Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Download Cardiac Growth And Regeneration full books in PDF, epub, and Kindle. Read online Cardiac Growth And Regeneration ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Author : William C. Claycomb
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (757 download)
Download or read book Cardiac Growth and Regeneration written by William C. Claycomb and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Felix B. Engel
Publisher : World Scientific
ISBN 13 : 9814299804
Total Pages : 393 pages
Book Rating : 4.8/5 (142 download)
Download or read book Heart Regeneration written by Felix B. Engel and published by World Scientific. This book was released on 2012 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: This title presents the major advances of the last decade in the field of cardiac regeneration.
Author : Masaki Ieda
Publisher : Springer
ISBN 13 : 3319561065
Total Pages : 274 pages
Book Rating : 4.3/5 (195 download)
Download or read book Cardiac Regeneration written by Masaki Ieda and published by Springer. This book was released on 2017-10-27 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged. The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration.
Author : Nadia Rosenthal
Publisher : Academic Press
ISBN 13 : 0123813336
Total Pages : 1126 pages
Book Rating : 4.1/5 (238 download)
Download or read book Heart Development and Regeneration written by Nadia Rosenthal and published by Academic Press. This book was released on 2010-05-28 with total page 1126 pages. Available in PDF, EPUB and Kindle. Book excerpt: The development of the cardiovascular system is a rapidly advancing area in biomedical research, now coupled with the burgeoning field of cardiac regenerative medicine. A lucid understanding of these fields is paramount to reducing human cardiovascular diseases of both fetal and adult origin. Significant progress can now be made through a comprehensive investigation of embryonic development and its genetic control circuitry. Heart Development and Regeneration, written by experts in the field, provides essential information on topics ranging from the evolution and lineage origins of the developing cardiovascular system to cardiac regenerative medicine. A reference for clinicians, medical researchers, students, and teachers, this publication offers broad coverage of the most recent advances. Volume One discusses heart evolution, contributing cell lineages; model systems; cardiac growth; morphology and asymmetry; heart patterning; epicardial, vascular, and lymphatic development; and congenital heart diseases. Volume Two includes chapters on transcription factors and transcriptional control circuits in cardiac development and disease; epigenetic modifiers including microRNAs, genome-wide mutagenesis, imaging, and proteomics approaches; and the theory and practice of stem cells and cardiac regeneration. - Authored by world experts in heart development and disease - New research on epigenetic modifiers in cardiac development - Comprehensive coverage of stem cells and prospects for cardiac regeneration - Up-to-date research on transcriptional and proteomic circuits in cardiac disease - Full-color, detailed illustrations
Download or read book גבורת יצחק written by and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Felix B Engel
Publisher : World Scientific
ISBN 13 : 9814465259
Total Pages : 393 pages
Book Rating : 4.8/5 (144 download)
Download or read book Heart Regeneration: Stem Cells And Beyond written by Felix B Engel and published by World Scientific. This book was released on 2012-03-22 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: Injured mammalian hearts do not regenerate but scar. This is a major medical problem, as ischemic heart disease is among the leading causes of morbidity and mortality worldwide. Essential clues for human heart repair are uncovered when zebrafish and newt are found to regenerate cardiac muscle after injury.This book presents the major advances of the last decade in the field of cardiac regeneration. These recent advances include: demonstration that zebrafish, a genetically tractable system, can regenerate heart; the identification of several new stem cell populations in the heart; demonstration that stem cells can be used to improve heart function; and demonstration that induction of cardiomyocyte proliferation is a realistic future option to repair injured hearts. This book also provides detailed reviews of the research on model organisms capable of heart regeneration as well as innovative translational research to achieve regeneration in mammals, that comprises work on blood born stem cells, endogenous cardiac stem cells, paracrine factors, reawakening of cardiomyocyte proliferation, and bioengineering. More importantly, the book, in the concluding chapter, dovetails the studies with a comprehensive overview of clinical trials.
Author : Richard P. Harvey
Publisher : Gulf Professional Publishing
ISBN 13 : 9780123298607
Total Pages : 574 pages
Book Rating : 4.2/5 (986 download)
Download or read book Heart Development written by Richard P. Harvey and published by Gulf Professional Publishing. This book was released on 1999 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contributors. -- Preface. -- C. Seidman, Introduction. -- I. Origins and Early Morphogenesis: -- P.P.L. Tam and G.C. Schoenwolf, Cardiac Fate Maps: Lineage Allocation, Morphogenetic Movement, and Cell Commitment. -- T. Mikawa, Cardiac Lineages. -- II. Cardiac Induction: -- T.J. Mohun and L.M. Leong, Heart Formation and the Heart Field in Amphibian Embryos. -- T.M. Schultheiss and A.B. Lassar, Vertebrate Heart Induction. -- III. Genetic Dissection of Heart Development: -- R. Bodmer and M. Frasch, Genetic Determination in Drosophilia Heart Development. -- J. Alexander and D.Y.R. Stainier, Mutations Affecting Cardiac Development in Zebrafish. -- R.P. Harvey, C. Biben, and D.A. Elliott, Transcriptional Control and Pattern Formation in the Developing Vertebrate Heart: Studies on NK-2 Class Homeodomain Factors. -- B.L. Black and E.N. Olson, Control of Cardiac Development by the Family of MEF2 Transcription Factors. -- D. Srivastava, Segmental Regulation of Cardiac Development by the Basic He ...
Author : William C. Claycomb
Publisher :
ISBN 13 :
Total Pages : 560 pages
Book Rating : 4.X/5 (2 download)
Download or read book Cardiac Growth and Regeneration written by William C. Claycomb and published by . This book was released on 1995 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mammalian cardiac muscle, unlike that in amphibians, reptiles and the mammalian atrium, cannot regenerate after injury, and the mechanism for the irreversible blockage of mitosis in these monocytes during early development is still not understood. This book attempts to study the mechanisms that control the cardiac muscle cell cycle so that treatments to initiate repair of the myocardium can be designed. An ideal model would allow study of cardiac muscle cells in the intact heart in the biochemical state they were in during foetal growth, when they were actively dividing. This volume gathers the most current information dealing with the regenerative potential of cardiac muscle in the vertebrate heart.
Author : Lazzaro Spallanzani
Publisher :
ISBN 13 :
Total Pages : 192 pages
Book Rating : 4.E/5 ( download)
Download or read book An Essay on Animal Reproductions written by Lazzaro Spallanzani and published by . This book was released on 1769 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : J. Gordon Betts
Publisher :
ISBN 13 : 9781947172807
Total Pages : 0 pages
Book Rating : 4.1/5 (728 download)
Download or read book Anatomy and Physiology written by J. Gordon Betts and published by . This book was released on 2013-04-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Chandrasekharan C. Kartha
Publisher : Springer Nature
ISBN 13 : 3030855368
Total Pages : 356 pages
Book Rating : 4.0/5 (38 download)
Download or read book Cardiomyocytes in Health and Disease written by Chandrasekharan C. Kartha and published by Springer Nature. This book was released on 2021-09-13 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a treatise on cardiomyocytes, the most important cell for the contractile function of the heart. There has been significant progress in our understanding of the function-related structure, developmental processes and their determinants, mechanisms of cell cycle regulation, post-natal growth, energy metabolism, and reversible and irreversible response of cardiomyocytes to diverse forms of physiological stress and injury. There is also more clarity on the alterations in the biological mechanisms in cardiomyocytes that lead to pathological states and the changes in the cells that occur secondary to disease conditions. Thanks to these advances in knowledge, there have been great gains in attempts to identify disease biomarkers and therapeutic targets for better management of patients with heart diseases. Possibilities to induce regeneration or proliferation of cardiomyocytes and thus repair and or regenerate the damaged heart are also on the horizon.
Author : Derek Hausenloy
Publisher : Oxford University Press
ISBN 13 : 019954476X
Total Pages : 138 pages
Book Rating : 4.1/5 (995 download)
Download or read book Cardioprotection written by Derek Hausenloy and published by Oxford University Press. This book was released on 2009-08-20 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: Coronary heart disease (CHD) is the leading cause of death worldwide. Cardioprotection refers to the prevention of CHD and the clinical improvement in patients suffering from cardiovascular problems.
Author : Annarosa Leri
Publisher : John Wiley & Sons
ISBN 13 : 0470994304
Total Pages : 248 pages
Book Rating : 4.4/5 (79 download)
Download or read book Cardiovascular Regeneration and Stem Cell Therapy written by Annarosa Leri and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the definitive reference on two of the most exciting areas of cardiovascular research – myocardial regeneration and stem cell therapy – for the treatment of disease. Edited by pioneers in the area, with contributions from every major investigator worldwide, it covers: The biology of stem cells The actions of stem cells from the bone marrow, the heart, and embryos on the normal restorative and repair functions of the heart and blood vessels How stem cells could contribute to myocardial recovery in the face of injury and aging How adjuvant therapy with growth factors might enhance stem cell activity in regeneration and repair Clinical applications and clinical experiences This fully referenced publication presents the current state of knowledge in both basic science and clinical practice, and is an essential reference for scientists, students, and clinicians.
Author : Gianfranco Sinagra
Publisher : Springer
ISBN 13 : 303013864X
Total Pages : 241 pages
Book Rating : 4.0/5 (31 download)
Download or read book Dilated Cardiomyopathy written by Gianfranco Sinagra and published by Springer. This book was released on 2019-05-17 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book presents a comprehensive overview of dilated cardiomyopathy, providing readers with practical guidelines for its clinical management. The first part of the book analyzes in detail the disease’s pathophysiology, its diagnostic work up as well as the prognostic stratification, and illustrates the role of genetics and gene-environment interaction. The second part presents current and future treatment options, highlighting the importance of long-term and individualized treatments and follow-up. Furthermore, it discusses open issues, such as the apparent healing phenomenon, the early prognosis of arrhythmic events or the use of genetic testing in clinical practice. Offering a multidisciplinary approach for optimizing the clinical management of DCM, this book is an invaluable aid not only for the clinical cardiologists, but for all physicians involved in the care of this challenging disease.
Author : Ira S. Cohen
Publisher : Springer Science & Business Media
ISBN 13 : 1617790214
Total Pages : 555 pages
Book Rating : 4.6/5 (177 download)
Download or read book Regenerating the Heart written by Ira S. Cohen and published by Springer Science & Business Media. This book was released on 2011-03-23 with total page 555 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medical research made huge strides in treating heart disease in the 20th century, from drug-eluding stents to automatic internal defibrillators. Public awareness of the dangers of heart disease has never been more pervasive. Now, though, ten years into a new millennium, scientists are gearing up for the next great challenges in tackling this pervasive condition. Cell therapy is going to be a key weapon in the fight against heart disease. It has the potential to address many cardiovascular conditions. From heart failure to atrioventricular nodal dysfunction, the young but promising field of cell therapy is set to play a significant role in developing the cures that the upcoming decades of hard work will yield. Regenerating the Heart: Stem Cells and the Cardiovascular System organizes the field into a digestible body of knowledge. Its four sections cover mechanical regeneration, electrical regeneration, cardiac tissues and in vivo stem cell therapies. An array of talented researchers share the fruits of their labors, with chapters covering such crucial issues as the cardiogenic potential of varying stem cell types, the ways in which they might be used to tackle arrhythmias, their possible application to biological replacements for cardiac tissues such as valves, and the varying approaches used in the in vivo evaluation of stem cell therapies, including methods of delivering stem cells to the myocardium. This comprehensive survey of an area of research with such exciting potential is an invaluable resource both for veteran stem cell researchers who need to monitor fresh developments, and for newly minted investigators seeking inspirational examples.
Author : Milica Radisic
Publisher : Humana Press
ISBN 13 : 9781493910465
Total Pages : 0 pages
Book Rating : 4.9/5 (14 download)
Download or read book Cardiac Tissue Engineering written by Milica Radisic and published by Humana Press. This book was released on 2014-07-29 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac Tissue Engineering: Methods and Protocols presents a collection of protocols on cardiac tissue engineering from pioneering and leading researchers around the globe. These include methods and protocols for cell preparation, biomaterial preparation, cell seeding, and cultivation in various systems. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cardiac Tissue Engineering: Methods and Protocols highlights the major techniques, both experimental and computational, for the study of cardiovascular tissue engineering.
Author : Nicholas Tak-Wah Lam
Publisher :
ISBN 13 :
Total Pages : 414 pages
Book Rating : 4.:/5 (11 download)
Download or read book Cardiac Regeneration written by Nicholas Tak-Wah Lam and published by . This book was released on 2013 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heart failure (HF) is a leading cause of death, disability and hospitalization particularly in individuals over 65 years of age. Current treatments provide symptomatic benefit and can also improve survival as well as reversing maladaptive ventricular remodelling. However, HF frequently progressively worsens in association with the ongoing loss of cardiomyocytes. Cardiomyocytes rarely proliferate and cardiac progenitor cells (CPCs) are scarce in the mammalian adult heart. As such, it is likely that insufficient cardiac regeneration following injury to the heart contributes to HF. In contrast to mammals, zebrafish are able to robustly regenerate their hearts sufficiently to prevent the onset of HF. Our group has shown that a key growth factor, Nerve growth factor (NGF), is lowered in failing hearts. Therefore, in this thesis, I hypothesised and investigated whether NGF may have a regenerative effect on the heart.To address this, a cardiotoxic model of heart failure/regeneration was established in larval zebrafish. I first optimised the exposure duration and concentration of a cardiotoxin (aristolochic acid, AA) to cause approximately half of the exposed larval zebrafish to develop HF. The addition of NGF following AA exposure significantly decreased the proportion of zebrafish from developing HF and dying prematurely. Conversely, the inhibition of the high affinity NGF (TrkA) receptor following AA exposure increased the incidence of HF and death. A common feature of HF is apoptosis in the heart, and NGF was previously shown to have an anti-apoptotic role in cardiomyocytes. However, in the current paradigm AA exposure increased apoptosis in zebrafish hearts, but surprisingly NGF did not attenuate apoptosis. My studies showed that NGF decreased the incidence of AA induced HF and death in zebrafish by promoting cardiac regeneration via cardiomyocyte proliferation. AA exposure decreased the total number of cardiomyocytes and inhibited cardiomyocyte proliferation. In contrast, the addition of NGF following AA exposure increased cardiomyocyte proliferation and total cardiomyocytes. In support of this finding, zebrafish in egg water supplemented with NGF also increased cardiomyocyte proliferation and total cardiomyocytes. Interestingly, isl1 mRNA was also increased in hearts from zebrafish exposed to AA with subsequent treatment to NGF compared to fish only exposed to AA. The regenerative effects of NGF were also validated in a mammalian system, using a mouse embryonic (E13.5) heart organ culture model. NGF promoted mouse embryonic cardiomyocytes to proliferate in vitro. In addition, NGF transiently upregulated Nrg1 and ErbB4 mRNA (a known signalling pathway involved in cardiomyocyte proliferation). Also, NGF increased Isl1 mRNA (at a developmental stage when Isl1+ CPCs are abundant), which suggests that NGF might also increase Isl1+ cardiac progenitor cells.This thesis has identified a novel cardiovascular role for NGF. NGF promotes cardiomyocyte proliferation in zebrafish and mice, possibly through the Nrg1-ErbB4 pathway. As such, the deficiency of NGF in the failing heart may contribute to the progressive nature of HF due to blunted regeneration. Further studies should address the therapeutic value of NGF in established HF.
