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Author : Leonid Padyukov
Publisher : Elsevier Inc. Chapters
ISBN 13 : 012806174X
Total Pages : 7 pages
Book Rating : 4.1/5 (28 download)
Download or read book Between the Lines of Genetic Code written by Leonid Padyukov and published by Elsevier Inc. Chapters. This book was released on 2013-09-28 with total page 7 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Klementy Shchetynsky
Publisher : Elsevier Inc. Chapters
ISBN 13 : 0128061715
Total Pages : 21 pages
Book Rating : 4.1/5 (28 download)
Download or read book Between the Lines of Genetic Code written by Klementy Shchetynsky and published by Elsevier Inc. Chapters. This book was released on 2013-09-28 with total page 21 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional analysis of genetic variants in association with human complex diseases remains a challenge for modern research. Discovery of gene–gene interactions may represent an additional tool for identifying specific polymorphisms involved in disease development. It not only identifies new candidate genes for mechanistic studies, but also suggests biological relations in the function of these genes with certain variants in developing disease. We describe a few examples of the studies where a link between statistical evidence of gene–gene interaction was found with the expression or function of genes of interest. Finally, we present future perspectives for integration genetic epidemiology data with biologically relevant mechanisms of disease.
Author : Leonid Padyukov
Publisher : Academic Press
ISBN 13 : 0123973023
Total Pages : 226 pages
Book Rating : 4.1/5 (239 download)
Download or read book Between the Lines of Genetic Code written by Leonid Padyukov and published by Academic Press. This book was released on 2013-09-28 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Between the Lines of Genetic Code lays out methodologies and tools for the measurement and evaluation of gene-gene and gene-environment studies and gives perspective on the future of this discipline. The book begins by defining terms for interaction studies, describing methodologies, and critically assessing the viability of current study designs and the possibilities for integrating designs. It then provides recent applications data with case studies in rheumatoid arthritis, multiple sclerosis, myositis and other complex human diseases. Last, it examines current studies and directions for future applications in patient care. Recent multivariate studies show that gene-gene and gene-environment interactions can explain significant variances in inheritance that have previously been undetectable in univariate analysis. These links among genes and between genes and their environments during the development of diseases may serve as important hints for understanding pathogenic mechanisms and for developing new tools for prognosis, diagnosis, and treatment of various diseases. - Systematically integrates methods of defining and detecting gene interactions to provide an overview of the field - Critically analyzes current methods and tools to aid researchers in integrating gene interaction studies - Includes examples of current biomedical applications and presents current research expected to shape clinical research in the near future
Author : Jesper Tegnér
Publisher : Elsevier Inc. Chapters
ISBN 13 : 0128061731
Total Pages : 27 pages
Book Rating : 4.1/5 (28 download)
Download or read book Between the Lines of Genetic Code written by Jesper Tegnér and published by Elsevier Inc. Chapters. This book was released on 2013-09-28 with total page 27 pages. Available in PDF, EPUB and Kindle. Book excerpt: Following the success of genome-wide association studies, it is now important to unravel interactions between genes as well as between genes and environment. Here we discuss how to interpret higher order statistical interactions in terms of underlying biological processes purportedly generating such dependencies. In this chapter, we specifically review how biological networks, such as those generated from systems biological approaches, could possibly facilitate the interpretation of observed interactions in the development of complex phenotypes, e.g., complex diseases. We conclude that the statistical challenge is essentially a high-dimensional feature selection problem and there is therefore a need to construct intelligent priors using biological networks as a tool for the discovery and interpretation of interactions.
Author : Ingrid Kockum
Publisher : Elsevier Inc. Chapters
ISBN 13 : 0128061685
Total Pages : 24 pages
Book Rating : 4.1/5 (28 download)
Download or read book Between the Lines of Genetic Code written by Ingrid Kockum and published by Elsevier Inc. Chapters. This book was released on 2013-09-28 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple sclerosis (MS) is a multifactorial disease where both environmental and genetic risk factors play a role. More than 50 genetic polymorphisms have been identified in association with MS mostly by mapping close to genes involved in immunoregulation. Several environmental factors have been associated with risk for developing MS, including smoking, obesity, EBV infections, and lack of sun exposure. Interactions between major genetic risk factors and environmental exposures have been observed making it possible to begin to form groups of risk factors that are jointly involved in MS pathogenesis.
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309038405
Total Pages : 128 pages
Book Rating : 4.3/5 (9 download)
Download or read book Mapping and Sequencing the Human Genome written by National Research Council and published by National Academies Press. This book was released on 1988-01-01 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.
Author : Marylyn D. Ritchie
Publisher : Elsevier Inc. Chapters
ISBN 13 : 0128061634
Total Pages : 20 pages
Book Rating : 4.1/5 (28 download)
Download or read book Between the Lines of Genetic Code written by Marylyn D. Ritchie and published by Elsevier Inc. Chapters. This book was released on 2013-09-28 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gene–gene interactions are a critical component of the genetic architecture of complex, human traits. Unfortunately, the detection and characterization of interactions is a challenge. This is due to a number of factors including the combinatorial explosion of possible interactions in large-scale genomic data, limited power in small sample sizes, and potential difficulty interpreting or validating the resulting interaction models. A number of data mining methods have been developed to deal with one or more of these challenges. In this chapter, we discuss the importance of looking for gene–gene interactions as well as some of the challenges facing this type of analysis. Additionally, we review the alternative analytic approaches being considered to improve our ability to detect and model gene–gene interactions. Finally, we conclude with the future directions of interaction analysis.
Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Bo Ding
Publisher : Elsevier Inc. Chapters
ISBN 13 : 0128061650
Total Pages : 34 pages
Book Rating : 4.1/5 (28 download)
Download or read book Between the Lines of Genetic Code written by Bo Ding and published by Elsevier Inc. Chapters. This book was released on 2013-09-28 with total page 34 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genome-wide interaction studies is an extremely challenging problem in statistics, in which conventional methods are often inadequate in terms of both power and computational efficiency. An exhaustive search for genome-wide gene–gene interactions becomes feasible with modern cluster computing run on graphics processing units. However, the large number of tests accompanying the search raises a serious multiple testing problem. A way to overcome these limits is to apply a filtering step prior to the combinatorial method and to analyze only interesting single nucleotide polymorphisms selected based on a priori (defined by statistical evidence, genetic impact, or biological plausibility). The advantage of the filter approach is speed, and the disadvantage is that attributes with poor quality scores are disregarded. Genome-wide gene–environment interaction is less problematic computational demand compared with pairwise genome-wide gene–gene interaction. Accounting for gene–gene and gene–environment interactions is important for future strategies of diagnosis, prognosis, and management of human diseases and will bring new data regarding pathogenetic mechanisms for human complex diseases.
Author : Camilla Bengtsson
Publisher : Elsevier Inc. Chapters
ISBN 13 : 0128061642
Total Pages : 22 pages
Book Rating : 4.1/5 (28 download)
Download or read book Between the Lines of Genetic Code written by Camilla Bengtsson and published by Elsevier Inc. Chapters. This book was released on 2013-09-28 with total page 22 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many diseases are believed to occur as a result of interactions between genes and environment. In epidemiology, there are several study designs, such as cohort and case-control studies, that can be used to analyze biological interaction. In this chapter, we discuss crucial issues in the design stage of epidemiologic studies, how different measures of disease occurrence and measures of associations are calculated, and how systematic and random errors might hamper the accuracy of the results. By properly addressing these issues, one can design accurate epidemiologic studies and thus also decent studies of interaction. Later in this chapter, we give an example of how alcohol consumption and the genetic risk factor HLA-DRB1 shared epitope alleles interact in the development of rheumatoid arthritis, by using data from a Swedish population-based case-control study. The example demonstrates how interaction analyses in practice might be performed within epidemiologic study designs.
Author : Shōzō Ōsawa
Publisher :
ISBN 13 :
Total Pages : 240 pages
Book Rating : 4.3/5 (91 download)
Download or read book Evolution of the Genetic Code written by Shōzō Ōsawa and published by . This book was released on 1995 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: The genetic code was deciphered experimentally around 1966 and for a number of years scientists considered it to be "universal" for all forms of life. In 1981 researchers shocked the scientific community with the discovery that the code differed in mitochondria and certain other organisms, evidence that the genetic code was still evolving. This book discusses the distribution and origin of the non-universal codes and examines the possible mechanisms of code changes, making it essential reading for all those interested in evolutionary genetics.
Author : Paul L. Bartel
Publisher : Oxford University Press, USA
ISBN 13 : 9780195109382
Total Pages : 362 pages
Book Rating : 4.1/5 (93 download)
Download or read book The Yeast Two-hybrid System written by Paul L. Bartel and published by Oxford University Press, USA. This book was released on 1997 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume, part of the Advances in Molecular Biology series, presents work by pioneers in the field and is the first publication devoted solely to the yeast two-hybrid system. It includes detailed protocols, practical advice on troubleshooting, and suggestions for future development. In addition, it illustrates how to construct an activation domain hybrid library, how to identify mutations that disrupt an interaction, and how to use the system in mammalian cells. Many of the contributors have developed new applications and variations of the technique.
Author : Francis Collins
Publisher : Simon and Schuster
ISBN 13 : 1847396151
Total Pages : 227 pages
Book Rating : 4.8/5 (473 download)
Download or read book The Language of God written by Francis Collins and published by Simon and Schuster. This book was released on 2008-09-04 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr Francis S. Collins, head of the Human Genome Project, is one of the world's leading scientists, working at the cutting edge of the study of DNA, the code of life. Yet he is also a man of unshakable faith in God. How does he reconcile the seemingly unreconcilable? In THE LANGUAGE OF GOD he explains his own journey from atheism to faith, and then takes the reader on a stunning tour of modern science to show that physics, chemistry and biology -- indeed, reason itself -- are not incompatible with belief. His book is essential reading for anyone who wonders about the deepest questions of all: why are we here? How did we get here? And what does life mean?
Author : Julianne Zedalis
Publisher :
ISBN 13 : 9781947172401
Total Pages : 1923 pages
Book Rating : 4.1/5 (724 download)
Download or read book Biology for AP ® Courses written by Julianne Zedalis and published by . This book was released on 2017-10-16 with total page 1923 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biology for AP® courses covers the scope and sequence requirements of a typical two-semester Advanced Placement® biology course. The text provides comprehensive coverage of foundational research and core biology concepts through an evolutionary lens. Biology for AP® Courses was designed to meet and exceed the requirements of the College Board’s AP® Biology framework while allowing significant flexibility for instructors. Each section of the book includes an introduction based on the AP® curriculum and includes rich features that engage students in scientific practice and AP® test preparation; it also highlights careers and research opportunities in biological sciences.
Author : John F. Atkins
Publisher : Springer Science & Business Media
ISBN 13 : 0387893822
Total Pages : 473 pages
Book Rating : 4.3/5 (878 download)
Download or read book Recoding: Expansion of Decoding Rules Enriches Gene Expression written by John F. Atkins and published by Springer Science & Business Media. This book was released on 2010-03-10 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: The literature on recoding is scattered, so this superb book ?lls a need by prov- ing up-to-date, comprehensive, authoritative reviews of the many kinds of recoding phenomena. Between 1961 and 1966 my colleagues and I deciphered the genetic code in Escherichia coli and showed that the genetic code is the same in E. coli, Xenopus laevis, and guinea pig tissues. These results showed that the code has been c- served during evolution and strongly suggested that the code appeared very early during biological evolution, that all forms of life on earth descended from a c- mon ancestor, and thus that all forms of life on this planet are related to one another. The problem of biological time was solved by encoding information in DNA and retrieving the information for each new generation, for it is easier to make a new organism than it is to repair an aging, malfunctioning one. Subsequently, small modi?cations of the standard genetic code were found in certain organisms and in mitochondria. Mitochondrial DNA only encodes about 10–13 proteins, so some modi?cations of the genetic code are tolerated that pr- ably would be lethal if applied to the thousands of kinds of proteins encoded by genomic DNA.
Author : Gregg Braden
Publisher : Hay House, Inc
ISBN 13 : 1401903002
Total Pages : 317 pages
Book Rating : 4.4/5 (19 download)
Download or read book The God Code written by Gregg Braden and published by Hay House, Inc. This book was released on 2005-01-01 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: “One of our great visionaries.” —Dr. Wayne W. Dyer “A rare blend of scientist, visionary, and scholar.” —Deepak Chopra A scholar and New York Times–bestselling author shares his shocking theory of an ancient language—found in the decoded elements of our DNA—that shines new light on the mysteries of existence. What would it mean to discover an ancient language—a literal message—hidden within the DNA of life itself? What we once believed of our past is about to change. A coded message has been found within the molecules of life, deep within the DNA in each cell of our bodies. Through a remarkable discovery linking Biblical alphabets to our genetic code, the “language of life” may now be read as the ancient letters of a timeless message. Regardless of race, religion, heritage, or lifestyle, the message is the same in each cell of every woman, child, and man, past and present. Sharing all-new, fascinating research, Gregg Braden discusses the life-changing discovery that led him from a successful career in the aerospace and defense industries to an extensive 12-year study of the most sacred and honored traditions of humankind.
Author : Altuna Akalin
Publisher : CRC Press
ISBN 13 : 1498781861
Total Pages : 463 pages
Book Rating : 4.4/5 (987 download)
Download or read book Computational Genomics with R written by Altuna Akalin and published by CRC Press. This book was released on 2020-12-16 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational Genomics with R provides a starting point for beginners in genomic data analysis and also guides more advanced practitioners to sophisticated data analysis techniques in genomics. The book covers topics from R programming, to machine learning and statistics, to the latest genomic data analysis techniques. The text provides accessible information and explanations, always with the genomics context in the background. This also contains practical and well-documented examples in R so readers can analyze their data by simply reusing the code presented. As the field of computational genomics is interdisciplinary, it requires different starting points for people with different backgrounds. For example, a biologist might skip sections on basic genome biology and start with R programming, whereas a computer scientist might want to start with genome biology. After reading: You will have the basics of R and be able to dive right into specialized uses of R for computational genomics such as using Bioconductor packages. You will be familiar with statistics, supervised and unsupervised learning techniques that are important in data modeling, and exploratory analysis of high-dimensional data. You will understand genomic intervals and operations on them that are used for tasks such as aligned read counting and genomic feature annotation. You will know the basics of processing and quality checking high-throughput sequencing data. You will be able to do sequence analysis, such as calculating GC content for parts of a genome or finding transcription factor binding sites. You will know about visualization techniques used in genomics, such as heatmaps, meta-gene plots, and genomic track visualization. You will be familiar with analysis of different high-throughput sequencing data sets, such as RNA-seq, ChIP-seq, and BS-seq. You will know basic techniques for integrating and interpreting multi-omics datasets. Altuna Akalin is a group leader and head of the Bioinformatics and Omics Data Science Platform at the Berlin Institute of Medical Systems Biology, Max Delbrück Center, Berlin. He has been developing computational methods for analyzing and integrating large-scale genomics data sets since 2002. He has published an extensive body of work in this area. The framework for this book grew out of the yearly computational genomics courses he has been organizing and teaching since 2015.
