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Author : Maria Josephina Vaessen
Publisher :
ISBN 13 :
Total Pages : 147 pages
Book Rating : 4.:/5 (656 download)
Download or read book Cellular Retinoic Acid Binding Protein: Cloning and Expression of the Gene written by Maria Josephina Vaessen and published by . This book was released on 1991 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Mary Ann Asson-Batres
Publisher : Springer
ISBN 13 : 9402409459
Total Pages : 267 pages
Book Rating : 4.4/5 (24 download)
Download or read book The Biochemistry of Retinoid Signaling II written by Mary Ann Asson-Batres and published by Springer. This book was released on 2016-11-09 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: The role of vitamin A in living organisms has been known throughout human history. In the last 100 years, the biochemical nature of vitamin A and its active derivative, retinoic acid, its physiological impact on growth processes, and the essential details of its mechanism of action have been revealed by investigations carried out by researchers using vertebrate and more recently invertebrate models to study a multiplicity of processes and conditions, encompassing embryogenesis, postnatal development to old age. A wealth of intercellular interactions, intracellular signaling systems, and molecular mechanisms have been described and the overall conclusion is that retinoic acid is essential for life. This book series, with chapters authored by experts in every aspect of this complex field, unifies the knowledge base and mechanisms currently known in detailed, engaging, well-illustrated, focused chapters that synthesize information for each specific area. In view of the recent information explosion in this field, it is timely to publish a contemporary, comprehensive, book series recapitulating the most exciting developments in the field and covering fundamental research in molecular mechanisms of vitamin A action, its role in physiology, development, and continued well-being, and the potential of vitamin A derivatives and synthetic mimetics to serve as therapeutic treatments for cancers and other debilitating human diseases. Volume II is divided into nine chapters contributed by prominent experts in their respective fields. Each chapter starts with the history of the area of research. Then, the key findings that contributed to development of the field are described, followed by a detailed look at key findings and progress that are being made in current, ongoing research. Each chapter is concluded with a discussion of the relevance of the research and a perspective on missing pieces and lingering gaps that the author recommends will be important in defining future directions in vitamin A research.
Author : Dirk Adrianus Kleinjan
Publisher :
ISBN 13 :
Total Pages : 148 pages
Book Rating : 4.:/5 (466 download)
Download or read book Regulation of the Gene for Cellular Retinoic Acid Binding Protein Type 1 written by Dirk Adrianus Kleinjan and published by . This book was released on 1998 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Anuradha Samantha Budhu
Publisher :
ISBN 13 :
Total Pages : 366 pages
Book Rating : 4.E/5 ( download)
Download or read book The Retinoid Receptors and Cellular Retinoic Acid Binding Proteins written by Anuradha Samantha Budhu and published by . This book was released on 2002 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Katayoun Alavi Jessen
Publisher :
ISBN 13 :
Total Pages : 222 pages
Book Rating : 4.:/5 (59 download)
Download or read book Regulation of Retinol Binding Protein Gene Expression written by Katayoun Alavi Jessen and published by . This book was released on 1999 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Paul Douglas Fiorella
Publisher :
ISBN 13 :
Total Pages : 472 pages
Book Rating : 4.:/5 (335 download)
Download or read book Expression, Purification and Characterization of Cellular Retinoic Acid Binding Protein Types I and II. A Role in Vitamin A Metabolism written by Paul Douglas Fiorella and published by . This book was released on 1995 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Mary Ann Asson-Batres
Publisher : Springer
ISBN 13 : 9401790507
Total Pages : 233 pages
Book Rating : 4.4/5 (17 download)
Download or read book The Biochemistry of Retinoic Acid Receptors I: Structure, Activation, and Function at the Molecular Level written by Mary Ann Asson-Batres and published by Springer. This book was released on 2014-06-24 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: A role for vitamin A in living organisms has been known throughout human history. In the last 100 years, the biochemical nature of vitamin A and its active derivative, retinoic acid, its physiological impact on growth processes and the essential details of its mechanism of action have been revealed by investigations carried out by researchers using vertebrate and more recently invertebrate models to study a multiplicity of processes and conditions, encompassing embryogenesis, postnatal development to old age. A wealth of intercellular interactions, intracellular signaling systems and molecular mechanisms have been described and the overall conclusion is that retinoic acid is essential for life. This book series, with chapters authored by experts in every aspect of this complex field, unifies the knowledge base and mechanisms currently known in detailed, engaging, well-illustrated, focused chapters that synthesize information for each specific area. In view of the recent explosion in this field, it is timely to publish a contemporary, comprehensive, book series recapitulating the most exciting developments in the field and covering fundamental research in molecular mechanisms of vitamin A action, its role in physiology, development and continued well-being and the potential of vitamin A derivatives and synthetic mimetics to serve as therapeutic treatments for cancers and other debilitating human diseases. VOLUME I: Here, we present the first volume of a multi-volume series on Retinoic Acid Signaling that will cover all aspects of this broad and diverse field. One aim of Volume I is to present a compilation of topics related to the biochemistry of nuclear retinoic acid receptors, from their architecture when bound to DNA and associated with their coregulators to their ability to regulate target gene transcription. A second aim is to provide insight into recent advances that have been made in identifying novel targets and non-genomic effects of retinoic acid. Volume I is divided into ten chapters contributed by prominent experts in their respective fields. Each chapter starts with the history of the area of research. Then, the key findings that contributed to development of the field are described, followed by a detailed look at key findings and progress that are being made in current, ongoing research. Each chapter is concluded with a discussion of the relevance of the research and a perspective on missing pieces and lingering gaps that the author recommends will be important in defining future directions in vitamin A research.
Author : Leslie Jo Willmert
Publisher :
ISBN 13 :
Total Pages : 288 pages
Book Rating : 4.E/5 ( download)
Download or read book The Retinoic Acid Receptors and Cellular Retinoic Acid Binding Protein II written by Leslie Jo Willmert and published by . This book was released on 2006 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : David Russell Sherman
Publisher :
ISBN 13 :
Total Pages : 186 pages
Book Rating : 4.:/5 (22 download)
Download or read book Rat Cellular Retinol Binding Protein Gene written by David Russell Sherman and published by . This book was released on 1987 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ana V. Perez
Publisher :
ISBN 13 :
Total Pages : 246 pages
Book Rating : 4.:/5 (318 download)
Download or read book Expression and Function of the Cellular Retinoic Acid-binding Protein I (CRABP I) During Mouse Development written by Ana V. Perez and published by . This book was released on 1992 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Run Zhuang
Publisher :
ISBN 13 :
Total Pages : 134 pages
Book Rating : 4.:/5 (34 download)
Download or read book Cloning, Expression, and Enzymatic Characterization of a New Cis- Retinol/androgen Dehydrogenase written by Run Zhuang and published by . This book was released on 2001 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Amanda C Vreeland
Publisher :
ISBN 13 :
Total Pages : 126 pages
Book Rating : 4.:/5 (96 download)
Download or read book Cellular Retinoic Acid-binding Protein 2 Cooperates with HuR to Stabilize RNA and Inhibit Tumor Growth written by Amanda C Vreeland and published by . This book was released on 2015 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular retinoic acid-binding protein 2 (CRABP2) enhances the transcriptional activation of the nuclear receptors termed retinoic acid receptors (RARs) by transporting retinoic acid (RA) from the cytosol to the nucleus and directly "channeling" it to RARs. One outcome of this cooperation is that CRABP2 enhances the RAR-mediated anti-carcinogenic activity of RA.Interestingly, it has been reported that CRABP2 also regulates the expression of some genes and displays pro-apoptotic activities in the absence of RA, using a mechanism that does not involve RAR. These observations suggest a novel function for the protein. The goal of this work was to determine the molecular mechanism by which apo-CRABP2 exerts its RA-independent activity and to examine whether it contributes to the tumor suppressive function of the protein. We found that apo-CRABP2 cooperates with the RNA-binding and stabilizing protein HuR to upregulate and stabilize mRNAs. CRABP2 directly interacts with HuR and enhances its affinity for target mRNAs. We found further that some transcripts that are co-regulated by CRABP2 and HuR include mRNAs for cancer-related proteins such as apoptotic peptidase activating factor-1, caspase 7, BRCA1, and BRCA2. Additional studies revealed that both functions of CRABP2 respectively mediated by RAR and by HuR contribute to the tumor suppressive activity of the protein.
Author :
Publisher :
ISBN 13 :
Total Pages : 8 pages
Book Rating : 4.:/5 (644 download)
Download or read book Cellular Retinoic Acid Binding Protein and Breast Cancer written by and published by . This book was released on 2004 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt: In attempts to understand how the signaling by retinoic acid (the active vitamin A metabolite) is regulated we have been studying the retinoic acid binding protein called CRABP-II. These studies revealed that CRABP-II acts to enhance the transcriptional activities of RA and that it does so by directly delivering the hormone to its cognate transcription factor, RAR. Consequently CRABP-II dramatically sensitized cultured mammary carcinoma cells to RA-induced growth inhibition. Similarly, over-expression of CRABP-II inhibited mammary tumor growth in two different mouse models of cancer. CRABP-II may be a novel target for therapeutic and preventive strategies for retinoid-treatment of breast cancer. This project aims to delineate the mechanism by which CRABP-II modulates RA activity, especially as related to its ability to enhance the anti-proliferative action of the ligand. The first aim is to determine the extent to which CRABP-II acts in activating different isotypes of RAR. The second aim is to dissect the mechanism by which RA-induced growth inhibition is mediated. This will then allow for closer inspection of particular target genes that are under such control. The third aim is to understand the basis for RA-resistance of mammary carcinoma cells and how CRABP-II functions to overcome this resistance.
Author : Jennifer Roundell
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (12 download)
Download or read book Cellular Retinoic Acid Binding Protein, CRABP, MRNA Expression in Splotch Mutant Mouse Embryos written by Jennifer Roundell and published by . This book was released on 1997 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
![Download Effects of Retinoic Acid on Importins [alpha] Expression Levels in Mammary Carcinoma Cells, and Electrophoretic Mobility and Stability of Cellular Retinoic Acid Binding Protein-II PDF Online Free](https://books.google.com/books/content/images/frontcover/6U6_HAAACAAJ?fife=w200-h370)
Author : Noel Chan
Publisher :
ISBN 13 :
Total Pages : 52 pages
Book Rating : 4.:/5 (767 download)
Download or read book Effects of Retinoic Acid on Importins [alpha] Expression Levels in Mammary Carcinoma Cells, and Electrophoretic Mobility and Stability of Cellular Retinoic Acid Binding Protein-II written by Noel Chan and published by . This book was released on 2006 with total page 52 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 134 pages
Book Rating : 4.:/5 (429 download)
Download or read book The Inhibitor of DNA Binding Proteins in Celluar Proliferation and Differentiation written by and published by . This book was released on 2007 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Id (Inhibitor of differentiation or DNA binding) helix-loop-helix proteins mediate cellular differentiation and proliferation in a variety of cell types through regulation of gene expression. The goal of the experiments in this thesis is to determine the effect of the retinoic acid signaling pathway on Id expression using cell culture and whole animal models. Retinoids, vitamin A analogues, are powerful regulators of cell growth and differentiation and are widely used in the prevention and treatment of a variety of cancers in humans. We found that exposure of normal human keratinocytes to all-trans retinoic acid (RA) results in increased expression of Id1 and Id3, which is mediated by increased transcription involving cis- acting elements in the distal portion of the promoter. To examine the effect of the Id proteins in development, we used the zebrafish (Danio rerio) model. Morpholino knockdown of Id1 in the developing zebrafish embryo results in pericardial, yolk sac and/or brain edema, as well as an undulating notochord. Loss of Id1 in early zebrafish embryogenesis results in defects in larval development, such as decreased body size, lack of swim bladder inflation, and craniofacial defects. We conclude that Id1 is critical for early and late zebrafish development. Our findings also demonstrate that RA exposure decreases expression of Id1 specifically in the heart, and RA deficiency results in increased Id1 expression. Id1 knockdown results in increased expression of the cardiac-specific transcription factors gata5 and nkx2.5 which are also targets of the RA signaling pathway. To further examine the role of Id1 in differentiation and proliferation, we examined Id expression during caudal fin regeneration. Our data demonstrate that Id1 expression is induced in the blastema during caudal fin regeneration, and that exposure to RA during regeneration decreases Id1 expression. Taken together, the data presented in this thesis demonstrate that Id1 is a target for RA signaling in both human skin cells and in zebrafish. Further, these data suggest that Id1 may be an important intermediate in the RA signaling pathway, by altering expression of genes involved in proliferation and differentiation.
Author : Kelly Elane Radtke
Publisher :
ISBN 13 : 9781303102790
Total Pages : 175 pages
Book Rating : 4.1/5 (27 download)
Download or read book Retinoic Acid Signaling Regulation and Its Contribution to Robust, Precise, and Complex Zebrafish Hindbrain Development written by Kelly Elane Radtke and published by . This book was released on 2013 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: Development is an orchestrated series of molecular interactions, each of which must occur in the right place, at the correct time, and of a particular amplitude. In order for each of these interactions to fulfill their necessary function, they must be regulated. This regulation is required so that development of the organism is robust to variation, precise in determining cell fates, and ultimately produces a complex, patterned organism. Development uses many different mechanisms for achieving the correct regulation of each step in each pathway. To begin to understand some of these mechanisms, we have studied the retinoic acid signaling pathway and how it is regulated in patterning the zebrafish hindbrain. Retinoic acid (RA) is a unique signaling molecule due to its synthesis from the dietary precursor vitamin A, and either too much or too little vitamin A leads to developmental defects. Despite this, retinoic acid is used in multiple ways during embryonic development over a large, but finite, concentration range. This suggests that synthesis, signaling, and degradation of retinoic acid must be regulated in such a way to account for differences in vitamin A availability. In my thesis, I investigate mechanisms by which RA is regulated during development. Facilitated transport of RA by cellular retinoic acid binding proteins (Crabps) is one mechanism that maintains robust hindbrain patterning despite variation in RA concentration. Noise in intracellular RA, due to small variations in synthesis, diffusion and degradation, combined with noise from transcription and translation of RA target genes, provides a mechanism for cell fate reversibility, which drives precise gene expression boundaries. RA is known to induce many cell fate decisions, and one potential mechanism that explains that ability is RA activation of two different receptor sub-types, leading to complex cell fates from a single signaling molecule. When examined as a whole, my thesis work provides insight into diverse mechanisms that regulate RA to achieve robust, precise, and complex development.
