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Cisplatin Current Status And New Developments
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Download or read book Cisplatin written by Archie W. Prestayko and published by Academic Press. This book was released on 2013-10-22 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cisplatin: Current Status and New Developments is a collection of papers presented at a symposium sponsored by the University of Alabama in Birmingham Comprehensive Cancer Center and the Bristol Laboratories in Syracuse, ?ew York, and held on September 27-28, 1979, in Atlanta, Georgia. The symposium provided a forum for assessing developments with regards to cisplatin as an anticancer drug, with emphasis on its clinical application in a wide variety of adult and pediatric malignancies as well as the mechanism by which the drug appears to cause tumor cell death. Comprised of 39 chapters, this book begins with a preclinical overview of cisplatin, focusing on its mechanism of action, pharmacology, antitumor activity, analogs, and toxicity. The discussion then turns to the effects of cisplatin on DNA and the possible relationships to cytotoxicity and mutagenicity in mammalian cells; lethal activity of platinum compounds in combination with pyrimidine derivatives; and ultrastructural effects of cisplatin. Subsequent chapters focus on the rationale of combination chemotherapy; toxic side effects of platinum analogs; radiopharmacokinetics of cisplatin; and the use of cisplatin for the treatment of malignancies such as ovarian cancer and advanced adenocarcinoma of the prostate. This monograph will be useful to oncologists and pharmacologists.
Book Synopsis Encyclopedia of Cancer by : Manfred Schwab
Download or read book Encyclopedia of Cancer written by Manfred Schwab and published by Springer Science & Business Media. This book was released on 2008-09-23 with total page 3307 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.
Download or read book Cisplatin written by Bernhard Lippert and published by John Wiley & Sons. This book was released on 1999 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: 30 years after its discovery as an antitumor agent, cisplatin represents today one of the most successful drugs in chemotherapy. This book is intended to reminisce this event, to take inventory, and to point out new lines of development in this field. Divided in 6 sections and 22 chapters, the book provides an up-to-date account on topics such as - the chemistry and biochemistry of cisplatin, - the clinical status of Pt anticancer drugs, - the impact of cisplatin on inorganic and coordination chemistry, - new developments in drug design, testing and delivery. It also includes a chapter describing the historical development of the discovery of cisplatin. The ultimate question - How does cisplatin kill a cell? - is yet to be answered, but there are now new links suggesting how Pt binding to DNA may trigger a cascade of cellular reactions that eventually result in apoptosis. p53 and a series of damage recognition proteins of the HMG-domain family appear to be involved. The book addresses the problem of mutagenicity of Pt drugs and raises the question of the possible relevance of the minor DNA adducts, e.g. of interstrand cross-links, and the possible use of trans-(NH3)2Pt(II)-modified oligonucleotides in antisense and antigene strategies. Our present understanding of reactions of cisplatin with DNA is based upon numerous model studies (from isolated model nucleobases to short DNA fragments) and application of a large body of spectroscopic and other physico-chemical techniques. Thanks to these efforts there is presently no other metal ion whose reactions with nucleic acids are better understood than Pt. In a series of chapters, basic studies on the interactions of Pt electrophiles with nucleobases, oligonucleotides, DNA, amino acids, peptides and proteins are reported, which use, among others, sophisticated NMR techniques or X-ray crystallography, to get remarkable understanding of details on such reactions. Reactivity of cisplatin, once bound to DNA and formerly believed to be inert enough to stay, is an emerging phenomenon. It has (not yet) widely been studied but is potentially extremely important. Medicinal bioinorganic chemistry - the role of metal compounds in medicine - has received an enormous boost from cisplatin, and so has bioinorganic chemistry as a whole. There is hardly a better example than cisplatin to demonstrate what bioinorganic chemistry is all about: The marriage between classic inorganic (coordination) chemistry and the other life sciences - medicine, pharmacy, biology, biochemistry. Cisplatin has left its mark also on areas that are generally considered largely inorganic. The subject of mixed-valance Pt compounds is an example: From the sleeping beauty it made its way to the headlines of scientific journals, thanks to a class of novel Pt antitumor agents, the so-called "platinum pyrimidine blues". In the aftermath diplatinum (III) compounds were recognized and studies in large numbers, and now an organometalic chemistry of these diplatinum (III) species is beginning to emerge. The final section of the book is concerned with new developments such as novel di- and trinuclear Pt(II) drugs with DNA binding properties different from those of cisplatin, with orally active Pt(IV) drugs which are presently in clinical studies, and with attempts to modify combinatorial chemistry in such a way that it may become applicable to fast screening of Pt antitumor drugs. The potential of including computational methods in solving questions of Pt-DNA interactions is critically dealt with in the concluding chapter.
Download or read book Cisplatin written by Charlotte Kenton and published by . This book was released on 1982 with total page 32 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Journal of the National Cancer Institute by :
Download or read book Journal of the National Cancer Institute written by and published by . This book was released on 1994 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Metallo-Drugs: Development and Action of Anticancer Agents by : Astrid Sigel
Download or read book Metallo-Drugs: Development and Action of Anticancer Agents written by Astrid Sigel and published by Walter de Gruyter GmbH & Co KG. This book was released on 2018-02-05 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 18, entitled Metallo-Drugs: Development and Action of Anticancer Agents of the series Metal Ions in Life Sciences centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transition and main group metal ions, among them Ru(II/III), Au(I/III), Ti(IV), V(IV/V), and Ga(III) including also the essential metal ions Fe(II/III), Cu(I/II), and Zn(II). Ionic as well as covalent and non-covalent interactions between structurally very different complexes and biomolecules like nucleic acids, proteins, and carbohydrates are studied and discussed with regard to their possible anticancer actions. Hence, MILS-18 summarizes the research at the forefront of medicinal inorganic chemistry, including studies on the next-generation, tailor-made anticancer drugs. All this and more is treated in an authoritative and timely manner in the 17 stimulating chapters of this book, written by 39 internationally recognized experts from 10 nations (from the US via Europe to China and Australia). The impact of this vibrant research area is manifested by more than 2700 references, nearly 150 illustrations (more than half in color) and several comprehensive tables. Metallo-Drugs: Development and Action of Anticancer Agents is an essential resource for scientists working in the wide range from enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that it also provides excellent information for teaching.
Book Synopsis Current Catalog by : National Library of Medicine (U.S.)
Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on with total page 1342 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.
Download or read book Cancer Treatment Reports written by and published by . This book was released on 1987 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Hepatobiliary Cancer by : Paul H. Sugarbaker
Download or read book Hepatobiliary Cancer written by Paul H. Sugarbaker and published by . This book was released on 2014-09-01 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cisplatin written by Archie W. Prestayko and published by . This book was released on 1980 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Tumors and Tumor-like Conditions of the Lung and Pleura E-Book by : Cesar A. Moran
Download or read book Tumors and Tumor-like Conditions of the Lung and Pleura E-Book written by Cesar A. Moran and published by Elsevier Health Sciences. This book was released on 2010-03-22 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tumors and Tumor-like Conditions of the Lung and Pleura is a superb visual resource that brings the state-of-the-art in thoracic diagnosis straight to the lab bench. Cesar A. Moran and Saul Suster are internationally recognized experts in pulmonary pathology who present a coherent and consistent approach to interpretation and diagnosis. Through more than 900 stunning photographs and a consistent, user-friendly format, this resource provides quality guidance on the diagnostic problems you face in everyday practice. You’ll get a host of innovative, practice-oriented features unavailable in any other text that streamline and facilitate diagnostic decision-making. Written by practitioners for practitioners, this visual resource is designed for quick and easy use. You can’t afford to be without it. Features over 900 high-quality full-color illustrations so you can recognize and diagnose any tissue sample under the microscope. Presents immunohistochemical and genetic features wherever relevant for comprehensive information on all of the investigative contexts important to formulating an accurate diagnosis. Includes summary tables throughout the text to simplify and clarify complex discussions and enable "at a glance" comparisons between entities. Provides practical advice from experts on pitfalls in differential diagnosis to help you avoid diagnostic errors.
Book Synopsis Carboplatin (JM-8) by : Paul A. Bunn
Download or read book Carboplatin (JM-8) written by Paul A. Bunn and published by . This book was released on 1990 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Ovarian Cancer by : David S. Alberts
Download or read book Ovarian Cancer written by David S. Alberts and published by Springer Science & Business Media. This book was released on 1985-02-28 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Where do you begin to look for a recent, authoritative article on the diag nosis or management of a particular malignancy? The few general oncology textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals fre quently publish good in-depth reviews of cancer topics, and published sym posium lectures are often the best overviews available. Unfortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes which aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion. First, by di viding the oncology literature into specific subdivisions such as lung cancer, genitourinary cancer, pediatric oncology, etc. Second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.
Book Synopsis Drug Determination in Therapeutic and Forensic Contexts by : Eric Reid
Download or read book Drug Determination in Therapeutic and Forensic Contexts written by Eric Reid and published by Springer Science & Business Media. This book was released on 2013-03-12 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acknowledgements. - Valuable support for the Forum came from the Cancer Research Campaign, from Johnson Matthey & Co., and from U. K. pharmaceutical companies - Beechams, Glaxo, ICI and Smith, Kline & French. Moreover, some speakers came without full financial coverage. The choice of presentations was guided by Honorary Advisers including Drs. S.H. Curry (Chairman), J.A.F. de Silva, L.E. Martin, J. Chamberlain and G.G. Skellern. Drs. Jim Leppard and Joan Reid are thanked for Index drafting. As mentioned in the text, some Figs. have already appeared in journals, whose publishers (e.g. Elsevier, Dekker, Preston) are thanked: sources include Journal of Chroma- tography, Journal of Liquid Chromatography and Journal of Chromatographic Science, also (art. #E-S) a Wiley book edited by M. Trimble. Abbreviations.- In connection with HPLC ('LC' is a pet aver- sion) this Editor has often deplored the upstart use of 'ECD'-a term hallowed by its GC usage as in art. #F -2 later in the book. To connote 'electrochemical' the term 'EC' is now used, but 'ECD' is reserved for the electron-capture detector.Other abbreviations which, although well known, are generally defined in each article concerned include NP, normal-phase HPLC); RP, reverse(d)-phase; i.s., internal standard; MS, mass spectrometry (EI, electron-impact; CI, chemic, al-ionization); RIA, radioimmunoassay; UV, ultraviolet (usually absorbance)
Book Synopsis Antitumor Drug Radiation Interactions by : Bridget T. Hill
Download or read book Antitumor Drug Radiation Interactions written by Bridget T. Hill and published by CRC Press. This book was released on 2018-01-10 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume reviews the experimental data on drug-radiation interactions. Special emphasis is placed on clinically-useful antitumor drugs. Particular reference is made to appropriate timing, concentration and sequencing of drug-radiation combinations. It includes discussions on the relative merits of experimental data derived from animal versus human tumors. This book also presents a section on the potential for new model systems or alternative test procedures for evaluating therapeutic benefits and cytotoxicities. Results of randomized clinical studies are reviewed with emphasis on recent studies involving protocols specifically designed to test the benefits from optimal integration of chemotherapy with radiotherapy. This book is intended for laboratory researchers in the field and clinicians interested in using the combined modality approach. It is also a useful resource for radiologists, oncologists, and all those interested in cancer research.
Download or read book The Journal of Rheumatology written by and published by . This book was released on 1982 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book NCI Monographs written by and published by . This book was released on 1987 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt:
