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Author : K. Dane Wittrup
Publisher : Garland Science
ISBN 13 : 9780815341390
Total Pages : 550 pages
Book Rating : 4.3/5 (413 download)
Download or read book Biomolecular Kinetics and Cellular Dynamics written by K. Dane Wittrup and published by Garland Science. This book was released on 2008-01 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Clive R. Bagshaw
Publisher : CRC Press
ISBN 13 : 1498727247
Total Pages : 446 pages
Book Rating : 4.4/5 (987 download)
Download or read book Biomolecular Kinetics written by Clive R. Bagshaw and published by CRC Press. This book was released on 2017-10-04 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: "a gem of a textbook which manages to produce a genuinely fresh, concise yet comprehensive guide" –Mark Leake, University of York "destined to become a standard reference.... Not just a ‘how to’ handbook but also an accessible primer in the essentials of kinetic theory and practice." –Michael Geeves, University of Kent "covers the entire spectrum of approaches, from the traditional steady state methods to a thorough account of transient kinetics and rapid reaction techniques, and then on to the new single molecule techniques" –Stephen Halford, University of Bristol This illustrated treatment explains the methods used for measuring how much a reaction gets speeded up, as well as the framework for solving problems such as ligand binding and macromolecular folding, using the step-by-step approach of numerical integration. It is a thoroughly modern text, reflecting the recent ability to observe reactions at the single-molecule level, as well as advances in microfluidics which have given rise to femtoscale studies. Kinetics is more important now than ever, and this book is a vibrant and approachable entry for anyone who wants to understand mechanism using transient or single molecule kinetics without getting bogged down in advanced mathematics. Clive R. Bagshaw is Emeritus Professor at the University of Leicester, U.K., and Research Associate at the University of California at Santa Cruz, U.S.A.
Author : K. Dane Wittrup
Publisher : MIT Press
ISBN 13 : 0262353970
Total Pages : 593 pages
Book Rating : 4.2/5 (623 download)
Download or read book Quantitative Fundamentals of Molecular and Cellular Bioengineering written by K. Dane Wittrup and published by MIT Press. This book was released on 2020-01-07 with total page 593 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive presentation of essential topics for biological engineers, focusing on the development and application of dynamic models of biomolecular and cellular phenomena. This book describes the fundamental molecular and cellular events responsible for biological function, develops models to study biomolecular and cellular phenomena, and shows, with examples, how models are applied in the design and interpretation of experiments on biological systems. Integrating molecular cell biology with quantitative engineering analysis and design, it is the first textbook to offer a comprehensive presentation of these essential topics for chemical and biological engineering. The book systematically develops the concepts necessary to understand and study complex biological phenomena, moving from the simplest elements at the smallest scale and progressively adding complexity at the cellular organizational level, focusing on experimental testing of mechanistic hypotheses. After introducing the motivations for formulation of mathematical rate process models in biology, the text goes on to cover such topics as noncovalent binding interactions; quantitative descriptions of the transient, steady state, and equilibrium interactions of proteins and their ligands; enzyme kinetics; gene expression and protein trafficking; network dynamics; quantitative descriptions of growth dynamics; coupled transport and reaction; and discrete stochastic processes. The textbook is intended for advanced undergraduate and graduate courses in chemical engineering and bioengineering, and has been developed by the authors for classes they teach at MIT and the University of Minnesota.
Author : Clive Richard Bagshaw
Publisher : CRC Press
ISBN 13 : 9781498727235
Total Pages : 0 pages
Book Rating : 4.7/5 (272 download)
Download or read book Biomolecular Kinetics written by Clive Richard Bagshaw and published by CRC Press. This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kinetic theory -- Some underlying physical principles -- Enzyme kinetics -- Beyond enzyme kinetics -- Experimental strategies -- Instrumentation -- Data analysis -- Single-molecule kinetics -- Kinetic thinking : back to the future
Author : K. Dane Wittrup
Publisher : MIT Press
ISBN 13 : 0262042657
Total Pages : 593 pages
Book Rating : 4.2/5 (62 download)
Download or read book Quantitative Fundamentals of Molecular and Cellular Bioengineering written by K. Dane Wittrup and published by MIT Press. This book was released on 2020-01-07 with total page 593 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive presentation of essential topics for biological engineers, focusing on the development and application of dynamic models of biomolecular and cellular phenomena. This book describes the fundamental molecular and cellular events responsible for biological function, develops models to study biomolecular and cellular phenomena, and shows, with examples, how models are applied in the design and interpretation of experiments on biological systems. Integrating molecular cell biology with quantitative engineering analysis and design, it is the first textbook to offer a comprehensive presentation of these essential topics for chemical and biological engineering. The book systematically develops the concepts necessary to understand and study complex biological phenomena, moving from the simplest elements at the smallest scale and progressively adding complexity at the cellular organizational level, focusing on experimental testing of mechanistic hypotheses. After introducing the motivations for formulation of mathematical rate process models in biology, the text goes on to cover such topics as noncovalent binding interactions; quantitative descriptions of the transient, steady state, and equilibrium interactions of proteins and their ligands; enzyme kinetics; gene expression and protein trafficking; network dynamics; quantitative descriptions of growth dynamics; coupled transport and reaction; and discrete stochastic processes. The textbook is intended for advanced undergraduate and graduate courses in chemical engineering and bioengineering, and has been developed by the authors for classes they teach at MIT and the University of Minnesota.
Author : Natasha Myers
Publisher : Duke University Press
ISBN 13 : 082237563X
Total Pages : 344 pages
Book Rating : 4.8/5 (223 download)
Download or read book Rendering Life Molecular written by Natasha Myers and published by Duke University Press. This book was released on 2015-08-07 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: What are living bodies made of? Protein modelers tell us that our cells are composed of millions of proteins, intricately folded molecular structures on the scale of nanoparticles. Proteins twist and wriggle as they carry out the activities that keep cells alive. Figuring out how to make these unruly substances visible, tangible, and workable is a challenging task, one that is not readily automated, even by the fastest computers. Natasha Myers explores what protein modelers must do to render three-dimensional, atomic-resolution models of these lively materials. Rendering Life Molecular shows that protein models are not just informed by scientific data: model building entangles a modeler’s entire sensorium, and modelers must learn to feel their way through the data in order to interpret molecular forms. Myers takes us into protein modeling laboratories and classrooms, tracking how gesture, affect, imagination, and intuition shape practices of objectivity. Asking, ‘What is life becoming in modelers' hands?’ she tunes into the ways they animate molecules through their moving bodies and other media. In the process she amplifies an otherwise muted liveliness inflecting mechanistic accounts of the stuff of life.
Author : Abdüllatif Ofli
Publisher : Abdüllatif Ofli
ISBN 13 :
Total Pages : 1216 pages
Book Rating : 4./5 ( download)
Download or read book Mnemonic English Learning written by Abdüllatif Ofli and published by Abdüllatif Ofli. This book was released on 2023-07-26 with total page 1216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mnemonic reference featuring nuanced definitions, idiomatic expressions, and extensive word coverage to aid young adults, academics, TOEFL and IELTS exam takers in enhancing their lexicon to master English the honest way for native fluency. Mnemonic Learning is an engaging and authentic dictionary with a holistic approach to sophisticated language training. Conceptual mapping facilitates each query to link with a multitude of others in dozens of different ways by interactive and native content for thousands of refined expressions (words, phrases, collocations, idioms, proverbs, and exclusive concordances). Key terms, each connected to the main term with variations at different rates, are cultivated under 17 sections, catering to proficient English speakers to escape from intermediate to advanced levels.
Author : Michael R. King
Publisher : Elsevier
ISBN 13 : 0080539637
Total Pages : 320 pages
Book Rating : 4.0/5 (85 download)
Download or read book Principles of Cellular Engineering written by Michael R. King and published by Elsevier. This book was released on 2011-04-28 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive work discusses novel biomolecular surfaces that have been engineered to either control or measure cell function at the atomic, molecular, and cellular levels. Each chapter presents real results, concepts, and expert perspectives of how cells interact with biomolecular surfaces, with particular emphasis on interactions within complex mechanical environments such as in the cardiovascular system. In addition, the book provides detailed coverage of inflammation and cellular immune response as a useful model for how engineering concepts and tools may be effectively applied to complex systems in biomedicine. -Accessible to biologists looking for new ways to model their results and engineers interested in biomedical applications -Useful to researchers in biomaterials, inflammation, and vascular biology -Excellent resource for graduate students as a textbook in cell & tissue engineering or cell mechanics courses
Author : Heinz Koeppl
Publisher : Springer Science & Business Media
ISBN 13 : 1441967664
Total Pages : 407 pages
Book Rating : 4.4/5 (419 download)
Download or read book Design and Analysis of Biomolecular Circuits written by Heinz Koeppl and published by Springer Science & Business Media. This book was released on 2011-05-21 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book deals with engineering aspects of the two emerging and intertwined fields of synthetic and systems biology. Both fields hold promise to revolutionize the way molecular biology research is done, the way today’s drug discovery works and the way bio-engineering is done. Both fields stress the importance of building and characterizing small bio-molecular networks in order to synthesize incrementally and understand large complex networks inside living cells. Reminiscent of computer-aided design (CAD) of electronic circuits, abstraction is believed to be the key concept to achieve this goal. It allows hiding the overwhelming complexity of cellular processes by encapsulating network parts into abstract modules. This book provides a unique perspective on how concepts and methods from CAD of electronic circuits can be leveraged to overcome complexity barrier perceived in synthetic and systems biology.
Author : Eric Bertrand
Publisher : Springer Science & Business Media
ISBN 13 : 1402059434
Total Pages : 390 pages
Book Rating : 4.4/5 (2 download)
Download or read book Subcellular Proteomics written by Eric Bertrand and published by Springer Science & Business Media. This book was released on 2007-08-29 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume summarizes the new developments that made subcellular proteomics a rapidly expanding area. It examines the different levels of subcellular organization and their specific methodologies. In addition, the book includes coverage of systems biology that deals with the integration of the data derived from these different levels to produce a synthetic description of the cell as a system.
Author : Daniel L. Purich
Publisher : Elsevier
ISBN 13 : 9780080521930
Total Pages : 788 pages
Book Rating : 4.5/5 (219 download)
Download or read book Handbook of Biochemical Kinetics written by Daniel L. Purich and published by Elsevier. This book was released on 1999-10-26 with total page 788 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biochemical kinetics refers to the rate at which a reaction takes place. Kinetic mechanisms have played a major role in defining the metabolic pathways, the mechanistic action of enzymes, and even the processing of genetic material. The Handbook of Biochemical Kinetics provides the "underlying scaffolding" of logic for kinetic approaches to distinguish rival models or mechanisms. The handbook also comments on techniques and their likely limitations and pitfalls, as well as derivations of fundamental rate equations that characterize biochemical processes. Key Features * Over 750 pages devoted to theory and techniques for studying enzymic and metabolic processes * Over 1,500 definitions of kinetic and mechanistic terminology, with key references * Practical advice on experimental design of kinetic experiments * Extended step-by-step methods for deriving rate equations * Over 1,000 enzymes, complete with EC numbers, reactions catalyzed, and references to reviews and/or assay methods * Over 5,000 selected references to kinetic methods appearing in the Methods in Enzymology series * 72-page Wordfinder that allows the reader to search by keywords * Summaries of mechanistic studies on key enzymes and protein systems * Over 250 diagrams, figures, tables, and structures
Author : Keith Moffat
Publisher : John Wiley & Sons
ISBN 13 : 1119696283
Total Pages : 292 pages
Book Rating : 4.1/5 (196 download)
Download or read book Dynamics and Kinetics in Structural Biology written by Keith Moffat and published by John Wiley & Sons. This book was released on 2024-01-03 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understand the latest experimental tools in structural biology with this pioneering work Structural biology seeks to understand the chemical mechanisms and functions of biological molecules, such as proteins, based on their atomic structures. Until recently, these structures have been studied only statically, using procedures which deliberately freeze atomic motion. However, freezing eliminates the rapid structural motions so essential to biological activity and function; the molecules are inactive. But with the recent development of X-ray free electron laser (XFEL) sources, efforts to conduct dynamic experiments have expanded using the principles of dynamics and kinetics to capture active biological molecules as they function. Dynamics and Kinetics in Structural Biology promotes the development of these experiments and their successful application. It grounds readers in the foundational principles of dynamics and kinetics; proceeds through extended discussions of experimental procedures, data analysis techniques; and explores experimental frontiers in structural dynamics. The book will aid researchers to gather and interpret cutting-edge data on the dynamic structure of biological molecules, under conditions where they retain their biological functions. Dynamics and Kinetics in Structural Biology offers readers: Authorship by founding figures in the field In-depth presentation of time-resolved X-ray crystallography, solution scattering, and more A pioneering contribution to a rapidly developing field of study Dynamics and Kinetics in Structural Biology is essential reading for graduate students, scientists, researchers and industry professionals engaged in structural studies of biological systems. Industry professionals considering dynamic studies in the development of new product lines will also benefit.
Author : Meyer B. Jackson
Publisher : Cambridge University Press
ISBN 13 : 1139447246
Total Pages : 590 pages
Book Rating : 4.1/5 (394 download)
Download or read book Molecular and Cellular Biophysics written by Meyer B. Jackson and published by Cambridge University Press. This book was released on 2006-01-12 with total page 590 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular and Cellular Biophysics provides advanced undergraduate and graduate students with a foundation in the basic concepts of biophysics. Students who have taken physical chemistry and calculus courses will find this book an accessible and valuable aid in learning how these concepts can be used in biological research. The text provides a rigorous treatment of the fundamental theories in biophysics and illustrates their application with examples. Conformational transitions of proteins are studied first using thermodynamics, and subsequently with kinetics. Allosteric theory is developed as the synthesis of conformational transitions and association reactions. Basic ideas of thermodynamics and kinetics are applied to topics such as protein folding, enzyme catalysis and ion channel permeation. These concepts are then used as the building blocks in a treatment of membrane excitability. Through these examples, students will gain an understanding of the general importance and broad applicability of biophysical principles to biological problems.
Author :
Publisher :
ISBN 13 :
Total Pages : 1200 pages
Book Rating : 4.F/5 ( download)
Download or read book Biomedical Index to PHS-supported Research written by and published by . This book was released on 1993 with total page 1200 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 1192 pages
Book Rating : 4.:/5 (319 download)
Download or read book Biomedical Index to PHS-supported Research: pt. A. Subject access A-H written by and published by . This book was released on 1992 with total page 1192 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Yasushi Sako
Publisher : Springer
ISBN 13 : 9789048198658
Total Pages : 330 pages
Book Rating : 4.1/5 (986 download)
Download or read book Cell Signaling Reactions written by Yasushi Sako and published by Springer. This book was released on 2011-03-25 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book encompasses the exciting developments and challenges in the fast-moving and rapidly expanding research field of single-molecule kinetic analysis of cell signaling that promises to be one of the most significant and exciting areas of biological research for the foreseeable future. Cell signaling is carried out by complicated reaction networks of macromolecules, and single-molecule analyses has already demonstrated its power to unravel complex reaction dynamics in purified systems. To date, most of the published research in the field of single-molecule processes in cells, focus on the dynamic properties (translational movements of the centre of mass) of biological molecules. However, we hope that this book presents as many kinetic analyses of cell signaling as possible. Although single-molecule kinetic analysis of cellular systems is a relatively young field when compared with the analysis of single-molecule movements in cells, this type of analysis is highly important because it directly relates to the molecular functions that control cellular behavior and in the future, single-molecule kinetic analysis will be largely directed towards cellular systems. Thus, we hope that this book will be of interest to all those working in the fields of molecular and cell biology, as well as biophysics and biochemistry.
Author : Krastan B. Blagoev
Publisher : Springer Nature
ISBN 13 : 3030986063
Total Pages : 265 pages
Book Rating : 4.0/5 (39 download)
Download or read book Physics of Molecular and Cellular Processes written by Krastan B. Blagoev and published by Springer Nature. This book was released on 2022-09-08 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a graduate-level introduction to quantitative concepts and methods in the science of living systems. It relies on a systems approach for understanding the physical principles operating in biology. Physical phenomena are treated at the appropriate spatio-temporal scale and phenomenological equations are used in order to reflect the system of interest. Biological details enter to the degree necessary for understanding specific processes, but in many cases the approach is not reductionist. This is in line with the approach taken by physics to many other complex systems. The book bridges the gap between graduate students’ general physics courses and research papers published in professional journals. It gives students the foundations needed for independent research in biological physics and for working in collaborations aimed at quantitative biology and biomedical research. Also included are modern mathematical and theoretical physics methods, giving the student a broad knowledge of tools that can shed light on the sophisticated mechanisms brought forth by evolution in biological systems. The content covers many aspects that have been the focus of active research over the past twenty years, reflecting the authors' experience as leading researchers and teachers in this field.
