. There is much to see and experience at The National Capital of Republic of India. The concept of Inter Disciplinary research was a topic of focus by various departments across the Engineering and Technology area. Flushing with major areas, this ICIDRET ’15 has addressed the E&T areas like Mechanical Engineering, Civil Engineering, Electrical Engineering, Bio-Technology, Bio-Engineering, Bio-Medical, Computer Science, Electronics & Communication Engineering, Management and Textile Engineering. This focus has brought a new insight on the learning methodologies and the terminology of accepting the cross definition of engineering and the research into it. We invite you to join us in this inspiring conversation. I am pretty sure that this conference would indulge the information from the various parts of the world and could coin as a global research gathering. With more and more researchers coming into ICIDRET, this event would be as an annual event. This conference is sure that, this edition and the future edition will serve as a wise platform for the people to come with better research methodologies integrating each and every social component globally. If there would have been a thought of not integrating the RJ45 and few pieces of metal / plastic along with a PCB, today we could haven’t used the telephones and mobile phones. With an ear-mark inspiration and constant support from the Global President Dr. S. Prithiv Rajan, ASDF International President Dr. P. Anbuoli, this publication stands in front of your eyes, without them this would haven’t been possible in a very shortest span. Finally, I thank my family, friends, students and colleagues for their constant encouragement and support for making this type of conference. -- Kokula Krishna Hari K Editor-in-Chief www.kokulakrishnaharik.in

Collaborative Computational Technologies for Biomedical Research

Author : Sean Ekins
Publisher : John Wiley & Sons
ISBN 13 : 1118026020
Total Pages : 462 pages
Book Rating : 4.1/5 (18 download)

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Book Synopsis Collaborative Computational Technologies for Biomedical Research by : Sean Ekins

Download or read book Collaborative Computational Technologies for Biomedical Research written by Sean Ekins and published by John Wiley & Sons. This book was released on 2011-08-04 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods, Processes, and Tools for Collaboration "The time has come to fundamentally rethink how we handle the building of knowledge in biomedical sciences today. This book describes how the computational sciences have transformed into being a key knowledge broker, able to integrate and operate across divergent data types." Bryn Williams-Jones, Associate Research Fellow, Pfizer The pharmaceutical industry utilizes an extended network of partner organizations in order to discover and develop new drugs, however there is currently little guidance for managing information and resources across collaborations. Featuring contributions from the leading experts in a range of industries, Collaborative Computational Technologies for Biomedical Research provides information that will help organizations make critical decisions about managing partnerships, including: Serving as a user manual for collaborations Tackling real problems from both human collaborative and data and informatics perspectives Providing case histories of biomedical collaborations and technology-specific chapters that balance technological depth with accessibility for the non-specialist reader A must-read for anyone working in the pharmaceuticals industry or academia, this book marks a major step towards widespread collaboration facilitated by computational technologies.

Engineering Complex Phenotypes in Industrial Strains

Author : Ranjan Patnaik
Publisher : John Wiley & Sons
ISBN 13 : 1118433041
Total Pages : 315 pages
Book Rating : 4.1/5 (184 download)

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Book Synopsis Engineering Complex Phenotypes in Industrial Strains by : Ranjan Patnaik

Download or read book Engineering Complex Phenotypes in Industrial Strains written by Ranjan Patnaik and published by John Wiley & Sons. This book was released on 2012-09-19 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights current trends and developments in the area of engineering strains. The book details the current and future tools used in the production of bulk chemicals and biofuels from renewable biomass using green technologies. Complex phenotypes are traits in a microbe that requires multiple genetic changes to be modulated simultaneously in the microorganism’s DNA. Knowing what those genetic changes are for a given trait and how to make those changes in the most efficient way forms the motivation behind writing this book. This book explains the newer tools to develop and enable engineered strains at time scales much faster that the natural evolution process so that we can increase a cells' production of a certain substance, increase process productivity, and extend metabolic capability. This book provides a one stop platform of reference for practicing researchers in the field of industrial biotechnology. This book also explains that the commercial success of a process that uses microbial catalysts over platforms that use chemical catalysts and fossil fuels depends on the time it takes to engineer these microbes to perform the desired reaction under harsh manufacturing conditions and at rates that meets the criteria for economic feasibility.