Carotid Body: A New Target for Rescuing Neural Control of Cardiorespiratory Balance in Disease

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Publisher : Frontiers Media SA
ISBN 13 : 2889199436
Total Pages : 136 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Carotid Body: A New Target for Rescuing Neural Control of Cardiorespiratory Balance in Disease by : Rodrigo Del Rio

Download or read book Carotid Body: A New Target for Rescuing Neural Control of Cardiorespiratory Balance in Disease written by Rodrigo Del Rio and published by Frontiers Media SA. This book was released on 2016-12-12 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: The carotid body (CB) is in charge of adjusting ventilatory and cardiovascular function during changes in arterial blood gases. Regardless this essential function, the CB has been implicated in the sensing of other physiological signals such as changes in blood flow and glucose levels. More important, malfunction of the CB chemoreceptors has been associated with the progression and deterioration of several disease states such as hypertension, heart failure, renal failure, insulin resistance, diabetes and sleep apnea. Although the mechanisms involved in the alterations of the CB function in pathophysiology are currently under intense research, the development of therapeutic approaches to restore normal CB chemoreflex function remains unsolved. Recent studies showing the effect of CB denervation in pathophysiology have unveiled a key role of these arterial chemoreceptors in the development of autonomic imbalance and respiratory disturbances, and suggest that targeting the CB could represent a novel strategy to improve disease outcome. Unfortunately, classical pharmacotherapy intended to normalize CB function may be hard to establish since several cellular pathways are involved in the CB dysfunction. Augmented levels of angiotensin II, endothelin-1, cytokines and free radicals along with decreases in nitric oxide had all been related to the CB dysfunction. Moreover, changes in expression of angiotensin receptors, nitric oxide synthases and cytokines that take place within the CB tissue in pathological states also contribute to the enhanced CB chemoreflex drive. It has been shown in heart failure, hypertension and obstructive sleep apnea that the CB becomes tonically hyper-reactive. During the progression of the disease this CB chemosensory facilitation process induces central nervous system plasticity. The altered autonomic-respiratory control leads to increased cardiorespiratory distress and the deterioration of the condition. The focus of this e-book will be to cover the role of the CB in pathophysiology and to provide new evidence of the pathways involved in the maladaptive potentiation of the CB chemoreflex function. In memory of Professor Mashiko Shirahata and Professor Constancio Gonzalez.

Carotid Body: A New Target for Rescuing Neural Control of Cardiorespiratory Balance in Disease

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Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (136 download)

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Book Synopsis Carotid Body: A New Target for Rescuing Neural Control of Cardiorespiratory Balance in Disease by :

Download or read book Carotid Body: A New Target for Rescuing Neural Control of Cardiorespiratory Balance in Disease written by and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The carotid body (CB) is in charge of adjusting ventilatory and cardiovascular function during changes in arterial blood gases. Regardless this essential function, the CB has been implicated in the sensing of other physiological signals such as changes in blood flow and glucose levels. More important, malfunction of the CB chemoreceptors has been associated with the progression and deterioration of several disease states such as hypertension, heart failure, renal failure, insulin resistance, diabetes and sleep apnea. Although the mechanisms involved in the alterations of the CB function in pathophysiology are currently under intense research, the development of therapeutic approaches to restore normal CB chemoreflex function remains unsolved. Recent studies showing the effect of CB denervation in pathophysiology have unveiled a key role of these arterial chemoreceptors in the development of autonomic imbalance and respiratory disturbances, and suggest that targeting the CB could represent a novel strategy to improve disease outcome. Unfortunately, classical pharmacotherapy intended to normalize CB function may be hard to establish since several cellular pathways are involved in the CB dysfunction. Augmented levels of angiotensin II, endothelin-1, cytokines and free radicals along with decreases in nitric oxide had all been related to the CB dysfunction. Moreover, changes in expression of angiotensin receptors, nitric oxide synthases and cytokines that take place within the CB tissue in pathological states also contribute to the enhanced CB chemoreflex drive. It has been shown in heart failure, hypertension and obstructive sleep apnea that the CB becomes tonically hyper-reactive. During the progression of the disease this CB chemosensory facilitation process induces central nervous system plasticity. The altered autonomic-respiratory control leads to increased cardiorespiratory distress and the deterioration of the condition. The focus of this e-book will be to cover the role of the CB in pathophysiology and to provide new evidence of the pathways involved in the maladaptive potentiation of the CB chemoreflex function. In memory of Professor Mashiko Shirahata and Professor Constancio Gonzalez.

Diagnostic Histopathology of Tumors

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Publisher : Elsevier Health Sciences
ISBN 13 : 0323636136
Total Pages : 2444 pages
Book Rating : 4.3/5 (236 download)

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Book Synopsis Diagnostic Histopathology of Tumors by : Christopher D. M. Fletcher

Download or read book Diagnostic Histopathology of Tumors written by Christopher D. M. Fletcher and published by Elsevier Health Sciences. This book was released on 2019-12-10 with total page 2444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Known for its clear writing style, easy-to-navigate format, and authoritative coverage of tumor pathology, Dr. Christopher Fletcher’s Diagnostic Histopathology of Tumors, 5th Edition, remains your go-to source for accurate, efficient evaluation and interpretation of histopathology specimens. This highly regarded reference provides superbly illustrated information on pathogenesis, diagnostic criteria, molecular/cytogenetic findings, and prognosis on the neoplastic diseases most likely to be encountered by general surgical pathologists, and helps you stay current with the latest diagnostic tumor markers to assist in daily sign-out. Discusses the latest developments in immunohistochemistry, molecular genetics, targeted therapy/personalized medicine, and prognostic/predictive markers to assist in the diagnosis of the complete range of neoplastic entities. Includes coverage of newly described variants and new histologic entities. Covers all modern diagnostic techniques while retaining a strong emphasis on morphologic diagnosis, which remains the cornerstone of diagnosis for most lesions. Features thousands of high-quality photographs, photomicrographs, and artwork throughout. Incorporates the latest TNM and WHO classification and staging systems. Contains diagnostic flow charts, correlations of gross appearances to microscopic findings, and differential diagnosis tables for better recognition and evaluation of similar-looking entities. Shares the knowledge and expertise of internationally renowned experts in tumor pathology, including Dr. Christopher Fletcher, as well as numerous global authorities in the field.

Autonomic Failure

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Publisher : Oxford University Press, USA
ISBN 13 :
Total Pages : 690 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Autonomic Failure by : Roger Bannister

Download or read book Autonomic Failure written by Roger Bannister and published by Oxford University Press, USA. This book was released on 1983 with total page 690 pages. Available in PDF, EPUB and Kindle. Book excerpt: Life is a journey and we all have to go thru this progress. When I make wrong choices it was for a reason, it was for a purpose. I had to learn from it.I can not be ashamed of No one.I can not think that I am better then No One Else.I can not think less of No one Else.I can not talk about No One.Because My Father was not ashamed of Me.Because My Father did not think less of Me.Because My Father did not talk about my dirt or my sins to Anyone.Because My Father did not think that he was Better then me.HE ONLY LOVE ME

How Tobacco Smoke Causes Disease

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Publisher :
ISBN 13 :
Total Pages : 728 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis How Tobacco Smoke Causes Disease by :

Download or read book How Tobacco Smoke Causes Disease written by and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

The Arterial Chemoreceptors

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Publisher : Springer Science & Business Media
ISBN 13 : 0387313117
Total Pages : 360 pages
Book Rating : 4.3/5 (873 download)

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Book Synopsis The Arterial Chemoreceptors by : Yoshiaki Hayashida

Download or read book The Arterial Chemoreceptors written by Yoshiaki Hayashida and published by Springer Science & Business Media. This book was released on 2006-04-24 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book represents an updated review of the physiology of the carotid body chemoreceptors. It contains results in the topics at the frontiers of future developments in O2-sensing in chemoreceptor cells. Additionally, this volume provides data from studies carried out in other O2-sensing tissues including pulmonary vasculature and erythropoietin producing cells. It is a prime source of information and a guideline for arterial chemoreception researchers.

The Carotid Body Chemoreceptors

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Publisher :
ISBN 13 : 9781570594656
Total Pages : 0 pages
Book Rating : 4.5/5 (946 download)

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Book Synopsis The Carotid Body Chemoreceptors by : Constancio Gonzalez

Download or read book The Carotid Body Chemoreceptors written by Constancio Gonzalez and published by . This book was released on 1997 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Practical Guide

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Publisher :
ISBN 13 :
Total Pages : 94 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis The Practical Guide by :

Download or read book The Practical Guide written by and published by . This book was released on 2002 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Perioperative Hemodynamic Monitoring and Goal Directed Therapy

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Publisher : Cambridge University Press
ISBN 13 : 1316061442
Total Pages : 301 pages
Book Rating : 4.3/5 (16 download)

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Book Synopsis Perioperative Hemodynamic Monitoring and Goal Directed Therapy by : Maxime Cannesson

Download or read book Perioperative Hemodynamic Monitoring and Goal Directed Therapy written by Maxime Cannesson and published by Cambridge University Press. This book was released on 2014-09-04 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique book provides clinicians and administrators with a comprehensive understanding of perioperative hemodynamic monitoring and goal directed therapy, emphasizing practical guidance for implementation at the bedside. Successful hemodynamic monitoring and goal directed therapy require a wide range of skills. This book will enable readers to: • Detail the rationale for using perioperative hemodynamic monitoring systems and for applying goal directed therapy protocols at the bedside • Understand the physiological concepts underlying perioperative goal directed therapy for hemodynamic management • Evaluate hemodynamic monitoring systems in clinical practice • Learn about new techniques for achieving goal directed therapy • Apply goal directed therapy protocols in the perioperative environment (including emergency departments, operating rooms and intensive care units) • Demonstrate clinical utility of GDT and hemodynamic optimization using case presentations. Illustrated with diagrams and case examples, this is an important resource for anesthesiologists, emergency physicians, intensivists and pneumonologists as well as nurses and administrative officers.

Educating the Student Body

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Publisher : National Academies Press
ISBN 13 : 0309283140
Total Pages : 503 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Educating the Student Body by : Committee on Physical Activity and Physical Education in the School Environment

Download or read book Educating the Student Body written by Committee on Physical Activity and Physical Education in the School Environment and published by National Academies Press. This book was released on 2013-11-13 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physical inactivity is a key determinant of health across the lifespan. A lack of activity increases the risk of heart disease, colon and breast cancer, diabetes mellitus, hypertension, osteoporosis, anxiety and depression and others diseases. Emerging literature has suggested that in terms of mortality, the global population health burden of physical inactivity approaches that of cigarette smoking. The prevalence and substantial disease risk associated with physical inactivity has been described as a pandemic. The prevalence, health impact, and evidence of changeability all have resulted in calls for action to increase physical activity across the lifespan. In response to the need to find ways to make physical activity a health priority for youth, the Institute of Medicine's Committee on Physical Activity and Physical Education in the School Environment was formed. Its purpose was to review the current status of physical activity and physical education in the school environment, including before, during, and after school, and examine the influences of physical activity and physical education on the short and long term physical, cognitive and brain, and psychosocial health and development of children and adolescents. Educating the Student Body makes recommendations about approaches for strengthening and improving programs and policies for physical activity and physical education in the school environment. This report lays out a set of guiding principles to guide its work on these tasks. These included: recognizing the benefits of instilling life-long physical activity habits in children; the value of using systems thinking in improving physical activity and physical education in the school environment; the recognition of current disparities in opportunities and the need to achieve equity in physical activity and physical education; the importance of considering all types of school environments; the need to take into consideration the diversity of students as recommendations are developed. This report will be of interest to local and national policymakers, school officials, teachers, and the education community, researchers, professional organizations, and parents interested in physical activity, physical education, and health for school-aged children and adolescents.

Clinical Case Studies for the Family Nurse Practitioner

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Publisher : John Wiley & Sons
ISBN 13 : 1118277856
Total Pages : 432 pages
Book Rating : 4.1/5 (182 download)

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Book Synopsis Clinical Case Studies for the Family Nurse Practitioner by : Leslie Neal-Boylan

Download or read book Clinical Case Studies for the Family Nurse Practitioner written by Leslie Neal-Boylan and published by John Wiley & Sons. This book was released on 2011-11-28 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Case Studies for the Family Nurse Practitioner is a key resource for advanced practice nurses and graduate students seeking to test their skills in assessing, diagnosing, and managing cases in family and primary care. Composed of more than 70 cases ranging from common to unique, the book compiles years of experience from experts in the field. It is organized chronologically, presenting cases from neonatal to geriatric care in a standard approach built on the SOAP format. This includes differential diagnosis and a series of critical thinking questions ideal for self-assessment or classroom use.

Arterial Chemoreceptors in Physiology and Pathophysiology

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Publisher : Springer
ISBN 13 : 3319184407
Total Pages : 404 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Arterial Chemoreceptors in Physiology and Pathophysiology by : Chris Peers

Download or read book Arterial Chemoreceptors in Physiology and Pathophysiology written by Chris Peers and published by Springer. This book was released on 2015-08-24 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every three years, the International Society for Arterial Chemoreception (ISAC) arranges a Meeting to bring together all of the major International research groups investigating the general topic of oxygen sensing in health and disease, with a prime focus upon systemic level hypoxia and carotid body function. This volume summarises the proceedings of the XIXth meeting of the Society, held in Leeds, UK during the summer of 2014. As such this volume represents a unique collection of state of the art reviews and original, brief research articles covering all aspects of oxygen sensing, ranging from the molecular mechanisms of chemotransduction in oxygen sensing cells such as the carotid body type I cells, to the adverse, reflex cardiovascular outcomes arising from carotid body dysfunction as seen, for example, in heart failure or obstructive sleep apnoea. This volume will be of tremendous interest to basic scientists with an interest in the cellular and molecular biology of oxygen sensing and integrative, whole organism physiologists as well as physicians studying or treating the clinical cardiovascular consequences of carotid body dysfunction.

Diet and Health

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Publisher : National Academies Press
ISBN 13 : 0309039940
Total Pages : 765 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Diet and Health by : National Research Council

Download or read book Diet and Health written by National Research Council and published by National Academies Press. This book was released on 1989-01-01 with total page 765 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diet and Health examines the many complex issues concerning diet and its role in increasing or decreasing the risk of chronic disease. It proposes dietary recommendations for reducing the risk of the major diseases and causes of death today: atherosclerotic cardiovascular diseases (including heart attack and stroke), cancer, high blood pressure, obesity, osteoporosis, diabetes mellitus, liver disease, and dental caries.

Vasculopathies

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Publisher : Springer
ISBN 13 : 3319893157
Total Pages : 888 pages
Book Rating : 4.3/5 (198 download)

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Book Synopsis Vasculopathies by : Marc Thiriet

Download or read book Vasculopathies written by Marc Thiriet and published by Springer. This book was released on 2019-02-18 with total page 888 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents one of the clinical foundations of vasculopathies: the biological markers and risk factors associated with cardiovascular disease. A detailed biological and clinical framework is provided as a prerequisite for adequate modeling. Chapter 1 presents cardiovascular risk factors and markers, where the search for new criteria is aimed at improving early detection of chronic diseases. The subsequent chapters focus on hypertension, which involves the kidney among other organs as well as many agents, hyperglycemia and diabetes, hyperlipidemias and obesity, and behavior. The last of these risk factors includes altered circadian rhythm, tobacco and alcohol consumption, physical inactivity, and diet. The volumes in this series present all of the data needed at various length scales for a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to nano- and microscopic events in a corrector scheme of regulated mechanisms. Therefore, investigation of flows of blood and air in anatomical conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning in quantitative terms.

Global Atlas on Cardiovascular Disease Prevention and Control

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Publisher : World Health Organization
ISBN 13 : 9789241564373
Total Pages : 155 pages
Book Rating : 4.5/5 (643 download)

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Book Synopsis Global Atlas on Cardiovascular Disease Prevention and Control by : Shanthi Mendis

Download or read book Global Atlas on Cardiovascular Disease Prevention and Control written by Shanthi Mendis and published by World Health Organization. This book was released on 2011 with total page 155 pages. Available in PDF, EPUB and Kindle. Book excerpt: "As the magnitude of cardiovascular diseases (CVDs) continue to accelerate globally, the pressing need for increased awareness and for stronger and more focused international and country responses is increasingly recognized. This atlas on cardiovascular disease prevention and control is part of the response to this need. It documents the magnitude of the problem, using global cardiovascular mortality and morbidity data. It demonstrates the inequities in access to protection, exposure to risk, and access to care as the cause of major inequalities between countries and populations in the occurrence and outcome of CVDs. The report has graphs showing mortality rates of CVDs by age, by country/region, and is divided into three main sections: Section A: Cardiovascular diseases due to atherosclerosis -- Section B: Other cardiovascular diseases -- Section C: Prevention and control of CVDs: Policies, strategies and interventions."--Provided by publisher.

Cerebral Blood Flow

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Author :
Publisher : Elsevier
ISBN 13 : 9780080861609
Total Pages : 436 pages
Book Rating : 4.8/5 (616 download)

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Book Synopsis Cerebral Blood Flow by :

Download or read book Cerebral Blood Flow written by and published by Elsevier. This book was released on 1972-01-01 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in Brain Research is the most acclaimed and accomplished series in neuroscience. The serial is well-established as an extensive documentation of contemporary advances in the field. The volumes contain authoritative reviews and original articles by invited specialists. The rigorous editing of the volumes assures that they will appeal to all laboratory and clinical brain research workers in the various disciplines: neuroanatomy, neurophysiology, neuropharmacology, neuroendocrinology, neuropathology, basic neurology, biological psychiatry and the behavioral sciences.

The ESC Textbook of Cardiovascular Medicine

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Publisher :
ISBN 13 : 9780198824879
Total Pages : 3198 pages
Book Rating : 4.8/5 (248 download)

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Book Synopsis The ESC Textbook of Cardiovascular Medicine by : A. John Camm

Download or read book The ESC Textbook of Cardiovascular Medicine written by A. John Camm and published by . This book was released on 2019 with total page 3198 pages. Available in PDF, EPUB and Kindle. Book excerpt: