Biological Basis Of Detoxication

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Biological Basis of Detoxication

Author : John Caldwell
Publisher : Elsevier
ISBN 13 : 0323150101
Total Pages : 444 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Biological Basis of Detoxication by : John Caldwell

Download or read book Biological Basis of Detoxication written by John Caldwell and published by Elsevier. This book was released on 2012-12-02 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological Basis of Detoxication focuses on the biological processes involved in detoxication, with emphasis on the biochemistry of the removal of xenobiotics from an organism. Topics range from the formation of toxic metabolites and compounds that are not metabolized at all to the tissue distribution and nutritional considerations, the kinetics and mechanisms of the metabolic and excretory processes, and the integration of xenobiotic metabolism in the activation and detoxication of carcinogens. Organized into 14 chapters, this book begins with an overview of the enzymatic basis for the metabolic activation of foreign compounds in forming reactive chemical intermediates. The first few chapters discuss the identification of reactive electrophiles derived from xenobiotics, intratissue distribution of activating and detoxicating enzymes, enzymatic and non-enzymatic modes of xenobiotic metabolism, and unmetabolized compounds. The middle chapters explore the biological basis of detoxication of oxygen free radicals, physiologic and kinetic aspects of the fate of xenobiotics, excretion of xenobiotics, and effects of nutrition on detoxication. The remaining chapters look at the relationships between the enzymes of detoxication and host defense mechanisms, metabolic basis of target organ toxicity, the enzymatic factor in selective toxicity, and intraindividual and interindividual variations in rates of hepatic metabolism of exogenous chemicals. Pharmacologists, toxicologists, and biochemists will find this book highly informative.

Biological Basis of Detoxication

Author : John Caldwell
Publisher :
ISBN 13 : 9780121550608
Total Pages : 429 pages
Book Rating : 4.5/5 (56 download)

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Book Synopsis Biological Basis of Detoxication by : John Caldwell

Download or read book Biological Basis of Detoxication written by John Caldwell and published by . This book was released on 1983 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological Basis of Detoxication...

Enzymatic Basis of Detoxication Volume 1

Author : William B. Jakoby
Publisher : Elsevier
ISBN 13 : 0323137989
Total Pages : 432 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Enzymatic Basis of Detoxication Volume 1 by : William B. Jakoby

Download or read book Enzymatic Basis of Detoxication Volume 1 written by William B. Jakoby and published by Elsevier. This book was released on 2012-12-02 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enzymatic Basis of Detoxication, Volume I focuses on the catalytic mechanisms and physiological expression of the enzymes that are involved in the detoxication of foreign compounds. The book explores foreign compound metabolism at the level of what specific enzymes can do. This book is organized into three sections and comprised of 17 chapters. The discussion begins with an overview of detoxication and covers both catalytic and non-catalytic removal of foreign substances, along with the general properties of the enzymes that are active in detoxication. The reader is then introduced to the physiological aspects of detoxication, paying particular attention to the kinetic aspects of metabolism and elimination of foreign compounds in animals, human genetic variation in detoxication enzymes, and how such enzymes are induced. The next section focuses on mixed function oxygenase systems and includes chapters on cytochrome P-450 and the detoxication reactions it catalyzes. The book also considers other oxidation-reduction systems, with reference to alcohol dehydrogenase, aldehyde reductase, aldehyde oxidizing enzymes, ketone reductases, xanthine oxidase and aldehyde oxidase, glutathione peroxidase, and superoxide dismutases. The final chapter is devoted to monoamine oxidase, its properties, substrate specificity, inhibitors, kinetics and mechanism, and multiple forms. Pharmacologists, toxicologists, and biochemists will find this book extremely helpful.

Metabolic Basis of Detoxication

Author : William B. Jakoby
Publisher : Elsevier
ISBN 13 : 0323137997
Total Pages : 392 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Metabolic Basis of Detoxication by : William B. Jakoby

Download or read book Metabolic Basis of Detoxication written by William B. Jakoby and published by Elsevier. This book was released on 2012-12-02 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolic Basis of Detoxication: Metabolism of Functional Groups considers the possible fates of the relatively circumscribed number of functional groups that xenobiotics bear. An understanding of the possible reactions, and the chemical and biological factors influencing them, will contribute to the overall predictability of the fate of "real" molecules. This approach attempts to knit together the understanding of metabolic pathways with that of the enzymes that catalyze the specific steps. The book contains 18 chapters and begins with a discussion of the biological oxidation of carbon atoms. This is followed by separate chapters on the metabolism of halogenated aliphatic hydrocarbons, aryl halides, heterocyclic rings, alcohols, aldehydes, and ketones. Subsequent chapters cover oxidative processes such as metabolic dealkylations and biological oxidation at nitrogen centers; the reduction of nitro and azo compounds and tertiary amine N-oxides; the oxidation, alkylation, acylation, and glycosylation of mercaptans; epoxide metabolism; and conjugation of phenols. The book aims to inform and interest the pharmacologist and toxicologist concerning the biochemical aspects and to orient the biochemist to the pharmacological insights required in dealing with the metabolism of xenobiotics.

Target Organ Toxicity

Author : Cohen
Publisher : CRC Press
ISBN 13 : 9780849357756
Total Pages : 246 pages
Book Rating : 4.3/5 (577 download)

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Book Synopsis Target Organ Toxicity by : Cohen

Download or read book Target Organ Toxicity written by Cohen and published by CRC Press. This book was released on 1986-08-31 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This two-volume set provides essential information on the general princi-ples of target organ toxicity. Pharmacokinetics, metabolic activation and key defense mechanisms, excretion, species variation, and tissue-specific biochemistry are explored comprehensively. These general principles are then illustrated using specific examples of toxicity to different target organs and systems. DNA modifi-cation and repair in tumor induction, and specificity in tumor initiation are also examined. Of primary interest to toxicologist, pharma-cologists, biochemists, and environmental toxicologists.

Target Organ Toxicity, Volume I

Author : Cohen
Publisher : CRC Press
ISBN 13 : 1000714543
Total Pages : 243 pages
Book Rating : 4.0/5 (7 download)

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Book Synopsis Target Organ Toxicity, Volume I by : Cohen

Download or read book Target Organ Toxicity, Volume I written by Cohen and published by CRC Press. This book was released on 2020-01-29 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: This two-volume set provides essential information on the general princi-ples of target organ toxicity. Pharmacokinetics, metabolic activation and key defense mechanisms, excretion, species variation, and tissue-specific biochemistry are explored comprehensively. These general principles are then illustrated using specific examples of toxicity to different target organs and systems. DNA modifi-cation and repair in tumor induction, and specificity in tumor initiation are also examined. Of primary interest to toxicologist, pharma-cologists, biochemists, and environmental toxicologists.

Annual Plant Reviews, Insect-Plant Interactions

Author : Claudia Voelckel
Publisher : John Wiley & Sons
ISBN 13 : 1118829808
Total Pages : 470 pages
Book Rating : 4.1/5 (188 download)

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Book Synopsis Annual Plant Reviews, Insect-Plant Interactions by : Claudia Voelckel

Download or read book Annual Plant Reviews, Insect-Plant Interactions written by Claudia Voelckel and published by John Wiley & Sons. This book was released on 2014-05-02 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: This latest volume in Wiley Blackwell’s prestigious Annual Plant Reviews brings together articles that describe the biochemical, genetic, and ecological aspects of plant interactions with insect herbivores.. The biochemistry section of this outstanding volume includes reviews highlighting significant findings in the area of plant signalling cascades, recognition of herbivore-associated molecular patterns, sequestration of plant defensive metabolites and perception of plant semiochemicals by insects. Chapters in the genetics section are focused on genetic mapping of herbivore resistance traits and the analysis of transcriptional responses in both plants and insects. The ecology section includes chapters that describe plant-insect interactions at a higher level, including multitrophic interactions, investigations of the cost-benefit paradigm and the altitudinal niche-breadth hypothesis, and a re-evaluation of co-evolution in the light of recent molecular research. Written by many of the world’s leading researchers in these subjects, and edited by Claudia Voelckel and Georg Jander, this volume is designed for students and researchers with some background in plant molecular biology or ecology, who would like to learn more about recent advances or obtain a more in-depth understanding of this field. This volume will also be of great use and interest to a wide range of plant scientists and entomologists and is an essential purchase for universities and research establishments where biological sciences are studied and taught. To view details of volumes in Annual Plant Reviews, visit: www.wiley.com/go/apr Also available from Wiley: Plant Defense Dale Walters 9781405175890 Herbicides and Plant Physiology, 2nd Edn Andrew Cobb & John Reade 9781405129350

Biological Reactive Intermediates V

Author : Robert R. Snyder
Publisher : Springer Science & Business Media
ISBN 13 : 1475794800
Total Pages : 449 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Biological Reactive Intermediates V by : Robert R. Snyder

Download or read book Biological Reactive Intermediates V written by Robert R. Snyder and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Much of organic chemistry is based on the ability of suitably structured chemicals to bind together through the formation of covalent bonds. Biochemistry is replete with exam ples of enzymatically catalyzed reactions in which normal body constituents can be linked through covalent bonds during the process of intermediary metabolism. The finding that xenobiotic chemicals that enter the body from the environment, are metabolized to highly reactive species, and then covalently react with cellular macromolecules to induce toxic and carcinogenic effects was an observation that spawned the research featured in the Fifth International Symposium on Biological Reactive Intermediates (BRI V). The group of investigators that became fascinated with this process and its signifi cance in terms of human health began their discussions in Turku, Finland (J 975), and continued them at Guildford, England (1980), College Park, Maryland (1985), Tucson, Arizona (1990), and Munich, Germany (1995). Among the results were a series of reports listed below, as well as the book for which this serves as the Preface. • Jollow, DJ., Kocsis, J.J., Snyder, R. and Vainio, H. (eds), Biological Reactive Intermediates: Formation, Toxicity and Inactivation, Plenum Press, NY, 1975. • Snyder, R., Park, D.V., Kocsis, J.J., Jollow, D.V., Gibson, G.G. and Witmer, C.M. (eds), Biological Reactive Intermediates II: Chemical Mechanisms and Biological Effects, Plenum Press, N.Y., 1982.

Early Phase Drug Evaluation in Man

Author : O'grady
Publisher : CRC Press
ISBN 13 : 1000717771
Total Pages : 748 pages
Book Rating : 4.0/5 (7 download)

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Book Synopsis Early Phase Drug Evaluation in Man by : O'grady

Download or read book Early Phase Drug Evaluation in Man written by O'grady and published by CRC Press. This book was released on 2020-02-03 with total page 748 pages. Available in PDF, EPUB and Kindle. Book excerpt: Early Phase Drug Evaluation in Man is a comprehensive, practical guide that covers pre-clinical information relevant to early human studies, including pharmaceutical, metabolic, toxicological, and regulatory aspects, as well as the general considerations relevant to all early human studies. Each major therapeutic area is considered by class of activity of drug. The chapters describe what measurements of drug activity are available in healthy human subjects and in patients, how to make the measurements, their value and their limitations. The contributors have been drawn internationally from the pharmaceutical industry and academia. Early Phase Drug Evaluation in Man will provide an important reference guide for industry and academic professionals involved in the development of new drugs.

Chemical Sensitivity, Volume I

Author : William J. Rea
Publisher : CRC Press
ISBN 13 : 1000945847
Total Pages : 554 pages
Book Rating : 4.0/5 (9 download)

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Book Synopsis Chemical Sensitivity, Volume I by : William J. Rea

Download or read book Chemical Sensitivity, Volume I written by William J. Rea and published by CRC Press. This book was released on 2023-07-28 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical Sensitivity is the first major scientific book series on chemical sensitivity, an increasingly important worldwide health problem. This four-volume series features results from the study of more than 20,000 environmentally sensitive patients at the Environmental Health Center (EHC) in Dallas. Results from the study at EHC are supplemented by information accumulated from the treatment and study of an estimated 100,000 patients by other environmentally oriented physicians and scientists around the world.

The Scientific Basis of Clinical Pharmacology

Author : Reynold Spector
Publisher : Little, Brown Medical Division
ISBN 13 :
Total Pages : 562 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Scientific Basis of Clinical Pharmacology by : Reynold Spector

Download or read book The Scientific Basis of Clinical Pharmacology written by Reynold Spector and published by Little, Brown Medical Division. This book was released on 1986 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Biodegradation and Detoxification of Environmental Pollutants

Author : A.M Chakrabarty
Publisher : CRC Press
ISBN 13 : 135108710X
Total Pages : 253 pages
Book Rating : 4.3/5 (51 download)

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Book Synopsis Biodegradation and Detoxification of Environmental Pollutants by : A.M Chakrabarty

Download or read book Biodegradation and Detoxification of Environmental Pollutants written by A.M Chakrabarty and published by CRC Press. This book was released on 2018-01-18 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: The basic objective of the book is to define and review the recent advances in our understand on the biological mechanisms in the biodegradation and detoxification of various environmental pollutants. The book encompasses recent studies on the mode of detoxication of such mercurial compounds by various microorganisms

Holland-Frei Cancer Medicine

Author : Robert C. Bast, Jr.
Publisher : John Wiley & Sons
ISBN 13 : 111900084X
Total Pages : 2008 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.

Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2008 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Cellular Antioxidant Defense Mechanisms

Author : Ching Kuang Chow
Publisher : CRC Press
ISBN 13 : 1000697312
Total Pages : 409 pages
Book Rating : 4.0/5 (6 download)

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Book Synopsis Cellular Antioxidant Defense Mechanisms by : Ching Kuang Chow

Download or read book Cellular Antioxidant Defense Mechanisms written by Ching Kuang Chow and published by CRC Press. This book was released on 2019-07-17 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: First Published in 1988, this three-volume set offers a full insight into the immune systems and its response to antioxidants. Carefully compiled and filled with diagrams, references and information this set is recommended for students of immunology and other professionals in their respective fields.

Biological Inorganic Chemistry

Author : Robert R. Crichton
Publisher : Elsevier
ISBN 13 : 9780080556222
Total Pages : 381 pages
Book Rating : 4.5/5 (562 download)

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Book Synopsis Biological Inorganic Chemistry by : Robert R. Crichton

Download or read book Biological Inorganic Chemistry written by Robert R. Crichton and published by Elsevier. This book was released on 2007-12-11 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: The importance of metals in biology, the environment and medicine has become increasingly evident over the last twenty five years. The study of the multiple roles of metal ions in biological systems, the rapidly expanding interface between inorganic chemistry and biology constitutes the subject called Biological Inorganic Chemistry. The present text, written by a biochemist, with a long career experience in the field (particularly iron and copper) presents an introduction to this exciting and dynamic field. The book begins with introductory chapters, which together constitute an overview of the concepts, both chemical and biological, which are required to equip the reader for the detailed analysis which follows. Pathways of metal assimilation, storage and transport, as well as metal homeostasis are dealt with next. Thereafter, individual chapters discuss the roles of sodium and potassium, magnesium, calcium, zinc, iron, copper, nickel and cobalt, manganese, and finally molybdenum, vanadium, tungsten and chromium. The final three chapters provide a tantalising view of the roles of metals in brain function, biomineralization and a brief illustration of their importance in both medicine and the environment. Relaxed and agreeable writing style. The reader will not only fiind the book easy to read, the fascinating anecdotes and footnotes will give him pegs to hang important ideas on. Written by a biochemist. Will enable the reader to more readily grasp the biological and clinical relevance of the subject. Many colour illustrations. Enables easier visualization of molecular mechanisms Written by a single author. Ensures homgeneity of style and effective cross referencing between chapters

How Tobacco Smoke Causes Disease

Author :
Publisher :
ISBN 13 :
Total Pages : 728 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis How Tobacco Smoke Causes Disease by :

Download or read book How Tobacco Smoke Causes Disease written by and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Molecular Biology of Metal Homeostasis and Detoxification

Author : Markus J. Tamás
Publisher : Springer Science & Business Media
ISBN 13 : 3540317198
Total Pages : 519 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Molecular Biology of Metal Homeostasis and Detoxification by : Markus J. Tamás

Download or read book Molecular Biology of Metal Homeostasis and Detoxification written by Markus J. Tamás and published by Springer Science & Business Media. This book was released on 2006-07-07 with total page 519 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the challenges faced by every cell as well as by whole organisms is to maintain appropriate concentrations of essential nutrient metals while excluding nonessential toxic metals. Toward that end, all organisms have developed mechanisms for metal homeostasis and detoxification to maintain metal levels within physiological limits. This book brings together current knowledge of the molecular basis of metal homeostasis and detoxification in various eukaryotic model systems, including yeasts, plants, and mammals. It focuses on the cellular systems controlling metal transport, intracellular distribution, and immobilization as well as on systems regulating metal-dependent transcription. In addition to environmental aspects (including phytoremediation), the book treats the pathophysiology of metal deficiency and overload in relation to disease.