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Metabolic Basis Of Detoxication
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Book Synopsis Metabolic Basis of Detoxication by : William B. Jakoby
Download or read book Metabolic Basis of Detoxication written by William B. Jakoby and published by Elsevier. This book was released on 2012-12-02 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolic Basis of Detoxication: Metabolism of Functional Groups considers the possible fates of the relatively circumscribed number of functional groups that xenobiotics bear. An understanding of the possible reactions, and the chemical and biological factors influencing them, will contribute to the overall predictability of the fate of "real" molecules. This approach attempts to knit together the understanding of metabolic pathways with that of the enzymes that catalyze the specific steps. The book contains 18 chapters and begins with a discussion of the biological oxidation of carbon atoms. This is followed by separate chapters on the metabolism of halogenated aliphatic hydrocarbons, aryl halides, heterocyclic rings, alcohols, aldehydes, and ketones. Subsequent chapters cover oxidative processes such as metabolic dealkylations and biological oxidation at nitrogen centers; the reduction of nitro and azo compounds and tertiary amine N-oxides; the oxidation, alkylation, acylation, and glycosylation of mercaptans; epoxide metabolism; and conjugation of phenols. The book aims to inform and interest the pharmacologist and toxicologist concerning the biochemical aspects and to orient the biochemist to the pharmacological insights required in dealing with the metabolism of xenobiotics.
Book Synopsis Enzymatic Basis of Detoxication by : William B. Jakoby
Download or read book Enzymatic Basis of Detoxication written by William B. Jakoby and published by Elsevier. This book was released on 2012-12-02 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enzymatic Basis of Detoxication, Volume I focuses on the catalytic mechanisms and physiological expression of the enzymes that are involved in the detoxication of foreign compounds. The book explores foreign compound metabolism at the level of what specific enzymes can do. This book is organized into three sections and comprised of 17 chapters. The discussion begins with an overview of detoxication and covers both catalytic and non-catalytic removal of foreign substances, along with the general properties of the enzymes that are active in detoxication. The reader is then introduced to the physiological aspects of detoxication, paying particular attention to the kinetic aspects of metabolism and elimination of foreign compounds in animals, human genetic variation in detoxication enzymes, and how such enzymes are induced. The next section focuses on mixed function oxygenase systems and includes chapters on cytochrome P-450 and the detoxication reactions it catalyzes. The book also considers other oxidation-reduction systems, with reference to alcohol dehydrogenase, aldehyde reductase, aldehyde oxidizing enzymes, ketone reductases, xanthine oxidase and aldehyde oxidase, glutathione peroxidase, and superoxide dismutases. The final chapter is devoted to monoamine oxidase, its properties, substrate specificity, inhibitors, kinetics and mechanism, and multiple forms. Pharmacologists, toxicologists, and biochemists will find this book extremely helpful.
Book Synopsis Biological Basis of Detoxication by : John Caldwell
Download or read book Biological Basis of Detoxication written by John Caldwell and published by Elsevier. This book was released on 2012-12-02 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological Basis of Detoxication focuses on the biological processes involved in detoxication, with emphasis on the biochemistry of the removal of xenobiotics from an organism. Topics range from the formation of toxic metabolites and compounds that are not metabolized at all to the tissue distribution and nutritional considerations, the kinetics and mechanisms of the metabolic and excretory processes, and the integration of xenobiotic metabolism in the activation and detoxication of carcinogens. Organized into 14 chapters, this book begins with an overview of the enzymatic basis for the metabolic activation of foreign compounds in forming reactive chemical intermediates. The first few chapters discuss the identification of reactive electrophiles derived from xenobiotics, intratissue distribution of activating and detoxicating enzymes, enzymatic and non-enzymatic modes of xenobiotic metabolism, and unmetabolized compounds. The middle chapters explore the biological basis of detoxication of oxygen free radicals, physiologic and kinetic aspects of the fate of xenobiotics, excretion of xenobiotics, and effects of nutrition on detoxication. The remaining chapters look at the relationships between the enzymes of detoxication and host defense mechanisms, metabolic basis of target organ toxicity, the enzymatic factor in selective toxicity, and intraindividual and interindividual variations in rates of hepatic metabolism of exogenous chemicals. Pharmacologists, toxicologists, and biochemists will find this book highly informative.
Book Synopsis Biological Basis of Detoxication by : John Caldwell
Download or read book Biological Basis of Detoxication written by John Caldwell and published by . This book was released on 1983 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological Basis of Detoxication...
Book Synopsis Enzymatic Basis of Detoxication Volume 1 by : William B. Jakoby
Download or read book Enzymatic Basis of Detoxication Volume 1 written by William B. Jakoby and published by Academic Press. This book was released on 1980-10-28 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enzymatic Basis of Detoxication, Volume I focuses on the catalytic mechanisms and physiological expression of the enzymes that are involved in the detoxication of foreign compounds. The book explores foreign compound metabolism at the level of what specific enzymes can do. This book is organized into three sections and comprised of 17 chapters. The discussion begins with an overview of detoxication and covers both catalytic and non-catalytic removal of foreign substances, along with the general properties of the enzymes that are active in detoxication. The reader is then introduced to the physiological aspects of detoxication, paying particular attention to the kinetic aspects of metabolism and elimination of foreign compounds in animals, human genetic variation in detoxication enzymes, and how such enzymes are induced. The next section focuses on mixed function oxygenase systems and includes chapters on cytochrome P-450 and the detoxication reactions it catalyzes. The book also considers other oxidation-reduction systems, with reference to alcohol dehydrogenase, aldehyde reductase, aldehyde oxidizing enzymes, ketone reductases, xanthine oxidase and aldehyde oxidase, glutathione peroxidase, and superoxide dismutases. The final chapter is devoted to monoamine oxidase, its properties, substrate specificity, inhibitors, kinetics and mechanism, and multiple forms. Pharmacologists, toxicologists, and biochemists will find this book extremely helpful.
Book Synopsis Enzymatic Basis of Detoxication Volume 2 by : William B. Jakoby
Download or read book Enzymatic Basis of Detoxication Volume 2 written by William B. Jakoby and published by Academic Press. This book was released on 1980-10-28 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enzymatic Basis of Detoxication, Volume II, reviews the state of knowledge on foreign compound metabolism at the level of what specific enzymes can do. The book attempts to provide a holistic view of the information gleaned from work with specific, purified enzymes encompassing as many mammalian sources as have been studied. The book is organized into two parts. Part I on conjugation reactions and related systems includes studies on the properties of glucuronide formation; the physiological function, assay, and purificatgion of function of bilirubin-glucuronoside glucuronosyltransferase; the roles of N- and O-methylation reactions and glutathione transferases in detoxication; and amino acid conjugation. Part II presents studies on hydrolytic systems, covering the role of epoxide hydrolase, carboxylesterases, and amidases in detoxication and the regulatory effects of these enzymes. This book provides pharmacologists and toxicologists with the biochemical view of detoxication, and biochemists with the corresponding pharmacological and toxicological aspects.
Book Synopsis Biochemical Mechanisms of Detoxification in Higher Plants by : George Kvesitadze
Download or read book Biochemical Mechanisms of Detoxification in Higher Plants written by George Kvesitadze and published by Springer Science & Business Media. This book was released on 2006-04-05 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plants play a key role in purifying the biosphere of the toxic effects of industrial activity. This book shows how systematic application of the results of investigations into the metabolism of xenobiotics (foreign, often toxic substances) in plants could make a vastly increased contribution to planetary well-being. Deep physiological knowledge gained from an accumulation of experimental data enables the great differences between the detoxifying abilities of different plants for compounds of different chemical nature to be optimally exploited. Hence planting could be far more systematically adapted to actual environmental needs than is actually the case at present. The book could form the basis of specialist courses in universities and polytechnics devoted to environmental management, and advanced courses in plant physiology and biochemistry, for botany and integrative biology students. Fundamental plant physiology and biochemistry from the molecular level to whole plants and ecosystems are interwoven in a powerful and natural way, making this a unique contribution to the field.
Book Synopsis Biochemical Basis of Medicine by : Eric D. Wills
Download or read book Biochemical Basis of Medicine written by Eric D. Wills and published by Butterworth-Heinemann. This book was released on 2014-04-24 with total page 654 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biochemical Basis of Medicine discusses academic biochemistry and the applications of biochemistry in medicine. This book deals with the biochemistry of the subcellular organelles, the biochemistry of the body , and of the specialized metabolism occurring in many body tissues. This text also discusses the various applications of biochemistry as regards environmental hazards, as well as in the diagnosis of illnesses and their treatment. This text explains the structure of the mammalian cell, the cell's metabolism, the nutritional requirements of the whole body, and the body's metabolism. This book explains the specialized metabolisms involved in tissues such as those occurring in blood clotting, in the liver during carbohydrate metabolism, or in the kidneys during water absorption. The text explains toxicology or biochemical damage caused by excess presence of copper, mercury, or lead in the body. Chelation therapy can remove these toxic metals. This book describes the effects of alcohol on plasma liquids, the multistage concept of carcinogenesis, and the biochemical basis of diagnosis. Diagnosis and treatment include the determination of typical enzymes found in the plasma, tests for genetic defects in blood proteins, and the use of chemotherapeutic drugs. This book is suitable for chemists, students and professors in organic chemistry, and laboratory technicians whose work is related to pharmacology.
Book Synopsis The Scientist's Guide to Cardiac Metabolism by : Michael Schwarzer
Download or read book The Scientist's Guide to Cardiac Metabolism written by Michael Schwarzer and published by Academic Press. This book was released on 2015-11-04 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Scientists Guide to Cardiac Metabolism combines the basic concepts of substrate metabolism, regulation, and interaction within the cell and the organism to provide a comprehensive introduction into the basics of cardiac metabolism. This important reference is the perfect tool for newcomers in cardiac metabolism, providing a basic understanding of the metabolic processes and enabling the newcomer to immediately communicate with the expert as substrate/energy metabolism becomes part of projects. The book is written by established experts in the field, bringing together all the concepts of cardiac metabolism, its regulation, and the impact of disease. Provides a quick and comprehensive introduction into cardiac metabolism Contains an integrated view on cardiac metabolism and its interrelation in metabolism with other organs Presents insights into substrate metabolism in relation to intracellular organization and structure as well as whole organ function Includes historical perspectives that reference important investigators that have contributed to the development of the field
Book Synopsis Activation and Detoxification Enzymes by : Chang-Hwei Chen
Download or read book Activation and Detoxification Enzymes written by Chang-Hwei Chen and published by Springer Science & Business Media. This book was released on 2011-11-16 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Humans are exposed to foreign compounds such as drugs, household products and environmental chemicals by swallowing or breathing. Also, food is considered a foreign compound. Such foreign compounds can be non-essential and non-functional to life, and commonly are referred to as xenobiotics. Some xenobiotics are not toxic; however, many of them are potentially toxic or become toxic after conversion to metabolic intermediates. A considerable number of foreign compounds belong to non-polar, lipophilic substances. Lipophilic compounds are not soluble in water. Metabolic conversion of lipophilic foreign compounds to facilitate their removal from the body is essentially carried out by biochemical reactions catalyzed by two classes of metabolizing enzymes, namely, activation enzymes and detoxification enzymes. Activation enzyme-catalyzed functionalization reaction introduces a functional group to a lipophilic compound. Functionalization modifies many foreign compounds to form reactive intermediates capable of interacting with cellular components (proteins, DNA and lipids), leading to a variety of conditions for diseases. Functionalized compounds are further metabolized through detoxification enzyme-catalyzed reactions, which result in an increase in the solubility of parent compounds and an inactivation of metabolic intermediates, thus facilitating their excretion from the body. To minimize the exposure of potentially toxic metabolic intermediates, it is essential to keep them at a minimum level. Extensive investigations have revealed that foreign compound-metabolizing enzymes exhibit genetic polymorphisms. Variations in their activities can produce different results as to the susceptibility to potential toxic effects. Moreover, the expressions of activation enzymes and detoxification enzymes are inducible. A number of chemical compounds are capable of acting as modulators for these two classes of enzymes. These findings have lead to the proposal of modulating metabolizing enzymes as a useful approach for human health benefits. Importantly, many of these chemical compounds are present in human daily diets. There are many advances that have been made in the past decades towards the understanding of functions and implications of activation enzymes and detoxification enzymes. An organized, concise overview is needed for the readers who are initially exposed to this important subject, particularly for students and researchers in the areas of biomedical sciences, biochemistry, nutrition, pharmacology and chemistry. This book is intended to serve this purpose as an introduction to the subject. Furthermore, major topics in the book, excluding catalytic reactions and structural properties, may have interest to other readers who have knowledge of basic sciences and understanding enzyme related information. The book discusses subjects associated with foreign compound metabolizing enzymes with emphasis on biochemical aspects, including lipophilic foreign compounds, catalytic properties, reactive intermediates, biomedical and biochemical effects, genetic polymorphisms, enzyme inducibility, enzyme modulation for health benefits, dietary related enzyme modulators, and structural characteristics of enzyme inducers.
Book Synopsis The Metabolism Reset Diet by : Alan Christianson
Download or read book The Metabolism Reset Diet written by Alan Christianson and published by Harmony. This book was released on 2019 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: "With a life-changing 4-week liver detox"--Jacket.
Download or read book Target Organ Toxicity written by Cohen and published by CRC Press. This book was released on 1986-08-31 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This two-volume set provides essential information on the general princi-ples of target organ toxicity. Pharmacokinetics, metabolic activation and key defense mechanisms, excretion, species variation, and tissue-specific biochemistry are explored comprehensively. These general principles are then illustrated using specific examples of toxicity to different target organs and systems. DNA modifi-cation and repair in tumor induction, and specificity in tumor initiation are also examined. Of primary interest to toxicologist, pharma-cologists, biochemists, and environmental toxicologists.
Book Synopsis The Blood Sugar Solution 10-Day Detox Diet by : Dr. Mark Hyman
Download or read book The Blood Sugar Solution 10-Day Detox Diet written by Dr. Mark Hyman and published by Little, Brown Spark. This book was released on 2014-02-25 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Hyman's revolutionary weight-loss program, based on the #1 New York Times bestseller The Blood Sugar Solution, supercharged for immediate results! The key to losing weight and keeping it off is maintaining low insulin levels. Based on Dr. Hyman's groundbreaking Blood Sugar Solution program, The Blood Sugar Solution 10-Day Detox Diet presents strategies for reducing insulin levels and producing fast and sustained weight loss. Dr. Hyman explains how to: activate your natural ability to burn fat -- especially belly fat; reduce inflammation; reprogram your metabolism; shut off your fat-storing genes; de-bug your digestive system; create effortless appetite control; and soothe the stress to shed the pounds. With practical tools designed to achieve optimum wellness, including meal plans, recipes, and shopping lists, as well as step-by-step, easy-to-follow advice on green living, supplements, medication, exercise, and more, The Blood Sugar Solution 10-Day Detox Diet is the fastest way to lose weight, prevent disease, and feel your best.
Book Synopsis Handbook of Mammalian Metabolism of Plant Compounds (1991) by : Ronald R. Scheline
Download or read book Handbook of Mammalian Metabolism of Plant Compounds (1991) written by Ronald R. Scheline and published by CRC Press. This book was released on 2017-12-14 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Mammalian Metabolism of Plant Compounds provides an extensive survey of how mammals metabolize compounds found in higher plants. Information about these compounds is important to researchers in pharmacology, toxicology, medical and natural products chemistry, and food sciences. Although there is plenty of literature about mammalian metabolism of plant compounds, it is scattered, and summaries of specific plant compounds are often difficult to obtain. This book contains 11 chapters discussing the metabolic fate of individual plant compounds grouped according to chemical class. It also features structural formulas of the compounds and their metabolites, including probable pathways of metabolism. This book provides a convenient single-volume reference source that will benefit all researchers requiring this type of information.
Book Synopsis The Alkaloids: Chemistry and Pharmacology by :
Download or read book The Alkaloids: Chemistry and Pharmacology written by and published by Academic Press. This book was released on 1987-10-01 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Alkaloids: Chemistry and Pharmacology
Book Synopsis Thyroid Hormone Metabolism by : Georg Hennemann
Download or read book Thyroid Hormone Metabolism written by Georg Hennemann and published by Marcel Dekker. This book was released on 1986 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Biodegradation and Detoxification of Environmental Pollutants by : A.M Chakrabarty
Download or read book Biodegradation and Detoxification of Environmental Pollutants written by A.M Chakrabarty and published by CRC Press. This book was released on 2018-01-18 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: The basic objective of the book is to define and review the recent advances in our understand on the biological mechanisms in the biodegradation and detoxification of various environmental pollutants. The book encompasses recent studies on the mode of detoxication of such mercurial compounds by various microorganisms
