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Charnolophagy In Health And Disease
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Book Synopsis Charnolophagy in Health and Disease by : Sushil Sharma
Download or read book Charnolophagy in Health and Disease written by Sushil Sharma and published by CRC Press. This book was released on 2021-09-03 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces charnolophagy (CP) as energy-driven, lysosomal-dependent mitochondrial inclusion-specific pleomorphic Charnoly body (CB) autophagy (ATG) involving free radical-induced Ca2+ dyshomeostasis, ΔΨ collapse, and ATP depletion in congenital diseases, pressure ulcers, metabolic diseases, hepatic diseases, diabetes, obesity, inflammatory diseases, musculoskeletal diseases, sarcopenia, cachexia, respiratory diseases, gastrointestinal diseases, hyperlipidemia, skin and hair diseases, pulmonary diseases, cardiovascular diseases, renal diseases, sepsis-induced multi-organ failure, reproductive diseases, inflammatory diseases, ophthalmic diseases, neurodegenerative diseases, drug addiction, aging, microbial (including COVID-19) infections, and belligerent malignancies implicated in early morbidity and mortality and disease-specific spatiotemporal, targeted, safe, and effective evidence-based personalized theranostic charnolopharmacotherapeutics to cure them. Basic DRESS and GELS principles, nanoparticles to cure chronic multidrug-resistant (MDR) diseases, antioxidants as free radical scavengers, CB antagonists, CP regulators, and CS stabilizers to curb CB molecular pathogenesis (CBMP) are described for better quality of life and longevity. Specific guidelines for environmental protection and preservation of zoological and botanical species at the verge of extinction, Triple "I" Hypothesis for mitochondrial quality control, and transcriptional regulation of CSexR and CSendoR to cure chronic diseases are presented. Novel CP index is introduced to evaluate MDR malignancies and other chronic diseases. WHO, CDC, FDA, NIH, policy planners, cosmetologists, trichologists, players, athletes, dancers, wrestlers, equestrians, young women, aging population, toxicologists, environmental protectionists, pharmaceutical industry, biomedical scientists, researchers, medical students, physicians, nurses, paramedical professionals, and global audience will be interested in this interesting book to prevent pandemics and raise healthcare awareness.
Book Synopsis The Charnoly Body by : Sushil Sharma
Download or read book The Charnoly Body written by Sushil Sharma and published by CRC Press. This book was released on 2019-01-30 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diversified physicochemical injuries trigger Charnoly body (CB) formation as pleomorphic, electron-dense, multi-lamellar stacks of nonfunctional mitochondrial membranes in the most vulnerable cell. Free radicals induce downregulation of mitochondrial DNA, microRNA, AgNOR, and epigenetics to trigger CB molecular pathogenesis. CB is eliminated by energy (ATP)-driven lysosome-dependent charnolophagy as a basic molecular mechanism of intracellular detoxification to prevent acute and chronic diseases. Accumulation of CB at the junction of axon hillock and charnolosome (CS) at the synapses causes cognitive impairments; whereas, nonspecific induction of CB causes GIT stress, myelosuppression, alopecia, neurotoxicity, cardiotoxicity, and infertility in multidrug-resistant malignancies. Hence, stem cell-specific CB, charnolophagy, and CS agonists/antagonists are introduced as novel charnolopharmacotherapeutics for the successful treatment of cardiovascular diseases, neurodegenerative diseases, infectious diseases, drug addiction, and cancer. Nanoparticles to improve drug delivery, CS exocytosis, and disease-specific spatiotemporal charnolosomics employing correlative and combinatorial bioinformatics boost mitochondrial bioenergetics through balanced diet, exercise, and antioxidants. The book will be of interest to medical scientists and practitioners.
Book Synopsis Mitochondrial Signaling in Health and Disease by : Sten Orrenius
Download or read book Mitochondrial Signaling in Health and Disease written by Sten Orrenius and published by CRC Press. This book was released on 2012-06-20 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria have traditionally been associated with metabolic functions; however recent research has uncovered a central role for these organelles in cell signaling, cell survival, and cell death. Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease. Mitochondrial Signaling in Health and Disease examines themes essential for the maintenance of the mitochondrial redox (reduction-oxidation) energy axis. With contributions from an impressive cadre of internationally recognized scientists, the book discusses coordinated mitochondrial functions that regulate cell function by discrete signaling pathways. Topics discussed include: Electron transport and energy production Mitochondrial biogenesis and dynamics Mitochondrial signaling Apoptosis and autophagy Pharmacology signaling Epigenetic signaling: mitochondrial methylation and acetylation reactions An essential resource for life and health scientists as well as pharmaceutical industry professionals, this volume highlights the importance of mitochondrial signaling and its role in establishing a harmonized communication between several cellular compartments. The information in this volume is critical to those developing mitochondrion-targeted therapies aimed at assuaging mitochondrial dysfunction or the specific factors contributing to its dysfunction.
Book Synopsis Neuropharmacology Methods in Epilepsy Research by : Steven L. Peterson
Download or read book Neuropharmacology Methods in Epilepsy Research written by Steven L. Peterson and published by CRC Press. This book was released on 2019-05-07 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is an estimated 2.5 million epileptics in the US and perhaps some 40 million worldwide. As research has become increasingly molecular in scope, fewer scientists are trained in the US on basic, integrated epilepsy techniques. One frustration in neuroscience today is the application of state-of-the-art molecular biology techniques to inappropriate animal models of epilepsy - frequently resulting in inconclusive results. Epilepsy research will be increasingly undertaken by scientists well-trained in reductionist methodology, but who may be unfamiliar with integrated, whole-animal techniques. This situation appears even more difficult considering there has been no updated textbook on experimental models of epilepsy over the last twenty years - until now. Neuropharmacology Methods in Epilepsy Research describes fundamental methodologies and procedures in this field, representing the only detailed text concerning experimental models of epilepsy published in the last 20 years. This guide studies the reproduction of well-characterized and readily interpretable experimental models of epilepsy to which state-of-the-art molecular biology techniques can be applied. Each chapter features: Introduction - providing a brief background and historical account of the techniques and their use Methodology - describing equipment, solutions, species, electrodes as well as considering variations of techniques and stimulation parameters Interpretations - demonstrating the relevance of techniques to epilepsy as well as describing what exactly is being studied and how the data is appropriately applied to understanding epilepsy Topics include electroshock, chemoconvulsions, kindling, audiogenic seizures, focal seizures, and brain slice preparations. Discussions also include: Recently developed seizure models, including status epilepticus and massed trial simulations Influence of circadian and diurnal rhythms on convulsive activity Behavior al and cognitive deficits associated with anticonvulsant drug testing Technical approaches, i.e. slice models, microdialysis techniques, intracranial implant surgery, audiogenic seizure testing, kindling paradigms, and the rhythmic nature of seizures This unique text provides a thorough reference for the diverse methodologies within this area of neuropharmacological research - providing the basis for on-going cellular and molecular investigations as well as novel therapeutic approaches to the treatment of epilepsy.
Book Synopsis Sustained Energy for Enhanced Human Functions and Activity by : Debasis Bagchi
Download or read book Sustained Energy for Enhanced Human Functions and Activity written by Debasis Bagchi and published by Academic Press. This book was released on 2017-08-07 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sustained Energy for Enhanced Human Functions and Activity addresses the basic mechanistic aspects of energy metabolisms, the chemistry, biochemistry and pharmacology of a variety of botanical ingredients, micronutrients, antioxidants, amino acids, selected complexes, and other nutracueticals which have demonstrated a boost in and the sustainability of functional energy. The role of exercise and physical activity is also discussed, and the conclusion addresses paradigm shifts in the field and envisions the future. Intended for researchers and industry professionals, the book is as an essential reference on the impact of proper nutrient balance on sustained energy. Serves as a comprehensive reference on natural products that can boost and sustain energy Encompasses information on diverse energy ingredients and their potential role in optimal health and sustained energy Conceptualizes the key features in diverse nutraceuticals that can boost sustained energy and well-being Presents the intricate mechanistic aspects and balance between optimal and sustained energy Addresses the pathophysiology and mechanistic insight of diverse nutraceuticals and functional foods that can help in maintaining optimal health and sustain functional energy
Book Synopsis The Self in Neuroscience and Psychiatry by : Tilo Kircher
Download or read book The Self in Neuroscience and Psychiatry written by Tilo Kircher and published by Cambridge University Press. This book was released on 2003-08-07 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: This 2003 book focuses on neuropsychiatric models of self-consciousness, set against introductory essays describing the philosophical, historical and psychological approaches.
Book Synopsis Analyzing Neural Time Series Data by : Mike X Cohen
Download or read book Analyzing Neural Time Series Data written by Mike X Cohen and published by MIT Press. This book was released on 2014-01-17 with total page 615 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive guide to the conceptual, mathematical, and implementational aspects of analyzing electrical brain signals, including data from MEG, EEG, and LFP recordings. This book offers a comprehensive guide to the theory and practice of analyzing electrical brain signals. It explains the conceptual, mathematical, and implementational (via Matlab programming) aspects of time-, time-frequency- and synchronization-based analyses of magnetoencephalography (MEG), electroencephalography (EEG), and local field potential (LFP) recordings from humans and nonhuman animals. It is the only book on the topic that covers both the theoretical background and the implementation in language that can be understood by readers without extensive formal training in mathematics, including cognitive scientists, neuroscientists, and psychologists. Readers who go through the book chapter by chapter and implement the examples in Matlab will develop an understanding of why and how analyses are performed, how to interpret results, what the methodological issues are, and how to perform single-subject-level and group-level analyses. Researchers who are familiar with using automated programs to perform advanced analyses will learn what happens when they click the “analyze now” button. The book provides sample data and downloadable Matlab code. Each of the 38 chapters covers one analysis topic, and these topics progress from simple to advanced. Most chapters conclude with exercises that further develop the material covered in the chapter. Many of the methods presented (including convolution, the Fourier transform, and Euler's formula) are fundamental and form the groundwork for other advanced data analysis methods. Readers who master the methods in the book will be well prepared to learn other approaches.
Book Synopsis Epigenetics of Aging and Longevity by : Alexey Moskalev
Download or read book Epigenetics of Aging and Longevity written by Alexey Moskalev and published by Academic Press. This book was released on 2017-11-17 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in regulating specific age-associated illnesses—including cancer and cardiovascular, metabolic, and neurodegenerative diseases—are explored in detail. This book will help researchers in genomic medicine, epigenetics, and biogerontology better understand the epigenetic determinants of aging and longevity, and ultimately aid in developing therapeutics to extend the human life-span and treat age-related disease. Offers a comprehensive overview of the epigenetic nature of aging, as well as the impact of epigenetic factors on longevity and regulating age-related disease Provides readers with clinical and epidemiological evidence for the role of epigenetic mechanisms in mediating the link between early-life experiences, life-course health and aging trajectory Applies current knowledge of epigenetic regulatory pathways towards developing therapeutic interventions for age-related diseases and extending the human lifespan
Book Synopsis Spike-timing dependent plasticity by : Henry Markram
Download or read book Spike-timing dependent plasticity written by Henry Markram and published by Frontiers E-books. This book was released on with total page 575 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hebb's postulate provided a crucial framework to understand synaptic alterations underlying learning and memory. Hebb's theory proposed that neurons that fire together, also wire together, which provided the logical framework for the strengthening of synapses. Weakening of synapses was however addressed by "not being strengthened", and it was only later that the active decrease of synaptic strength was introduced through the discovery of long-term depression caused by low frequency stimulation of the presynaptic neuron. In 1994, it was found that the precise relative timing of pre and postynaptic spikes determined not only the magnitude, but also the direction of synaptic alterations when two neurons are active together. Neurons that fire together may therefore not necessarily wire together if the precise timing of the spikes involved are not tighly correlated. In the subsequent 15 years, Spike Timing Dependent Plasticity (STDP) has been found in multiple brain brain regions and in many different species. The size and shape of the time windows in which positive and negative changes can be made vary for different brain regions, but the core principle of spike timing dependent changes remain. A large number of theoretical studies have also been conducted during this period that explore the computational function of this driving principle and STDP algorithms have become the main learning algorithm when modeling neural networks. This Research Topic will bring together all the key experimental and theoretical research on STDP.
Book Synopsis Zika Virus Disease by : Sushil Sharma
Download or read book Zika Virus Disease written by Sushil Sharma and published by . This book was released on 2017 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: The author was motivated to write this important book because currently there is no systematically-written document on the ZIKV disease, which could serve at this crucial moment as a textbook for medical students, physicians, nurses, and other healthcare providers as well as a reference book for basic researchers, professors, and the general public. The original concept of ZIKV-Charnolopathy due to compromised mitochondrial bioenergetics in highly vulnerable (neural progenitor cells, spermatocytes, oocytes etc.) cells and its amelioration by physiological and/or pharmacological interventions is based on years of research experience. This book describes unique organ and disease-specific Charnoly body (CB) inhibitors, charnolophagy inducers, CB sequestration inhibitors, and chanolophagosome stabilizers as promising charnolopharmacotherapeutics. They are meant to aid in the prevention and treatment of the ZIKV-linked diversified spectrum of neurodevelopmental anomalies (embryopathies) in newborn infants and Guillain Barre' Syndrome (GBS) in adults. Clinical management of ZIKV-induced GBS employing IV immunoglobulin and plasmapheresis (plasma exchange) is also described.
Book Synopsis The Great Psychotherapy Debate by : Bruce E. Wampold
Download or read book The Great Psychotherapy Debate written by Bruce E. Wampold and published by Routledge. This book was released on 2015-01-30 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of The Great Psychotherapy Debate has been updated and revised to expand the presentation of the Contextual Model, which is derived from a scientific understanding of how humans heal in a social context and explains findings from a vast array of psychotherapies studies. This model provides a compelling alternative to traditional research on psychotherapy, which tends to focus on identifying the most effective treatment for particular disorders through emphasizing the specific ingredients of treatment. The new edition also includes a history of healing practices, medicine, and psychotherapy, an examination of therapist effects, and a thorough review of the research on common factors such as the alliance, expectations, and empathy.
Book Synopsis Simulating, Analyzing, and Animating Dynamical Systems by : Bard Ermentrout
Download or read book Simulating, Analyzing, and Animating Dynamical Systems written by Bard Ermentrout and published by SIAM. This book was released on 2002-01-01 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Simulating, Analyzing, and Animating Dynamical Systems: A Guide to XPPAUT for Researchers and Students provides sophisticated numerical methods for the fast and accurate solution of a variety of equations, including ordinary differential equations, delay equations, integral equations, functional equations, and some partial differential equations, as well as boundary value problems. It introduces many modeling techniques and methods for analyzing the resulting equations. Instructors, students, and researchers will all benefit from this book, which demonstrates how to use software tools to simulate and study sets of equations that arise in a variety of applications. Instructors will learn how to use computer software in their differential equations and modeling classes, while students will learn how to create animations of their equations that can be displayed on the World Wide Web. Researchers will be introduced to useful tricks that will allow them to take full advantage of XPPAUT's capabilities.
Book Synopsis The Multitasking Mind by : Dario D. Salvucci
Download or read book The Multitasking Mind written by Dario D. Salvucci and published by Oxford University Press. This book was released on 2011 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the theory of threaded cognition, a theory that aims to explain the multitasking mind. The theory states that multitasking behavior can be expressed as cognitive threads-independent streams of thought that weave through the mind's processing resources to produce multitasking behavior, and sometimes experience conflicts to produce multitasking interference. Grounded in the ACT-R cognitive architecture, threaded cognition incorporates computational representations and mechanisms used to simulate and predict multitasking behavior and performance.
Book Synopsis Personalized Medicine (Beyond PET Biomarkers) by : Sushil Sharma
Download or read book Personalized Medicine (Beyond PET Biomarkers) written by Sushil Sharma and published by Nova Science Publishers. This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nova Science Publishers, New York, U.S.A has now released Personalized Medicine (Beyond PET Biomarkers), which is an extension of the authors recently published book Progress in PET Radiopharmaceuticals: Quality Control and Theranostics. In addition to recently-developed clinically-significant PET-RPs as biomarkers, this book describes various other emerging biotechnologies including: genomic medicine, nanotechnology, novel molecular biomarkers, and noninvasive imaging biotechnologies for early theranostics and personalised patient care, with minimum or no adverse effects. New therapeutic interventions including gene and cell therapies, pharmacogenomics, next generation sequencing, genome-wide association studies, proteomics, metabolomics, bioinformatics, systems biology complementing areas of pharmacokinetics and pharmacodynamics, human investigations and clinical trials, pharmacovigilance, pharmacoepidemiology, and population pharmacology are some of the most significant disciplines of predictive, precision, and personalised medicine (PM) as described in this book. More specifically, different sub-specialties of omics biotechnology including: genomic, proteomic, glycomic, lipidomic, metabolomics, metalomic, and microRNA biomarkers are described to accomplish early and personalised theranostics of chronic illnesses with currently limited therapeutic options and success. Recent advances in nanotechnology and novel biomarkers to accomplish personalised theranostics of chronic diseases including, but not limited to: cancer, fetal alcohol syndrome, Alzheimers disease, Parkinsons disease, vascular dementia, amyotrophic lateral sclerosis, and multiple sclerosis. Usually, nanoparticles (NPs) are trapped in the reticuloendothelial system (RES) comprising the lungs, liver, and spleen. To prevent their entry into the RES system and enhance drug targeting, stealth property of polyethylene glycol (PEG) as a covalent linker is utilised. However, pegylation may reduce the biological activity of the antibody or other labile molecule attached to NPs. Therefore, positively-charged chitosans and negatively charged alginates have been developed. Liposomal encapsulated Doxorubicin (Adriamycin) was approved in the early seventies for the treatment of breast cancer. In addition, enhanced permeability and retention (EPR) property of newly synthesised micro vessels of a hyper proliferating tumor is utilised to selectively invade the cancer stem cells is intricately described. Various noninvasive in-vivo imaging technologies including computerised tomography (CT), magnetic resonance imaging (MRI) along with magnetic-resonance spectroscopic (MRS) capability, single photon emission tomography (SPECT), positron emission tomography (PET), ultra sound alone or as hybrid images to obtain precise 5D anatomical landmarks, regional physiology, and biochemistry of the human body organs at cellular, molecular, and genetic level in health and disease are described. The book also describes in-vitro methods to acquire images of tissues and cells in culture employing digital infrared imaging, digital fluorescence microscopic, confocal microscopic, and fluorescence resonance transfer (FRET) resonance imaging for detecting apoptosis and/or necrosis at the cellular, molecular and genetic level. This timely-released manuscript will attract basic scientists, researchers, and physicians interested in further developing the emerging concept of personalised medicine (PM), and will serve as a textbook for Masters, M.D., and Ph. D students, and a reference book for doctors, professors, basic researchers, scientists, and general public. The author has explained recently-discovered novel biomarkers for the personalised diagnosis and treatment of cancer, cardiovascular diseases, neurodegenerative diseases, and other chronic inflammatory diseases such as asthma, COPD, cystic fibrosis, migraine, and rheumatoid arthritis to accomplish the long quested goal of evidence-based personalised theranostics (EBPT). Recently-discovered disease-specific biomarkers can be successfully employed alone or in combination for the personalised treatment of chronic multidrug-resistant illnesses. Particularly, progressive neurodegenerative diseases such as fetal alcohol syndrome, Parkinsons disease, drug addiction, Alzheimers disease, vascular dementia, amyotrophic lateral sclerosis, and demyelinating relapse and remission multiple sclerosis (RRMS) are described in detail because personalised treatment of these devastating diseases is currently a significant challenge. There are several other chronic drug resistant pro-inflammatory and infectious diseases, which could not be covered in sufficient detail owing to the lack of expertise, time, and limited space allocated to write this dedicated and clinically significant book. The author apologises to the entire global scientific community for his own ignorance, and humbly requests readers to go through the books interesting and most recent contents to enhance their basic knowledge regarding personalised medicine beyond PET biomarkers, which is one of the most demanding disciplines of modern medicine.
Book Synopsis Monoamine Oxidase Inhibitors by : Sushil K. Sharma
Download or read book Monoamine Oxidase Inhibitors written by Sushil K. Sharma and published by Nova Science Publishers. This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides basic and applied knowledge about monoamine oxidase inhibitors (MAOIs), their classification, and clinical application as neuroprotective agents and will be a valuable source of new knowledge for doctors, patients, medical students, teachers, researchers, and basic biomedical scientists interested in learning the appropriate clinical application of MAOIs without any misunderstanding for the prevention and/or treatment of neurological and neuropsychiatric disorders. The book will be of immediate interest to patients suffering from Parkinson's disease (PD), Alzheimer's disease (AD), post-traumatic stress disorders (PTSD), panic disorders, attention deficit hyperactivity disorders (ADHD), and major depression. Physicians interested in learning more about MAOIs and their molecular and pharmacological mechanism of action will highly benefit from the book's clinically-interesting contents. In general, this book will be a valuable source of knowledge for the basic researcher, clinically useful for the physician, and therapeutically-beneficial for the patients. The book can also serve as a guide for Masters and Ph.D students interested in conducting research on MAOIs. Particularly, MD doctors, students, and professors will find this book interesting to enhance their basic knowledge about MAOIs and their potential benefits and adverse effects for the better clinical management of drug-resistant PD, AD, and MDDs. Furthermore, recent knowledge regarding the molecular mechanism of MAOIs-mediated protection at the cellular, molecular, and genetic level is thought-provoking and motivates the young scientists to augment research on developing novel drugs with minimum or no adverse effects. It is envisaged that future research on specific CB-targeted MAOIs will have superior pharmacogenomics profiles, enhanced margin of safety, maximum therapeutic index, and minimum or no adverse effects.'
Book Synopsis Fetal Alcohol Spectrum Disorders by : Sushil Sharma
Download or read book Fetal Alcohol Spectrum Disorders written by Sushil Sharma and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alcoholism exerts a high genetic as well as epigenetic load and may be regarded as one of the most prevalent, identifiable, and preventable neuropsychiatric illnesses afflicting modern society today. Alcohol constituted 3.2% of all worldwide deaths in the year 2006 and is associated with >60 diseases, including foetal alcohol spectrum disorder (FASD), cancers, cardiovascular diseases, liver cirrhosis, neuropsychiatric disorders and life-threatening injuries. Fatal alcohol spectrum disorder (FASD) is a collective term representing foetal abnormalities associated with maternal alcohol abuse. FASD is a devastating developmental disorder resulting from alcohol exposure during foetal development. It is a considerable public health problem worldwide and is characterised by CNS abnormalities, dysmorphic facial features, and growth deficiency. Although it is well-established that intra-uterine alcohol exposure can lead to FASD, characterised by cognitive and behavioural impairments, alcohol abuse is still highly prevalent and contributes to a significant loss of economy and productivity throughout the entire world. Children with FASD become a serious and persistent socioeconomic burden to society, as they require specialised healthcare liabilities throughout their entire lives as a consequence of their parents irresponsible drinking behaviour. The primary aim of the inter-disciplinary and integrated genome research network (consisting of molecular biologists, psychopharmacologists, system biologists with mathematicians, human geneticists, and clinicians) is to better understand the genetics and epigenetics of alcohol addiction by identifying candidate genes and molecular mechanisms involved in the etiopathogenesis of FASD, and to provide recommendations to the government and scientific community for global dissemination of emerging knowledge and implementation of FASD interventions. In this book the author has presented the novel concept of charnolopharmacology, which plays a crucial role in determining the life and death of the foetus during intrauterine foetal alcohol exposure (FAE). More specifically, it proposes mitochondrial bioenergetics-based charnolopharmacotherapeutics for personalised theranostics of FASD, involving diversified charnolopathies, embryopathies, and infertility; resulting in poor quality of life. Although several concepts, mechanisms and potential therapies have been proposed recently to overcome the deleterious consequences of FASD, the author has now proposed charnolopharmacotherapeutics, which is based on ethanol-induced compromised mitochondrial bioenergetics and the induction of charnolopathies initially in the spermatocyte and oocyte during the prezygotic phase, and subsequently in the neural progenitor cells (NPCs) during the post-zygotic phase of pregnancy. Hence, drugs inhibiting CB formation and/or augmenting charnolophagy as a basic molecular mechanism of intracellular detoxification during the acute phase, stabilising charnolophagosome and preventing charnolosome sequestration and budding during chronic phase, will have therapeutic potential in FASD embryopathies, which is elegantly described in this book. The most unique feature of this book is that it introduces original concepts of mitochondrial bioenergetics, genomics, and epigenomics to successfully manage FASD. Particularly, mitochondrial bioenergetics-based CB prevention/inhibition, charnolophagy induction, and charnolophagosome and charnolosome stabilisation are novel therapeutic targets for safe and effective clinical management of FASD. These concepts and mechanisms are based on several years of basic research and original discoveries by the author.
Book Synopsis Alleviating Stress of the Soldier and Civilian by : Sushil K. Sharma
Download or read book Alleviating Stress of the Soldier and Civilian written by Sushil K. Sharma and published by Nova Science Publishers. This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Initially, the author intended to write a book entitled "Alleviating Stress of the Soldier". However, after going through the extensive literature and recalling his childhood memories of war times, he decided to write "Alleviating Stress of the Soldier and Civilian". Sufficient historical evidence indicates that both soldiers as well as civilians have faced the war and tolerated its deleterious consequences simultaneously. However, a soldier and his/her family face unexpected and unpredictable stresses requiring: physical and mental fitness, character, dedication, commitment, communication, mutual understanding, adjustment, discipline, tolerance, patience, isolation, resilience, hyper-vigilance, minimum vulnerability, sanitation, nutritional stress, sleep deprivation, patriotism, and sacrifice. This book (i) confers basic knowledge of diversified stresses; (ii) prepares readers to face stresses with patience, endurance, and resilience; (iii) and presents novel strategies of alleviating physical, psychological, and physiological stresses of war-wounded soldiers, prisoners of war (POWs), and veterans. The book guides the soldiers of the Army, Navy, Air Force, SEALS (sea, air, and land), POWs, and civilians to handle their professional and family stresses without having to suffer from Combat Stress Reaction (CSR) or Post-Traumatic Stress Disorder (PTSD) before, during, and/or after the war or conflict. It also guides those who experienced early childhood neglect, physical and/or sexual abuse, and other stresses of diversified origin. It is envisaged that this timely released book will be particularly of great interest to the soldier's family members, their spouses, children, parents, relatives, and friends because of its motivational messages, immediate demand, and versatility. The author hopes that this unique manuscript will encourage, motivate, excite, and guide young soldiers, civilians, and their families to tackle stresses with courage, patience, and resilience to successfully accomplish their trainings, adventurous professional career, and married life.
