Cellular Therapies For Retinal Disease

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Cellular Therapies for Retinal Disease

Author : Steven D. Schwartz
Publisher : Springer
ISBN 13 : 3319494791
Total Pages : 149 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Cellular Therapies for Retinal Disease by : Steven D. Schwartz

Download or read book Cellular Therapies for Retinal Disease written by Steven D. Schwartz and published by Springer. This book was released on 2017-06-20 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book familiarizes the reader with the current landscape of cell-based therapies for the treatment of retinal disease, including diseases that affect the choriocapillaris, retinal pigment epithelium, photoreceptors, and retinal ganglion cells. Instead of utilizing a disease-centric approach to the topic, this book—edited by two world-renowned stem cell scientists—focuses on strategies for developing and transplanting the cells. This includes the creation of replacement cells, cell-based neuroprotection, and in vitro disease modeling and testing. The final chapters briefly review parallel approaches that do not directly utilize cellular transplantation. The use of cellular transplantation to treat retinal disease has recently become a viable and exciting therapeutic approach. The visibility of the retina and its laminar cellular architecture render it an ideal organ for the development of surgically delivered cellular therapies. Having an in-depth understanding of the current state of cell therapy for the eye is an essential first step toward utilizing similar approaches in other organs. Ophthalmologists, translational clinician-scientists, stem cell scientists, and researchers interested in eye disease will find Cellular Therapies for Retinal Disease: A Strategic Approach essential reading and it is also suitable for workshops or courses at the undergraduate or Ph.D. level.

Cell-Based Therapy for Degenerative Retinal Disease

Author : Marco A. Zarbin
Publisher : Springer
ISBN 13 : 3030052222
Total Pages : 280 pages
Book Rating : 4.0/5 (3 download)

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Book Synopsis Cell-Based Therapy for Degenerative Retinal Disease by : Marco A. Zarbin

Download or read book Cell-Based Therapy for Degenerative Retinal Disease written by Marco A. Zarbin and published by Springer. This book was released on 2019-03-01 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses why specific diseases are being targeted for cell-based retinal therapy, what evidence exists that justifies optimism for this approach, and what challenges must be managed in order to bring this technology from the laboratory into routine clinical practice. There are a number of unanswered questions (e.g., surgical approach to cell delivery, management of immune response, optimum cell type to transplant) that very likely are not going to be answered until human trials are undertaken, but there is a certain amount of “de-risking” that can be done with preclinical experimentation. This book is essential reading for scientists, clinicians, and advanced students in stem cell research, cell biology, and ophthalmology.

Cell-Based Therapy for Retinal Degenerative Disease

Author : R.P. Casaroli-Marano
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318025852
Total Pages : 220 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis Cell-Based Therapy for Retinal Degenerative Disease by : R.P. Casaroli-Marano

Download or read book Cell-Based Therapy for Retinal Degenerative Disease written by R.P. Casaroli-Marano and published by Karger Medical and Scientific Publishers. This book was released on 2014-04-22 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this volume, some of the leading authorities present their exploration of applications of stem cell therapy to the treatment of major causes of blindness, including degenerative diseases and glaucoma. The diagnostic approach to patients, general concepts of cell-based therapy, immunological considerations, approaches to cell delivery (including engineered scaffolds), combined cell and gene therapy, nanomedicine applications to cell therapy and regulatory issues pertaining to manufacture and production are all considered in detail. The book serves as an excellent introduction to a field that is now entering early-stage clinical trials and promises to operate at the leading edge of regenerative medicine. Retina specialists, general ophthalmologists as well as researchers will find here a wealth of information on the translational aspects of cell-based therapies. Further, business executives and students interested in understanding the potential applications of stem cell therapy to retinal degenerative disease and glaucoma will also find this book informative reading.

Ocular Neuroprotection

Author : Leonard A. Levin
Publisher : CRC Press
ISBN 13 : 0203911946
Total Pages : 343 pages
Book Rating : 4.2/5 (39 download)

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Book Synopsis Ocular Neuroprotection by : Leonard A. Levin

Download or read book Ocular Neuroprotection written by Leonard A. Levin and published by CRC Press. This book was released on 2003-07-15 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many retinal and optic nerve disorders have no effective therapy, or are treated incompletely and with considerable side effects. Recent advances have suggested the significant benefits associated with neuroprotection - that is, when treatment strategies are directed to photoreceptors, retinal ganglion cells, or other neural targets. Enter Ocular N

Pluripotent Stem Cells in Eye Disease Therapy

Author : Kapil Bharti
Publisher : Springer Nature
ISBN 13 : 3030284719
Total Pages : 201 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Pluripotent Stem Cells in Eye Disease Therapy by : Kapil Bharti

Download or read book Pluripotent Stem Cells in Eye Disease Therapy written by Kapil Bharti and published by Springer Nature. This book was released on 2019-10-25 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses applications of pluripotent stem cells to study eye disease in vitro and to create novel therapies for degenerative eye diseases. Chapters are contributed by experts in the field and cover such topics as the use of pluripotent stem cells in 2D and 3D engineering of ocular tissues for disease modelling and drug testing as well as approaches to replace degenerated RPE and photoreceptors in macular degeneration and retinitis pigmentosa. Pluripotent Stem Cells in Eye Disease Therapy presents a comprehensive discussion of basic science and clinical applications and is an indispensable resource for everyone from advanced graduate students to advanced professionals who want to learn about the potential of stem cell biology and its role in the field of retinal diseases.

Regenerative Medicine and Stem Cell Therapy for the Eye

Author : Brian G. Ballios
Publisher : Springer
ISBN 13 : 3319980807
Total Pages : 212 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis Regenerative Medicine and Stem Cell Therapy for the Eye by : Brian G. Ballios

Download or read book Regenerative Medicine and Stem Cell Therapy for the Eye written by Brian G. Ballios and published by Springer. This book was released on 2019-02-18 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of the types, sources, and applications of stem cells in regenerating various ocular tissues, with a perspective on both potential applications of stem cells and possible challenges. The scope of the chapters include both preclinical and clinical applications, including stem cell-derived therapies based on endogenous tissue repair; stem cell transplantation and cell replacement therapy; gene therapy; and in vitro disease modelling. Additionally, the volume presents applications in both anterior and posterior ocular disease, with a particular focus on diseases of the ocular surface, cornea, limbus, and retina, including inherited retinal dystrophies as well as acquired diseases, such as age-related macular degeneration. Regenerative Medicine and Stem Cell Therapy for the Eye is an ideal book for advanced researchers in stem cell and ocular biology as well as clinical ophthalmologists, and will be of interest to readers with backgrounds in developmental biology and bioengineering. This book also Skillfully reviews cutting-edge advances in stem cell biology as applied to regenerative medicine and ocular disease Provides expert viewpoints on key hurdles and challenges to successful implementation of stem cell-derived therapies in the clinical domain Offers a multi-disciplinary, broad understanding of cell-based therapies for ocular diseases by incorporating perspectives from biomedical scientists, physicians, and engineers Examines the connection between cell therapy and gene editing, in particular relation to ocular disease

Retinal Degenerative Diseases

Author : Matthew M. LaVail
Publisher : Springer Science & Business Media
ISBN 13 : 1461406315
Total Pages : 867 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Retinal Degenerative Diseases by : Matthew M. LaVail

Download or read book Retinal Degenerative Diseases written by Matthew M. LaVail and published by Springer Science & Business Media. This book was released on 2011-12-21 with total page 867 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will contain the proceedings of the XIV International Symposium on Retinal Degeneration (RD2010), held July 13-17, 2010, in Mont-Tremblant, Quebec, Canada. The volume will present representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy.

Inherited Retinal Disease

Author : Hyeong-Gon Yu
Publisher : Springer Nature
ISBN 13 : 9811673373
Total Pages : 237 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Inherited Retinal Disease by : Hyeong-Gon Yu

Download or read book Inherited Retinal Disease written by Hyeong-Gon Yu and published by Springer Nature. This book was released on 2022-03-11 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the latest knowledge and expert guidance on all aspects of inherited retinal diseases, including molecular genetics, diagnosis, clinical features, general principles of treatment, novel treatment methods, and genetic counseling. Recent years have witnessed great advances in understanding of the genetic and cytological background of these diseases. Genetic analysis methods such as next generation sequencing have remarkably reduced the cost and time required for massive analysis of patients’ samples. Studies on gene therapy and stem cell therapy have been successfully carried out in animal models, and gene therapy is now available for Leber congenital amaurosis caused by RPE65 mutations. Against this background, Inherited Retinal Disease will be an invaluable up-to-date resource for ophthalmologists, medical students, and researchers in ocular inflammation. In addition to supplying essential information on each individual disorder, it features many interesting cases contributed by global leaders in the field as well as clinical photographs obtained with newer imaging techniques and numerous images of rare but clinically important diseases.

The Molecular and Cellular Basis of Retinal Diseases

Author : Steven J. Pittler
Publisher : MDPI
ISBN 13 : 3039366548
Total Pages : 336 pages
Book Rating : 4.0/5 (393 download)

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Book Synopsis The Molecular and Cellular Basis of Retinal Diseases by : Steven J. Pittler

Download or read book The Molecular and Cellular Basis of Retinal Diseases written by Steven J. Pittler and published by MDPI. This book was released on 2020-12-29 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are more than 300 genes that have been identified which carry mutations that cause various forms of retinal dysfunction and degeneration, making the study of retinal diseases a subject of high relevance. In this compendium of original and review articles, many of the diseases and pathways associated with disorders of the retina are examined using animal models, to provide the reader with a good overview of current retinal research. Within this volume, you will find research reports on many of the most prominent retinal disorders, such as diabetic retinopathy (DR), age-related macular degeneration (AMD), choroidal neovascularization (CNV), and retinitis pigmentosa (RP). We hope that the work presented here will stimulate new ideas and lead to effective treatments for retinal diseases.

Retinal Degenerative Diseases

Author : Catherine Bowes Rickman
Publisher : Springer
ISBN 13 : 3319171216
Total Pages : 805 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Retinal Degenerative Diseases by : Catherine Bowes Rickman

Download or read book Retinal Degenerative Diseases written by Catherine Bowes Rickman and published by Springer. This book was released on 2015-10-01 with total page 805 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contains the proceedings of the XVI International Symposium on Retinal Degeneration (RD2014), to be held July 13-18, 2014 at the Asilomar Conference Center in Pacific Grove, California. A majority of those who will speak and present posters at the meeting will contribute to this volume. The Symposium addresses the blinding diseases of inherited retinal degenerations, which have no effective treatments and age-related macular degeneration, which has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 75. The RD2014 Symposium will focus on the exciting new developments aimed at understanding these diseases and providing therapies for them. The volume will present representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy; and several sight restoration approaches, including optogenetics. While advances in these areas of retinal degenerations will be included, several new topics either were in their infancy or did not exist at the time of the last RD Symposium, RD2012. These include many new developments in sight restoration using optogenetics, retinal or RPE cell transplantation, stem cell approaches and visual prosthetic devices. In addition, major advances will be presented in other basic mechanisms in age-related macular degeneration, several new aspects of gene and antioxidant therapy and revolutionary new imaging and functional testing that will have a huge impact on the diagnosis and following the course of retinal degenerations, as well as to provide new quantitative endpoints for clinical trials. The retina is an approachable part of the central nervous system (CNS), and there is a major interest in neuroprotective and gene therapy for CNS diseases and neurodegenerations, in general. It should be noted that with successful and exciting initial clinical trials in neuroprotective and gene therapy, including the restoration of sight in blind children, the retinal degeneration therapies are leading the way towards new therapeutic measures for neurodegenerations of the CNS. Many of the successes recently reported in these areas of retinal degeneration sprang from collaborations established at previous RD Symposia, and many of those will be reported at the RD2014 meeting and included.

Cell-Based Therapy for Degenerative Retinal Disease

Author : Marco A. Zarbin
Publisher :
ISBN 13 : 9783030052232
Total Pages : 280 pages
Book Rating : 4.0/5 (522 download)

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Book Synopsis Cell-Based Therapy for Degenerative Retinal Disease by : Marco A. Zarbin

Download or read book Cell-Based Therapy for Degenerative Retinal Disease written by Marco A. Zarbin and published by . This book was released on 2019 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses why specific diseases are being targeted for cell-based retinal therapy, what evidence exists that justifies optimism for this approach, and what challenges must be managed in order to bring this technology from the laboratory into routine clinical practice. There are a number of unanswered questions (e.g., surgical approach to cell delivery, management of immune response, optimum cell type to transplant) that very likely are not going to be answered until human trials are undertaken, but there is a certain amount of "de-risking" that can be done with preclinical experimentation. This book is essential reading for scientists, clinicians, and advanced students in stem cell research, cell biology, and ophthalmology.

High Resolution Imaging in Microscopy and Ophthalmology

Author : Josef F. Bille
Publisher : Springer
ISBN 13 : 3030166384
Total Pages : 407 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis High Resolution Imaging in Microscopy and Ophthalmology by : Josef F. Bille

Download or read book High Resolution Imaging in Microscopy and Ophthalmology written by Josef F. Bille and published by Springer. This book was released on 2019-08-13 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book provides a comprehensive overview of the application of the newest laser and microscope/ophthalmoscope technology in the field of high resolution imaging in microscopy and ophthalmology. Starting by describing High-Resolution 3D Light Microscopy with STED and RESOLFT, the book goes on to cover retinal and anterior segment imaging and image-guided treatment and also discusses the development of adaptive optics in vision science and ophthalmology. Using an interdisciplinary approach, the reader will learn about the latest developments and most up to date technology in the field and how these translate to a medical setting. High Resolution Imaging in Microscopy and Ophthalmology – New Frontiers in Biomedical Optics has been written by leading experts in the field and offers insights on engineering, biology, and medicine, thus being a valuable addition for scientists, engineers, and clinicians with technical and medical interest who would like to understand the equipment, the applications and the medical/biological background. Lastly, this book is dedicated to the memory of Dr. Gerhard Zinser, co-founder of Heidelberg Engineering GmbH, a scientist, a husband, a brother, a colleague, and a friend.

Stem Cell Therapies for Treatment of Age-Related Macular Degeneration

Author : Raj Bhakta
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (134 download)

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Book Synopsis Stem Cell Therapies for Treatment of Age-Related Macular Degeneration by : Raj Bhakta

Download or read book Stem Cell Therapies for Treatment of Age-Related Macular Degeneration written by Raj Bhakta and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Unfornatutely, there still is no proven treatment for age-related macular degeneration, the leading cause of blindness in people age 55 and above in developed countries. However, more and more research and development has been put into stem cell research and its uses in treating retinal conditions such as ARMD. This paper is a literature review analyzing the different sources of stem cells for treatment, methods of delivery, limitations and challenges and its implications on future modalities and methods of treament for not only ARMD but other progressive retinal diseases as well. More research needs to be done before stem cells should be considered an effective treatment for age-related macular degeneration. While there are still many obstacles to get through, current research has shown promising results that can potentially lead to stem cells being used as a first line of treatment in the very near future.

The Retina in Health and Disease

Author : Maurice Ptito
Publisher : Mdpi AG
ISBN 13 : 9783036526539
Total Pages : 498 pages
Book Rating : 4.5/5 (265 download)

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Book Synopsis The Retina in Health and Disease by : Maurice Ptito

Download or read book The Retina in Health and Disease written by Maurice Ptito and published by Mdpi AG. This book was released on 2021-12-27 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vision is the most important sense in higher mammals. The retina is the first step in visual processing and the window to the brain. It is not surprising that problems arising in the retina lead to moderate to severe visual impairments. We offer here a collection of reviews as well as original papers dealing with various aspects of retinal function as well as dysfunction. New approaches in retinal research are described, such as the expression and localization of the endocannabinoid system in the normal retina and the role of cannabinoid receptors that could offer new avenues of research in the development of potential treatments for retinal diseases. Moreover, new insights are offered in advancing knowledge towards the prevention and cure of visual pathologies, mainly AMD, RP, and diabetic retinopathy.

Stem Cell Biology and Regenerative Medicine in Ophthalmology

Author : Stephen Tsang
Publisher : Springer Science & Business Media
ISBN 13 : 146145493X
Total Pages : 196 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Stem Cell Biology and Regenerative Medicine in Ophthalmology by : Stephen Tsang

Download or read book Stem Cell Biology and Regenerative Medicine in Ophthalmology written by Stephen Tsang and published by Springer Science & Business Media. This book was released on 2012-12-09 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Patient specific and disease specific stem cell lines have already introduced groundbreaking advances into the research and practice of ophthalmology. This volume provides a comprehensive and engaging overview of the latest innovations in the field. Twelve chapters discuss the fastest growing areas in ophthalmological stem cell research, from disease modelling, drug screening and gene targeting to clinical genetics and regenerative treatments. Innovative results from stem cell research of the past decade are pointing the way toward practicable treatments for retinitis pigmentosa, age related macular degeneration, and Stargardt disease. What future directions will stem cell research take? Researchers, graduate students, and fellows alike will find food for thought in this insightful guide tapping into the collective knowledge of leaders in the field. Stem Cells in Ophthalmology is part of the Stem Cells in Regenerative Medicine series dedicated to discussing current challenges and future directions in stem cell research.

Human Embryonic Stem Cells

Author : Jon Odorico
Publisher : Garland Science
ISBN 13 : 0203487346
Total Pages : 391 pages
Book Rating : 4.2/5 (34 download)

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Book Synopsis Human Embryonic Stem Cells by : Jon Odorico

Download or read book Human Embryonic Stem Cells written by Jon Odorico and published by Garland Science. This book was released on 2004-02-01 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the first successful isolation and cultivation of human embryonic stem cells at the University of Wisconsin, Madison in 1998, there has been high levels of both interest and controversy in this area of research. This book provides a concise overview of an exciting field, covering the characteristics of both human embryonic stem cells and pluripotent stem cells from other human cell lineages. The following chapters describe state-of-the-art differentiation and characterization of specific ectoderm, mesoderm and endoderm-derived lineages from human embryonic stem cells, emphasizing how these can be used to study human developmental mechanisms. A further chapter discusses genetic manipulation of human ES cells. The concluding section covers therapeutic applications of human ES cells, as well as addressing the ethical and legal issues that this research have raised.

Retinal Degenerative Diseases XIX

Author : John D. Ash
Publisher : Springer Nature
ISBN 13 : 3031276817
Total Pages : 547 pages
Book Rating : 4.0/5 (312 download)

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Book Synopsis Retinal Degenerative Diseases XIX by : John D. Ash

Download or read book Retinal Degenerative Diseases XIX written by John D. Ash and published by Springer Nature. This book was released on 2023-07-13 with total page 547 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains the proceedings of the XVIII International Symposium on Retinal Degeneration (RD2018). A majority of those who spoke and presented posters at the meeting contributed to this volume. The blinding diseases of inherited retinal degenerations have no treatments, and age-related macular degeneration has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 70. The RD Symposium focused on the exciting new developments aimed at understanding these diseases and providing therapies for them. Since most major scientists in the field of retinal degenerations attend the biennial RD Symposia, they are known by most as the “best” and “most important” meetings in the field. The volume presents representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy. While advances in these areas of retinal degenerations were described, there will be many new topics that either are in their infancy or did not exist at the time of the last RD Symposium. These include the role of inflammation and immunity, as well as other basic mechanisms, in age-related macular degeneration, several new aspects of gene therapy, and revolutionary new imaging and functional testing that will have a huge impact on the diagnosis and following the course of retinal degenerations, as well as to provide new quantitative endpoints for clinical trials. The retina is an approachable part of the central nervous system (CNS), and there is a major interest in neuroprotective and gene therapy for CNS diseases and neurodegenerations, in general. It should be noted that with successful and exciting initial clinical trials in neuroprotective and gene therapy, including the restoration of sight in blind children, the retinal degeneration therapies are leading the way towards new therapeutic measures for neurodegenerations of the CNS. Many of the successes recently reported in these areas of retinal degeneration sprang from collaborations established at previous RD Symposia, and many of those were reported at the RD2016 meeting and included in the current volume. We anticipate the excitement of those working in the field and those afflicted with retinal degenerations is reflected in the volume.