Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Beta Humans
Download Beta Humans full books in PDF, epub, and Kindle. Read online Beta Humans ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis Control of Pancreatic Beta Cell Function and Plasticity in Health and Diabetes by : David J. Hill
Download or read book Control of Pancreatic Beta Cell Function and Plasticity in Health and Diabetes written by David J. Hill and published by Bentham Science Publishers. This book was released on 2016-12-02 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plasticity in insulin-producing cells (β-cells) of the pancreas is a major contributor to metabolic control. Targeted regeneration of pancreatic β-cells for the reversal of diabetes (by optimizing β-cells mass and proliferation to meet metabolic requirements and counter autoimmune response) is still a theoretical intervention. This monograph reviews the biology, ontogeny, capabilities, and present practical limitations of β-cell plasticity. Relevant biochemical pathways are described with the inclusion of information about how they change with aging, during pregnancy, and with diet. Readers will learn the following key aspects about β-cell plasticity: -current knowledge of pancreatic β-cells development, and how β-cell mass and proliferation change throughout the human lifespan -the mechanisms responsible for β-cell plasticity, based on animal models and clinical studies revealing environmental, epigenetic, endocrine and paracrine regulators -the therapeutic potential of resident stem cells within the pancreas / bone marrow and β-cell progenitors This monograph is essential reading for researchers interested in updated knowledge about the molecular and cellular biology of β-cells in the quest to find a reliable therapy for diabetes.
Book Synopsis Beta Cells in Health and Disease by : Shahzad Irfan
Download or read book Beta Cells in Health and Disease written by Shahzad Irfan and published by BoD – Books on Demand. This book was released on 2024-01-17 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt: Beta Cells in Health and Disease presents the latest information on the novel and widely studied physiology of pancreatic cells in homeostasis and under pathogenic conditions. This book includes chapters on a variety of topics, including the importance and the biology of insulin hormone, pancreatic beta cell dysfunction in type 1 diabetes, the biological importance of physical activity in managing type 1 diabetes, the use of stem cell therapy for the treatment of diabetes, the role of microRNAs in modulating beta cell function, and more.
Book Synopsis Pancreatic Beta Cell in Health and Disease by : Susumu Seino
Download or read book Pancreatic Beta Cell in Health and Disease written by Susumu Seino and published by Springer Science & Business Media. This book was released on 2008-04-08 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: The beta cells of the pancreatic islets of Langerhans are the only cells in the body that produce and secrete insulin. This metabolic hormone plays a central role in the maintenance of glucose homeostasis. This book provides a comprehensive review of the beta cell in health and disease. The book’s primary aim is to encourage investigators to become actively involved in diabetes research and the search for new approaches to prevent and treat diabetes.
Book Synopsis Insulin Signalling in Human Adipocytes and its Interplay with beta-Adrenergic Control of Lipolysis by : Cecilia Karlsson
Download or read book Insulin Signalling in Human Adipocytes and its Interplay with beta-Adrenergic Control of Lipolysis written by Cecilia Karlsson and published by Linköping University Electronic Press. This book was released on 2018-04-27 with total page 49 pages. Available in PDF, EPUB and Kindle. Book excerpt: The prevalence of obesity has over the last 40 years nearly tripled and obesity is one of the major risk factors of developing type 2 diabetes. Type 2 diabetes was formerly called adultonset diabetes but today, probably due to the rise in childhood obesity, it is also seen in children and adolescents. Type 2 diabetes is diagnosed when the body no longer can control the glucose levels in the blood. This is due to an insulin resistant state in the insulin responding tissues, liver, adipose and muscle and insufficient production of insulin in the pancreas. However, in spite of extensive research the mechanisms behind insulin resistance is still not known. The adipose tissue is believed to play a major role in the development of whole body insulin resistance. Adipocytes are the most important sites for storage of the high energy containing triacylglycerols. Insulin stimulation causes the adipocyte to increase the uptake of glucose and to reduce lipolysis: the hydrolysis of triacylglycerol and release of glycerol and fatty acids. The insulin signalling network is complex with numerous proteins involved. These signaling proteins not only transmit the insulin signal but also create negative and positive feedbackloops and induce cross talk between different parts of the network and with the signalling of other hormones. One important positive feedback in insulin signalling is the mTORC1 mediated feedback to phosphorylation of IRS1 at serine 307. In paper I we found that in human adipocytes this feedback is not likely catalysed by the assumed kinase S6K1. However we find an immunoprecipitate of mTOR to contain a ser307 phosphorylating kinase. Scaffolding proteins serve as docking sites for several proteins to promote protein-protein interactions that facilitate signal transduction. In paper II we demonstrate the existence of the scaffolding protein IQGAP1 in human adipocytes and that the expression of IQGAP1 is downregulated in type 2 diabetes. We reveal that IQGAP1 co-localises with caveolae, invaginations of the plasma membrane where the insulin receptor is situated, and that this interaction is increased upon insulin stimulation. In paper III we focus on the control of lipolysis, and sought to understand the interplay between insulin and beta-adrenergic stimulation. We demonstrated that the re-esterification of fatty acids is downregulated in type 2 diabetes causing an increased release of fatty acids from the cells. We showed that beta-adrenergic stimulation with isoproterenol induced a negative feedback via PKA/Epac1 -> PI3K -> PKB -> PDE3B that reduced the cAMP levels and thereby also reduced lipolysis. We also showed that insulin, in addition to its well-known anti-lipolytic effect, at high concentrations had a positive effect on lipolysis. In conclusion we reveal an intricate control of the stimulation as well as the inhibition of lipolysis induced by both isoproterenol and insulin.
Book Synopsis Toxicological Profile for Alpha-, Beta-, Gamma- and Delta- Hexachlorocyclohexane by :
Download or read book Toxicological Profile for Alpha-, Beta-, Gamma- and Delta- Hexachlorocyclohexane written by and published by . This book was released on 1989 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Beta written by Rachel Cohn and published by Little, Brown Books for Young Readers. This book was released on 2012-10-16 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Elysia was born without a soul, her only purpose to serve the wealthy inhabitants of Io, an island paradise. But sensations are clouding her mind...anger...loneliness???love. Before long, Elysia learns that she is a Defect. And If any human on the island discovers the truth, it will cost her her life.
Book Synopsis The Fall of the Alphas by : Dana Ardi
Download or read book The Fall of the Alphas written by Dana Ardi and published by Macmillan. This book was released on 2013-10 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new model for business success: replace top-down Alpha management with collaboration, connection, and increased job satisfaction—the Beta model The Fall of the Alphas explores the sweeping changes taking place in the corporate and social cultures of today's most successful organizations. Utilizing years of advising companies of all sizes, hypergrowth startups to Fortune 500 company management teams, Dana Ardi identifies a pivotal evolutionary moment: the decline of the traditional Alpha-model (the top-down, male-dominated, authoritarian, corner-office hierarchy that has ruled organizational landscapes for so long), as it is replaced by collaboration, connectivity, and the sharing of power. As Ardi persuasively demonstrates, in the new Beta organization, it is the team players, the sage advisors, the network experts, the trusted assistants, and the communications facilitators who are coming to the fore, as savvy managers learn to lead through influence and collaboration rather than authority and competition. From technology behemoths to small and medium-sized businesses, Beta has become the new paradigm for success in today's challenging market. With insight and practical guidance, Dana Ardi shows how any business organization or team can re-organize from Alpha to Beta—and be more effective, flexible, and profitable
Book Synopsis TGF-β in Human Disease: Friend or Foe? by : Guoping Zheng
Download or read book TGF-β in Human Disease: Friend or Foe? written by Guoping Zheng and published by Frontiers Media SA. This book was released on 2021-11-26 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Beta-Cell Fate: From Gene Circuits to Disease Mechanisms by : Simona Chera
Download or read book Beta-Cell Fate: From Gene Circuits to Disease Mechanisms written by Simona Chera and published by Frontiers Media SA. This book was released on 2022-03-16 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Beta Humans written by Michael Macfarlane and published by . This book was released on 2020-07-02 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Can humans reach the next stage of our evolution and become 'beta' versions of ourselves by embracing the technological revolution to upgrade the world around us? What conditions would be needed for 'beta humans' to rise? It is possible to upgrade the world's 'operating systems' for the betterment of all human beings? And where in the world is the crucible from which the very first beta humans might emerge?As income inequality widens and social mobility stagnates within nations who built their twentieth century prosperity upon the values of the Enlightenment, they face seemingly intractable problems which threaten their very identity and existence. Trust levels and educational outcomes are in decline and politics has become divisive and polarised as deadlocked Governments are unable to deal with entrenched human problems.Becoming 'beta humans' may now be the only way to break the deadlock and elevate all human beings beyond current limitations. As the chain reaction of rapid technological development accelerates, humans have the opportunity to attain a new stage of evolution. But the elevation of humanity onto a new concourse will not come from human-robot augmentation or from brain implants. It will come from the upgrading of every aspect of the world in which humans live and the environments in which humans choose to exist and to interact and to live our lives.Whilst the nations of the Enlightenment continue to support their legacy operating systems with expedient and iterative patches, other nations have already started to embrace the full upgrade of their own operating systems to build toward, at least theoretically, superior societies. And travel through the United Arab Emirates, China, Russia, Japan and Singapore shows that the world's first beta humans may not emerge from the nations who led the twentieth century. Beta Humans: Travelling To The Future Of Humanity charts the first-hand experience of travelling through the countries and cities that are surging ahead through their embrace of technology to upgrade the operating systems of their society and everyday life. A final chapter of 'Lessons For A Beta Future' offers ideas for preparing the world for beta humans, and warns that dark forces could usurp the values of the Enlightenment if human progress is allowed to stagnate.Mapped against his experiences of growing up in a deprived region of a Great Britain during a time when the country was wrestling with the prospect of decline, and with deference to the repeating tropes of modern human history, author Michael Macfarlane is however optimistic that "as humans we are programmed to co-exist"; but says that technology has risk because "our internal software has been augmented by access to artificial forms of higher intelligence that increasingly makes our programmed disposition for inter-human cooperation seem obsolete".Macfarlane says that as humans we stand at a juncture between the biological limitations of the 'internal software' created during our relatively primitive beginnings, which cannot be 'upgraded' far beyond our biological limitations, and the opportunity to substantially improve and augment human life by upgrading the things that we can improve. Through highly personal stories he argues that we can create a new 'beta' version of our world. We can become beta humans.
Book Synopsis TGF-β in Human Disease by : Aristidis Moustakas
Download or read book TGF-β in Human Disease written by Aristidis Moustakas and published by Springer Science & Business Media. This book was released on 2013-06-18 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transforming growth factor-β (TGF-β) is a secreted polypeptide with multifunctional properties manifested during embryonic development, adult organ physiology, and pathobiology of major diseases, including cancer and fibrotic and cardiovascular diseases. The signaling pathway of TGF-β now is rather well understood. Continuing revelations in the mechanisms of action of TGF-β provide specific mechanistic examples of how human cells lose their controlled function and behave wrongly during the development of diverse diseases. Equally important, however, is the current promise of exploiting the TGF-β pathway in combating human disease. This book comprehensively covers major areas of human disease where the involvement of TGF-β is firmly established. Simultaneously, the book highlights major gaps in knowledge and the future directions of research that can benefit human medical science. The core set of diseases where TGF-β action is well documented and are included in the book are cancer and cardiovascular and fibrotic disorders. The central aim of the book is to stimulate young scientists to enter the prolific TGF-β field and find new solutions to the problems remaining in this area of study. For this purpose the book provides authoritative educational chapters that furnish a good introduction to the field for young doctoral students, postdocs, and clinical fellows. The book also serves as a valuable reference for the aficionados in the field, who can find accessible and well-illustrated material for their teaching and lecturing activities, via which the importance of TGF-β biology is disseminated to the world of science and to the public.
Book Synopsis β-Casomorphins by : Mohammad Raies Ul Haq
Download or read book β-Casomorphins written by Mohammad Raies Ul Haq and published by Springer Nature. This book was released on 2020-03-27 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book compiles the latest research on the A1 and A2 forms of cow milk, and attempts to show a correlation between the type of cow milk consumption and reported incidence of certain diseases (type 1 diabetes mellitus, cardiovascular diseases, sudden infant death syndrome and neurological disorders). Cow milk generally contains two types of β-casein, A1 or A2. The book describes the A1/A2 hypothesis, its foundation and the genetics behind it. It discusses the two forms of milk and why one is considered more harmful than the other. Seeking to provide a balanced view of the milk types, the book’s initial chapters highlight the structure, function and physiological activity of β-casomorphins. Subsequent sections describe the health concerns associated with A1 milk, and the various case studies and research surrounding it. In turn, the arguments against the hypothesis put forward by EFSA, American Nutritionists and Truswell are also highlighted. The book does not make any recommendations for dairy consumers; rather, it is a collection of essential data both in favour and against the hypothesis. Further mechanistic studies involving well-designed animal and human trials at the cellular, molecular, biochemical and immunological levels will be needed in order to draw sound conclusions. Overall, the hypothesis is fascinating, and possibly significant. However, verified and authenticated research with reproducible results is needed to make final consumer recommendations. This timely book offers a valuable resource for researchers and students of dairy science, as well as industry experts.
Book Synopsis Biology and Chemistry of Beta Glucan by : Václav Větvička
Download or read book Biology and Chemistry of Beta Glucan written by Václav Větvička and published by Bentham Science Publishers. This book was released on 2011-04-13 with total page 91 pages. Available in PDF, EPUB and Kindle. Book excerpt: "?-Glucan is generally considered to be a very safe immunomodulator. It is a well-known biological response modifier (BRM) that has been used as an adjuvant therapy for cancer since 1980, mostly in Japan. ?-Glucan enhances the innate host defense against c"
Book Synopsis Environmental Health Perspectives by :
Download or read book Environmental Health Perspectives written by and published by . This book was released on with total page 1132 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Psychopharmacology Bulletin written by and published by . This book was released on 1966 with total page 956 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Alpha Seed, Beta Need by : Mark van Stratum
Download or read book Alpha Seed, Beta Need written by Mark van Stratum and published by . This book was released on 2021-09-14 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Do Men and Women Experience Love Differently? Mark van Stratum is a modern day Charles Bukowski, moving through life with a coterie of women in tow and a whirlwind of drama surrounding his every move. Heartbroken and depressed after the love of his life devastated him by cheating shortly after their son was born, van Stratum goes on a no-holds-barred rampage through the women and capitals of Western Europe. As the truth emerges from their shattered marriage, everything is thrown into question, including whether his son is actually from his seed. Alpha Seed, Beta Need is a love story like no other, alternating between jaw-dropping romantic interludes and deep psychological analysis into the nature of love.
Book Synopsis The isotypes of α, β and γ tubulin: From evolutionary origins to roles in metazoan development and ligand binding differences by : Jeffrey Moore
Download or read book The isotypes of α, β and γ tubulin: From evolutionary origins to roles in metazoan development and ligand binding differences written by Jeffrey Moore and published by Frontiers Media SA. This book was released on 2023-04-25 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt:
