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Cancer In Organ Transplant Recipients
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Book Synopsis Cancer in Organ Transplant Recipients by : Dietrich Schmähl
Download or read book Cancer in Organ Transplant Recipients written by Dietrich Schmähl and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: In about 5% of all organ (kidney, liver) transplant recipients, malignancies occur as a late complication of the massive immunosuppression. The malignancies are mainly skin cancers, lymphomas and renal carcinomas. The present book discusses the possible mechanisms of this type of tumorigenesis and inquires into possibilities of prevention. In particular, the described malignancies might be of viral origin. The book informs about a completely new type of carcinogenesis. Apart from the scientific aspects, it is of great practical value.
Book Synopsis Skin Cancer after Organ Transplantation by : Eggert Stockfleth
Download or read book Skin Cancer after Organ Transplantation written by Eggert Stockfleth and published by Springer Science & Business Media. This book was released on 2009-05-05 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organ transplantation has been performed for almost 40 years with steadily increasing success regarding long-time survival of the graft, as well as quality of life for the patient. However, graft tolerance only can be achieved via induction and maintenance of an impaired immunological surveillance. An increase of skin cancers as a consequence of the lowered cellular immunoresponse seems to parallel the overall increased long-time survival rate of organ transplant recipients. Against the background of chronic immunosuppression known risk factors like the amount of sun exposure prior and post transplantation, oncogenic viruses as well as the genetic background, and place of residence (latitude) are strongly related with the increased skin cancer incidence. The increasing incidence of non-melanoma skin cancer, paralleling a prolonged survival of patients after organ transplantation, represents a significant reason for morbidity and long-term morbidity in organ transplant recipients worldwide. The incidence of non-melanoma skin cancer in liver-, kidney- and heart transplant recipients varies from 1.5 to 22 %, 2 to 24 % and 6 to 34 % after 5 years post transplant. Ultraviolet radiation as well as immunosuppressive therapy are crucial risk-factors regarding the induction and progression of skin cancer. Ultraviolet radiation is related to the induction of DNA damage, as well as interference with Langerhans cell antigen presentation and a Th1 – Th2 shift induced via a release of IL-10. Whereas the overall duration of immunosuppression and the cumulative dosage applied are relevant parameters in the evaluation of an increased tumor risk, individual differences between specific immunosuppressive agents remain unclear. The workup of genetic as well as other unclear phenomenon like the reverse BCC/SCC ratio might shed some further light into the genesis and immunology of the non-melanoma skin cancer in general.
Book Synopsis Primary Care of the Solid Organ Transplant Recipient by : Christopher J. Wong
Download or read book Primary Care of the Solid Organ Transplant Recipient written by Christopher J. Wong and published by Springer Nature. This book was released on 2020-09-02 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: Solid organ transplantation offers a new chance at life to those suffering from failing organs. With these successes, however, comes the everyday management that is required to maintain health. The field of solid organ transplantation has become a part of medicine that generalists should be familiar with, as recipients are living longer and frequently returning to primary care for management. While specialists will still need to be involved with the care of solid organ transplant recipients on a life-long basis, many conditions will still need initial and often ongoing care by generalists, including infections, metabolic conditions, psychiatric illnesses, and malignancy. This book focuses on the care of adult solid organ transplant recipients, and is targeted at the level of the primary care provider. It begins with an introduction and overviews of solid organ transplantation and anti-rejection medications. It then delves into organ-specific chapters that provide the primary care provider with an overview of how to take care of patients with the most commonly-transplanted solid organs: kidney, kidney-pancreas, liver, heart, and lung. The final section focuses on specific complications that arise from transplantation including cancer, metabolic conditions, infections, and common presenting syndromes. Preventative health is also discussed, and the book concludes with a chapter on palliative care. Primary Care of the Solid Organ Transplant Recipient is a unique text that provides the reader with organ and complication-specific sections that can be independently read as they relate to the individual physicians and their patients. Written by experts in the field, this text is a valuable resource for primary care providers, medical students, residents and anyone involved in the care of solid organ transplant recipients.
Book Synopsis Pediatric Solid Organ Transplantation by : Richard N. Fine
Download or read book Pediatric Solid Organ Transplantation written by Richard N. Fine and published by John Wiley & Sons. This book was released on 2009-04-08 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pediatric Solid Organ Transplantation is acomprehensive and succinct text on all aspects of pediatric solidorgan transplantation. It provides a ready source of reference, toboth the basic science and organ specific surgical technique andafter care. This second edition has been extensively updated inlight of recent developments in this rapidly advancing area. The only textbook devoted to the field of pediatrictransplantation A definitive reference for all those interested in improvingthe care and quality of life of children undergoing solid organtransplantation Section on immunosuppression has been expanded by four chaptersto include sections on; - mechanisms of action - therapies for the sensitized patient - post-transplant lymphoproliferative disorders - organ toxicities of immunosuppressive therapy A new section has been added on the many topics related toquality of life that effect survivors of pediatrictransplantation International editorial and contributor team represents a widegeographical range and contains both recognized leaders andemerging experts Whether you are an established sub-specialist in pediatrictransplantation, a transplant surgeon, or a pediatric specialist ina related area, this book will answer all your questions about careof the pediatric patient before, during, and aftertransplantation.
Book Synopsis Therapeutic Immunosuppression by : A.W. Thomson
Download or read book Therapeutic Immunosuppression written by A.W. Thomson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Therapeutic immunosuppression has very broad applications in clinical medicine, ranging from prevention and treatment of organ and bone marrow transplant rejection, management of various autoimmune disorders (e.g., rheumatoid arthritis), skin disease, and asthma. Whereas traditionally only a small repertoire of immunosuppressive agents was available for clinical use, recent discoveries have significantly increased the number of approved agents, resulting in numerous trials to further evaluate their potential. In addition, products of the biotechnology industry - monoclonal antibodies, cytokines, cytokine antagonists, and other products of genetic engineering that target key molecular pathways in disease pathogenesis - have either already made, or are on the verge of making an important impact on treatment. There is also considerable interest in the potential of cell-based therapies (particularly hematopoietic stem and dendritic cell therapy) of allo- and autoimmunity. Important recent advances in the immunotherapy of allergic diseases are also covered in this book. Gene therapy offers considerable promise for suppressing pathogenic processes in either transplantation or autoimmune disorders. The possibility of combining these important new advances to maximize benefit to the patient, and to minimize possible untoward effects (which are also given extensive coverage in this book), is one of the most exciting challenges of contemporary medicine. This volume is intended both for practising physicians and surgeons and for biomedical scientists at the graduate/postdoctoral levels, and is designed to provide the theory behind these various approaches to immunosuppression, and to provide state-of-the-art reviews of current developments in each area. Each chapter is contributed by one or more experts in the field. There was a need to bring this information together in a single volume, as much of the key recent developments have been dispersed throughout the biomedical literature, largely in specialized journals. Since, as in the past, important developments in immunosuppressive therapy in one branch of medicine (i.e. transplantation) are likely to benefit another (e.g., dermatology, rheumatology, gastroenterology), cross-disciplinary coverage of the mechanistic basis of the various therapeutic strategies in a single volume is likely to convey the potential of advances in therapy in the most coherent manner possible.
Book Synopsis Skin Cancer Management by : Deborah MacFarlane
Download or read book Skin Cancer Management written by Deborah MacFarlane and published by Springer Science & Business Media. This book was released on 2010-03-11 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: The editor of Skin Cancer Management: A Practical Approach, Dr. Deborah MacFarlane, gathers experts in selected techniques related to the assessment and management of skin cancer and has them critically review the existing literature in light of their considerable experience delivering care. The authors make recommendations for the best way to perform procedures. The tables provided in each chapter then become a manual of how to perform these procedures, and may in time be adopted by the wider universe of dermatologists as the standard of performance. The detailed descriptions of technique and treatment pearls lead the novice through the sequence of events in a way that instills confidence in their ability to safely perform the procedure. An example of the painstaking expla- tions is found in Chapter 5, Intralesional and Perilesional Treatment of Skin Cancers. The reader is advised to place eye protection on the patient and those performing the injection of methotrexate into a keratoacanthoma with a central crust. Rest assured that there will be a spray or stream of methotrexate emitted from the crusted area. Having eye protection will prevent methotrexate from accidentally getting into someone’s eye. Since we all learn to assimilate new information by taking action on the recommendations that we read, it would be a good idea for the physician to create, where relevant, a checklist for each procedure in the text. The checklist can be given to the office staff to set up the equipment for the procedure.
Book Synopsis Cancer in Transplantation: Prevention and Treatment by : J.-L. Touraine
Download or read book Cancer in Transplantation: Prevention and Treatment written by J.-L. Touraine and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malignancies are frequent complications in organ transplantation, mainly as the result of infection with certain viruses and of long-term immunosuppression. The epidemiology confirms that the increased incidence concerns certain cancers, especially HIV-related skin cancers and EBV-related lymphoproliferative malignancies. This book covers all currently available information on this important topic of the relationships between transplantation and malignancies: preexisting cancers, posttransplant cancers, their etiology and pathophysiology, their prevention and treatment. A significant part of the volume is devoted to prophylaxis, early detection and modern forms of therapy in posttransplant lymphomas. As a conclusion of all these new data, the theory of immunosurveillance deserves to be significantly modified.
Book Synopsis Liver Transplantation by : James Neuberger
Download or read book Liver Transplantation written by James Neuberger and published by John Wiley & Sons. This book was released on 2021-02-25 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explore this practical and step-by-step guide to managing liver transplant patients from leading international clinicians in Hepatology The newly revised Second Edition of Liver Transplantation: Clinical Assessment and Management delivers expert clinical guidance on best practices in managing the care of liver transplant patients. Authors are all experts in their field and cover a world-wide perspective. Organized in an accessible, stepwise fashion and packed with text features such as key points, the book covers all critical areas of each stage of the liver transplant journey, from assessment, to management on the list, to long term care. Readers will learn when to refer a patient for liver transplantation, how to assess a potential liver transplant recipient, learn the principles of the procedure and the long term management of the transplant recipient. Liver Transplantation provides the entire hepatology and surgical team the information required for a sound understanding of the entire procedure, from pre- to post-operative care and management. Clinically oriented and management-focused, the book is far more accessible than the liver transplant sections in traditional hepatology textbooks. Readers will also enjoy: A thorough discussion of when to refer a patient for liver transplantation, including general considerations and the use and abuse of prognostic models An exploration of the selection, assessment, and management of patients on the transplant list, including how to manage a patient with chronic liver disease while on the waiting list A treatment of liver transplantation for acute liver failure (ALF), including assessment and management of ALF patients on the transplant waiting list A discussion of care of the liver transplant recipient after the procedure in the short and long term Perfect for gastroenterologists, hepatologists, and surgeons and other health care professionals managing patients with liver disease who are awaiting, undergoing and following liver transplantation, Liver Transplantation: Clinical Assessment and Management will also earn a place in the libraries of medical students, residents, internal medicine physicians, and GI/Hepatology trainees and all health care professionals providing clinical care to people with liver disease, before, during and after transplantation.
Book Synopsis Malignant Tumors in Organ Transplant Recipients by : Israel Penn
Download or read book Malignant Tumors in Organ Transplant Recipients written by Israel Penn and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 63 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is a great deal of experimental work leading to the conclusion that immuno suppression of any kind increases susceptibility to clinical or viral carcinogenesis. Human epidemiology had already given some intimation of the abnormally high incidence of neoplasms in persons suffering from immunologic insufficiency. The first statistics on the incidence of cancer in organ transplant recipients tend to support this thesis. Transplantation can favor metastasis in a recipient who already has a malignancy; similarly, it can encourage the development of tumor cells which may be present in an organ transplanted from a cancerous donor; and finally, the frequency of lymphomas and carcinomas is higher in transplant recipients than in the general population. Immunodepression induced to facilitate tolerance clearly falls under suspicion on the basis of the experimental and clinical findings mentioned above. Anti-lymphocyte serum is not the only suspect-tumors have also occurred in patients treated with prednisone and Imuran alone. Now comes Dr. PENN'S monograph with a detailed account of these phenomena, together with an analysis and discussion. Clearly, induced carcinogenesis in man must be taken seriously. Not only must every precaution be taken in the screening of donor and recipient and the choice of immunosuppressive therapy in order to reduce it to the minimum, there is also the question whether the long-term immunosuppressive treatments inflicted upon patients in whom an auto-immune mechanism is thought to be the cause of the disease-treat ments whose efficacy is even more questionable than the mechanism-might not themselves be contributing to malignancy.
Book Synopsis Skin Disease in Organ Transplantation by : Clark C. Otley
Download or read book Skin Disease in Organ Transplantation written by Clark C. Otley and published by Cambridge University Press. This book was released on 2008-01-21 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: Skin disease is a serious long-term problem for the recipients of solid organ transplants. The potent systemic immunosuppression therapy necessary to sustain a life-saving solid organ transplant is associated with many adverse cutaneous effects, including significantly increased rates of cutaneous malignancies, difficult-to-treat cutaneous infections, and cutaneous adverse manifestations of multiple medications. This book is the first scholarly compilation of the knowledge base surrounding the care of solid organ transplant recipients with dermatologic diseases. Supplemented with dozens of full-color photographs, this work brings together decades of knowledge into a cohesive format and establishes transplant dermatology as an important subspecialty within the field of dermatology and transplant medicine. Skin Disease in Organ Transplantation is an outstanding resource for transplant providers and dermatologists to determine the optimal diagnostic and therapeutic approach to the difficult problems of cutaneous disease in organ transplant recipients.
Book Synopsis Multiple Primary Malignancies by : Andrea Renda
Download or read book Multiple Primary Malignancies written by Andrea Renda and published by Springer Science & Business Media. This book was released on 2009-02-11 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 2006, when my colleague Andrea Renda proposed multiple primary malignancies (MPM) as the subject of the Biennial Report to the 2008 Congress of the Italian - ciety of Surgery, I, together with the Steering Committee, quickly agreed. Recent progress in our understanding of the etiopathology of these neoplasms has led to - novative and significant progress on the clinical level. Importantly, the incidence of the onset of two or more tumors in the same patient suggests a more than casual - lationship. Furthermore, the occurrence of MPM derives from several different me- anisms—viral, iatrogenic, immunologic, environmental, and hereditary—such that any form of treatment must take into account the etiology of these tumors. After an epidemiological introduction, this monograph analyzes various aspects of multitumoral syndromes based on the experience of the Department of Surgical Sciences, along with that of other clinical departments of the University Federico II of Naples. In the discussion of inherited tumors, reference is made to the series of patients treated at the Department of Surgery at the University of Siena. The many topics that comprise this volume range from carcinogenesis to diagnostic strategies, and from epidemiology to innovations in imaging and endoscopic techniques. Among the clinical aspects, particular emphasis is given to sporadic and hereditary syndromes, as these patients are frequently treated by general surgery departments.
Book Synopsis Dermatology and Solid Organ Transplantation by : Nathalie C. Zeitouni
Download or read book Dermatology and Solid Organ Transplantation written by Nathalie C. Zeitouni and published by CRC Press. This book was released on 2021-08-15 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook brings together experts in the field of transplant dermatology to review both state of the art and practical knowledge regarding the clinical presentation and management of the various cutaneous diseases seen in patients with solid organ transplant. Practicing dermatologists, trainees, and other health care providers involved in the care of transplant patients can learn the current diagnostic and management options, and how to apply these guidelines and principles in their everyday practice.
Book Synopsis Core Concepts in Renal Transplantation by : Anil Chandraker
Download or read book Core Concepts in Renal Transplantation written by Anil Chandraker and published by Springer Science & Business Media. This book was released on 2012-02-02 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Though kidney transplantation is considered a routine procedure, there are still significant challenges in post-transplant management. Core Concepts in Renal Transplantation is a clinically focused authoritative guide to the management of kidney transplantation. This comprehensive, state-of-the-art reference summarizes the recent changes in the field of transplantation, offering the complete range of up-to-date information on all the various aspects of basic immunobiology and the medical care of the transplant recipient. Written by a team of renowned authorities in renal transplantation, this concise resource is intended for both the nephrologist and the non-specialist with an interest in kidney transplantation.
Book Synopsis Skin Cancer after Organ Transplantation by : Eggert Stockfleth
Download or read book Skin Cancer after Organ Transplantation written by Eggert Stockfleth and published by Springer. This book was released on 2010-11-16 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organ transplantation has been performed for almost 40 years with steadily increasing success regarding long-time survival of the graft, as well as quality of life for the patient. However, graft tolerance only can be achieved via induction and maintenance of an impaired immunological surveillance. An increase of skin cancers as a consequence of the lowered cellular immunoresponse seems to parallel the overall increased long-time survival rate of organ transplant recipients. Against the background of chronic immunosuppression known risk factors like the amount of sun exposure prior and post transplantation, oncogenic viruses as well as the genetic background, and place of residence (latitude) are strongly related with the increased skin cancer incidence. The increasing incidence of non-melanoma skin cancer, paralleling a prolonged survival of patients after organ transplantation, represents a significant reason for morbidity and long-term morbidity in organ transplant recipients worldwide. The incidence of non-melanoma skin cancer in liver-, kidney- and heart transplant recipients varies from 1.5 to 22 %, 2 to 24 % and 6 to 34 % after 5 years post transplant. Ultraviolet radiation as well as immunosuppressive therapy are crucial risk-factors regarding the induction and progression of skin cancer. Ultraviolet radiation is related to the induction of DNA damage, as well as interference with Langerhans cell antigen presentation and a Th1 – Th2 shift induced via a release of IL-10. Whereas the overall duration of immunosuppression and the cumulative dosage applied are relevant parameters in the evaluation of an increased tumor risk, individual differences between specific immunosuppressive agents remain unclear. The workup of genetic as well as other unclear phenomenon like the reverse BCC/SCC ratio might shed some further light into the genesis and immunology of the non-melanoma skin cancer in general.
Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.
Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2008 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Book Synopsis Sunlight, Vitamin D and Skin Cancer by : Jörg Reichrath
Download or read book Sunlight, Vitamin D and Skin Cancer written by Jörg Reichrath and published by Springer Nature. This book was released on 2020-09-11 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: The third edition is a comprehensive and updated overview of positive and negative effects of UV-exposure, with a focus on Vitamin D and skin cancer. Researchers, oncologists,and students will be provided with the most significant and timely information related to topics such as the epidemiology of skin cancer, the immune system and skin cancer, ultraviolet damage, DNA repair and Vitamin D in Nonmelanoma skin cancer and malignant melanoma. There have been a number of new, scientific findings in this fast moving field that necessitated a thoroughly updated and revised edition including new Vitamin D metabolites and skin cancer, new findings on the beneficial effects of UV and solar UV and skin cancer, adverse effects of sun protection and sunscreens, sun exposure and mortality, and more. The book will summarize essential, up-to-date information for every clinician or scientist interested in how to balance the positive and negative effects of UV‐exposure to minimize the risks of developing vitamin D deficiency and skin cancer.
Book Synopsis Chalk Talks in Internal Medicine by : Somnath Mookherjee
Download or read book Chalk Talks in Internal Medicine written by Somnath Mookherjee and published by Springer Nature. This book was released on 2020-09-30 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides teaching scripts for medical educators in internal medicine and coaches them in creating their own teaching scripts. Every year, thousands of attending internists are asked to train the next generation of physicians to master a growing body of knowledge. Formal teaching time has become increasingly limited due to rising clinical workload, medical documentation requirements, duty hour restrictions, and other time pressures. In addition, today’s physicians-in-training expect teaching sessions that deliver focused, evidence-based content that is integrated into clinical workflow. In keeping with both time pressures and trainee expectations, academic internists must be prepared to effectively and efficiently teach important diagnostic and management concepts. A teaching script is a methodical and structured plan that aids in effective teaching. The teaching scripts in this book anticipate learners’ misconceptions, highlight a limited number of teaching points, provide evidence to support the teaching points, use strategies to engage the learners, and provide a cognitive scaffold for teaching the topic that the teacher can refine over time. All divisions of internal medicine (e.g. cardiology, rheumatology, and gastroenterology) are covered and a section on undifferentiated symptom-based presentations (e.g. fatigue, fever, and unintentional weight loss) is included. This book provides well-constructed teaching scripts for commonly encountered clinical scenarios, is authored by experienced academic internists and allows the reader to either implement them directly or modify them for their own use. Each teaching script is designed to be taught in 10-15 minutes, but can be easily adjusted by the reader for longer or shorter talks. Teaching Scripts in Internal Medicine is an ideal tool for internal medicine attending physicians and trainees, as well as physician’s assistants, nurse practitioners, and all others who teach and learn internal medicine.
