Cause And Correlation In Biology

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Cause and Correlation in Biology

Author : Bill Shipley
Publisher : Cambridge University Press
ISBN 13 : 9780521529211
Total Pages : 330 pages
Book Rating : 4.5/5 (292 download)

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Book Synopsis Cause and Correlation in Biology by : Bill Shipley

Download or read book Cause and Correlation in Biology written by Bill Shipley and published by Cambridge University Press. This book was released on 2002-08 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book goes beyond the truism that 'correlation does not imply causation' and explores the logical and methodological relationships between correlation and causation. It presents a series of statistical methods that can test, and potentially discover, cause-effect relationships between variables in situations in which it is not possible to conduct randomised or experimentally controlled experiments. Many of these methods are quite new and most are generally unknown to biologists. In addition to describing how to conduct these statistical tests, the book also puts the methods into historical context and explains when they can and cannot justifiably be used to test or discover causal claims. Written in a conversational style that minimises technical jargon, the book is aimed at practising biologists and advanced students, and assumes only a very basic knowledge of introductory statistics.

Cause and Correlation in Biology

Author : Bill Shipley
Publisher : Cambridge University Press
ISBN 13 : 1316539164
Total Pages : 493 pages
Book Rating : 4.3/5 (165 download)

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Book Synopsis Cause and Correlation in Biology by : Bill Shipley

Download or read book Cause and Correlation in Biology written by Bill Shipley and published by Cambridge University Press. This book was released on 2016-04-18 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many problems in biology require an understanding of the relationships among variables in a multivariate causal context. Exploring such cause-effect relationships through a series of statistical methods, this book explains how to test causal hypotheses when randomised experiments cannot be performed. This completely revised and updated edition features detailed explanations for carrying out statistical methods using the popular and freely available R statistical language. Sections on d-sep tests, latent constructs that are common in biology, missing values, phylogenetic constraints, and multilevel models are also an important feature of this new edition. Written for biologists and using a minimum of statistical jargon, the concept of testing multivariate causal hypotheses using structural equations and path analysis is demystified. Assuming only a basic understanding of statistical analysis, this new edition is a valuable resource for both students and practising biologists.

Causality

Author : Judea Pearl
Publisher : Cambridge University Press
ISBN 13 : 052189560X
Total Pages : 487 pages
Book Rating : 4.5/5 (218 download)

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Book Synopsis Causality by : Judea Pearl

Download or read book Causality written by Judea Pearl and published by Cambridge University Press. This book was released on 2009-09-14 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: Causality offers the first comprehensive coverage of causal analysis in many sciences, including recent advances using graphical methods. Pearl presents a unified account of the probabilistic, manipulative, counterfactual and structural approaches to causation, and devises simple mathematical tools for analyzing the relationships between causal connections, statistical associations, actions and observations. The book will open the way for including causal analysis in the standard curriculum of statistics, artificial intelligence ...

The Book of Why

Author : Judea Pearl
Publisher : Penguin UK
ISBN 13 : 0241242649
Total Pages : 432 pages
Book Rating : 4.2/5 (412 download)

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Book Synopsis The Book of Why by : Judea Pearl

Download or read book The Book of Why written by Judea Pearl and published by Penguin UK. This book was released on 2018-05-15 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: A pioneer of artificial intelligence shows how the study of causality revolutionized science and the world 'Correlation does not imply causation.' This mantra was invoked by scientists for decades in order to avoid taking positions as to whether one thing caused another, such as smoking and cancer and carbon dioxide and global warming. But today, that taboo is dead. The causal revolution, sparked by world-renowned computer scientist Judea Pearl and his colleagues, has cut through a century of confusion and placed cause and effect on a firm scientific basis. Now, Pearl and science journalist Dana Mackenzie explain causal thinking to general readers for the first time, showing how it allows us to explore the world that is and the worlds that could have been. It is the essence of human and artificial intelligence. And just as Pearl's discoveries have enabled machines to think better, The Book of Why explains how we can think better.

Elements of Causal Inference

Author : Jonas Peters
Publisher : MIT Press
ISBN 13 : 0262037319
Total Pages : 289 pages
Book Rating : 4.2/5 (62 download)

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Book Synopsis Elements of Causal Inference by : Jonas Peters

Download or read book Elements of Causal Inference written by Jonas Peters and published by MIT Press. This book was released on 2017-11-29 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: A concise and self-contained introduction to causal inference, increasingly important in data science and machine learning. The mathematization of causality is a relatively recent development, and has become increasingly important in data science and machine learning. This book offers a self-contained and concise introduction to causal models and how to learn them from data. After explaining the need for causal models and discussing some of the principles underlying causal inference, the book teaches readers how to use causal models: how to compute intervention distributions, how to infer causal models from observational and interventional data, and how causal ideas could be exploited for classical machine learning problems. All of these topics are discussed first in terms of two variables and then in the more general multivariate case. The bivariate case turns out to be a particularly hard problem for causal learning because there are no conditional independences as used by classical methods for solving multivariate cases. The authors consider analyzing statistical asymmetries between cause and effect to be highly instructive, and they report on their decade of intensive research into this problem. The book is accessible to readers with a background in machine learning or statistics, and can be used in graduate courses or as a reference for researchers. The text includes code snippets that can be copied and pasted, exercises, and an appendix with a summary of the most important technical concepts.

Fundamentals of Molecular Structural Biology

Author : Subrata Pal
Publisher : Academic Press
ISBN 13 : 012814856X
Total Pages : 518 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Fundamentals of Molecular Structural Biology by : Subrata Pal

Download or read book Fundamentals of Molecular Structural Biology written by Subrata Pal and published by Academic Press. This book was released on 2019-08-13 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamentals of Molecular Structural Biology reviews the mathematical and physical foundations of molecular structural biology. Based on these fundamental concepts, it then describes molecular structure and explains basic genetic mechanisms. Given the increasingly interdisciplinary nature of research, early career researchers and those shifting into an adjacent field often require a "fundamentals" book to get them up-to-speed on the foundations of a particular field. This book fills that niche. Provides a current and easily digestible resource on molecular structural biology, discussing both foundations and the latest advances Addresses critical issues surrounding macromolecular structures, such as structure-based drug discovery, single-particle analysis, computational molecular biology/molecular dynamic simulation, cell signaling and immune response, macromolecular assemblies, and systems biology Presents discussions that ultimately lead the reader toward a more detailed understanding of the basis and origin of disease

Causality, Correlation and Artificial Intelligence for Rational Decision Making

Author : Tshilidzi Marwala
Publisher : World Scientific
ISBN 13 : 9814630888
Total Pages : 208 pages
Book Rating : 4.8/5 (146 download)

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Book Synopsis Causality, Correlation and Artificial Intelligence for Rational Decision Making by : Tshilidzi Marwala

Download or read book Causality, Correlation and Artificial Intelligence for Rational Decision Making written by Tshilidzi Marwala and published by World Scientific. This book was released on 2015-01-02 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Causality has been a subject of study for a long time. Often causality is confused with correlation. Human intuition has evolved such that it has learned to identify causality through correlation. In this book, four main themes are considered and these are causality, correlation, artificial intelligence and decision making. A correlation machine is defined and built using multi-layer perceptron network, principal component analysis, Gaussian Mixture models, genetic algorithms, expectation maximization technique, simulated annealing and particle swarm optimization. Furthermore, a causal machine is defined and built using multi-layer perceptron, radial basis function, Bayesian statistics and Hybrid Monte Carlo methods. Both these machines are used to build a Granger non-linear causality model. In addition, the Neyman–Rubin, Pearl and Granger causal models are studied and are unified. The automatic relevance determination is also applied to extend Granger causality framework to the non-linear domain. The concept of rational decision making is studied, and the theory of flexibly-bounded rationality is used to extend the theory of bounded rationality within the principle of the indivisibility of rationality. The theory of the marginalization of irrationality for decision making is also introduced to deal with satisficing within irrational conditions. The methods proposed are applied in biomedical engineering, condition monitoring and for modelling interstate conflict. Contents:Introduction to Artificial Intelligence based Decision MakingWhat is a Correlation Machine?What is a Causal Machine?Correlation Machines Using Optimization MethodsNeural Networks for Modeling Granger CausalityRubin, Pearl and Granger Causality Models: A Unified ViewCausal, Correlation and Automatic Relevance Determination Machines for Granger CausalityFlexibly-bounded RationalityMarginalization of Irrationality in Decision MakingConclusions and Further Work Readership: Graduate students, researchers and professionals in the field of artificial intelligence. Key Features:It proposes fresh definition of causality and proposes two new theories i.e. flexibly bounded rationality and marginalization of irrationality theory for decision makingIt also applies these techniques to a diverse areas in engineering, political science and biomedical engineeringKeywords:Causality;Correlation;Artificial Intelligence;Rational Decision Making

Evolutionary Causation

Author : Tobias Uller
Publisher : MIT Press
ISBN 13 : 0262039923
Total Pages : 361 pages
Book Rating : 4.2/5 (62 download)

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Book Synopsis Evolutionary Causation by : Tobias Uller

Download or read book Evolutionary Causation written by Tobias Uller and published by MIT Press. This book was released on 2019-09-03 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive treatment of the concept of causation in evolutionary biology that makes clear its central role in both historical and contemporary debates. Most scientific explanations are causal. This is certainly the case in evolutionary biology, which seeks to explain the diversity of life and the adaptive fit between organisms and their surroundings. The nature of causation in evolutionary biology, however, is contentious. How causation is understood shapes the structure of evolutionary theory, and historical and contemporary debates in evolutionary biology have revolved around the nature of causation. Despite its centrality, and differing views on the subject, the major conceptual issues regarding the nature of causation in evolutionary biology are rarely addressed. This volume fills the gap, bringing together biologists and philosophers to offer a comprehensive, interdisciplinary treatment of evolutionary causation. Contributors first address biological motivations for rethinking evolutionary causation, considering the ways in which development, extra-genetic inheritance, and niche construction challenge notions of cause and process in evolution, and describing how alternative representations of evolutionary causation can shed light on a range of evolutionary problems. Contributors then analyze evolutionary causation from a philosophical perspective, considering such topics as causal entanglement, the commingling of organism and environment, and the relationship between causation and information. Contributors John A. Baker, Lynn Chiu, David I. Dayan, Renée A. Duckworth, Marcus W Feldman, Susan A. Foster, Melissa A. Graham, Heikki Helanterä, Kevin N. Laland, Armin P. Moczek, John Odling-Smee, Jun Otsuka, Massimo Pigliucci, Arnaud Pocheville, Arlin Stoltzfus, Karola Stotz, Sonia E. Sultan, Christoph Thies, Tobias Uller, Denis M. Walsh, Richard A. Watson

The Selfish Gene

Author : Richard Dawkins
Publisher : Oxford University Press, USA
ISBN 13 : 9780192860927
Total Pages : 372 pages
Book Rating : 4.8/5 (69 download)

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Book Synopsis The Selfish Gene by : Richard Dawkins

Download or read book The Selfish Gene written by Richard Dawkins and published by Oxford University Press, USA. This book was released on 1989 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Science need not be dull and bogged down by jargon, as Richard Dawkins proves in this entertaining look at evolution. The themes he takes up are the concepts of altruistic and selfish behaviour; the genetical definition of selfish interest; the evolution of aggressive behaviour; kinshiptheory; sex ratio theory; reciprocal altruism; deceit; and the natural selection of sex differences. 'Should be read, can be read by almost anyone. It describes with great skill a new face of the theory of evolution.' W.D. Hamilton, Science

The Whole-Body Microbiome

Author : B. Brett Finlay
Publisher : The Experiment
ISBN 13 : 1615194819
Total Pages : 322 pages
Book Rating : 4.6/5 (151 download)

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Book Synopsis The Whole-Body Microbiome by : B. Brett Finlay

Download or read book The Whole-Body Microbiome written by B. Brett Finlay and published by The Experiment. This book was released on 2019-01-08 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learn the secret to total, lifelong health: the teeming world of microbes inside and all around us Modern-day science has allowed us to prolong and improve life in astonishing ways, often by fending off germs and other invisible foes. But there’s no “immunity” to the inevitable signs of aging . . . or is there? In The Whole-Body Microbiome, the father-daughter team of Dr. Brett Finlay (a microbiologist) and Dr. Jessica Finlay (a specialist on aging) offers a different—and truly revolutionary—solution to the quest for the fountain of youth. While much has been written about bacteria in the gut, exciting new research shows that there are millions of microbes both inside our bodies—supporting our brain, teeth, heart, lungs, bones, immune system, and more; plus the microbes on our bodies, coming from the air we breathe and the things we touch all day long—cell phones and kitchen sponges, pets and doorknobs, and even other humans. These microbial “lifelong companions” have an immense impact on our daily health—and, as groundbreaking research is showing, they have the power to help prevent and reverse the most common age-related diseases. In this eye-opening new take on the significance of the microbiome, the Finlays offer empowering knowledge, surprising myth-busters, and simple yet effective daily tips that prove “dirty” is the new clean. Whether it’s by changing your diet, enjoying a glass of wine, getting more exercise, trading your antibacterial gel for good old soap and water, or spending more time outdoors, you can change your life today; so that you and your microbes live long—and prosper.

Understanding Genes

Author : Kostas Kampourakis
Publisher : Cambridge University Press
ISBN 13 : 1108858635
Total Pages : 241 pages
Book Rating : 4.1/5 (88 download)

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Book Synopsis Understanding Genes by : Kostas Kampourakis

Download or read book Understanding Genes written by Kostas Kampourakis and published by Cambridge University Press. This book was released on 2021-11-04 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: What are genes? What do genes do? These questions are not simple and straightforward to answer; at the same time, simplistic answers are quite prevalent and are taken for granted. This book aims to explain the origin of the gene concept, its various meanings both within and outside science, as well as to debunk the intuitive view of the existence of 'genes for' characteristics and disease. Drawing on contemporary research in genetics and genomics, as well as on ideas from history of science, philosophy of science, psychology and science education, it explains what genes are and what they can and cannot do. By presenting complex concepts and research in a comprehensible and rigorous manner, it examines the potential impact of research in genetics and genomics and how important genes actually are for our lives. Understanding Genes is an accessible and engaging introduction to genes for any interested reader.

How Tobacco Smoke Causes Disease

Author :
Publisher :
ISBN 13 :
Total Pages : 728 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis How Tobacco Smoke Causes Disease by :

Download or read book How Tobacco Smoke Causes Disease written by and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Molecular Biology of The Cell

Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of The Cell by : Bruce Alberts

Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Mismeasure of Man (Revised and Expanded)

Author : Stephen Jay Gould
Publisher : W. W. Norton & Company
ISBN 13 : 0393340406
Total Pages : 448 pages
Book Rating : 4.3/5 (933 download)

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Book Synopsis The Mismeasure of Man (Revised and Expanded) by : Stephen Jay Gould

Download or read book The Mismeasure of Man (Revised and Expanded) written by Stephen Jay Gould and published by W. W. Norton & Company. This book was released on 2006-06-17 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: The definitive refutation to the argument of The Bell Curve. When published in 1981, The Mismeasure of Man was immediately hailed as a masterwork, the ringing answer to those who would classify people, rank them according to their supposed genetic gifts and limits. And yet the idea of innate limits—of biology as destiny—dies hard, as witness the attention devoted to The Bell Curve, whose arguments are here so effectively anticipated and thoroughly undermined by Stephen Jay Gould. In this edition Dr. Gould has written a substantial new introduction telling how and why he wrote the book and tracing the subsequent history of the controversy on innateness right through The Bell Curve. Further, he has added five essays on questions of The Bell Curve in particular and on race, racism, and biological determinism in general. These additions strengthen the book's claim to be, as Leo J. Kamin of Princeton University has said, "a major contribution toward deflating pseudo-biological 'explanations' of our present social woes."

Molecular Biology of B Cells

Author : Tasuku Honjo
Publisher : Elsevier
ISBN 13 : 0123984904
Total Pages : 600 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Molecular Biology of B Cells by : Tasuku Honjo

Download or read book Molecular Biology of B Cells written by Tasuku Honjo and published by Elsevier. This book was released on 2014-10-09 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular Biology of B Cells, Second Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with updated research on microRNAs in B cell development and immunity, new developments in understanding lymphoma biology, and therapeutic targeting of B cells for clinical application. With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, Second Edition is the definitive resource, vital for researchers across molecular biology, immunology and genetics. Covers signaling mechanisms regulating B cell differentiation Provides information on the development of therapeutics using monoclonal antibodies and clinical application of Ab Contains studies on B cell tumors from various stages of B lymphocytes Offers an integrated view of all aspects of B cells to produce a normal immune response

An Introduction to Causal Inference

Author : Judea Pearl
Publisher : Createspace Independent Publishing Platform
ISBN 13 : 9781507894293
Total Pages : 0 pages
Book Rating : 4.8/5 (942 download)

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Book Synopsis An Introduction to Causal Inference by : Judea Pearl

Download or read book An Introduction to Causal Inference written by Judea Pearl and published by Createspace Independent Publishing Platform. This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This paper summarizes recent advances in causal inference and underscores the paradigmatic shifts that must be undertaken in moving from traditional statistical analysis to causal analysis of multivariate data. Special emphasis is placed on the assumptions that underly all causal inferences, the languages used in formulating those assumptions, the conditional nature of all causal and counterfactual claims, and the methods that have been developed for the assessment of such claims. These advances are illustrated using a general theory of causation based on the Structural Causal Model (SCM) described in Pearl (2000a), which subsumes and unifies other approaches to causation, and provides a coherent mathematical foundation for the analysis of causes and counterfactuals. In particular, the paper surveys the development of mathematical tools for inferring (from a combination of data and assumptions) answers to three types of causal queries: (1) queries about the effects of potential interventions, (also called "causal effects" or "policy evaluation") (2) queries about probabilities of counterfactuals, (including assessment of "regret," "attribution" or "causes of effects") and (3) queries about direct and indirect effects (also known as "mediation"). Finally, the paper defines the formal and conceptual relationships between the structural and potential-outcome frameworks and presents tools for a symbiotic analysis that uses the strong features of both. The tools are demonstrated in the analyses of mediation, causes of effects, and probabilities of causation. -- p. 1.

Dementia Care

Author : Jonathan Waite
Publisher : Oxford University Press
ISBN 13 : 0199228825
Total Pages : 437 pages
Book Rating : 4.1/5 (992 download)

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Book Synopsis Dementia Care by : Jonathan Waite

Download or read book Dementia Care written by Jonathan Waite and published by Oxford University Press. This book was released on 2009 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: This care manual covers a wide range of information in a short, easily accessible handbook format. It follows the pathway of dementia, from first presentation through to final stages of the illness, and is aimed at the multipdisciplinary care team.