Butyrylcholinesterase

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Butyrylcholinesterase

Author : Ezio Giacobini
Publisher : CRC Press
ISBN 13 : 9781841842097
Total Pages : 192 pages
Book Rating : 4.8/5 (42 download)

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Book Synopsis Butyrylcholinesterase by : Ezio Giacobini

Download or read book Butyrylcholinesterase written by Ezio Giacobini and published by CRC Press. This book was released on 2003-06-05 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Two types of cholinesterases (ChEs) are found in the mammalian brain: acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). They are products of two different genes and exhibit different localizations and kinetic properties. Until recently, the function of BuChE and its role in the regulation of acetylcholine levels in the central nervous system have been largely unknown. There is now evidence that BuChE plays a vital role in the brain cholinergic system, and that it may have a key role in the development of Alzheimer's disease. Butyrylcholinesterase: Its Function and Inhibitors is for neurologists, psychiatrists, geriatricians and neuroscientists who want a full profile of BuChE.

The Neuroscience of Cocaine

Author : Victor R. Preedy
Publisher : Academic Press
ISBN 13 : 012803792X
Total Pages : 774 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis The Neuroscience of Cocaine by : Victor R. Preedy

Download or read book The Neuroscience of Cocaine written by Victor R. Preedy and published by Academic Press. This book was released on 2017-05-23 with total page 774 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Neuroscience of Cocaine: Mechanisms and Treatment explores the complex effects of this drug, addressing the neurobiology behind cocaine use and the psychosocial and behavioral factors that impact cocaine use and abuse. This book provides researchers with an up-to-date understanding of the mechanisms behind cocaine use, and aids them in deriving new pharmacological compounds and therapeutic regimens to treat dependency and withdrawal symptoms. Cocaine is one of the most highly abused illicit drugs worldwide and is frequently associated with other forms of drug addiction and misuse, but researchers are still struggling to understand cocaine’s neuropharmacological profile and the mechanisms of its effects and manifestations at the cognitive level. Cessation of cocaine use can lead to numerous adverse withdrawal conditions, from the cellular and molecular level to the behavioral level of the individual user. Written by worldwide experts in cocaine addiction, this book assists neuroscientists and other addiction researchers in unraveling the many complex facets of cocaine use and abuse. Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding Illustrated in full color Provides unique full coverage of all aspects of cocaine and its related pathology Provides researchers with an up-to-date understanding of the mechanisms behind cocaine use, and aids them in deriving new pharmacological compounds and therapeutic regimens to treat dependency and withdrawal symptoms

Human Cholinesterases and Anticholinesterases

Author : Hermona Soreq
Publisher : Academic Press
ISBN 13 : 0323155731
Total Pages : 331 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Human Cholinesterases and Anticholinesterases by : Hermona Soreq

Download or read book Human Cholinesterases and Anticholinesterases written by Hermona Soreq and published by Academic Press. This book was released on 2012-12-02 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Cholinesterases and Anticholinesterases summarizes the many fundamental concepts of human cholinesterases (ChEs) and their inhibitors. This book is divided into three chapters that represent human cholinesterase research studies from different points of view. Chapter 1 deals with the biochemical and biological background of human ChEs. This chapter also examines the molecular polymorphism, genomic origin, genetic variants, and biological roles of these enzymes. Chapter 2 provides the molecular characterization of human ChE genes and their multileveled regulation, with a special emphasis on butyrylcholinesterase. Chapter 3 discusses the scientific, ecological, and clinical implications of the studies presented in the previous chapters. Protein scientists, engineers, and researchers will find this work invaluable.

Anticholinesterase Pesticides

Author : Tetsuo Satoh
Publisher : John Wiley & Sons
ISBN 13 : 0470640499
Total Pages : 645 pages
Book Rating : 4.4/5 (76 download)

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Book Synopsis Anticholinesterase Pesticides by : Tetsuo Satoh

Download or read book Anticholinesterase Pesticides written by Tetsuo Satoh and published by John Wiley & Sons. This book was released on 2011-03-25 with total page 645 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers an important reference source about the most common classes of pesticides for researchers engaged in the area of neurotoxicology, metabolism, and epidemiology. The book presents details about thorough characterization of target and non-target enzymes and proteins involved in toxicity and metabolism; and epidemiology of poisonings and fatalities in people from short- and long- term exposures to these pesticides in different occupational settings on an individual country basis as well as on a global basis. The early portion of the book deals with metabolism, mechanisms and biomonitoring of anticholinesterase pesticides, while the later part deals with epidemiological studies, regulatory issues, and therapeutic intervention.

Discovery and Development of Neuroprotective Agents from Natural Products

Author : Goutam Brahmachari
Publisher : Elsevier
ISBN 13 : 0128097698
Total Pages : 490 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Discovery and Development of Neuroprotective Agents from Natural Products by : Goutam Brahmachari

Download or read book Discovery and Development of Neuroprotective Agents from Natural Products written by Goutam Brahmachari and published by Elsevier. This book was released on 2017-05-18 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discovery and Development of Neuroprotective Agents from Natural Products draws together global research on medicinal agents from natural sources as starting points for the design of neuroprotective drugs. From the prediction of promising leads and identification of active agents to the extraction of complex molecules, the book explores a range of important topics to support the development of safer, more economical therapeutics for these increasingly prevalent diseases. Beginning with an overview of current developments in the field, the book goes on to explore the identification, extraction and phytochemistry of such neuroprotective agents as antioxidants, biophenols and naturally occurring anti-inflammatory steroid analogues. Specific natural sources of bioactive agents are reviewed, and the development of these agents into therapeutics for a number of specific neurological disorders, including Alzheimer’s disease, Parkinson’s disease and ischemic brain stroke, are discussed. Combining the expertise of specialists from around the world, this in the Natural Products Drug Discovery series aims to support and encourage researchers in the investigation of natural sources as starting points for the development of standardized, safe and effective neuroprotective drugs. Features chapters written by active researchers and leading global experts deeply engaged in the research field of natural product chemistry for drug discovery Includes comprehensive coverage of cutting-edge research advances in the design of drugs from natural products targeted at different kinds of neurodegenerative diseases Offers a practical review of identification, isolation and extraction techniques to support medicinal chemists in the lab

Enzymes of the Cholinesterase Family

Author : A.S. Balasubramanian
Publisher : Springer Science & Business Media
ISBN 13 : 1489910514
Total Pages : 524 pages
Book Rating : 4.4/5 (899 download)

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Book Synopsis Enzymes of the Cholinesterase Family by : A.S. Balasubramanian

Download or read book Enzymes of the Cholinesterase Family written by A.S. Balasubramanian and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Fifth International Meeting on Cholinesterases convened in Madras, India, in September of 1994. The long and rich history and culture of India provided an excellent setting for the meeting. More than 120 delegates from Asia, Australia, Europe and North America heard 54 oral presentations and viewed 54 posters on current research on enzymes of the cholinesterase family. The aim of this book is to compile the presentations of the Fifth International Meeting on Cholinesterases into a volume that describes recent investigations on the structure and catalytic function of acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and related enzymes, as well as studies on the molecular and cellular biology of these enzymes and the genes which encode them. Cholinesterases enjoy a long and storied history in diverse areas. In basic biochemical research, AChE is one of the best studied, though yet enigmatic, of enzymes. The efficient catalytic function of this enzyme presents the biochemist with a fundamental challenge in understanding the relationship between structure and function. AChE and BuChE belong to a family of proteins, the alB hydrolase fold family, whose constituents evolutionarily diverged from a common ancestor. Proteins in this family have a wide range of physiological functions. In commerce, AChE is a prime target for agricultural insect control, and for the development of therapeutic agents for Alzheimer's disease.

Cholinesterases and Anticholinesterase Agents

Author : George B. Koelle
Publisher : Springer Science & Business Media
ISBN 13 : 3642998755
Total Pages : 1228 pages
Book Rating : 4.6/5 (429 download)

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Book Synopsis Cholinesterases and Anticholinesterase Agents by : George B. Koelle

Download or read book Cholinesterases and Anticholinesterase Agents written by George B. Koelle and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 1228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although the anticholinesterase (anti-ChE) agents have only limited applica tions in therapy, and from the viewpoint of practical significance they are more appropriately classified as toxic compounds or insecticides than as drugs, in their capacity of pharmacological tools they have few equals. The concept of neuro humoral transmission was originally established largely from experiments in which physostigmine, or eserine, was employed to protect acetylcholine (ACh), the trans mitter of the cholinergic nerves, from rapid hydrolytic destruction by acetyl cholinesterase (AChE) and other cholinesterases (ChE's). Since then, a great num ber of additional reversible and irreversible anti-ChE agents also have been indis pensable in studies of synaptic and neuroeffector transmission, and of other physiological processes. At the same time, there is practically no other class of compounds for which a mechanism of pharmacological action can be described in such concrete biochemical and physiological terms. Consequently, it is not sur prising that a huge literature has developed on these several closely interdependent topics. The assembling anrl proper correlation of this material for the present volume has taken the collaborative efforts of over two dozen . investigators. It iR believed that their contributions to this end will prove invaluable to future in vestigators in providing a ready, inclusive source of established information, in defining areas where further studies are indicated, and in preventing unnecessary duplication of past work. How well these aims have been accomplished will be for time and the reader to judge.

Marine Ecotoxicology

Author : Julián Blasco
Publisher : Academic Press
ISBN 13 : 012803372X
Total Pages : 334 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Marine Ecotoxicology by : Julián Blasco

Download or read book Marine Ecotoxicology written by Julián Blasco and published by Academic Press. This book was released on 2016-08-05 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Marine Ecotoxicology: Current Knowledge and Future Issues is the first unified resource to cover issues related to contamination, responses, and testing techniques of saltwater from a toxicological perspective. With its unprecedented focus on marine environments and logical chapter progression, this book is useful to graduate students, ecotoxicologists, risk assessors, and regulators involved or interested in marine waters. As human interaction with these environments increases, understanding of the pollutants and toxins introduced into the oceans becomes ever more critical, and this book builds a foundation of knowledge to assist scientists in studying, monitoring, and making decisions that affect both marine environments and human health. A team of world renowned experts provide detailed analyses of the most common contaminants in marine environments and explain the design and purpose of toxicity testing methods, while exploring the future of ecotoxicology studies in relation to the world’s oceans. As the threat of increasing pollution in marine environments becomes an ever more tangible reality, Marine Ecotoxicology offers insights and guidance to mitigate that threat. Provides practical tools and methods for assessing and monitoring the accumulation and effects of contaminants in marine environments Unites world renowned experts in marine ecotoxicology to deliver thorough and diverse perspectives Builds the foundation required for risk assessors and regulators to adequately assess and monitor the impact of pollution in marine environments Offers helpful insights and guidance to graduate students, ecotoxicologists, risk assessors, and regulators interested in mitigating threats to marine waters

Adipose Tissue and Adipokines in Health and Disease

Author : Giamila Fantuzzi
Publisher : Springer Science & Business Media
ISBN 13 : 1597453706
Total Pages : 400 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Adipose Tissue and Adipokines in Health and Disease by : Giamila Fantuzzi

Download or read book Adipose Tissue and Adipokines in Health and Disease written by Giamila Fantuzzi and published by Springer Science & Business Media. This book was released on 2007-11-06 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a comprehensive survey of adipose tissue, its physiological functions, and its role in disease. The volume spans the entire range of adipose tissue studies, from basic anatomical and physiological research to epidemiology and clinical studies. Groundbreaking recent studies are incorporated into traditional models of adipose tissue properties. A description of the role of macrophages in obesity and metabolism in included.

Structure and Function of Cholinesterases and Related Proteins

Author : Bhupendra P. Doctor
Publisher : Springer Science & Business Media
ISBN 13 : 1489915400
Total Pages : 627 pages
Book Rating : 4.4/5 (899 download)

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Book Synopsis Structure and Function of Cholinesterases and Related Proteins by : Bhupendra P. Doctor

Download or read book Structure and Function of Cholinesterases and Related Proteins written by Bhupendra P. Doctor and published by Springer Science & Business Media. This book was released on 2013-11-27 with total page 627 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Sixth International Meeting on Cholinesterases and Related Proteins, Choli nesterases '98, was organized by Palmer Taylor and his associates at the University of California-San Diego and convened in La Jolla, California, USA, in March of 1998. This was the first conference of the series to be held in the United States, let alone on the Pa cific Rim. Nearly 200 delegates from twenty countries-from Asia, Australia, Europe, and North and South America-heard 75 oral presentations and viewed 90 posters on current research on cholinesterases and related proteins. The meeting framework was structured to include two days of plenary sessions, followed by two days of concurrent sessions and workshops in specific areas. Communication at the concurrent sessions was facilitated by the conference settings of the Martin Johnson House, on a scenic bluff overlooking the blue Pacific Ocean, and the San Diego Supercomputer Center, which enabled projection and rotation of protein structures in three dimensions for a large audience. This book is the compilation of the presentations at the Sixth International Meeting on Cholinesterases and Related Proteins into a volume that describes recent investigations on the structure, catalytic and non-catalytic functions of acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), and related proteins, as well as studies on the molecular and cellular biology of these enzymes and the genes that encode them.

Comprehensive Toxicology

Author :
Publisher : Elsevier
ISBN 13 : 0081006128
Total Pages : 8639 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Comprehensive Toxicology by :

Download or read book Comprehensive Toxicology written by and published by Elsevier. This book was released on 2017-12-01 with total page 8639 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Toxicology, Third Edition, Fifteen Volume Set discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology. Organized to cover both the fundamental principles of toxicology and unique aspects of major organ systems Thoroughly revised to include the latest advances in the toxicological effects of chemicals on the immune system Features additional coverage throughout and a new volume on toxicology of the hematopoietic system Presents in-depth, comprehensive coverage from an international author base of domain experts

Neuroscientific Foundations of Anesthesiology

Author : George A. Mashour
Publisher : Oxford University Press
ISBN 13 : 0190453303
Total Pages : 296 pages
Book Rating : 4.1/5 (94 download)

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Book Synopsis Neuroscientific Foundations of Anesthesiology by : George A. Mashour

Download or read book Neuroscientific Foundations of Anesthesiology written by George A. Mashour and published by Oxford University Press. This book was released on 2011-10-05 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although the perioperative care of patients by anesthesiologists draws on diverse clinical skills, the principles of anesthesiology and pain management are rooted in the neurosciences. The Neuroscientific Foundations of Anesthesiology thoroughly examines the anesthetic modulation of the central, peripheral, and autonomic nervous systems and will help redefine anesthesiology as a fundamentally neuroscientific field. The book is organized by sections, with each focusing on a different part of the nervous system. State-of-the-art chapters written by thought-leaders in anesthesiology and neuroscience provide a novel and invaluable resource.

Emerging Drugs and Targets for Alzheimer's Disease

Author : Ana Martínez
Publisher : Royal Society of Chemistry
ISBN 13 : 1849730636
Total Pages : 343 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Emerging Drugs and Targets for Alzheimer's Disease by : Ana Martínez

Download or read book Emerging Drugs and Targets for Alzheimer's Disease written by Ana Martínez and published by Royal Society of Chemistry. This book was released on 2010 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume describes the discovery and development history of the most promising drugs now in development for combating Alzheimer's disease.

Anesthesia E-Book

Author : Ronald D. Miller
Publisher : Elsevier Health Sciences
ISBN 13 : 1437720617
Total Pages : 3220 pages
Book Rating : 4.4/5 (377 download)

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Book Synopsis Anesthesia E-Book by : Ronald D. Miller

Download or read book Anesthesia E-Book written by Ronald D. Miller and published by Elsevier Health Sciences. This book was released on 2009-06-24 with total page 3220 pages. Available in PDF, EPUB and Kindle. Book excerpt: From fundamental principles to advanced subspecialty procedures, Miller’s Anesthesia covers the full scope of contemporary anesthesia practice. It is the go-to reference for masterful guidance on the technical, scientific, and clinical challenges you face. Now new chapters, new authors, meticulous updates, an increased international presence, and a new full-color design ensure that the 7th edition continues the tradition of excellence that you depend on. Covers the full scope of contemporary anesthesia practice. Offers step-by-step instructions for patient management and an in-depth analysis of ancillary responsibilities and problems. Incorporates ‘Key Points’ boxes in every chapter that highlight important concepts. Extends the breadth of international coverage with contributions from prominent anesthesiologists from all over the world, including China, India, and Sweden. Features 30 new authors and 13 new chapters such as Sleep, Memory and Consciousness; Perioperative Cognitive Dysfunction; Ultrasound Guidance for Regional Anesthesia; Anesthesia for Correction of Cardiac Arrhythmias; Anesthesia for Bariatric Surgery; Prehospital Emergency and Trauma Care; Critical Care Protocols; Neurocritical Care; and Renal Replacement Therapy. Dedicates an entire section to pediatric anesthesia, to help you address the unique needs of pediatric patients. Presents a new full-color design -- complete with more than 1,500 full-color illustrations -- for enhanced visual guidance.

Miller's Anesthesia, 2-Volume Set E-Book

Author : Michael A. Gropper
Publisher : Elsevier Health Sciences
ISBN 13 : 0323612644
Total Pages : 3490 pages
Book Rating : 4.3/5 (236 download)

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Book Synopsis Miller's Anesthesia, 2-Volume Set E-Book by : Michael A. Gropper

Download or read book Miller's Anesthesia, 2-Volume Set E-Book written by Michael A. Gropper and published by Elsevier Health Sciences. This book was released on 2019-10-07 with total page 3490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering everything from historical and international perspectives to basic science and current clinical practice, Miller's Anesthesia, 9th Edition, remains the preeminent reference in the field. Dr. Michael Gropper leads a team of global experts who bring you the most up-to-date information available on the technical, scientific, and clinical issues you face each day – whether you’re preparing for the boards, studying for recertification, or managing a challenging patient care situation in your practice. Includes four new chapters: Clinical Care in Extreme Environments: High Pressure, Immersion, and Hypo- and Hyperthermia; Immediate and Long-Term Complications; Clinical Research; and Interpreting the Medical Literature. Addresses timely topics such as neurotoxicity, palliation, and sleep/wake disorders. Streamlines several topics into single chapters with fresh perspectives from new authors, making the material more readable and actionable. Features the knowledge and expertise of former lead editor Dr. Ronald Miller, as well as new editor Dr. Kate Leslie of the University of Melbourne and Royal Melbourne Hospital. Provides state-of-the-art coverage of anesthetic drugs, guidelines for anesthetic practice and patient safety, new techniques, step-by-step instructions for patient management, the unique needs of pediatric patients, and much more – all highlighted by more than 1,500 full-color illustrations for enhanced visual clarity.

Traditional Chinese Medicine

Author : Chun-Su Yuan
Publisher : CRC Press
ISBN 13 : 1841848433
Total Pages : 318 pages
Book Rating : 4.8/5 (418 download)

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Book Synopsis Traditional Chinese Medicine by : Chun-Su Yuan

Download or read book Traditional Chinese Medicine written by Chun-Su Yuan and published by CRC Press. This book was released on 2011-03-04 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: The authors of the Textbook of Complementary and Alternative Medicine present practitioners, physicians, and allied health workers with detailed material for a wide ranging understanding of what Traditional Chinese Medicine can offer.

Cumulated Index Medicus

Author :
Publisher :
ISBN 13 :
Total Pages : 1808 pages
Book Rating : 4.3/5 (243 download)

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Book Synopsis Cumulated Index Medicus by :

Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1808 pages. Available in PDF, EPUB and Kindle. Book excerpt: