Clinical Application of Radiolabelled Platelets

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Publisher : Springer Science & Business Media
ISBN 13 : 9400905815
Total Pages : 307 pages
Book Rating : 4.4/5 (9 download)

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Book Synopsis Clinical Application of Radiolabelled Platelets by : C. Kessler

Download or read book Clinical Application of Radiolabelled Platelets written by C. Kessler and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: AIMS OF THE COLOGNE-SYMPOSIUM ON RADIOLABELLED PLATELETS In 1976, M. Thakur et al (1) were the first to publish a paper concerning the in vivo thrombus detection with 111- In-labelled platelets. Previous attempts at scintigraphic thrombus localisation had been disappointing because of the unspecific binding of a number of the isotopes used, as well as the poor labelling efficiency or an insufficient low gamma-emitting property. Because of its physical characteristics (2.8 days half-life, 94% gamma emission) 111 Indium turned out to be the best isotope for platelet kinetic studies as well as for the measurement of platelet incorporation by Thrombi to be used up until now. The lipophile complexes of Ill-In (8-hydroxyquinoline, acetylacetone, tropolone) diffuse passively into the platelets without altering the function or the life span of the platelets. This advantage has let to an increase in the clinical applications of 1211-In labelled platelets. Today, radiolabelled platelets are used for thrombus detection in several different medical areas such as cardiology, nephrology. angiology or neurology. Even though many scientists and hospital doctors now routinely use radiolabelled platelet as a diagnostic tool, there is as yet not a standardized labelling method. In addition to this, there are neither standardized image procedures for the different clinical applications nor an agreement about specificity and sensitivity of the method. In 1983, a symposium on Radiolabelled Cellular Blood Elements was organized by M.Thakur, M.R.Hardeman and M.D.

Radiolabeled Blood Elements

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Publisher : Springer Science & Business Media
ISBN 13 : 1461524628
Total Pages : 354 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Radiolabeled Blood Elements by : J. Martin-Comin

Download or read book Radiolabeled Blood Elements written by J. Martin-Comin and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scintigraphic imaging with radiolabeled blood elements has continued to be a useful diagnostic modality. The major trust of recent investigation has been in simplifying labeling techniques and developing new agents that will label blood elements selectively in vitro. The VI Symposium of the International Society of Radiolabeled Blood Elements was held in Barcelona (Spain) during November 23 to 27, 1992.The conference was sponsored by the NATO Scientific Affairs Division, the USA Department of Energy and the Spanish National Health Service. This monograph comprises articles that represent most of the 85 papers (70 oral and 15 posters) presented during the symposium. The meeting was attended by 110 investigators hailed from 21 countries. Although lllIn-oxine and 99mTc-HMPAO remain the choice agents for labeling blood components for routine applications, there was heavy emphasis on developing new labeling agents that will either simplify the in vitro labeling procedure, or, even better, will label blood components selectively in vivo, by injecting the radioactive agents directly into patients. The degree of success in imaging target lesions in humans by using these agents has been excellent.

National Library of Medicine Current Catalog

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ISBN 13 :
Total Pages : 1032 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis National Library of Medicine Current Catalog by : National Library of Medicine (U.S.)

Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1990 with total page 1032 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Current Catalog

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ISBN 13 :
Total Pages : 1024 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Current Catalog by : National Library of Medicine (U.S.)

Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on with total page 1024 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.

Energy Research Abstracts

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ISBN 13 :
Total Pages : 872 pages
Book Rating : 4.3/5 (129 download)

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Book Synopsis Energy Research Abstracts by :

Download or read book Energy Research Abstracts written by and published by . This book was released on 1988 with total page 872 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Radioiodination: Theory, Practice, and Biomedical Applications

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Publisher : Springer Science & Business Media
ISBN 13 : 1461535085
Total Pages : 627 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Radioiodination: Theory, Practice, and Biomedical Applications by : Mrinal K. Dewanjee

Download or read book Radioiodination: Theory, Practice, and Biomedical Applications written by Mrinal K. Dewanjee and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 627 pages. Available in PDF, EPUB and Kindle. Book excerpt: Among the readily available -emitting radionuclides, the nuclides of iodine have the greatest versatility in labeling both the hydrophilic and the lipophilic compounds that are used in biology and medicine. Biologically important micrmolecules, semimacromolecules, and macromolecules have been identified which, after iodination, almost maintain the same molecular configuration and similar biologic specificity as those of the parent molecules. The multiple techniques for iodination and the clinical use of iodinated products have made possible the present status of the development of diagnostic nuclear medicine. 125r, with a half-life of 60 days, has a crucial role in competitive protein-binding studies. 131r is useful for measuring thyroid uptake, for the diagnosis of thyroid carcinoma and metastasis, and for therapy. 1nr , with a reasonably shorter half-life, is almost ideal for thyroid workup and for a few useful labeled radiopharmaceutical. Although ~c is used more widely in diagnostic procedures, the radionuclides of iodine will always have a major role in biology and medicine. A considerable amount of information is scattered in the literature regarding the chemistry of radioiodination and the mechanism of tracer localization in cells and tissues. Labeled peptides, proteins, and antibodies are extensively used for protein turnover studies, receptor binding and tumor imaging studies, and radioimmunoassay. The general trend in the use of tracers in clinical nuclear medicine has been an evolution from 3H, 14C, 11C, and 13 to 125 , 131 and 123r to ~c and 111rn.

What’s New in Cardiac Imaging?

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Publisher : Springer Science & Business Media
ISBN 13 : 9401124566
Total Pages : 563 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis What’s New in Cardiac Imaging? by : Ernst E. van der Wall

Download or read book What’s New in Cardiac Imaging? written by Ernst E. van der Wall and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 563 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the introduction of myocardial perfusion imaging and radionuclide angiography in the mid-seventies, cardiovascular nuclear medicine has undergone an explosive growth. The use of nuclear cardiology techniques has become one of the cornerstones of the noninvasive assessment of coronary artery disease. In the past 15 years major steps have been made from visual analysis to quantitative analysis, from planar imaging to tomographic imaging, from detection of disease to prognosis, and from separate evaluations of perfusion, metabolism, and function to an integrated assessment of myocardial viability. In recent years many more advances have been made in cardiovascular nuclear imaging, such as the development of new imaging agents, reevaluation of existing procedures, and new clinical applications. This book describes the most recent developments in nuclear cardiology and also addresses new contrast agents in MRI. What's New in Cardiac Imaging will assist the clinical cardiologist, the cardiology fellow, the nuclear medicine physician, and the radiologist in understanding the most recent achievements in clinical cardiovascular nuclear imaging.

Nuclear Medicine in Tropical and Infectious Diseases

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Publisher : Springer Science & Business Media
ISBN 13 : 9781402071911
Total Pages : 282 pages
Book Rating : 4.0/5 (719 download)

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Book Synopsis Nuclear Medicine in Tropical and Infectious Diseases by : Francisco José H.N. Braga

Download or read book Nuclear Medicine in Tropical and Infectious Diseases written by Francisco José H.N. Braga and published by Springer Science & Business Media. This book was released on 2002-09-30 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: "More than half of the world's population is at risk of the tropical diseases malaria, leprosy, schistosomiasis, lymphatic filariasis, onchocerciasis, Chagas' disease, African trypanosomiasis and leishmaniasis and half a billion are infected with at least one of these diseases". J. H. F. Remme, World Health Organisation, 1993. "If it is true that science is not limited by frontiers and all research Institutions then belong to mankind, so it is natural for each Institution to be responsible for the problems of those who live in the geographic area under its influence. There are no specific aspects concerning physical, chemical or philosophical concepts and facts, but specificity does exist concerning geology, sociology and pathology. It is the duty of each Institution to study the particular aspects concerning its geographic region, as missing links of the chain of universal knowledge may be found there." H. L. de Oliveira, fonner Rector of the University ofSiio Paulo, 1967. "Nuclear Medicine is cost effective, especially in the developing countries. ( ... ).

PET Studies on Amino Acid Metabolism and Protein Synthesis

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Publisher : Springer Science & Business Media
ISBN 13 : 9401116202
Total Pages : 270 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis PET Studies on Amino Acid Metabolism and Protein Synthesis by : B.M. Mazoyer

Download or read book PET Studies on Amino Acid Metabolism and Protein Synthesis written by B.M. Mazoyer and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parameters such as membrane transport, metabolism and protein incorporation govern the fate of amino acids in living tissue. Is it possible to use positron tomography to measure some of them, and what is their meaning in normal and pathological situations? These questions have been addressed for a long time and no satisfactory answer has yet been given. This book, which derives from an EEC workshop organized in the frame of the Concerted Action on `PET Investigation of Cellular Regeneration and Degeneration', held in Lyon in February 1992, gives the present state of knowledge in this field based on the most recent studies. Contributions from 24 leading European and American scientists are presented and discussed in the following four parts: biochemistry and animal studies; amino acids labelling with positron emittors, quality control and metabolites measurement; kinetic modelling of amino acids transport, metabolism, and protein incorporation; clinical use of amino acids. This book will aid and interest biochemists, radiochemists, pharmacologists, neurologists, oncologists and medical imaging scientists.

Brain Dopaminergic Systems: Imaging with Positron Tomography

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Publisher : Springer Science & Business Media
ISBN 13 : 9401135282
Total Pages : 206 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis Brain Dopaminergic Systems: Imaging with Positron Tomography by : J.C Baron

Download or read book Brain Dopaminergic Systems: Imaging with Positron Tomography written by J.C Baron and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Imaging of the Dopaminergic system in the human brain with the in vivo use of Positron Emis sion Tomography has emerged in the late 1980s as a tool of major importance in Clinical Neuros ciences and Pharmacology. The last few years have witnessed the rapid development of new radiotracers specific to receptors, reuptake sites and enzymes of the dopamine system; the application of these radiotracers has led to major breakthroughs in the pathophysiology and therapy of movement disorders and schizophrenic-like psychoses. This book is the first to collect, in a single volume, state-of-the-art contributions to the various aspects of this research. Its contents address methodological issues related to the design, labelling, quantitative imaging and compartmental modelisation of radioligands of the post-synaptic, pre-synaptic and enzyme sites of the dopamine system and to their use in clinical research in the fields of Parkinson's disease as well as other movement disorders, psychoses and neuroleptic receptor occupancy. The chapters were written by leading European scientists in the field of Positron Emission Tomography, gathered together in Caen (France, November 1990) under the aegis of the EEC Concerted Action on "PET Investigations of Cellular Regeneration and Degeneration. This book provides a current and comprehensive overview on PET studies of the brain dopamine system which should aid and interest neurologists, psychiatrists, pharmacologists and medical imaging scientists. J.C. Baron D. Comar L. Farde J.L. Martinot B. Mazoyer August 1991 ix LIST OF CONTRffiUTORS Dr Yves Agid DrL.

Radiopharmaceuticals for Positron Emission Tomography - Methodological Aspects

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Publisher : Springer Science & Business Media
ISBN 13 : 9780792323402
Total Pages : 210 pages
Book Rating : 4.3/5 (234 download)

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Book Synopsis Radiopharmaceuticals for Positron Emission Tomography - Methodological Aspects by : G. Stöcklin

Download or read book Radiopharmaceuticals for Positron Emission Tomography - Methodological Aspects written by G. Stöcklin and published by Springer Science & Business Media. This book was released on 1993-06-30 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radiochemical methodology constitutes the most important base for the successful functioning of a PET group in the routine production and development of radiopharmaceuticals. Of the several hundred products which have been labelled with positron emitters during the past two decades about 35 are presently considered to be of major interest. The time for a state-of-the-art review is right, since this field has advanced over the past fifteen years to reach a level where guidelines can now be suggested. Chapters of this book deal with each of the main methodological aspects of the chemistry needed to develop an effective radiopharmaceutical, namely radionuclide production, automation and metabolite analysis. A further chapter on QA/QC is written by a broadly-based expert group and is meant to provide a guideline and a base for future monographs and regulations on major PET radiopharmaceuticals of today. This book will help the increasing numbers of scientists who are now entering the field of PET to appreciate the methodological aspects that are normally addressed by chemists in relation to PET radiopharmaceuticals; it provides many useful practical guidelines and will promote early success in their own endeavours, since these will often necessarily begin by establishing chemical methodology of the kind discussed here.

Radiolabelled Cellular Blood Elements

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ISBN 13 :
Total Pages : 414 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Radiolabelled Cellular Blood Elements by : Helmut Sinzinger

Download or read book Radiolabelled Cellular Blood Elements written by Helmut Sinzinger and published by . This book was released on 1990 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Clinical Nuclear Medicine

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Publisher : Springer
ISBN 13 : 1489933565
Total Pages : 757 pages
Book Rating : 4.4/5 (899 download)

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Book Synopsis Clinical Nuclear Medicine by : K. E. Britton

Download or read book Clinical Nuclear Medicine written by K. E. Britton and published by Springer. This book was released on 2013-11-11 with total page 757 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear medicine is the bridge between a particular clinical problem and a relevant test using radionuclides. It began as a minor technical tool used in a few branches of medicine, notably endocrinology and nephrology. However, throughout the world it has now become established as a clinical discipline in its own right, with specific training programmes, special skills and a particular approach to patient management. Although the practising nuclear medicine physician must necessarily learn a great deal of basic science and technology, a sound medical training and a clinical approach to the subject remains of fundamental importance. It is for this reason that we have attempted in this book to approach the subject from a clinical standpoint, including where necessary relevant physiological material. There exist many excellent texts which cover the basic science and technology of nuclear medicine. We have, therefore, severely limited our coverage of these aspects of the subject to matters which we felt to be essential, particularly those which have been less well covered in other texts - for example, the contents of Chapter 21 on Quantitation by Royal and McNeil. Similarly, we have included at the end of some chapters descriptions of particular techniques where we and the authors felt that it would be helpful. In order to emphasize the clinical approach of this book we have inverted the traditional sequence of material in chapters, presenting the clinical problems first in each instance.

Platelets and Their Factors

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Publisher : Springer Science & Business Media
ISBN 13 : 3642606393
Total Pages : 771 pages
Book Rating : 4.6/5 (426 download)

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Book Synopsis Platelets and Their Factors by : Franz von Bruchhausen

Download or read book Platelets and Their Factors written by Franz von Bruchhausen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 771 pages. Available in PDF, EPUB and Kindle. Book excerpt: Platelets playa fundamental, life-saving role in hemostasis and blood clotting at sites of vascular injury. Unwanted platelet activation and arterial thombus formation are, however, implicated in the onset of myocardial infarction, stroke, and other cardiovascular diseases. Acceptance that platelets play a major role in the pathogenesis of atherosclerosis including coronary heart disease has revolutionized the pharmacological treatment of cardiovascular diseases, and aspirin is now an essential antiplatelet drug and the golden standard for future developments. Yet the search for better and perhaps safer antiplatelet drugs is one of the most active areas of investigation in both basic and clinical research. Platelets, especially human platelets, have also emerged as one of the major models for the study of inter- and intracellular signal transduction pathways. Many biochemists, cell biologists, pharmacologists, pathologists, hematologists, and cardiologists find platelets useful for studying processes such as adhesion, inside-out and outside-in signalling through the plasma membrane, channels, calcium homeostasis, protein kinases, the network of intracellular signal transduction cascades, and the release of vasoactive substances. The aim of the editors has been to compile chapters summarizing the current state-of-the-art information on the biochemistry, cell biology, pharmacology, and physiologic and pathophysiologic roles of human platelets. We hope that this volume represents the major aspects of current platelet research although it is perhaps inevitable that certain areas are covered less thoroughly than others. We would like to acknowledge the excellent help and support of the Springer-Verlag staff, in particular that of Ms. Doris Walker.

Radiolabeled Cellular Blood Elements

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Publisher : Springer Science & Business Media
ISBN 13 : 1468449222
Total Pages : 435 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Radiolabeled Cellular Blood Elements by : M. L. Thakur

Download or read book Radiolabeled Cellular Blood Elements written by M. L. Thakur and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: Preparing manuscripts with figures and tables for camera repro duction was a formidable task. Care has been taken for consistency and typographic accuracy. However, I make no claim that no errors exist in this volume. ,I hope, however, that the reader will under stand and ignore any error and find this compendious volume useful for numerous biologic studies, physiologic explorations and clinical app lications of radiolabeled cellular blood elements in years to come. M. L. Thakur Editor, and the ASI Director ACKNOWLEDGEMENTS Dr. Max Hardeman of the University of Amsterdam and Dr. Michael Ezekowitz of Yale University served as the codirectors of the Advanced Study Institute (ASI). Dr. Hardeman spent countless hours and contri buted to the scientific program, took care of mailings in Europe, organized transportation in Italy, and communicated with the hotel management on numerous occasions. I cannot thank him enough! Dr. Ezekowitz collected some manuscripts and corrected a few. I am grateful to him. I take this opportunity once again to thank all the guest fac ulty, who, despite their busy schedules and time constraints, accepted my invitation and made valuable contributions to the ASI. I am also grateful to all participants, who were so friendly and were primary resources for many lively discussions. They made the ASI profession ally beneficial and socially enjoyable.

Library of Congress Subject Headings

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ISBN 13 :
Total Pages : 1164 pages
Book Rating : 4.:/5 (1 download)

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Book Synopsis Library of Congress Subject Headings by : Library of Congress

Download or read book Library of Congress Subject Headings written by Library of Congress and published by . This book was released on 2013 with total page 1164 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Library of Congress Subject Headings

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ISBN 13 :
Total Pages : 1698 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Library of Congress Subject Headings by : Library of Congress. Office for Subject Cataloging Policy

Download or read book Library of Congress Subject Headings written by Library of Congress. Office for Subject Cataloging Policy and published by . This book was released on 1991 with total page 1698 pages. Available in PDF, EPUB and Kindle. Book excerpt: