Blood And Brains

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The Cerebral Circulation

Author : Marilyn J. Cipolla
Publisher : Biota Publishing
ISBN 13 : 1615047239
Total Pages : 82 pages
Book Rating : 4.6/5 (15 download)

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Book Synopsis The Cerebral Circulation by : Marilyn J. Cipolla

Download or read book The Cerebral Circulation written by Marilyn J. Cipolla and published by Biota Publishing. This book was released on 2016-07-28 with total page 82 pages. Available in PDF, EPUB and Kindle. Book excerpt: This e-book will review special features of the cerebral circulation and how they contribute to the physiology of the brain. It describes structural and functional properties of the cerebral circulation that are unique to the brain, an organ with high metabolic demands and the need for tight water and ion homeostasis. Autoregulation is pronounced in the brain, with myogenic, metabolic and neurogenic mechanisms contributing to maintain relatively constant blood flow during both increases and decreases in pressure. In addition, unlike peripheral organs where the majority of vascular resistance resides in small arteries and arterioles, large extracranial and intracranial arteries contribute significantly to vascular resistance in the brain. The prominent role of large arteries in cerebrovascular resistance helps maintain blood flow and protect downstream vessels during changes in perfusion pressure. The cerebral endothelium is also unique in that its barrier properties are in some way more like epithelium than endothelium in the periphery. The cerebral endothelium, known as the blood-brain barrier, has specialized tight junctions that do not allow ions to pass freely and has very low hydraulic conductivity and transcellular transport. This special configuration modifies Starling's forces in the brain microcirculation such that ions retained in the vascular lumen oppose water movement due to hydrostatic pressure. Tight water regulation is necessary in the brain because it has limited capacity for expansion within the skull. Increased intracranial pressure due to vasogenic edema can cause severe neurologic complications and death.

The Blood Brain Barrier (BBB)

Author : Gert Fricker
Publisher : Springer
ISBN 13 : 3662437872
Total Pages : 169 pages
Book Rating : 4.6/5 (624 download)

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Book Synopsis The Blood Brain Barrier (BBB) by : Gert Fricker

Download or read book The Blood Brain Barrier (BBB) written by Gert Fricker and published by Springer. This book was released on 2014-10-24 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Blood, Brains and Beer

Author : David Ogilvy
Publisher :
ISBN 13 :
Total Pages : 136 pages
Book Rating : 4.X/5 ( download)

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Book Synopsis Blood, Brains and Beer by : David Ogilvy

Download or read book Blood, Brains and Beer written by David Ogilvy and published by . This book was released on 1978 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Overloaded

Author : Ginny Smith
Publisher : Bloomsbury Publishing
ISBN 13 : 1472969367
Total Pages : 337 pages
Book Rating : 4.4/5 (729 download)

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Book Synopsis Overloaded by : Ginny Smith

Download or read book Overloaded written by Ginny Smith and published by Bloomsbury Publishing. This book was released on 2021-04-01 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: A NEW SCIENTIST BOOK OF THE YEAR From adrenaline to dopamine, our lives are shaped by the chemicals that control us. They are the hormones and neurotransmitters that our brains run on, and Overloaded looks at the roles they play in all aspects of our experiences, from how we make decisions, who we love, what we remember to basic survival drives such as hunger, fear and sleep. Author Ginny Smith explores what these tiny molecules do: what roles do cortisol and adrenaline play in memory formation? How do hormones and neurotransmitters affect the trajectory of our romantic relationships? Ginny meets scientists at the cutting-edge of brain chemistry research who are uncovering unexpected connections between these crucial chemicals. An eye-opening route through the remarkable world of neuro-transmitters, Overloaded unveils the chemicals inside each of us that touch every facet of our lives.

Brains

Author : Robin Becker
Publisher : Harper Collins
ISBN 13 : 0062000306
Total Pages : 193 pages
Book Rating : 4.0/5 (62 download)

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Book Synopsis Brains by : Robin Becker

Download or read book Brains written by Robin Becker and published by Harper Collins. This book was released on 2010-05-18 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: “A witty and unexpected take on the zombie genre; I had a great time.” —Charlaine Harris, #1 New York Times bestselling author of the Sookie Stackhouse novels Subtitled “A Zombie Memoir,” Brains looks at America’s favorite walking-dead flesh-eaters from an audaciously original and deliciously gruesome new perspective. Debut author Robin Becker blazes new ground with this story of former college professor-cum-sentient zombie Jack Barnes, who recounts the tale of the resistance he organized in the wake of the recent zombie apocalypse. World War Z; Shaun of the Dead;Pride, Prejudice, and Zombies… Becker tops them all with Brains—a witty, tasty treat for anyone who every spent a midnight glued to a classic George A. Romero zombie epic!

Mr. Humble and Dr. Butcher

Author : Brandy Schillace
Publisher : Simon & Schuster
ISBN 13 : 1982113774
Total Pages : 320 pages
Book Rating : 4.9/5 (821 download)

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Book Synopsis Mr. Humble and Dr. Butcher by : Brandy Schillace

Download or read book Mr. Humble and Dr. Butcher written by Brandy Schillace and published by Simon & Schuster. This book was released on 2021-03-02 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mesmerizing biography of a brilliant and eccentric surgeon and his quest to transplant the human soul. In the early days of the Cold War, a spirit of desperate scientific rivalry birthed a different kind of space race: not the race to outer space that we all know, but a race to master the inner space of the human body. While surgeons on either side of the Iron Curtain competed to become the first to transplant organs like the kidney and heart, a young American neurosurgeon had an even more ambitious thought: Why not transplant the brain? Dr. Robert White was a friend to two popes and a founder of the Vatican’s Commission on Bioethics. He developed lifesaving neurosurgical techniques still used in hospitals today and was nominated for the Nobel Prize. But like Dr. Jekyll before him, Dr. White had another identity. In his lab, he was waging a battle against the limits of science, and against mortality itself—working to perfect a surgery that would allow the soul to live on after the human body had died. Mr. Humble and Dr. Butcher follows his decades-long quest into tangled matters of science, global politics, and faith, revealing the complex (and often murky) ethics of experimentation and remarkable innovations that today save patients from certain death. It’s an enthralling tale that offers a window into our greatest fears and our greatest hopes—and the long, strange journey from science fiction to science fact.

Seven and a Half Lessons about the Brain

Author : Lisa Feldman Barrett
Publisher : Houghton Mifflin
ISBN 13 : 0358157145
Total Pages : 197 pages
Book Rating : 4.3/5 (581 download)

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Book Synopsis Seven and a Half Lessons about the Brain by : Lisa Feldman Barrett

Download or read book Seven and a Half Lessons about the Brain written by Lisa Feldman Barrett and published by Houghton Mifflin. This book was released on 2020-11-17 with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the author of How Emotions Are Made, a myth-busting primer on the brain, in the tradition of Seven Brief Lessons on Physics and Astrophysics for People in a Hurry

Am I Just My Brain?

Author : Sharon Dirckx
Publisher : The Good Book Company
ISBN 13 : 1784984035
Total Pages : 146 pages
Book Rating : 4.7/5 (849 download)

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Book Synopsis Am I Just My Brain? by : Sharon Dirckx

Download or read book Am I Just My Brain? written by Sharon Dirckx and published by The Good Book Company. This book was released on 2019-05-01 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: Looking at the body, mind and soul to answer the question: What exactly is a human being? Modern research is uncovering more and more detail of what our brain is and how it works. We are living, thinking creatures who carry around with us an amazing organic supercomputer in our heads. But what is the relationship between our brains and our minds-and ultimately our sense of identity as a person? Are we more than machines? Is free-will an illusion? Do we have a soul? Brain Imaging Scientist Sharon Dirckx lays out the current understanding of who we are from biologists, philosophers, theologians and psychologists, and points towards a bigger picture that suggests answers to the fundamental questions of our existence. Not just "What am I?", but "Who am I?"-and "Why am I?" Read this book to gain valuable insight into what modern research is telling us about ourselves, or to give a sceptical friend to challenge the idea that we are merely material beings living in a material world.

Blood-Brain Barrier in Drug Discovery

Author : Li Di
Publisher : John Wiley & Sons
ISBN 13 : 1118788540
Total Pages : 600 pages
Book Rating : 4.1/5 (187 download)

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Book Synopsis Blood-Brain Barrier in Drug Discovery by : Li Di

Download or read book Blood-Brain Barrier in Drug Discovery written by Li Di and published by John Wiley & Sons. This book was released on 2014-12-29 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focused on central nervous system (CNS) drug discovery efforts,this book educates drug researchers about the blood-brain barrier(BBB) so they can affect important improvements in one of the mostsignificant – and most challenging – areas of drugdiscovery. • Written by world experts to provide practicalsolutions to increase brain penetration or minimize CNSside-effects • Reviews state-of-the-art in silico, in vitro, and invivo tools to assess brain penetration and advanced CNS drugdelivery strategies • Covers BBB physiology, medicinal chemistry designprinciples, free drug hypothesis for the BBB, and transportmechanisms including passive diffusion, uptake/efflux transporters,and receptor-mediated processes • Highlights the advances in modelling BBBpharmacokinetics and dynamics relationships (PK/PD) andphysiologically-based pharmacokinetics (PBPK) • Discusses case studies of successful CNS and non-CNSdrugs, lessons learned and paths to the market

Discovering the Brain

Author : National Academy of Sciences
Publisher : National Academies Press
ISBN 13 : 0309045290
Total Pages : 195 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Discovering the Brain by : National Academy of Sciences

Download or read book Discovering the Brain written by National Academy of Sciences and published by National Academies Press. This book was released on 1992-01-01 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a "field guide" to the brainâ€"an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines: How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attentionâ€"and how a "gut feeling" actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the "Decade of the Brain," with a look at medical imaging techniquesâ€"what various technologies can and cannot tell usâ€"and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakersâ€"and many scientists as wellâ€"with a helpful guide to understanding the many discoveries that are sure to be announced throughout the "Decade of the Brain."

Shit, Piss, Blood, Pus & Brains

Author : John Giorno
Publisher :
ISBN 13 : 9780916978006
Total Pages : 48 pages
Book Rating : 4.9/5 (78 download)

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Book Synopsis Shit, Piss, Blood, Pus & Brains by : John Giorno

Download or read book Shit, Piss, Blood, Pus & Brains written by John Giorno and published by . This book was released on 1977 with total page 48 pages. Available in PDF, EPUB and Kindle. Book excerpt:

How People Learn

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309131979
Total Pages : 384 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis How People Learn by : National Research Council

Download or read book How People Learn written by National Research Council and published by National Academies Press. This book was released on 2000-08-11 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: First released in the Spring of 1999, How People Learn has been expanded to show how the theories and insights from the original book can translate into actions and practice, now making a real connection between classroom activities and learning behavior. This edition includes far-reaching suggestions for research that could increase the impact that classroom teaching has on actual learning. Like the original edition, this book offers exciting new research about the mind and the brain that provides answers to a number of compelling questions. When do infants begin to learn? How do experts learn and how is this different from non-experts? What can teachers and schools do-with curricula, classroom settings, and teaching methods--to help children learn most effectively? New evidence from many branches of science has significantly added to our understanding of what it means to know, from the neural processes that occur during learning to the influence of culture on what people see and absorb. How People Learn examines these findings and their implications for what we teach, how we teach it, and how we assess what our children learn. The book uses exemplary teaching to illustrate how approaches based on what we now know result in in-depth learning. This new knowledge calls into question concepts and practices firmly entrenched in our current education system. Topics include: How learning actually changes the physical structure of the brain. How existing knowledge affects what people notice and how they learn. What the thought processes of experts tell us about how to teach. The amazing learning potential of infants. The relationship of classroom learning and everyday settings of community and workplace. Learning needs and opportunities for teachers. A realistic look at the role of technology in education.

Neurotoxicology

Author : G. Jean Harry
Publisher : CRC Press
ISBN 13 : 1420054880
Total Pages : 334 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Neurotoxicology by : G. Jean Harry

Download or read book Neurotoxicology written by G. Jean Harry and published by CRC Press. This book was released on 2016-04-19 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new edition presents an integrated approach to neurotoxicology, the study of organisms' responses to changes in their environment and how interruption of the flow of information by chemical exposure causes a wide range of effects - from learning deficits, sensory disturbances in the extremities, and muscle weakness to seizures and signs simila

Implications of the Blood-Brain Barrier and Its Manipulation

Author : E.A. Neuwelt
Publisher : Springer Science & Business Media
ISBN 13 : 1461307015
Total Pages : 424 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Implications of the Blood-Brain Barrier and Its Manipulation by : E.A. Neuwelt

Download or read book Implications of the Blood-Brain Barrier and Its Manipulation written by E.A. Neuwelt and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the structure and function of the blood-brain barrier (BBB) and recogniz ing its clinical relevance require a concert of scientific disciplines applied from a view point of integrative physiology rather than from only molecular or analytical approaches. It is this broad scope that is emphasized in this book. In my opinion, four original contributions define the field as it exists today. The first, a monograph by Broman,1 entitled The Permeability of the Cerebrospinal Vessels in Normal and Pathological Conditions, was the model for many subsequent clinical and 3 experimental studies on BBB pathology. Second, experiments by Davson, summarized in his book entitled Physiology of the Ocular and Cerebrospinal Fluids, indicated that passive entry of nonelectrolytes into brain from blood is governed largely by their lipid 4 solubility. This research supported the original suggestion by Gesell and Hertzman that cerebral membranes have the semipermeability properties of cell membranes. The modem era of the barrier was introduced with the 1965 paper by Crone,2 entitled "Facilitated transfer of glucose from blood to brain tissue. " This paper identified stereospecific, facilitated transport of glucose as part of a system of regulatory barrier properties at a time when only a barrier to passive diffusion had been contemplated. Finally, the 1967 paper by Reese and Kamovsky, 11 entitled "Fine structural localization of a blood-brain barrier to exogenous peroxidase," sited the barrier at the continuous layer of cerebrovascular endothelial cells, which are connected by tight junctions.

Connectivity and Functional Specialization in the Brain

Author : Thomas Heinbockel
Publisher : BoD – Books on Demand
ISBN 13 : 1839627964
Total Pages : 176 pages
Book Rating : 4.8/5 (396 download)

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Book Synopsis Connectivity and Functional Specialization in the Brain by : Thomas Heinbockel

Download or read book Connectivity and Functional Specialization in the Brain written by Thomas Heinbockel and published by BoD – Books on Demand. This book was released on 2021-06-02 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: ‘Connectivity and Functional Specialization in the Brain’ is a topic that describes nerve cells in terms of their anatomical and functional connections. The term connectome refers to a comprehensive map of neural connections, like a wiring diagram of an organism’s nervous system. Connectomics, the study of connectomes, can be applied to individual neurons and their synaptic connections, as well as to connections between neuronal populations or to functional and structural connectivity of different brain regions. This book addresses neural connectivity at these various scales in health and disease. The chapters review novel findings related to neuroanatomy and cell biology, neurophysiology, neural plasticity, changes of connectivity in neurological disorders, and sensory system connectivity. The book provides the reader with an overview of the current state-of-the-art of research of neural connectivity and focuses on the most important evidence-based developments in this area. Individual chapters focus on recent advances in specific areas of neural connectivity and in different brain regions. All chapters represent recent contributions to the rapidly developing field of neural connectivity.

The XX Brain

Author : Lisa Mosconi PhD
Publisher : Penguin
ISBN 13 : 0593542134
Total Pages : 369 pages
Book Rating : 4.5/5 (935 download)

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Book Synopsis The XX Brain by : Lisa Mosconi PhD

Download or read book The XX Brain written by Lisa Mosconi PhD and published by Penguin. This book was released on 2022-11-08 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: The instant New York Times bestseller! "In The XX Brain, Lisa meticulously guides us in the ways we can both nourish and protect ourselves, body and mind, to ensure our brains remain resilient throughout our lives." --from the foreword by Maria Shriver The first book to address cognitive enhancement and Alzheimer's prevention specifically in women--and to frame brain health as an essential component of Women's Health. In this revolutionary book, Dr. Lisa Mosconi, director of the Women's Brain Initiative at Weill Cornell Medical College, provides women with the first plan to address the unique risks of the female brain. Until now, medical research has focused on "bikini medicine," assuming that women are essentially men with breasts and tubes. Yet women are far more likely than men to suffer from anxiety, depression, migraines, brain injuries, and strokes. They are also twice as likely to end their lives suffering from Alzheimer's disease, even when their longer lifespans are taken into account. But in the past, the female brain has received astonishingly little attention and was rarely studied by medical researchers-- resulting in a wealth of misinformation about women's health. The XX Brain confronts this crisis by revealing how the two powerful X chromosomes that distinguish women from men impact the brain first and foremost and by focusing on a key brain-protective hormone: estrogen. Taking on all aspects of women's health, including brain fog, memory lapses, depression, stress, insomnia, hormonal imbalances, and the increased risk of dementia, Dr. Mosconi introduces cutting-edge, evidence-based approaches to protecting the female brain, including a specific diet proven to work for women, strategies to reduce stress, and useful tips for restorative sleep. She also examines the controversy about soy and hormonal replacement therapy, takes on the perils of environmental toxins, and examines the role of our microbiome. Perhaps best of all, she makes clear that it is never too late to take care of yourself. The XX Brain is a rallying cry for women to have full access to information regarding what is going on in their brains and bodies as well as a roadmap for the path to optimal, lifelong brain health.

Neuroscience at the Intersection of Mind and Brain

Author : Jack M. Gorman
Publisher : Oxford University Press
ISBN 13 : 0190850132
Total Pages : 240 pages
Book Rating : 4.1/5 (98 download)

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Book Synopsis Neuroscience at the Intersection of Mind and Brain by : Jack M. Gorman

Download or read book Neuroscience at the Intersection of Mind and Brain written by Jack M. Gorman and published by Oxford University Press. This book was released on 2018-08-15 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroscience, the study of the structure and function of the brain, has captured our imaginations. Breakthrough technologies permit neuroscientists to probe how the human brain works in ever-more fascinating detail, revealing what happens when we think, move, love, hate, and fear. We know more than ever before about what goes wrong in the brain when we develop psychiatric and neurological illnesses like depression, dementia, epilepsy, panic attacks, and schizophrenia. We also now have clues about how treatments for those disorders change the way our brains look and function. Neuroscience at the Intersection of Mind and Brain has three main purposes. First, it makes complicated concepts and findings in modern neuroscience accessible to anyone with an interest in how the brain works. Second, it explains in detail how every experience we have from the moment we are conceived changes our brains. Third, it advances the idea that psychotherapy is a type of life experience that alters brain function and corrects aberrant brain connections. Among the topics covered are: what makes our brains different from those of other primates, our nearest genetic neighbors? How do life's experiences affect genetic expression of the brain and the way neurons connect with each other? Why are connections between different parts of the brain important in both health and disease? What happens in the brains of animals and humans when we are suddenly afraid of something, get depressed, or fall in love? How do medications and psychotherapies work? The information in this book is based on cutting-edge research in neuroscience, psychiatry, and psychology. Written by an author who studied human behavior and brain function for three decades, it is presented in a highly accessible manner, full of personal anecdotes and observations, and touches on many of the controversies in contemporary mental health practice.