Bioassays In Experimental And Preclinical Pharmacology

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Bioassays in Experimental and Preclinical Pharmacology

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Author : Karuppusamy Arunachalam
Publisher :
ISBN 13 : 9781071612330
Total Pages : 271 pages
Book Rating : 4.6/5 (123 download)

Book Synopsis Bioassays in Experimental and Preclinical Pharmacology by : Karuppusamy Arunachalam

Download or read book Bioassays in Experimental and Preclinical Pharmacology written by Karuppusamy Arunachalam and published by . This book was released on 2021 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed book explores protocols for a wide array of preclinical pharmacology and toxicology evaluations to be applied to chemical drugs and their development through in vitro, involving tissues and cell lines, and in vivo models, using animals as experimental systems, utilized to conduct pharmacological research. Written for the Springer Protocols Handbooks series, the methodologies included in this collection have been standardized by the authors through extensive use in the lab so that they are ready to be applied in the labs of readers around the world. Authoritative and practical, Bioassays in Experimental and Preclinical Pharmacology aims to assist undergraduate and postgraduate students, research scholars, scientists, and other academicians performing research in the vital field of drug discovery.

Bioassay Techniques for Drug Development

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Author : Atta-ur-Rahman
Publisher : CRC Press
ISBN 13 : 1135287228
Total Pages : 214 pages
Book Rating : 4.1/5 (352 download)

Book Synopsis Bioassay Techniques for Drug Development by : Atta-ur-Rahman

Download or read book Bioassay Techniques for Drug Development written by Atta-ur-Rahman and published by CRC Press. This book was released on 2001-10-04 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of an activity-directed isolation process is to isolate bioactive compounds which may provide structural leads of therapeutic importance. Whereas the traditional process of drug development is long and expensive, simple and rapid bioassays can serve as the starting point for drug discovery. This book presents a range of "bench top" bioassa

Improving and Accelerating Therapeutic Development for Nervous System Disorders

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Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309292492
Total Pages : 107 pages
Book Rating : 4.3/5 (92 download)

Book Synopsis Improving and Accelerating Therapeutic Development for Nervous System Disorders by : Institute of Medicine

Download or read book Improving and Accelerating Therapeutic Development for Nervous System Disorders written by Institute of Medicine and published by National Academies Press. This book was released on 2014-02-06 with total page 107 pages. Available in PDF, EPUB and Kindle. Book excerpt: Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.

Pharmaceutical Bioassays

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Author : Shiqi Peng
Publisher : John Wiley & Sons
ISBN 13 : 0470522194
Total Pages : 523 pages
Book Rating : 4.4/5 (75 download)

Book Synopsis Pharmaceutical Bioassays by : Shiqi Peng

Download or read book Pharmaceutical Bioassays written by Shiqi Peng and published by John Wiley & Sons. This book was released on 2009-12-09 with total page 523 pages. Available in PDF, EPUB and Kindle. Book excerpt: The definitive compendium of bioassay procedures and applications A virtual encyclopedia of key bioassay protocols, this up-to-date, essential resource reviews the methods and applications of bioassays that quantify drug activity and evaluate the validity of pharmacological models. Demonstrating the specific ways in which various pharmaceutical bioassays interpret the activity of drug molecules, the book covers the evaluation and screening of drug compounds in a wide spectrum of therapeutic categories. Throughout, the authors use various models to link experimental observations with findings that clarify the effect of drug compounds on cellular biology and measure the pharmacological activity of chemical substances. This provides an important technological platform for successful drug research and clinical therapy, making Pharmaceutical Bioassays an ideal sourcebook for pharmacologists, pharmaceutical and medical researchers, analytical chemists, toxicologists, and students. Just as a fundamental knowledge of pharmaceutical bioassays is vital to understanding how bioactive agents and new drugs are defined, discovered, and developed, so too is this indispensable reference, which: Offers a complete reference on pharmaceutical bioassays and their specific applications in the assessment of therapies for cancer, Alzheimer’s, diabetes, epilepsy, inflammation, antimalarials, pharmacogenomics, and other major therapeutic areas Covers bioassays that measure toxicity, including those for chemical toxicity and hepatoxicity—a particularly significant consideration in the development of safe and tolerable medications Highlights clinically relevant methods, ideas, and techniques to support any pharmaceutical researcher Suggests guidelines and systems to enhance communication between pharmacologists, chemists, and biologists Provides an informative analysis of pharmaceutical bioassay technologies and lab applications

Principles of Safety Pharmacology

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Author : Michael K. Pugsley
Publisher : Springer
ISBN 13 : 366246943X
Total Pages : 477 pages
Book Rating : 4.6/5 (624 download)

Book Synopsis Principles of Safety Pharmacology by : Michael K. Pugsley

Download or read book Principles of Safety Pharmacology written by Michael K. Pugsley and published by Springer. This book was released on 2015-06-19 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates, in a comprehensive manner, the most current areas of importance to Safety Pharmacology, a burgeoning unique pharmacological discipline with important ties to academia, industry and regulatory authorities. It provides readers with a definitive collection of topics containing essential information on the latest industry guidelines and overviews current and breakthrough topics in both functional and molecular pharmacology. An additional novelty of the book is that it constitutes academic, pharmaceutical and biotechnology perspectives for Safety Pharmacology issues. Each chapter is written by an expert in the area and includes not only a fundamental background regarding the topic but also detailed descriptions of currently accepted, validated models and methods as well as innovative methodologies used in drug discovery.

Drug Delivery

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Author : Monika Schäfer-Korting
Publisher : Springer Science & Business Media
ISBN 13 : 3642004776
Total Pages : 506 pages
Book Rating : 4.6/5 (42 download)

Book Synopsis Drug Delivery by : Monika Schäfer-Korting

Download or read book Drug Delivery written by Monika Schäfer-Korting and published by Springer Science & Business Media. This book was released on 2010-03-10 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the view of most experts pharmacology is on drugs, targets, and actions. In the context the drug as a rule is seen as an active pharmaceutical ingredient and not as a complex mixture of chemical entities of a well defined structure. Today, we are becoming more and more aware of the fact that delivery of the active compound to the target site is a key. The present volume gives a topical overview on various modern approaches to drug targeting covering today’s options for specific carrier systems allowing successful drug treatment at various sites of the body difficult to address and allowing to increase the benefit-risk-ratio to the optimum possible.

Drug Discovery and Evaluation

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Author : Hans G. Vogel
Publisher : Springer Science & Business Media
ISBN 13 : 366203333X
Total Pages : 790 pages
Book Rating : 4.6/5 (62 download)

Book Synopsis Drug Discovery and Evaluation by : Hans G. Vogel

Download or read book Drug Discovery and Evaluation written by Hans G. Vogel and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 790 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference book contains a comprehensive selection of the most frequently used assays for reliably detecting pharmacological effects of potential drugs, including tests for cardiovascular, analgesic, psychotropic, metabolic, endocrine, respiratory, renal, and immunomodulatory activities. Each of the over 700 assays comprises a detailed protocol with the purpose and rationale of the method, a description of the experimental procedure, a critical assessment of the results and their pharmacological and clinical relevance, and pertinent references. Identification of specific tests is facilitated by the enclosed CD-ROM which allows for a quick and full text research. An appendix with guidelines and legal regulations for animal experiments in various countries will help to plan these experiments properly in accordance with the welfare of laboratory animals.

Textbook of Pharmacology-II (As per PCI regulations and for medical students)

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Author : Prof. Prasad Neerati
Publisher : Shashwat Publication
ISBN 13 : 9360871370
Total Pages : 439 pages
Book Rating : 4.3/5 (68 download)

Book Synopsis Textbook of Pharmacology-II (As per PCI regulations and for medical students) by : Prof. Prasad Neerati

Download or read book Textbook of Pharmacology-II (As per PCI regulations and for medical students) written by Prof. Prasad Neerati and published by Shashwat Publication. This book was released on 2024-11-04 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacology is the study of how drugs interact with biological systems, playing a pivotal role in understanding disease mechanisms and treatment. The content is designed to guide students, healthcare professionals, and researchers through more complex therapeutic classes, drug interactions, and the evolving landscape of pharmacological research. In this book, we explore the pharmacodynamics and pharmacokinetics of various drug classes, as well as their clinical applications and adverse effects. Additionally, we address recent advances in molecular pharmacology, including personalized medicine and the role of biotechnology in drug development. By integrating case studies and real-world examples, we aim to enhance practical understanding and foster critical thinking in applying pharmacological principles to clinical practice. We would like to express our gratitude to the contributors, researchers, and healthcare professionals whose insights and efforts have enriched the content of this volume. This edition also reflects feedback from students and educators, ensuring that the material remains both relevant and accessible. We hope that Pharmacology II serves as a comprehensive resource for mastering advanced pharmacological concepts and equips readers with the knowledge and skills necessary to excel in the dynamic and ever-changing field of pharmacology.

Textbook of Pharmacology-II

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Author : Dr. Ravindra Chandrakant Sutar, Ms. Krishna Vag , Dr. Anand Mundada , Ms. Varsha Nadkar , Dr. Anant S. Deshpande
Publisher : Shashwat Publication
ISBN 13 : 9360878669
Total Pages : 406 pages
Book Rating : 4.3/5 (68 download)

Book Synopsis Textbook of Pharmacology-II by : Dr. Ravindra Chandrakant Sutar, Ms. Krishna Vag , Dr. Anand Mundada , Ms. Varsha Nadkar , Dr. Anant S. Deshpande

Download or read book Textbook of Pharmacology-II written by Dr. Ravindra Chandrakant Sutar, Ms. Krishna Vag , Dr. Anand Mundada , Ms. Varsha Nadkar , Dr. Anant S. Deshpande and published by Shashwat Publication. This book was released on 2024-09-23 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: The titled book, “Textbook of Pharmacology II” (As per PCI regulation). The idea of book originated by authors to convey a combined database for easy understanding of Pharmacology. The major aim to write this textbook is to provide information in articulate summarized manner to accomplish necessities of undergraduates as per PCI regulation. This volume is designed not only according to curriculum of undergraduate courses in pharmacy by PCI but also to communicate knowledge on Phamacology for post graduate learners. We assured this book will be originated very valuable by graduates, post graduates, professors and industrial learners.

Pharmacological Experiments on Isolated Preparations

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Author : University of Edinburgh. Department of Pharmacology
Publisher : Churchill Livingstone
ISBN 13 :
Total Pages : 148 pages
Book Rating : 4.3/5 (91 download)

Book Synopsis Pharmacological Experiments on Isolated Preparations by : University of Edinburgh. Department of Pharmacology

Download or read book Pharmacological Experiments on Isolated Preparations written by University of Edinburgh. Department of Pharmacology and published by Churchill Livingstone. This book was released on 1968 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Holland-Frei Cancer Medicine

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Author : Robert C. Bast, Jr.
Publisher : John Wiley & Sons
ISBN 13 : 111900084X
Total Pages : 2004 pages
Book Rating : 4.1/5 (19 download)

Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.

Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Methods for Measuring the Acute Toxicity of Effluents and Receiving Waters to Freshwater and Marine Organisms

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Author :
Publisher : DIANE Publishing
ISBN 13 : 1428905375
Total Pages : 275 pages
Book Rating : 4.4/5 (289 download)

Book Synopsis Methods for Measuring the Acute Toxicity of Effluents and Receiving Waters to Freshwater and Marine Organisms by :

Download or read book Methods for Measuring the Acute Toxicity of Effluents and Receiving Waters to Freshwater and Marine Organisms written by and published by DIANE Publishing. This book was released on 2002 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt:

How Tobacco Smoke Causes Disease

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Author : United States. Public Health Service. Office of the Surgeon General
Publisher :
ISBN 13 :
Total Pages : 728 pages
Book Rating : 4.:/5 (318 download)

Book Synopsis How Tobacco Smoke Causes Disease by : United States. Public Health Service. Office of the Surgeon General

Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Atkinson's Principles of Clinical Pharmacology

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Author : Shiew-Mei Huang
Publisher : Academic Press
ISBN 13 : 0128198842
Total Pages : 764 pages
Book Rating : 4.1/5 (281 download)

Book Synopsis Atkinson's Principles of Clinical Pharmacology by : Shiew-Mei Huang

Download or read book Atkinson's Principles of Clinical Pharmacology written by Shiew-Mei Huang and published by Academic Press. This book was released on 2021-10-16 with total page 764 pages. Available in PDF, EPUB and Kindle. Book excerpt: **Selected for Doody's Core Titles® 2024 in Pharmacology**Atkinson's Principles of Clinical Pharmacology, Fourth Edition is the essential reference on the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This well-regarded survey continues to focus on the basics of clinical pharmacology for the development, evaluation and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the fourth edition has been thoroughly updated to provide readers with an ideal reference on the wide range of important topics impacting clinical pharmacology. - Presents the essential knowledge for effective practice of clinical pharmacology - Includes a new chapter and extended discussion on the role of personalized and precision medicine in clinical pharmacology - Offers an extensive regulatory section that addresses US and international issues and guidelines - Provides extended coverage of earlier chapters on transporters, pharmacogenetics and biomarkers, along with further discussion on "Phase 0" studies (microdosing) and PBPK

Introduction to Basics of Pharmacology and Toxicology

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Author : Abialbon Paul
Publisher : Springer Nature
ISBN 13 : 9813360097
Total Pages : 1156 pages
Book Rating : 4.8/5 (133 download)

Book Synopsis Introduction to Basics of Pharmacology and Toxicology by : Abialbon Paul

Download or read book Introduction to Basics of Pharmacology and Toxicology written by Abialbon Paul and published by Springer Nature. This book was released on 2021-03-13 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explains the pharmacological relationships between the various systems in the human body. It offers a comprehensive overview of the pharmacology concerning the autonomic, central, and peripheral nervous systems. Presenting up-to-date information on chemical mediators and their significance, it highlights the therapeutic aspects of several diseases affecting the cardiovascular, renal, respiratory, gastrointestinal, endocrinal, and hematopoietic systems. The book also includes drug therapy for microbial and neoplastic diseases. It also comprises sections on immunopharmacology, dermatological, and ocular pharmacology providing valuable insights into these emerging and recent topics. Covering the diverse groups of drugs acting on different systems, the book reviews their actions, clinical uses, adverse effects, interactions, and subcellular mechanisms of action. It is divided into 11 parts, subdivided into several chapters that evaluate the basic pharmacological principles that govern the different types of body systems. This book is intended for academicians, researchers, and clinicians in industry and academic institutions in pharmaceutical, pharmacological sciences, pharmacy, medical sciences, physiology, neurosciences, biochemistry, molecular biology and other allied health sciences.

Guide for the Care and Use of Laboratory Animals

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Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309154006
Total Pages : 246 pages
Book Rating : 4.3/5 (91 download)

Book Synopsis Guide for the Care and Use of Laboratory Animals by : National Research Council

Download or read book Guide for the Care and Use of Laboratory Animals written by National Research Council and published by National Academies Press. This book was released on 2011-01-27 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The Guide incorporates new scientific information on common laboratory animals, including aquatic species, and includes extensive references. It is organized around major components of animal use: Key concepts of animal care and use. The Guide sets the framework for the humane care and use of laboratory animals. Animal care and use program. The Guide discusses the concept of a broad Program of Animal Care and Use, including roles and responsibilities of the Institutional Official, Attending Veterinarian and the Institutional Animal Care and Use Committee. Animal environment, husbandry, and management. A chapter on this topic is now divided into sections on terrestrial and aquatic animals and provides recommendations for housing and environment, husbandry, behavioral and population management, and more. Veterinary care. The Guide discusses veterinary care and the responsibilities of the Attending Veterinarian. It includes recommendations on animal procurement and transportation, preventive medicine (including animal biosecurity), and clinical care and management. The Guide addresses distress and pain recognition and relief, and issues surrounding euthanasia. Physical plant. The Guide identifies design issues, providing construction guidelines for functional areas; considerations such as drainage, vibration and noise control, and environmental monitoring; and specialized facilities for animal housing and research needs. The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers involved in research issues, and animal welfare advocates.

Practical Manual of Experimental and Clinical Pharmacology

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Author : Bikash Mehdi
Publisher : Jaypee Brothers,Medical Publishers Pvt. Limited
ISBN 13 : 9789386150721
Total Pages : 430 pages
Book Rating : 4.1/5 (57 download)

Book Synopsis Practical Manual of Experimental and Clinical Pharmacology by : Bikash Mehdi

Download or read book Practical Manual of Experimental and Clinical Pharmacology written by Bikash Mehdi and published by Jaypee Brothers,Medical Publishers Pvt. Limited. This book was released on 2016-10-26 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: