Bioactive Peptides Produced By Limited Proteolysis

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Bioactive Peptides Produced by Limited Proteolysis

Author : Antonio C. M. Camargo
Publisher : Morgan & Claypool Publishers
ISBN 13 : 1615043683
Total Pages : 95 pages
Book Rating : 4.6/5 (15 download)

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Book Synopsis Bioactive Peptides Produced by Limited Proteolysis by : Antonio C. M. Camargo

Download or read book Bioactive Peptides Produced by Limited Proteolysis written by Antonio C. M. Camargo and published by Morgan & Claypool Publishers. This book was released on 2012 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteins are considered supremely important for the organization, survival, and functioning of living organisms. They were considered stable and static molecules until the early 1940s, when RudolphSchoenheimer demonstrated that proteins exist in a constant dynamic process of synthesis and degradation (proteostasis), absolutely essential for life. Since then, general and limited protein degradation became some of the most fascinating aspects of biological sciences. This book is focused on a particular aspect of protein degradation, namely, limited proteolysis, which gives rise to bioactive peptides as a result of the enzymatic action of proteinases and peptidases, which are enzymes that hydrolyze specific peptide bonds of proteins and peptides, respectively. In a broad sense, bioactive peptides are any fragment of endogenous or exogenous proteins able to elicit either physiological or pathological activities. Here, we aim at presenting to the readers that bioactive peptides are not merely produced through random processes during protein degradation, but rather through a well-organized enzymatic process that is deeply integrated in the homeostatic processes of living organisms. Table of Contents: Overview and Historical Background / Bioactive Peptides Produced by Extracellular Proteolysis / Bioactive Peptides Generated by Intracellular Proteolysis / Proteolytic Enzymes / Concluding Remarks / References / Author Biographies

Biologically Active Peptides

Author : Fidel Toldra
Publisher : Academic Press
ISBN 13 : 0128214384
Total Pages : 819 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Biologically Active Peptides by : Fidel Toldra

Download or read book Biologically Active Peptides written by Fidel Toldra and published by Academic Press. This book was released on 2021-06-17 with total page 819 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biologically Active Peptides: From Basic Science to Applications for Human Health stands as a comprehensive resource on bioactive peptide science and applications. With contributions from more than thirty global experts, topics discussed include bioactive peptide science, structure-activity relationships, best practices for their study and production, and their applications. In the interdisciplinary field of bioactive peptides, this book bridges the gap between basic peptide chemistry and human physiology, while reviewing recent advances in peptide analysis and characterization. Methods and technology-driven chapters offer step-by-step guidance in peptide preparation from different source materials, bioactivity assays, analysis and identification of bioactive peptides, encoding bioactive peptides. Later, applications across disease areas and medical specialties are examined in-depth, including the use of bioactive peptides in treating obesity, diabetes, osteoporosis, mental health disorders, food allergies, and joint health, among other disorders, as well as bioactive peptides for sensory enhancement, sports and clinical nutrition, lowering cholesterol, improving cardiovascular health, and driving advances in biotechnology. - Discusses the latest advances in bioactive peptide chemistry, functionality and analysis - Offers step-by-step instruction in applying new technologies for peptide extraction, protection, production and encoding, as well as employing bioactive peptide sequencing and bioactivity assays in new research - Effectively links basic peptide chemistry, human biology and disease - Features chapter contributions from international experts across disciplines and applications

Bioactive Peptides

Author : John Howl
Publisher : CRC Press
ISBN 13 : 9780367385736
Total Pages : 503 pages
Book Rating : 4.3/5 (857 download)

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Book Synopsis Bioactive Peptides by : John Howl

Download or read book Bioactive Peptides written by John Howl and published by CRC Press. This book was released on 2019-08-30 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focuses on Biology, Pharmacology, and Therapeutic Applications The study and diverse applications of bioactive peptides traverse many sub-disciplines within chemistry, biology, physics, and medicine. Answering a long-standing need, Bioactive Peptides focuses on the biology, pharmacology, and therapeutic applications of endogenous peptide mediators and their analogues. Moving peptide science beyond chemical synthesis strategies and into the realms of peptide biology and therapeutics, it presents the overall contribution that peptide science has made to molecular, cellular, and whole organism biology, while also discussing future targets and therapeutic applications. Beneficial for Experts and Novices Alike Part I provides details of bioactive peptides that interact with common drug targets and analyzes some of the most competitive areas of current research worldwide. While it is widely known that mammalian physiological systems utilize bioactive peptides that have yet to be discovered, other animals provide a rich and valuable source of bioactive peptides. This fascinating area of science is the theme of Part II. Parts III and IV investigate the unique bioactivities of various peptides that are ripe for further exploration. This definitive reference also includes: A detailed description and analysis of a broad range of peptides that interact with G protein-coupled receptors, the quantitatively dominant drug target A discussion of non-ribosomal peptides, which hold promise as sources of endogenous mediators Important examples of common methodologies employed to identify, characterize, and further develop bioactive peptides from a range of natural sources With mounting worldwide interest in their therapeutic potential, bioactive peptides--includ

Food Proteins and Bioactive Peptides

Author : Maria Hayes
Publisher : MDPI
ISBN 13 : 3038428639
Total Pages : 179 pages
Book Rating : 4.0/5 (384 download)

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Book Synopsis Food Proteins and Bioactive Peptides by : Maria Hayes

Download or read book Food Proteins and Bioactive Peptides written by Maria Hayes and published by MDPI. This book was released on 2018-06-01 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Food Proteins and Bioactive Peptides" that was published in Foods

Peptidomics

Author : Mikhail Soloviev
Publisher : John Wiley & Sons
ISBN 13 : 0470196491
Total Pages : 432 pages
Book Rating : 4.4/5 (71 download)

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Book Synopsis Peptidomics by : Mikhail Soloviev

Download or read book Peptidomics written by Mikhail Soloviev and published by John Wiley & Sons. This book was released on 2007-12-21 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The definitive guide to peptidomics- a hands-on lab reference The first truly comprehensive book about peptidomics for protein and peptide analysis, this reference provides a detailed description of the hows and whys of peptidomics and how the techniques have evolved. With chapters contributed by leading experts, it covers naturally occurring peptides, peptidomics methods and new developments, and the peptidomics approach to biomarker discovery. Explaining both the principles and the applications, Peptidomics: Methods and Applications: * Features examples of applications in diverse fields, including pharmaceutical science, toxicity biomarkers, and neuroscience * Details the successful peptidomic analyses of biological material ranging from plants to mammals * Describes a cross section of analytical techniques, including traditional methodologies, emerging trends, and new techniques for high throughput approaches An enlightening reference for experienced professionals, this book is sufficiently detailed to serve as a step-by-step guide for beginning researchers and an excellent resource for students taking biotechnology and proteomics courses. It is an invaluable reference for protein chemists and biochemists, professionals and researchers in drug and biopharmaceutical development, analytical and bioanalytical chemists, toxicologists, and others.

Fermented Foods in Health and Disease Prevention

Author : Juana Frías
Publisher : Academic Press
ISBN 13 : 0128025492
Total Pages : 790 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Fermented Foods in Health and Disease Prevention by : Juana Frías

Download or read book Fermented Foods in Health and Disease Prevention written by Juana Frías and published by Academic Press. This book was released on 2016-09-12 with total page 790 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fermented Foods in Health and Disease Prevention is the first scientific reference that addresses the properties of fermented foods in nutrition by examining their underlying microbiology, the specific characteristics of a wide variety of fermented foods, and their effects in health and disease. The current awareness of the link between diet and health drives growth in the industry, opening new commercial opportunities. Coverage in the book includes the role of microorganisms that are involved in the fermentation of bioactive and potentially toxic compounds, their contribution to health-promoting properties, and the safety of traditional fermented foods. Authored by worldwide scientists and researchers, this book provides the food industry with new insights on the development of value-added fermented foods products, while also presenting nutritionists and dieticians with a useful resource to help them develop strategies to assist in the prevention of disease or to slow its onset and severity. - Provides a comprehensive review on current findings in the functional properties and safety of traditional fermented foods and their impact on health and disease prevention - Identifies bioactive microorganisms and components in traditional fermented food - Includes focused key facts, helpful glossaries, and summary points for each chapter - Presents food processors and product developers with opportunities for the development of fermented food products - Helps readers develop strategies that will assist in preventing or slowing disease onset and severity

Co- and Post-Translational Modifications of Therapeutic Antibodies and Proteins

Author : T. Shantha Raju
Publisher : John Wiley & Sons
ISBN 13 : 111905334X
Total Pages : 316 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Co- and Post-Translational Modifications of Therapeutic Antibodies and Proteins by : T. Shantha Raju

Download or read book Co- and Post-Translational Modifications of Therapeutic Antibodies and Proteins written by T. Shantha Raju and published by John Wiley & Sons. This book was released on 2019-03-15 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Comprehensive Guide to Crucial Attributes of Therapeutic Proteins in Biological Pharmaceuticals With this book, Dr. Raju offers a valuable resource for professionals involved in research and development of biopharmaceutical and biosimilar drugs. This is a highly relevant work, as medical practitioners have increasingly turned to biopharmaceutical medicines in their search for safe and reliable treatments for complex diseases, while pharmaceutical researchers seek to expand the availability of biopharmaceuticals and create more affordable biosimilar alternatives. Readers receive a thorough overview of the major co-translational modifications (CTMs) and post-translational modifications (PTMs) of therapeutic proteins relevant to the development of biotherapeutics. The majority of chapters detail individual CTMs and PTMs that may affect the physicochemical, biochemical, biological, pharmacokinetic, immunological, toxicological etc. properties of proteins. In addition, readers are guided on the methodology necessary to analyze and characterize these modifications. Thus, readers gain not only an understanding of CTMs/PTMs, but also the ability to design and assess their own structure-function studies for experimental molecules. Specific features and topics include: Discussion of the research behind and expansion of biopharmaceuticals Twenty chapters detailing relevant CTMs and PTMs of proteins, such as glycosylation, oxidation, phosphorylation, methylation, proteolysis, etc. Each chapter offers an introduction and guide to the mechanisms and biological significance of an individual CTM or PTM, including practical guidance for experiment design and analysis An appendix of biologic pharmaceuticals currently on the market, along with an assessment of their PTMs and overall safety and efficacy This volume will prove a key reference on the shelves of industry and academic researchers involved in the study and development of biochemistry, molecular biology, biopharmaceuticals and proteins in medicine, particularly as biopharmaceuticals and biosimilars become ever more prominent tools in the field of healthcare.

Handbook of Functional Dairy Products

Author : Colette Shortt
Publisher : CRC Press
ISBN 13 : 0203009738
Total Pages : 314 pages
Book Rating : 4.2/5 (3 download)

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Book Synopsis Handbook of Functional Dairy Products by : Colette Shortt

Download or read book Handbook of Functional Dairy Products written by Colette Shortt and published by CRC Press. This book was released on 2003-11-24 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Functional Dairy Products reveals key advances in the field, explores the product development process, and identifies the market dynamics driving product innovation. Chapters examine specific ingredients and products, safety and technology issues, the impact of biotechnology, the regulatory environment, and the communication of health benefits. With an emphasis on the potential contribution of functional dairy products in the maintenance of health and prevention of disease, the book includes in-depth discussions of probiotics, dairy-derived carbohydrates and prebiotics, bioactive peptides, the immune modulating effects of dairy ingredients, the health effects of conjugated linoleic acid (CLA), and calcium and iron fortifi

Bioactive Food Peptides in Health and Disease

Author : Blanca Hernández-Ledesma
Publisher : BoD – Books on Demand
ISBN 13 : 9535109642
Total Pages : 279 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Bioactive Food Peptides in Health and Disease by : Blanca Hernández-Ledesma

Download or read book Bioactive Food Peptides in Health and Disease written by Blanca Hernández-Ledesma and published by BoD – Books on Demand. This book was released on 2013-01-30 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Bioactive Food Peptides in Health and Disease" highlights recent developments on bioactive food peptides for the promotion of human health and the prevention/management of chronic diseases. The book provides a comprehensive revision of bioactive peptides obtained from both animal and plant food sources. Aspects related to their bioactivity, mechanism of action, and bioavailability are extensively described along the different chapters. Also, the chapters describe the impact of bioactive peptides on the physiological absorption, regulation and disease prevention. The book also covers the recent technological advances for the production of food peptides. Bioactive Food Peptides in Health and Disease provides updated and interesting information, being a good reference book for nutritional and food scientists, biochemists, industry producers, and consumers.

Probiotics 3

Author : R. Fuller
Publisher : Springer Science & Business Media
ISBN 13 : 9401727686
Total Pages : 276 pages
Book Rating : 4.4/5 (17 download)

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Book Synopsis Probiotics 3 by : R. Fuller

Download or read book Probiotics 3 written by R. Fuller and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: The way in which probiotics work is still not clearly defined, but it is becoming more and more apparent that immune stimulation is an important feature in some of the observed effects. In the previous two books in this series the scientific basis and the practical applications were considered. It seemed that the immunogenic potential of probiotics merited a book of its own with experts from all over the world covering the general effect of the gut microflora on immunity as well as the particular response that pro biotic microorganisms generate. The importance of immune stimulation by probiotic organisms cannot be overemphasised. It opens up the technique for use, not only as a treatment for intestinal diseases, but also as a treatment that could be effective against infections outside the gastrointestinal tract. This book considers how the body reacts to the presence of orally administered microorganisms (normally lactic acid bacteria). The responses may be in the form of antibodies (lgA, IgG, IgM), cytokines, killer cells or macrophage activity. Do these responses result in antagonism of the stimulating bacteria, do they affect the composition of the indigenous gut microflora and are they sufficienty strong to kill bacterial pathogens or tumour cells? Where we have answers these will be reported and discussed; where there are no answers there will be speculation and prediction.

Dietary Polyphenols

Author : Francisco A . Tomás-Barberán
Publisher : John Wiley & Sons
ISBN 13 : 1119563720
Total Pages : 560 pages
Book Rating : 4.1/5 (195 download)

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Book Synopsis Dietary Polyphenols by : Francisco A . Tomás-Barberán

Download or read book Dietary Polyphenols written by Francisco A . Tomás-Barberán and published by John Wiley & Sons. This book was released on 2020-12-15 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents recent research on metabolism and the health effects of polyphenols Consumer interest in the health benefits of many phenolic compounds found in plant foods and derivatives has grown considerably in recent years, giving rise to an increased demand for functional foods. Although preclinical and observational studies have promoted the protective properties of polyphenols for a range of chronic diseases, evidence has shown that most dietary polyphenols have little bioavailability. Once ingested, most of them are metabolized by either the intestinal enzymes or by the gut microbiota and then undergo extensive phase-II metabolism reaching significant concentrations of conjugated metabolites. They remain in the systemic circulation and target systemic tissues where trigger biological effects. The polyphenol-derived metabolites produced in humans are dependent upon the composition of the gut microbiota and the subject genetics. Thus all the metabolites do not show the same biological activity in different individuals. To fully understand the health effects of polyphenols, further clinical investigations are required. Dietary Polyphenols describes the latest findings on the polyphenol metabolism and reviews the current evidence on their health effects and that of their bioavailable metabolites. Emphasizing the importance of interindividual variability and the critical role of gut microbiota, this authoritative volume features contributions from recognized experts in the field, exploring specific families of extractable and non-extractable phenolic compounds that exhibit potential health effects. Topics include structural diversity of polyphenols and distribution in foods, bioavailability and bioaccessibility of phenolics, metabolism, and gastrointestinal absorption of various metabolites and their health effects. This comprehensive volume: Discusses the bioavailability, bioaccessibility, pharmacokinetics studies, and microbial metabolism of different groups of phenolic compounds Examines the interaction between polyphenols and gut microbiota Describes analytical methods for identifying and quantifying polyphenols in foods and biological samples Reviews recent epidemiological and clinical intervention studies showing protective effects of polyphenols Dietary Polyphenols: Metabolism and Health Effects is an important resource for scientists working in the area of dietary polyphenols and health effects, microbiota, and their interaction with other nutritional compounds, and for health professionals, nutritionists, dieticians, and clinical researchers with interest in the role of polyphenols in the prevention and treatment of chronic diseases.

Lactic Acid Bacteria: Genetics, Metabolism and Applications

Author : W.N. Konings
Publisher : Springer Science & Business Media
ISBN 13 : 9401720274
Total Pages : 399 pages
Book Rating : 4.4/5 (17 download)

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Book Synopsis Lactic Acid Bacteria: Genetics, Metabolism and Applications by : W.N. Konings

Download or read book Lactic Acid Bacteria: Genetics, Metabolism and Applications written by W.N. Konings and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: In ancient times foods fermented with lactic acid bacteria already constituted an important part of the human diet. From then on, lactic acid bacteria have played an essential role in the preservation of food raw materials and have contributed to the nutritional, organoleptic and health properties of human food products and animal feed. The important function that lactic acid bacteria still have in the production of foods all over the world has resulted in a growing scientific interest in these micro-organisms by academic research groups as well as by industry. During the last 15 years, this research has been stimulated by major internationally coordinated funding efforts that have resulted in a variety of important scientific breakthroughs and have led to new applications. Written by international experts in the field, this issue of Antonie van Leeuwenhoek documents these developments with respect to genetics, metabolism and the application of lactic acid bacteria for industrial and potential medical applications. In this book the first complete genome of a lactic acid bacterium is presented. The book will serve as a reference source and also as an indispensable source of information for further development and exploration of the field.

Neuropeptide Receptors

Author : Ivone Gomes
Publisher : Biota Publishing
ISBN 13 : 1615044698
Total Pages : 169 pages
Book Rating : 4.6/5 (15 download)

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Book Synopsis Neuropeptide Receptors by : Ivone Gomes

Download or read book Neuropeptide Receptors written by Ivone Gomes and published by Biota Publishing. This book was released on 2013-04-01 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuropeptides mediate their effects by binding and activating receptors that are responsible for converting these extracellular stimuli into intracellular responses. Most neuropeptides interact with G protein-coupled receptors that transduce the signal by activating heterotrimeric G proteins leading to alterations in second messenger systems to amplify the signal and elicit the intracellular response. In this review, we describe the general structure of G protein-coupled receptors including the information obtained from crystal structure determination that has given an insight into the activation mechanism of these receptors. In addition, we summarize the components of the signal transduction system (including G proteins, effectors and second messengers generally activated by the neuropeptide receptors). Using select examples of neuropeptide-receptor systems, we highlight the neuropeptides and corresponding receptors involved in modulation of pain and analgesia, body weight regulation, and hormonal regulation. Finally, we discuss the enzyme-linked tyrosine kinase receptors activated by growth factors and discuss the emerging concepts in targeting neuropeptide receptors for the identification of novel therapeutics targeting these systems. Table of Contents: Abbreviations / Overview of Neuropeptide Receptors / G Protein-Coupled Receptors: General Structure & Function / G Protein-Coupled Receptor Signaling / Neuropeptide Processing and Regulation / Neuropeptide Receptors / Perspectives / References

Bioactive Molecules in Food

Author : Jean-Michel Mérillon
Publisher : Springer Nature
ISBN 13 : 3319780301
Total Pages : 2353 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Bioactive Molecules in Food by : Jean-Michel Mérillon

Download or read book Bioactive Molecules in Food written by Jean-Michel Mérillon and published by Springer Nature. This book was released on 2019-01-25 with total page 2353 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference work provides comprehensive information about the bioactive molecules presented in our daily food and their effect on the physical and mental state of our body. Although the concept of functional food is new, the consumption of selected food to attain a specific effect existed already in ancient civilizations, namely of China and India. Consumers are now more attentive to food quality, safety and health benefits, and the food industry is led to develop processed- and packaged-food, particularly in terms of calories, quality, nutritional value and bioactive molecules. This book covers the entire range of bioactive molecules presented in daily food, such as carbohydrates, proteins, lipids, isoflavonoids, carotenoids, vitamin C, polyphenols, bioactive molecules presented in wine, beer and cider. Concepts like French paradox, Mediterranean diet, healthy diet of eating fruits and vegetables, vegan and vegetarian diet, functional foods are described with suitable case studies. Readers will also discover a very timely compilation of methods for bioactive molecules analysis. Written by highly renowned scientists of the field, this reference work appeals to a wide readership, from graduate students, scholars, researchers in the field of botany, agriculture, pharmacy, biotechnology and food industry to those involved in manufacturing, processing and marketing of value-added food products.

Enzymes in Food Biotechnology

Author : Mohammed Kuddus
Publisher : Academic Press
ISBN 13 : 0128132817
Total Pages : 912 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Enzymes in Food Biotechnology by : Mohammed Kuddus

Download or read book Enzymes in Food Biotechnology written by Mohammed Kuddus and published by Academic Press. This book was released on 2018-08-23 with total page 912 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enzymes in Food Biotechnology: Production, Applications, and Future Prospects presents a comprehensive review of enzyme research and the potential impact of enzymes on the food sector. This valuable reference brings together novel sources and technologies regarding enzymes in food production, food processing, food preservation, food engineering and food biotechnology that are useful for researchers, professionals and students. Discussions include the process of immobilization, thermal and operational stability, increased product specificity and specific activity, enzyme engineering, implementation of high-throughput techniques, screening to relatively unexplored environments, and the development of more efficient enzymes. - Explores recent scientific research to innovate novel, global ideas for new foods and enzyme engineering - Provides fundamental and advanced information on enzyme research for use in food biotechnology, including microbial, plant and animal enzymes - Includes recent cutting-edge research on the pharmaceutical uses of enzymes in the food industry

Milk Proteins - From Structure to Biological Properties and Health Aspects

Author :
Publisher :
ISBN 13 : 9789535154518
Total Pages : pages
Book Rating : 4.1/5 (545 download)

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Book Synopsis Milk Proteins - From Structure to Biological Properties and Health Aspects by :

Download or read book Milk Proteins - From Structure to Biological Properties and Health Aspects written by and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Nutraceutical Proteins and Peptides in Health and Disease

Author : Yoshinori Mine
Publisher : CRC Press
ISBN 13 : 1420028839
Total Pages : 678 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Nutraceutical Proteins and Peptides in Health and Disease by : Yoshinori Mine

Download or read book Nutraceutical Proteins and Peptides in Health and Disease written by Yoshinori Mine and published by CRC Press. This book was released on 2005-09-29 with total page 678 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reports of the beneficial health effects of some peptides have begun to make their way into the scientific literature. Peptides can act as immunomodulators, and have been shown to have a positive influence on calcium absorption, and on regulation of serum cholesterol. A number of peptides may also possess antimicrobial properties that enhance the b