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Author : Martin Adiels
Publisher :
ISBN 13 : 9789172915404
Total Pages : 116 pages
Book Rating : 4.9/5 (154 download)
Download or read book Compartmental Models of Lipoprotein Kinetics written by Martin Adiels and published by . This book was released on 2004 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Study Guide Masters Course 1 written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Mones Berman
Publisher : Elsevier
ISBN 13 : 032314764X
Total Pages : 511 pages
Book Rating : 4.3/5 (231 download)
Download or read book Lipoprotein Kinetics and Modeling written by Mones Berman and published by Elsevier. This book was released on 2012-12-02 with total page 511 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lipoprotein Kinetics and Modeling contains some of the papers presented at a conference on the analysis and modeling of lipoprotein kinetic data held in Phoenix, Arizona. Contributions from both theorists and experimentalists who attended the conference focus on the developments in the use of mathematical modeling in analyzing the lipoprotein kinetics. The conference highlights the role of kinetic modeling in elucidating the dynamic processes involved in lipoprotein metabolism, the result of improper data analysis that can lead to erroneous physiological interpretations, and the emerging complexities in the lipoprotein system. Organized into six sections comprised of 37 chapters, this book begins with an overview of the theory and applications of kinetic analysis and modeling to lipoproteins. It then discusses the role of kinetic modeling in physiology, the kinetics of apoprotein B in humans, the use of kinetics in investigating the metabolism of very low and intermediate-density lipoproteins, and the models of plasma lipoprotein triglyceride kinetics. It explains the cholesterol kinetics and modeling, the kinetics of high density lipoprotein metabolism in humans, and various techniques for the analysis and modeling of lipoprotein kinetic data such as KABIS (kinetic analysis by interactive simulation) and CONSAM (conversational version of the SAAM modeling program). This book will be of interest to biologists, physiologists, clinical researchers and experts in computer technology and mathematics.
Author : Richard Elroy Neubauer
Publisher :
ISBN 13 :
Total Pages : 212 pages
Book Rating : 4.:/5 (243 download)
Download or read book Compartmental Analysis of Lipoprotein Kinetics written by Richard Elroy Neubauer and published by . This book was released on 1971 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : David H. Anderson
Publisher : Springer Science & Business Media
ISBN 13 : 3642518613
Total Pages : 312 pages
Book Rating : 4.6/5 (425 download)
Download or read book Compartmental Modeling and Tracer Kinetics written by David H. Anderson and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph is concerned with mathematical aspects of compartmental an alysis. In particular, linear models are closely analyzed since they are fully justifiable as an investigative tool in tracer experiments. The objective of the monograph is to bring the reader up to date on some of the current mathematical prob lems of interest in compartmental analysis. This is accomplished by reviewing mathematical developments in the literature, especially over the last 10-15 years, and by presenting some new thoughts and directions for future mathematical research. These notes started as a series of lectures that I gave while visiting with the Division of Applied ~1athematics, Brown University, 1979, and have developed in to this collection of articles aimed at the reader with a beginning graduate level background in mathematics. The text can be used as a self-paced reading course. With this in mind, exercises have been appropriately placed throughout the notes. As an aid in reading the material, the e~d of a proof is indicated by ~. Sub section titles are utilized to make it easier for the reader to skim over detailed material on a first reading and make the entire manuscript somewhat more accessible, especially to nonmathematicians in the biosciences. The preparation of this monograph has been a long task that would not have been completed without the influence of a number of individuals. I am especially indebted to H. T. Banks, J. W. Drane, J. Eisenfe1d, J. A. Jacquez, D. J.
Author : Andrew J. Clifford
Publisher : Springer Science & Business Media
ISBN 13 : 1489919597
Total Pages : 413 pages
Book Rating : 4.4/5 (899 download)
Download or read book Mathematical Modeling in Experimental Nutrition written by Andrew J. Clifford and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nutrients have been recognized as essential for maximum growth, successful reproduction, and infection prevention since the 1940s; since that time, the lion's share of nutrient research has focused on defining their role in these processes. Around 1990, however, a major shift began in the way that researchers viewed some nutrients particularly the vitamins. This shift was motivated by the discovery that modest declines in vitamin nutritional status are associated with an increased risk of ill-health and disease (such as neural tube defects, heart disease, and cancer), especially in those populations or individuals who are genetically predisposed. In an effort to expand upon this new understanding of nutrient action, nutritionists are increasingly turning their focus to the mathematical modeling of nutrient kinetic data. The availability of suitably-tagged (isotope) nutrients (such as B-carotene, vitamin A, folate, among others), sensitive analytical methods to trace them in humans (mass spectrometry and accelerator mass spectrometry), and powerful software (capable of solving and manipulating differential equations efficiently and accurately), has allowed researchers to construct mathematical models aimed at characterizing the dynamic and kinetic behavior of key nutrients in vivo in humans at an unparalleled level of detail.
Author : Rodolfo Paoletti
Publisher : Elsevier
ISBN 13 : 1483215423
Total Pages : 504 pages
Book Rating : 4.4/5 (832 download)
Download or read book Advances in Lipid Research written by Rodolfo Paoletti and published by Elsevier. This book was released on 2014-06-28 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Lipid Research, Volume 21 covers several significant and emerging areas in lipid metabolism, including apolipoprotein metabolism and leukotrienes. This book discusses the role of fat in the functioning of the immune system. Organized into eight chapters, this volume begins with an overview of the metabolism of apolipoprotein B, which is the principal protein of chylomicrons, very low density, and low density lipoprotein. This text then describes the metabolism, biosynthesis, and pharmacology of leukotrienes. Other chapters consider the relation of lipids to immunology and explain the roles played by lipids in the structure and function of yeast membrane. This book discusses as well the general importance in the plant kingdom and the place of some carotenoids in human biology. The final chapter deals with the influence of proteins on configuration and function of reconstituted lipid membranes. This book is a valuable resource for biologists, chemists, biochemists, scientists, and research workers.
Author : Adil Mardinoglu
Publisher : Frontiers Media SA
ISBN 13 : 2889451402
Total Pages : 98 pages
Book Rating : 4.8/5 (894 download)
Download or read book The Impact of Systems Medicine on Human Health and Disease written by Adil Mardinoglu and published by Frontiers Media SA. This book was released on 2017-03-24 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt: Complex disorders including obesity, diabetes, fatty liver disease, cardiovascular disease and cancer are results from a combination of genetic, environmental and lifestyle factors. The prevalence of such disorders has increased dramatically in the last two decades and there is an urgent need for the development of new prognostic tools for the treatment of such diseases. However, this requires a deep understanding of the underlying molecular mechanisms involved in the occurrence of the diseases. With the advances in high throughput technologies, biological components of cells can be measured with a very high resolution and these data can be used for investigating whole systems properties using a network-based approach. Systems medicine provides an integrative platform for studying the interactions between the biological components of the cell using a holistic approach and generating mechanistic explanations for the emergent systems properties. This inter-disciplinary field of study allows for understanding biological processes of cells in health and disease states, gaining new insights into what drives the appearance of the disease and finally identifying proteins and metabolites implicated in human disease. Systems medicine utilizes mathematical approaches to generate models which can be employed for designing new sets of experiments and for mapping the response of the system to perturbations quantitatively. These models as well as the developed tools can accelerate the emergence of personalized medicine which can transform the practice of medicine and offer better targets for drug development with minimum side effects.
Author : Meryl E. Wastney
Publisher : Academic Press
ISBN 13 : 0080926452
Total Pages : 401 pages
Book Rating : 4.0/5 (89 download)
Download or read book Investigating Biological Systems Using Modeling written by Meryl E. Wastney and published by Academic Press. This book was released on 2012-12-02 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: Investigating Biological Systems Using Modeling describes how to apply software to analyze and interpret data from biological systems. It is written for students and investigators in lay person's terms, and will be a useful reference book and textbook on mathematical modeling in the design and interpretation of kinetic studies of biological systems. It describes the mathematical techniques of modeling and kinetic theory, and focuses on practical examples of analyzing data. The book also uses examples from the fields of physiology, biochemistry, nutrition, agriculture, pharmacology, and medicine. Contains practical descriptions of how to analyze kinetic data Provides examples of how to develop and use models Describes several software packages including SAAM/CONSAM Includes software with working models
Author : Giulian Mariant
Publisher : Springer Science & Business Media
ISBN 13 : 1461327938
Total Pages : 409 pages
Book Rating : 4.4/5 (613 download)
Download or read book Pathophysiology of Plasma Protein Metabolism written by Giulian Mariant and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book represents a factual account of the proceedings of an international symposium on the pathophysiology of plasma protein metabolism, which was organised in October 1982 by the Plasmaprotein and Immunology Division of the C.N.R. Institute of Clinical Physiology at the University of Pisa (Italy). Several of the contributors are former members of the International Study Group on Plasma Protein Metabolism, the last meeting of which was held in Turin (Italy) in 1974, under the auspices of the scientific organisation of the same institute. The symposium took the form of a series of lectures, with the main objective of providing a positive contribution to the state of the art of several topics related to the kinetic and pathophysiological factors regulating the synthesis, distribution and degradation of plasma proteins. The first four chapters form a group, each one considering a special aspect of the kinetics of turnover and distribution of plasma proteins in general; particular attention is paid to the recent advances in the field of kinetic modelling, the choice of the best models and the optimisation of the experimental designs. The next seven chapters consider the regulation of synthesis, distribution and catab olism of various classes of plasma proteins including albumin, immunoglobulins, complement fractions and acute-phase proteins. The remaining chapters deal with metabolic studies of various plasma proteins (including tumour markers, coagUlation proteins and lipoproteins) in different disease states, such as malig nancies, coagulative disorders, malnutrition and the extensive group of athero sclerotic cardiovascular diseases.
Author : James L. Hargrove
Publisher : Springer Science & Business Media
ISBN 13 : 1461216443
Total Pages : 316 pages
Book Rating : 4.4/5 (612 download)
Download or read book Dynamic Modeling in the Health Sciences written by James L. Hargrove and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book and CD-ROM package integrates the use of STELLA software into the teaching of health, nutrition and physiology, and may be used on its own in nutrition and physiology courses, or can serve as a supplement to introduce the role that simulation modelling can play. The author presents key subjects ranging from the theory of metabolic control, through weight regulation to bone metabolism, and gives readers the tools to simulate these using the STELLA software. Topics include methods for simulation of gene expression, a multi-stage model of tumour development, theories of ageing, circadian rhythms and physiological time, as well as a model for managing weight loss and preventing obesity.
Author : Zdenek Deyl
Publisher : CRC Press
ISBN 13 : 1351082922
Total Pages : 449 pages
Book Rating : 4.3/5 (51 download)
Download or read book Methods In Animal Physiology written by Zdenek Deyl and published by CRC Press. This book was released on 2019-08-08 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of the present volume was to give an overview over different available methodological approaches. The specialists may, perhaps, object that in their particular field the level of information is superficial. However, let them look at other chapters in which different approaches are discussed and which, surely, will appear less superficial from the more general point of view. We hope, at least, that crucial references can be traced throughout the book that would enable the readers to go in more detail when desired. It can be traced throughout the book that would enable the readers to go in more detail when desired. It was really one of our ideas to draw the survey of possibilities available. If this can stimulate the readers to use ideas to draw the survey of possibilities available. If this can stimulate the readers to use other methods that those they are routinely using the goals will be met.
Author : Andrew J. Krentz
Publisher : Springer
ISBN 13 : 1447149203
Total Pages : 316 pages
Book Rating : 4.4/5 (471 download)
Download or read book Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development written by Andrew J. Krentz and published by Springer. This book was released on 2014-11-29 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: The world is beset by a pandemic of obesity and type 2 diabetes and the need for new drugs is startlingly clear; recent years have seen a huge increase in research activity to fill this gap. The development of new drugs for diabetes and obesity must be founded upon a sound appreciation of the pathophysiology of these common disorders. The dual defects of insulin resistance and impaired insulin secretion are fundamental to the pathogenesis and progression of obesity-associated type 2 diabetes. There is a need to explain how new drugs can counter insulin resistance and insulin deficiency to a broad range of professionals, from clinical scientists active in early (and later) phase drug development to specialist physicians and increasingly primary care doctors who must tailor drug regimens to the individual patient. Clinical research methods for measuring insulin action and insulin secretion have become well-established in proof-of-mechanism studies; however, selection of the best techniques is by no means straightforward. The purpose of the book is to aid the selection of the most appropriate techniques for assessing insulin action, insulin secretion and body composition in humans (with particular reference to new drugs) in phase 1 and 2 studies and aid the understanding of drug effects and non-drug treatment strategies on key biochemical-hormonal defects of obesity and type 2 diabetes. The book will assume a working knowledge of human physiology relating to glucose metabolism and will be of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.
Author : National Heart, Lung, and Blood Institute
Publisher :
ISBN 13 :
Total Pages : 614 pages
Book Rating : 4.:/5 (3 download)
Download or read book Annual Report written by National Heart, Lung, and Blood Institute and published by . This book was released on 1980 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Gerhard Kostner
Publisher : BoD – Books on Demand
ISBN 13 : 9535107739
Total Pages : 778 pages
Book Rating : 4.5/5 (351 download)
Download or read book Lipoproteins written by Gerhard Kostner and published by BoD – Books on Demand. This book was released on 2012-10-03 with total page 778 pages. Available in PDF, EPUB and Kindle. Book excerpt: By typing into databases such as Medline or PubMed the word lipoprotein one gets more than 100.000 hits that highlight the common interest in this topic. It is actually impossible to cover all aspects of lipoprotein structure, function, metabolism and pathophysiology in one issue like the present volume, but attempts have been made to concentrate on topics that are in focus of current lipoprotein research. These topics have been divided into 10 sections. This volume will help new investigators in the field to get acquainted with the general topic of lipoprotein research and will guide scientists interested in this area to emerging new fields.
Author : National Cancer Institute (U.S.). Division of Basic Sciences
Publisher :
ISBN 13 :
Total Pages : 476 pages
Book Rating : 4.:/5 (319 download)
Download or read book Division of Basic Sciences Annual Research Directory written by National Cancer Institute (U.S.). Division of Basic Sciences and published by . This book was released on 1996 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : K. N. Siva Subramanian
Publisher : CRC Press
ISBN 13 : 1000714314
Total Pages : 420 pages
Book Rating : 4.0/5 (7 download)
Download or read book Kinetic Models of Trace Element and Mineral Metabolism During Development written by K. N. Siva Subramanian and published by CRC Press. This book was released on 2020-01-29 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kinetic models are becoming standard tools in the research of biological systems. They are used to represent hypotheses, analyze data, and design experiments to maximize the information obtained from a study. Kinetic Models of Trace Element and Mineral Metabolism During Development describes models for calcium, chromium, copper, iron, iodide, lead, mercury, selenium, zinc, and others in health and disease.
