Biomarkers of Periodontal Disease and Its Link to Systemic Disease

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Publisher : LAP Lambert Academic Publishing
ISBN 13 : 9783838387246
Total Pages : 296 pages
Book Rating : 4.3/5 (872 download)

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Book Synopsis Biomarkers of Periodontal Disease and Its Link to Systemic Disease by : Balwant Rai

Download or read book Biomarkers of Periodontal Disease and Its Link to Systemic Disease written by Balwant Rai and published by LAP Lambert Academic Publishing. This book was released on 2010-08 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first edition of Biomarkers of periodontal disease and its link to systemic disease: BR study group brings to its readers iteration of the unrivalled, supreme work on the specialty of biomarkers and periodontal disease. The authors have written together contributions from own experience to provide the reader with a comprehensive, cohesive text that fuses scholarship and science with clinical and research instruction and practicality. This monograph provided a forum for leading researchers from dental medicine and dental science to present cutting edge research on the linkage between periodontal infections and cardiovascular disease, adverse pregnancy outcomes and diabetes.

Biomarkers in Periodontal Health and Disease

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Publisher : Springer
ISBN 13 : 9783030373153
Total Pages : 0 pages
Book Rating : 4.3/5 (731 download)

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Book Synopsis Biomarkers in Periodontal Health and Disease by : Nurcan Buduneli

Download or read book Biomarkers in Periodontal Health and Disease written by Nurcan Buduneli and published by Springer. This book was released on 2020-01-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines all aspects of the progress being made towards the development of highly specific and sensitive biomarkers that will overcome the shortcomings of clinical assessments in periodontics. The opening chapters present the basic anatomic features of periodontal tissues, outline the nature and pathogenic mechanisms of periodontal diseases, and discuss both conventional and novel methods of diagnosis with reference to their specificity and sensitivity. The potential role of biomarkers in periodontal diagnosis is then presented in the light of the published data. The biological samples in which potential biomarkers are sought are evaluated comparatively, drawing attention to their strengths and weaknesses, and the available technologies for biomarker studies are reviewed. The potential benefits of biomarkers are also discussed with regard to the possible bidirectional interactions between periodontal diseases and systemic health. Finally, the past, present, and future of periodontics are examined from a broader perspective. Readers will find the book to be an ideal summary of the state of the art in the field as biomarkers emerge that promise to facilitate periodontal diagnostics and permit timely, personally tailored interventions.

Periodontitis and Systemic Diseases

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Publisher : Quintessenz Verlag
ISBN 13 : 3868675574
Total Pages : 502 pages
Book Rating : 4.8/5 (686 download)

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Book Synopsis Periodontitis and Systemic Diseases by : Josefine Hirschfeld

Download or read book Periodontitis and Systemic Diseases written by Josefine Hirschfeld and published by Quintessenz Verlag. This book was released on 2021-04-19 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: The association between periodontitis and systemic diseases has become a hot topic in recent years. This comprehensive book reviews the clinical evidence and biological plausibility of the many systemic diseases that have been linked to periodontitis. Edited by Dr Josefine Hirschfeld and Prof Iain L.C. Chapple, experts in each field discuss the mechanisms at work, citing the available key literature and clearly summarising current knowledge and understanding of the associations between periodontitis and diabetes mellitus, cardiovascular diseases, chronic kidney disease, inflammatory bowel diseases, rheumatoid arthritis, respiratory diseases, pregnancy and fertility, malignancy, neurodegenerative diseases, stress and depression, and autoimmunity. Each chapter critically appraises the existing evidence, providing comprehensive, contemporary and well-considered insights into the clinical evidence and biological plausibility of each condition, as well as the limitations of existing studies and how these can be overcome in the future. Periodontitis and Systemic Diseases: Clinical Evidence and Biological Plausibility is an indispensable reference for both clinicians and researchers.

Biomarkers in Periodontal Health and Disease

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Publisher : Springer Nature
ISBN 13 : 3030373177
Total Pages : 90 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Biomarkers in Periodontal Health and Disease by : Nurcan Buduneli

Download or read book Biomarkers in Periodontal Health and Disease written by Nurcan Buduneli and published by Springer Nature. This book was released on 2019-12-31 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines all aspects of the progress being made towards the development of highly specific and sensitive biomarkers that will overcome the shortcomings of clinical assessments in periodontics. The opening chapters present the basic anatomic features of periodontal tissues, outline the nature and pathogenic mechanisms of periodontal diseases, and discuss both conventional and novel methods of diagnosis with reference to their specificity and sensitivity. The potential role of biomarkers in periodontal diagnosis is then presented in the light of the published data. The biological samples in which potential biomarkers are sought are evaluated comparatively, drawing attention to their strengths and weaknesses, and the available technologies for biomarker studies are reviewed. The potential benefits of biomarkers are also discussed with regard to the possible bidirectional interactions between periodontal diseases and systemic health. Finally, the past, present, and future of periodontics are examined from a broader perspective. Readers will find the book to be an ideal summary of the state of the art in the field as biomarkers emerge that promise to facilitate periodontal diagnostics and permit timely, personally tailored interventions.

Salivary Diagnostics

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Publisher : John Wiley & Sons
ISBN 13 : 081380664X
Total Pages : 321 pages
Book Rating : 4.8/5 (138 download)

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Book Synopsis Salivary Diagnostics by : David T. Wong

Download or read book Salivary Diagnostics written by David T. Wong and published by John Wiley & Sons. This book was released on 2009-03-16 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: Salivary Diagnostics surveys one of the most exciting areas of research in oral biology. Regarded as the mirror of the body, saliva has immense potential to yield real clinical improvements in our ability to diagnose, and hence treat, oral and systemic conditions. The composition of saliva and other oral fluids reflects the tissue fluid levels of therapeutic, hormonal, and immunological molecules, as well as the presence of markers for systemic and oral disease.

Glossary of Periodontal Terms

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Publisher :
ISBN 13 :
Total Pages : 64 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Glossary of Periodontal Terms by :

Download or read book Glossary of Periodontal Terms written by and published by . This book was released on 1992 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Studies on Periodontal Disease

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Publisher : Springer Science & Business Media
ISBN 13 : 1461495571
Total Pages : 368 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Studies on Periodontal Disease by : Daisuke Ekuni

Download or read book Studies on Periodontal Disease written by Daisuke Ekuni and published by Springer Science & Business Media. This book was released on 2014-01-09 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: The chapters of Studies on Periodontal Disease comprise four parts. Part 1 provides basic sciences from the general to the particular. The findings of cell culture and animal models supply the mechanism between periodontal disease and oxidative stress. In part 2, human clinical studies are mainly addressed. The effects of periodontal therapy on circulating oxidative stress are also discussed. The relationships between periodontal disease and systemic diseases are examined in part 3. The involvement of oxidative stress and inflammation are discussed through in vivo and in vitro study results. Part 4 discusses future strategies, including the effects of antioxidants and nutrition on periodontal disease. This thorough examination of the relationship between oxidative stress and periodontal disease is essential reading for researchers in oxidative stress and periodontal clinicians, alike.

Periodontitis

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Publisher : BoD – Books on Demand
ISBN 13 : 9535136054
Total Pages : 200 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Periodontitis by : Pachiappan Arjunan

Download or read book Periodontitis written by Pachiappan Arjunan and published by BoD – Books on Demand. This book was released on 2017-11-15 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Periodontitis - A Useful Reference is a comprehensive book compiled by a team of experts with the objective of providing an overview of the basic pathology of "periodontitis" and its implication on oral health and general systemic health. Periodontitis has become a global health burden in recent days. It is noteworthy that oral health is being considered as the mirror of general health and the study of oral-systemic health connections has advanced among scientists, clinicians, and the public as well. We wish the array of chapters that highlights the importance and impact of periodontal health could be a useful guide for the community of public, students, and clinicians.

Periodontal Disease

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Publisher : BoD – Books on Demand
ISBN 13 : 1789844606
Total Pages : 100 pages
Book Rating : 4.7/5 (898 download)

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Book Synopsis Periodontal Disease by :

Download or read book Periodontal Disease written by and published by BoD – Books on Demand. This book was released on 2020-02-05 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to provide readers with the latest updates and an informative overview of the most successful diagnostic aids for periodontal diseases. This book is divided into three sections. Section 1 discusses the periodontal disease pathogenesis and how the disease develops and the contributing factors in disease development. Section 2 includes three chapters that focus mainly on the most common and recent biomarkers that aid in diagnosis of periodontal diseases. Section 3 includes one chapter and discusses a non-surgical treatment modality that could provide definite improvement in the mild to moderate conditions in periodontal diseases.

Use of Saliva in Diagnosis of Periodontitis: Cumulative Use of Bacterial and Host-Derived Biomarkers

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Publisher : Frontiers Media SA
ISBN 13 : 2889451240
Total Pages : 107 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Use of Saliva in Diagnosis of Periodontitis: Cumulative Use of Bacterial and Host-Derived Biomarkers by : Ulvi Kahraman Gürsoy

Download or read book Use of Saliva in Diagnosis of Periodontitis: Cumulative Use of Bacterial and Host-Derived Biomarkers written by Ulvi Kahraman Gürsoy and published by Frontiers Media SA. This book was released on 2017-03-15 with total page 107 pages. Available in PDF, EPUB and Kindle. Book excerpt: Periodontitis is an infection-induced inflammatory disease of the tooth supporting tissues. Treatment of periodontal diseases and regeneration of the effected tissues can be possible only in the early diagnosis of the disease. If left undiagnosed or untreated, periodontitis leads to irreversible soft and hard tissue destruction and finally to tooth loss. Saliva is known to contain inflammatory mediators, host tissue and cell degradation products as well as microbial metabolites and enzymes, reflecting the health status of the oral cavity. In this topic, in collaboration with the well-known scientists working on the field of salivary diagnostics, we demonstrate evidence on monitoring periodontitis by salivary analysis.

Salivary Biomakers in Periodontal Health and Disease

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Publisher : LAP Lambert Academic Publishing
ISBN 13 : 9783659625749
Total Pages : 76 pages
Book Rating : 4.6/5 (257 download)

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Book Synopsis Salivary Biomakers in Periodontal Health and Disease by : Priyanka N.

Download or read book Salivary Biomakers in Periodontal Health and Disease written by Priyanka N. and published by LAP Lambert Academic Publishing. This book was released on 2014-11-21 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides information on biomarkers found in oral fluids relevant to oral and systemic diseases, with emphasis on salivary molecules and their potential to provide screening diagnosis for periodontal disease. The book will provide greater impact on clinician education in diagnostics, disease-risk and disease prevention through the public health sector before diagnostics will be integrated into routine clinical periodontal practice. Although challenges remain ahead, the use of saliva based oral fluid diagnostics appear promising for future application to diagnose periodontal diseases and to prognosticate periodontal treatment outcomes.

Biomarkers in Periodontal Disease

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Publisher :
ISBN 13 : 9783659741975
Total Pages : 124 pages
Book Rating : 4.7/5 (419 download)

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Book Synopsis Biomarkers in Periodontal Disease by : Pavan Kumar Addanki

Download or read book Biomarkers in Periodontal Disease written by Pavan Kumar Addanki and published by . This book was released on 2018-01-09 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Oral Biomarkers and Periodontal Disease

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Publisher : LAP Lambert Academic Publishing
ISBN 13 : 9783848480678
Total Pages : 132 pages
Book Rating : 4.4/5 (86 download)

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Book Synopsis Oral Biomarkers and Periodontal Disease by : Afaf Zia

Download or read book Oral Biomarkers and Periodontal Disease written by Afaf Zia and published by LAP Lambert Academic Publishing. This book was released on 2012-04 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: Periodontitis is a disease characterized by loss of connective tissue attachment and bone around the teeth in conjunction with the formation of periodontal pockets due to the apical migration of the junctional epithelium.Early diagnosis and treatment of progressive periodontitis is important because of the irreversible nature of this disease. Traditional clinical measurements used for periodontal diagnosis are often of limited usefulness in that they are indicators of previous periodontal disease rather than present disease activity. There is a need for development of new diagnostic tests that can detect the presence of active disease, predict future disease progression and evaluate the response to periodontal therapy, thereby improving the clinical management of periodontal patients. This book discusses the role of oral bio-markers in the diagnosis and progression of periodontal disease and describes the role of GCF -Glucuronidase levels as a diagnostic tool and measure of treatment outcome in patients with chronic periodontitis."

Role of Salivary Biomarkers in Periodontal Diseases

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Publisher : LAP Lambert Academic Publishing
ISBN 13 : 9783659193149
Total Pages : 88 pages
Book Rating : 4.1/5 (931 download)

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Book Synopsis Role of Salivary Biomarkers in Periodontal Diseases by : Mona Dagar

Download or read book Role of Salivary Biomarkers in Periodontal Diseases written by Mona Dagar and published by LAP Lambert Academic Publishing. This book was released on 2014-02-25 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt: Periodontitis is an inflammatory condition of the supporting tissues of the teeth. Intracellular enzymes are increasingly released from the damaged cells of periodontal tissues into the gingival crevicular fluid and saliva. It has been a great challenge to determine biomarkers for screening and predicting the early onset of disease (prognostic tests) or evaluating the disease activity and the efficacy of therapy.Various enzymes evaluated for the early diagnosis of periodontal disease are aspartate and alanine aminotransferases ( AST, ALT ), lactate dehydrogenase ( LDH ), creatine kinase ( CK ), alkaline and acid phosphatase ( ALP, ACP ) and gamma glutamiltransferase ( GGT ), myeloperoxidase ( MPO ). The activities of CK, LDH, AST, ALT, GGT, ALP, ACP, MPO, enzymes are found to be increased in periodontal diseases. Thus, an attempt has been made to review the diagnostic value of salivary enzymes in the diagnosis and progression of periodontal disease.

Periodontal Medicine and Systems Biology

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Publisher : John Wiley & Sons
ISBN 13 : 1405122196
Total Pages : 465 pages
Book Rating : 4.4/5 (51 download)

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Book Synopsis Periodontal Medicine and Systems Biology by : Brian Henderson

Download or read book Periodontal Medicine and Systems Biology written by Brian Henderson and published by John Wiley & Sons. This book was released on 2009-07-07 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a systems-based approach to periodontology and offers a scientific roadmap of the interactions which can lead to periodontal disease.

Periodontal Disease and Cancer

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Publisher :
ISBN 13 :
Total Pages : 434 pages
Book Rating : 4.:/5 (912 download)

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Book Synopsis Periodontal Disease and Cancer by : Ngozi Nnonyelum Nwizu

Download or read book Periodontal Disease and Cancer written by Ngozi Nnonyelum Nwizu and published by . This book was released on 2014 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Background: Periodontal disease typically presents as a chronic, low grade inflammatory process involving the periodontium. However, it also has the potential to produce systemic effects at distant organs sites and has been linked to several systemic conditions including cancer. Epidemiological studies on the association between periodontal disease and cancer risk are however limited, but most suggest a positive association. Only three studies (3) so far have examined total cancer risk in a prospective study. With respect to individual cancer sites, to our knowledge, no large epidemiological prospective study has examined the association between periodontal disease and colorectal cancer. This is in spite of evidence from experimental studies linking an established periodontal pathogen, Fusobacterium nucleatum, to premalignant and cancerous lesions of the colorectum. This prospective study evaluated the association between periodontal disease and risk of diagnosis of incident total-, as well as, colorectal cancer. Since periodontal disease may influence cancer risk through its ability to induce a chronic, low-grade, systemic inflammation, and serum CRP is an established biomarker of systemic inflammation; this study also investigated the association between prevalence and severity of measured periodontal disease, and serum hsCRP levels. Furthermore, independent evaluations of the role of active gingival inflammation, and presence of select periodontal pathogens, in influencing serum hsCRP levels respectively were conducted. Potential interactions of each of these measures with periodontal disease in relation to serum hsCRP levels were also explored. Methods: These studies were conducted utilizing data from the Women's Health Initiative Observational Study (WHI-OS). The study included three aims. Aim 1: evaluated the associations between periodontal disease and total cancer; Aim 2: evaluated the association of periodontal disease and colorectal cancer; and Aim 3 evaluated the association of periodontal disease and serum CRP levels. For the total cancer risk study, an analytic cohort of 65,869 postmenopausal women was used, while the colorectal cancer risk study involved 78,835 postmenopausal women. Periodontal disease status for these 2 studies was determined by self-report from the Year 5 Women's Health Initiative Observational Study (WHI-OS) follow-up questionnaire administered from 1999 through 2003. These women were between the ages of 54-86 years at the time the periodontal questionnaire was administered and were followed up for a maximum period of 15 years. Total cancer and colorectal cancer were evaluated using the first diagnosis of any incident cancer or colorectal cancer reported after the year-5 visit respectively.^Adjudication of cancer cases was determined via medical records by physicians. The risk of diagnosis of incident total-, regional-, site-specific and colorectal cancers were evaluated using Cox proportional hazards regression. For the association between periodontal disease and serum CRP levels, we conducted a cross-sectional study utilizing data from 620 postmenopausal women (aged 53-83 years) in an ancillary study of the Women's Health Initiative Observational Study (WHI-OS) in Buffalo NY, the OsteoPerio Study. Periodontal disease status was determined using clinical measures based on the Center for Disease Control and Prevention/American Academy of Periodontology (CDC/AAP) clinical case definition for periodontal disease; and independent measures of whole mouth mean, and worst site involvement of periodontal probing depth (PPD), and clinical attachment loss (CAL), respectively. Serum hsCRP concentration was evaluated using an immunoturbidimetric assay. Mean percentage of bleeding sites on gentle probing (>50% cut point), was used to confirm the presence of active gingival inflammation; while presence of select periodontal pathogens (Porphyromonas gingivalis, Tannerella Forsythia, Fusobacterium nucleatum, Prevotella intermedia, and Campylobacter rectus), were detected by immunofluorescence and phase contrast microscopy using pooled sub-gingival plaque samples. All statistical tests were two-sided. Results: 7,678 cases of primary incident cancer were diagnosed over a mean follow-up of 8. 32 years. Periodontal disease history was associated with a 12% statistically significant increased risk of diagnosis of cancer overall, after adjusting for potential confounders [HR 1. 12, 95% CI 1. 07-1. 18]. This finding remained significant among the sample of 34,097 women who had never smoked [HR 1. 11, 95% CI 1. 02-1. 20]. Statistically significant associations were also observed for cancers of the breast [HR 1. 10, 95% CI 1. 01-1. 19]; lung [HR 1. 31, 95% CI 1. 14-1. 51]; esophagus [HR 3. 28, 95% CI 1. 64-6. 53]; gallbladder [HR 1. 73, 95% CI 1. 01-2. 95]; and melanoma skin cancers [HR 1. 23, 95% CI 1. 02-1. 48]. There was a near significant association with stomach cancer [HR 1. 58, 95% CI 0. 94-2. 67], but no associations with cancers of the pancreas or genitourinary system. There was no association between periodontal disease and risk diagnosis of colorectal cancer, after adjusting for potential confounders [hazard ratio (HR) = 1. 08, 95% confidence interval (CI): 0. 92-1. 26]. Similarly, no associations were observed with respect to anatomic location (colon, rectum and recto-sigmoid cancers) and tumor characteristics respectively. There was significant interaction between periodontal disease and diagnosis of colorectal cancer according to hormone therapy (HT) use (p =0. 03), and stratified analyses suggest current HT users, particularly of estrogen plus progestin (E+P), with a history of periodontal disease have a higher risk of being diagnosed with colorectal cancer [HR =1. 76, 95% CI: 1. 20-2. 59]. This effect was enhanced on restriction to colon cancer alone [HR =2. 02, 95% CI: 1. 34-3. 05}. However, dose-response effect was not consistent with time on HT use. Other results from our study indicate that participants with "severe" periodontal disease according to the CDC/AAP Clinical Case Definition demonstrated an almost 2-fold higher odds of having high serum CRP concentrations (>3. 0mg/l), compared to those with no/mild disease, after adjusting for potential confounders (OR 1. 86, 95% CI 1. 06-3. 27). Positive, linear, but statistically insignificant associations were observed between whole mouth mean and worst site PPD and CAL measures. None of the select pathogens examined (alone or in groups), or the presence of active gingival inflammation evidenced by percentage of sites that bled on probing (>50%), were associated with serum hsCRP levels. Also, no significant interaction effects were observed between periodontal disease, and any of the pathogens, (alone or in groups), or mean percentage bleeding sites (>50% cut point), on the serum hsCRP concentrations. Conclusion: Periodontal disease may enhance the risk of being diagnosed with total cancer risk in postmenopausal women; this finding persisted when restricting to never smokers. This risk appears to be higher for certain anatomic sites, particularly those in close proximity to the oral cavity such as the esophagus and upper gastrointestinal regions, but does not appear to extend to lower gastrointestinal tract sites such as the colon and rectum. The observed association between women with periodontal disease who are on hormone therapy and risk of being diagnosed with incident colorectal cancer requires further exploration, and we cannot rule out that it may be due to chance. This study also affirms that chronic inflammation may be one mechanism by which periodontal disease is associated with cancer risk. Additional research in other prospective cohorts is needed.

Periodontal Manifestations of Local and Systemic Diseases

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Author :
Publisher : Springer Nature
ISBN 13 : 3031108280
Total Pages : 316 pages
Book Rating : 4.0/5 (311 download)

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Book Synopsis Periodontal Manifestations of Local and Systemic Diseases by : George Laskaris

Download or read book Periodontal Manifestations of Local and Systemic Diseases written by George Laskaris and published by Springer Nature. This book was released on 2023-03-27 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive atlas illustrates the important relationship between periodontal and systemic health and disease with a wealth of superb illustrations. The periodontium as a part of the oral tissues is of great interest to dentists and its importance extends beyond local disorders to a wide range of conditions that may affect periodontal health. The atlas covers both local and systemic disorders including inflammatory diseases, developmental disorders, metabolic disorders, endocrine disorders, cancer and a vast number of other diseases, that may present with gingival or periodontal lesions. Now in its 2nd edition, Periodontal Manifestations of Local and Systemic Diseases helps periodontists, oral medicine specialists, general dentists, and dental students to diagnose and manage patients with complex medical problems. The book is unique because no other books specifically focused on the periodontal manifestations of oral and systemic diseases have been available in this form. Nineteen years after the first edition the book has been almost entirely rewritten, expanded and updated. Over 50% of the pictorial material has been renewed and enriched with high quality color images. The book is written by a team of experienced experts and will be a valuable resource for the community.