Cancer Stem Cells Basic Concept And Therapeutic Implications

Download Cancer Stem Cells Basic Concept And Therapeutic Implications full books in PDF, epub, and Kindle. Read online Cancer Stem Cells Basic Concept And Therapeutic Implications ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

Cancer Stem Cells: Basic Concept and Therapeutic Implications

Author : Farhadul Islam
Publisher : Springer Nature
ISBN 13 : 9819931851
Total Pages : 375 pages
Book Rating : 4.8/5 (199 download)

DOWNLOAD NOW!

Book Synopsis Cancer Stem Cells: Basic Concept and Therapeutic Implications by : Farhadul Islam

Download or read book Cancer Stem Cells: Basic Concept and Therapeutic Implications written by Farhadul Islam and published by Springer Nature. This book was released on 2023-07-26 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively reviews the role of cancer stem cells (CSCs) in cancer initiation, progression, and resistance to anticancer therapies. The initial chapters examine the methods and procedure of the detection, isolation, and characterization of CSCs. It also introduces various epigenetic pathways that contribute to cancer initiation and tumorigenesis, particularly regarding the maintenance and survival of CSCs. It also explores the role of CSCs metabolism and the mechanisms of metabolic plasticity of CSCs in cancer biology. Further, it also presents the implications of CSCs on the origin of tumor heterogeneity and on heterogeneity of the therapeutic response. Towards the end, this book highlights the different immunotherapeutic approaches targeting CSCs with the potential of strongly improving cancer outcomes. This book offers a broad framework to scientists and clinicians into the state-of-the-art knowledge on cancer stem cell biology and highlights their therapeutic implications.

Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology

Author : Sadegh Babashah
Publisher : Springer
ISBN 13 : 3319210300
Total Pages : 560 pages
Book Rating : 4.3/5 (192 download)

DOWNLOAD NOW!

Book Synopsis Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology by : Sadegh Babashah

Download or read book Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology written by Sadegh Babashah and published by Springer. This book was released on 2015-11-12 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept of cancer stem cells has great clinical implications. This is due to the fact that small subpopulations of these cells have been identified in a variety of neoplastic conditions ranging from solid tumors to liquid malignancies. Although there are some huge gaps in our current understanding of the role played by cancer stem cells in cancer biology, a growing body of evidence provides strong support for the principal functions of these cells in tumorigenesis. This has represented the potential of cancer stem cells in the development of novel and innovative tools for the treatment of metastatic tumors. This book aims to offer a broad framework for obtaining insight into the state-of-the-art knowledge on cancer stem cell biology and highlight the therapeutic implications of these cells in the future of clinical oncology.

The Heterogeneity of Cancer Metabolism

Author : Anne Le
Publisher : Springer
ISBN 13 : 331977736X
Total Pages : 186 pages
Book Rating : 4.3/5 (197 download)

DOWNLOAD NOW!

Book Synopsis The Heterogeneity of Cancer Metabolism by : Anne Le

Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer. This book was released on 2018-06-26 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

Stem Cells and Cancer Stem Cells, Volume 5

Author : M.A. Hayat
Publisher : Springer Science & Business Media
ISBN 13 : 9400729006
Total Pages : 309 pages
Book Rating : 4.4/5 (7 download)

DOWNLOAD NOW!

Book Synopsis Stem Cells and Cancer Stem Cells, Volume 5 by : M.A. Hayat

Download or read book Stem Cells and Cancer Stem Cells, Volume 5 written by M.A. Hayat and published by Springer Science & Business Media. This book was released on 2012-02-21 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is pointed out that a cancer stem cell is a type within a tumor that possesses the capacity of self-renewal and can give rise to the heterogeneous lineages of cancer cells, which comprise the tumor. It is emphasized that a unique feature of cancer stem cells is that, although conventional chemotherapy kills most cells in a tumor, cancer stem cells remain intact. Vast applications of the following specific stem cells in disease and tissue injury are discussed: embryonic stem cells, human mesenchymal stem cells, cancer stem cells, arterial stem cells, neural stem cells, cardiac stem cells, dental stem cells, limbal stem cells, and hematopoietic stem cells. Because human embryonic stem cells possess the potential to produce unlimited quantities of any human cell type, considerable focus is placed on their therapeutic potential in this volume. These cells are used in tissue engineering, regenerative medicine, pharmacological and toxicological studies, and fundamental studies of cell differentiation. It is pointed out that the formation of embryoid bodies, which are three-dimensional aggregates of embryonic cells, is the initial step in the differentiation of these cells. Therapeutic implications of signalling pathways in cancer stem cells are pointed out. Targeting self-renewal pathways in cancer stem cells are also included. Application of mesenchymal stem cells for treating ischemic brain injury is explained. Neural stem cells proliferation into the surrounding area of the traumatic brain injury is explained.

Cancer Stem Cells

Author : Huiping Liu
Publisher : Elsevier
ISBN 13 : 0128039345
Total Pages : 542 pages
Book Rating : 4.1/5 (28 download)

DOWNLOAD NOW!

Book Synopsis Cancer Stem Cells by : Huiping Liu

Download or read book Cancer Stem Cells written by Huiping Liu and published by Elsevier. This book was released on 2016-08-16 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Stem Cells: Targeting the Roots of Cancer, Seeds of Metastasis, and Sources of Therapy Resistance introduces the basic concepts and advanced understanding of cancer stem cells, covering general overviews, organ-specific identifications, and their characteristic mechanisms. The book also explores innovative therapeutic strategies in preclinical and clinical trials to target cancer stem cells, remove the roots of cancer, eliminate the seeds of metastasis, overcome the resistance of therapies, and contribute to the eradication of cancer. The book includes contributions from leading, worldwide experts in the field, helping readers embrace new hope in their quest to eradicate cancer with emerging clinical trials on treating cancer stem cells in combination with other therapies. Provides an authoritative and complete overview of cancer stem cells Includes comprehensive coverage of current therapeutic strategies targeting cancer stem cells Deepens a reader’s technical expertise in cancer stem cell biology

Role of Cancer Stem Cells in Cancer Biology and Therapy

Author : Thomas Dittmar
Publisher : CRC Press
ISBN 13 : 1466577363
Total Pages : 330 pages
Book Rating : 4.4/5 (665 download)

DOWNLOAD NOW!

Book Synopsis Role of Cancer Stem Cells in Cancer Biology and Therapy by : Thomas Dittmar

Download or read book Role of Cancer Stem Cells in Cancer Biology and Therapy written by Thomas Dittmar and published by CRC Press. This book was released on 2016-04-19 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes the latest findings about the role of cancer stem cells (CSCs) in cancer biology and how this knowledge could be used for novel anticancer therapies. It provides an overview of CSCs in selected malignancies with particular emphasis on hematopoietic neoplasias. It then reviews the role of CSCs in metastasis formation and initiat

The Cancer Stem Cell Niche

Author : Susie Nilsson
Publisher : Academic Press
ISBN 13 : 0323853250
Total Pages : 246 pages
Book Rating : 4.3/5 (238 download)

DOWNLOAD NOW!

Book Synopsis The Cancer Stem Cell Niche by : Susie Nilsson

Download or read book The Cancer Stem Cell Niche written by Susie Nilsson and published by Academic Press. This book was released on 2021-02-09 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Cancer Stem Cell Niche, Volume Five in the Advances in Stem Cells and their Niches series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Acute lymphoblastic leukemia and the bone marrow microenvironment, Stem cell niches in bone and their roles in cancer metastasis, The role of vasculature in cancer stem cell niches, The lung cancer stem cell niche, The prostate cancer stem cell niche: Genetic drivers and therapeutic approaches, Impact of prostate cancer stem cell niches on prostate cancer tumorigenesis and progression, The testicular cancer stem cell niche. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Stem Cells and their Niches series Includes the latest information on the Cancer Stem Cell Niche

New Aspects of Cancer Stem Cell Biology

Author : Ugo Cavallaro
Publisher : MDPI
ISBN 13 : 3039434063
Total Pages : 208 pages
Book Rating : 4.0/5 (394 download)

DOWNLOAD NOW!

Book Synopsis New Aspects of Cancer Stem Cell Biology by : Ugo Cavallaro

Download or read book New Aspects of Cancer Stem Cell Biology written by Ugo Cavallaro and published by MDPI. This book was released on 2020-11-23 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cancer stem cell (CSC) paradigm represents one of the most prominent breakthroughs of the last decades in tumor biology. CSCs are that subpopulation within a tumor that can survive conventional therapies and as a consequence are able to fuel tumor recurrence. Nevertheless, the biological characteristics of CSCs and even their existence, remain the main topic among tumor biologists debates. The difficulty in achieving a better definition of CSC biology may actually be explained by the plasticity of such a cell subpopulation. Indeed, the emerging view is that CSCs represent a dynamic “state” of tumor cells that can acquire stemness-related properties under specific circumstances, rather than referring to a well-defined group of cells. Regardless of their origin, it is clear that designing novel antitumor treatments based on the eradication of CSCs will only be possible upon unraveling the biological mechanisms that underlie their pathogenic role in tumor progression and therapy resistance. The Special Issue on “New aspects of cancer stem cell biology: implications for innovative therapies” aims at highlighting recent insights into CSC features that can make them an attractive target for novel therapeutic strategies.

Cancer Stem Cells

Author : Lucie Laplane
Publisher : Harvard University Press
ISBN 13 : 0674088743
Total Pages : 265 pages
Book Rating : 4.6/5 (74 download)

DOWNLOAD NOW!

Book Synopsis Cancer Stem Cells by : Lucie Laplane

Download or read book Cancer Stem Cells written by Lucie Laplane and published by Harvard University Press. This book was released on 2016-06-06 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: A new therapeutic strategy could break the stalemate in the war on cancer by targeting not all cancerous cells but the small fraction that lie at the root of cancers. Lucie Laplane offers a comprehensive analysis of cancer stem cell theory, based on an original interdisciplinary approach that combines biology, biomedical history, and philosophy.

Origin of Cancers

Author : Shi-Ming Tu
Publisher : Springer Science & Business Media
ISBN 13 : 1441959688
Total Pages : 247 pages
Book Rating : 4.4/5 (419 download)

DOWNLOAD NOW!

Book Synopsis Origin of Cancers by : Shi-Ming Tu

Download or read book Origin of Cancers written by Shi-Ming Tu and published by Springer Science & Business Media. This book was released on 2010-07-20 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: Précis This book is a treatise about the origin of cancers. I would like to convince readers that the basic tenets of the theory of a stem-cell origin of cancers also constitute a unified theory of cancer. Stem-cell origin of normal (and cancer) cells: Vitruvian version Every truth passes through three stages before it is recognized. In the first it is ridiculed, in the second, it is opposed, in the third, it is regarded as self-evident. – Arthur Schopenhauer v vi Preface Every person has a unique story to tell. My story is about cancer. Cancer touches the lives of countless people. Often enough, it leaves indelible tracks. Many lives have been lost; others are forever changed. For those who confront this deadly scourge, there is a sense of urgency, if not of desperation. For those who face im- nent death, life becomes even more precious and carries a special meaning. As an oncologist, I am touched daily by cancer. I feel its inception, evolution, and aft- math. It seems as though we are fighting an incessant war against cancer at the front line in the trenches. This is my story about cancer. Some people are terrific storytellers. Others have incredible tales to tell.

Cancer Stem Cells in Solid Tumors

Author : Alison L. Allan
Publisher : Springer Science & Business Media
ISBN 13 : 1617792462
Total Pages : 479 pages
Book Rating : 4.6/5 (177 download)

DOWNLOAD NOW!

Book Synopsis Cancer Stem Cells in Solid Tumors by : Alison L. Allan

Download or read book Cancer Stem Cells in Solid Tumors written by Alison L. Allan and published by Springer Science & Business Media. This book was released on 2011-08-12 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: The “cancer stem cell” hypothesis postulates that cancer arises from a subpopulation of tumor-initiating cells or cancer stem cells (CSCs). While the idea of cancer stem cells has been around for more than a hundred years, evidence from the fields of hematology and cancer biology has now demonstrated the critical role of stem cells in hematological malignancies and suggested that these same mechanisms are also central to the initiation, progression, and treatment of solid cancers. Clinical and experimental studies have shown that CSCs exhibit many classical properties of normal stem cells, including a high self-renewal capacity and the ability to generate heterogeneous lineages; the requirement for a specific “niche”/microenvironment to grow; and an increased capacity for self-protection against harsh environments, toxins, and drugs. Cancer Stem Cells in Solid Tumors represents a detailed overview of cancer stem cells and their role in solid cancers. Comprised of 24 chapters, this volume will provide readers with a comprehensive understanding of this important and evolving field. Topics covered include: Introduction of the CSC hypothesis Historical perspectives and the contributing lessons from leukemia Current knowledge regarding the identification and role of CSCs in various forms of solid cancer including breast, brain, colorectal, pancreatic, prostate, melanoma, lung, ovarian, hepatocellular, and head and neck cancer Molecular pathways involved in driving CSC function, with a particular focus on the novel convergence of embryonic and tumorigenic signaling pathways In vitro and in vivo assays, model systems, and imaging modalities for studying CSCs The clinical importance of CSCs for cancer management and treatment, including important implications for prognosis, prediction, and treatment resistance Consideration of the controversy surrounding the CSC hypothesis and important unanswered questions in this field This collective work was written by a group of prominent international experts in cancer biology, oncology, and/or stem cell biology. It will serve as a valuable resource for established researchers, professors, health care professionals, and students in the medical and scientific community who are investigating stem cells and/or oncology.

Cancer Stem Cells

Author : Otmar D. Wiestler
Publisher : Springer Science & Business Media
ISBN 13 : 3540708529
Total Pages : 243 pages
Book Rating : 4.5/5 (47 download)

DOWNLOAD NOW!

Book Synopsis Cancer Stem Cells by : Otmar D. Wiestler

Download or read book Cancer Stem Cells written by Otmar D. Wiestler and published by Springer Science & Business Media. This book was released on 2007-09-04 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer stem cells have originally been identified in leukemia and later in several solid tumor types. They have very different properties from the bulk of the tumor as they divide much more slowly and have very efficient drug resistance mechanisms. Current treatments might largely spare cancer stem cells. This book looks at recent developments in the field of cancer stem cells and the possible impact for the identification of novel treatment paradigms for cancer.

Cancer Stem Cells: New Horizons in Cancer Therapies

Author : Surajit Pathak
Publisher : Springer Nature
ISBN 13 : 9811551200
Total Pages : 369 pages
Book Rating : 4.8/5 (115 download)

DOWNLOAD NOW!

Book Synopsis Cancer Stem Cells: New Horizons in Cancer Therapies by : Surajit Pathak

Download or read book Cancer Stem Cells: New Horizons in Cancer Therapies written by Surajit Pathak and published by Springer Nature. This book was released on 2020-10-17 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the recent developments in the therapeutic implications of cancer stem cells for the effective diagnosis, prognosis, and treatment of cancer. It summarizes the various stem cells of common cancers including colon, pancreas, lungs, prostate, melanoma, and glioblastoma, and reviews the potential role of cancer stem cells in tissue aggressiveness, examining the functional contribution of cancer stem cells in the establishment and recurrence of cancerous tumors. Further, it explores the potential of cancer stem cells as novel therapeutic targets for the treatment and prevention of tumor progression. The book also discusses the various approaches for detecting, isolating, and characterizing different cancer stem cells and signaling pathways that control their replication, survival, and differentiation. Lastly, it explores the key features and mechanisms of drug resistance, chemo-resistance, and radio-resistance in cancer stem cells to improve therapeutic rationale.

Stem Cells and Cancer Stem Cells, Volume 6

Author : M.A. Hayat
Publisher : Springer Science & Business Media
ISBN 13 : 9400729936
Total Pages : 445 pages
Book Rating : 4.4/5 (7 download)

DOWNLOAD NOW!

Book Synopsis Stem Cells and Cancer Stem Cells, Volume 6 by : M.A. Hayat

Download or read book Stem Cells and Cancer Stem Cells, Volume 6 written by M.A. Hayat and published by Springer Science & Business Media. This book was released on 2012-02-27 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: The difference among pluripotent stem cells, multipotent stem cells, and unipotent stem cells is pointed out. Vast therapeutic applications of the following specific stem cells in disease and tissue injury are discussed: human embryonic stem cells, human mesenchymal stem cells, germ cell-derived pluripotent stem cells, induced pluripotent stem cells, human umbilical cord blood-derived stem cells, breast tumor stem cells,and hematopoietic stem cells. Because of the potential of human embryonic stem cells to produce unlimited quantities of any human cell type, considerable focus is placed on their therapeutic potential. Because of their pluripotency, these cells have been used in various applications such as tissue engineering, regenerative medicine, pharmacological and toxicological studies, and fundamental studies of cell differentiation. The formation of embryoid bodies, which are three-dimensional aggregates of embryonic stem cells, is explained as this is the first step in cell differentiation. Such embryoid body culture has been widely used as a trigger for the in vitro differentiation of embryonic stem cells. The basic capacity of self-renewal of human embryogenic stem cells is explained. The role of TGF-beta in the propagation of human embryonic stem cells is discussed. The differentiation of human embryonic stem cells into neurons, hepatocytes, cardiomyocytes, and retinal cells is fully explained. Donor policies for hematopoietic stem cells are also explained.

Stem Cells and Cancer Stem Cells, Volume 12

Author : M.A. Hayat
Publisher : Springer Science & Business Media
ISBN 13 : 9401780323
Total Pages : 284 pages
Book Rating : 4.4/5 (17 download)

DOWNLOAD NOW!

Book Synopsis Stem Cells and Cancer Stem Cells, Volume 12 by : M.A. Hayat

Download or read book Stem Cells and Cancer Stem Cells, Volume 12 written by M.A. Hayat and published by Springer Science & Business Media. This book was released on 2014-02-20 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 12 in this series explores the latest experimental and clinical uses of stem cells in the treatment of disease and of injuries and reviews methods for isolating multipotent endothelial-like cells from human adipose tissue and discusses clinical applications in cell therapy and regenerative medicine. The book is organized in five parts: Cancer Stem Cells, Pluripotent Stem Cells, Dendritic Stem Cells, Regenerative Medicine and General Applications. The first section includes chapters on histamine in the neural and cancer stem cell niches and emerging concepts of stem cell organization in the normal lung and in lung cancer. The section on Pluripotent Stem Cells includes discussion of the differentiation of dendritic cells from human induced pluripotent stem cell and the molecular mechanisms involved in reprogramming human somatic cells to generate induced pluripotent stem cells. Additional chapters cover the differentiation of induced pluripotent stem cells into functional cardiomyocytes, characteristics of satellite cells and multipotent adult stem cells in the skeletal muscle. The section on Dendritic Stem Cells explores the critical role of notch signaling in the differentiation and function of dendrite. Other chapters cover hypertensive emergencies in children after stem cell transplantation and overcoming the radio resistance of lung cancer stem cells. The section on Regenerative Medicine reports on experiments on improved renal revascularization in pigs using stem cells and phenotypic correction of murine Hemophilia A using cell-based therapy. The concluding section, General Applications, discusses such topics as methods in mathematical modeling for stem cells, as well as molecular and functional characterization of human adipocytes. Like its eleven predecessors in the series, this volume stands out for its comprehensive approach, its roster of some 51 expert contributors representing a dozen different countries and its up-to-date review of leading-edge technology and methods.

Cancer Stem Cells

Author : William L. Farrar
Publisher : Cambridge University Press
ISBN 13 : 0521896282
Total Pages : 191 pages
Book Rating : 4.5/5 (218 download)

DOWNLOAD NOW!

Book Synopsis Cancer Stem Cells by : William L. Farrar

Download or read book Cancer Stem Cells written by William L. Farrar and published by Cambridge University Press. This book was released on 2010 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explores the emerging field of research in cancer stem cells; covers the basic biology, genetic pathways and therapeutic targeting.

Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology

Author : Sadegh Babashah
Publisher :
ISBN 13 : 9783319210315
Total Pages : pages
Book Rating : 4.2/5 (13 download)

DOWNLOAD NOW!

Book Synopsis Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology by : Sadegh Babashah

Download or read book Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology written by Sadegh Babashah and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept of cancer stem cells has great clinical implications. This is due to the fact that small subpopulations of these cells have been identified in a variety of neoplastic conditions ranging from solid tumors to liquid malignancies. Although there are some huge gaps in our current understanding of the role played by cancer stem cells in cancer biology, a growing body of evidence provides strong support for the principal functions of these cells in tumorigenesis. This has represented the potential of cancer stem cells in the development of novel and innovative tools for the treatment of metastatic tumors. This book aims to offer a broad framework for obtaining insight into the state-of-the-art knowledge on cancer stem cell biology and highlight the therapeutic implications of these cells in the future of clinical oncology.