Author : Siegfried Hoyer
Publisher : Springer Science & Business Media
ISBN 13 : 3709193508
Total Pages : 413 pages
Book Rating : 4.7/5 (91 download)
Book Synopsis Cell and Animal Models in Aging and Dementia Research by : Siegfried Hoyer
Download or read book Cell and Animal Models in Aging and Dementia Research written by Siegfried Hoyer and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although age has been recognized as a risk factor for late-onset dementia of Alzheimer type, its etiology is unknown as yet. Several age-related metabolic abnormalities may thus become important for the pathogenesis of the late-onset form. Studies at the cellular/molecular level in brain tissue are possible post mortem, but lack information on the beginning of the disorder. In this supplement, different approaches are dealt with how to induce structural and/or metabolic abnormalities in relevant cell cultures, in brain slices and in experimental animals, and how behavioral changes parallel the metabolic variations.