Barriers To Integrity

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Tissue Barriers in Disease, Injury and Regeneration

Author : Nikolai V. Gorbunov
Publisher : Elsevier
ISBN 13 : 0128227567
Total Pages : 208 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Tissue Barriers in Disease, Injury and Regeneration by : Nikolai V. Gorbunov

Download or read book Tissue Barriers in Disease, Injury and Regeneration written by Nikolai V. Gorbunov and published by Elsevier. This book was released on 2021-06-19 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tissue Barriers in Disease, Injury and Regeneration focuses on the molecular and cellular fundamentals of homeostatic and defense responses of tissue barriers, covering the damaging impacts and exposure to pathogens and engineered nanomaterials. Sections emphasize the role of mesenchymal stoma, vascular, epithelial, telocyte, myofibroblast, lymphoid and reticuloendothelial cells, along with reactions that bridge the effects of ambient factors, medical treatments, drag delivery systems with alterations in barrier integrity, tissue/organ functions, and metabolic status. Other sections cover the role of progenitor cells of different origins in the remodeling and regeneration of tissue stroma, vasculature of blood-tissue barriers, and more. - Includes special emphasis on the role of mesenchymal stoma, vascular, epithelial, telocyte, myofibroblast, lymphoid and reticuloendothelial cells in the development of reactions that bridge the effects of ambient factors, medical treatments, drag delivery systems with alterations in barrier integrity, tissue/organ functions, and in metabolic status - Examines the role of progenitor cells of different origins in the remodeling and regeneration of tissue stroma, the vasculature of blood-tissue barriers, and mucosa and external epithelium

The Soul of the Firm

Author : C. William Pollard
Publisher : Zondervan
ISBN 13 : 0310234875
Total Pages : 184 pages
Book Rating : 4.3/5 (12 download)

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Book Synopsis The Soul of the Firm by : C. William Pollard

Download or read book The Soul of the Firm written by C. William Pollard and published by Zondervan. This book was released on 1996 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'Bill Pollard speaks with a voice of experience. His book deals with the practice of leadership- over time, under pressure, living with reality, getting the desired results. The Soul of the Firm tells how ServiceMaster has successfully grapple with the key issues of leadership. That is why it is so worthwhile.' -Max De Pree 'Bill Pollard demonstrates in great detail ServiceMaster's value system, a system that emphasizes the importance of the dignity of the individual. Readers will benefit greatly from Bill's wisdom. This is an important book that should be widely read.' -W. Earl Sasser, James L. Heskett, and Leonard A. Schlesinger 'Rarely are we given an open and generous look inside the corporate leader who is the embodiment of the mission and values of the enterprise. . . A powerful book.' -Frances Hesselbein 'A fascinating story about servant leadership and an extraordinary culture at ServiceMaster.' -Richard L. Thomas 'A remarkable book. . . . ServiceMaster invented 'lea production' for the service sector by listening to and empowering its employees on the front line. This book is the moving story of the wellspring of that culture and philosophy, told by a reflective, modest corporate leader.' -Elmer Johnson

Assessment of the Performance of Engineered Waste Containment Barriers

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309134064
Total Pages : 134 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Assessment of the Performance of Engineered Waste Containment Barriers by : National Research Council

Download or read book Assessment of the Performance of Engineered Waste Containment Barriers written by National Research Council and published by National Academies Press. This book was released on 2007-08-22 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: President Carter's 1980 declaration of a state of emergency at Love Canal, New York, recognized that residents' health had been affected by nearby chemical waste sites. The Resource Conservation and Recovery Act, enacted in 1976, ushered in a new era of waste management disposal designed to protect the public from harm. It required that modern waste containment systems use "engineered" barriers designed to isolate hazardous and toxic wastes and prevent them from seeping into the environment. These containment systems are now employed at thousands of waste sites around the United States, and their effectiveness must be continually monitored. Assessment of the Performance of Engineered Waste Containment Barriers assesses the performance of waste containment barriers to date. Existing data suggest that waste containment systems with liners and covers, when constructed and maintained in accordance with current regulations, are performing well thus far. However, they have not been in existence long enough to assess long-term (postclosure) performance, which may extend for hundreds of years. The book makes recommendations on how to improve future assessments and increase confidence in predictions of barrier system performance which will be of interest to policy makers, environmental interest groups, industrial waste producers, and industrial waste management industry.

Loss of Epithelial Barrier Integrity in Inflammatory Diseases: Cellular Mediators and Therapeutic Targets

Author : Imke Atreya
Publisher : Frontiers Media SA
ISBN 13 : 2889742210
Total Pages : 160 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Loss of Epithelial Barrier Integrity in Inflammatory Diseases: Cellular Mediators and Therapeutic Targets by : Imke Atreya

Download or read book Loss of Epithelial Barrier Integrity in Inflammatory Diseases: Cellular Mediators and Therapeutic Targets written by Imke Atreya and published by Frontiers Media SA. This book was released on 2022-01-28 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Role of Physical and Biological Gut Barriers in Modulating Crosstalk between the Microbiota and the Immune System

Author : Marika Falcone
Publisher : Frontiers Media SA
ISBN 13 : 2832552382
Total Pages : 190 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis The Role of Physical and Biological Gut Barriers in Modulating Crosstalk between the Microbiota and the Immune System by : Marika Falcone

Download or read book The Role of Physical and Biological Gut Barriers in Modulating Crosstalk between the Microbiota and the Immune System written by Marika Falcone and published by Frontiers Media SA. This book was released on 2024-07-29 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: The intestine has several means for maintaining immune homeostasis and for avoiding inflammation despite massive antigenic stimulation by food components and by commensal bacteria residing in the gut mucosa. These mechanisms include physical and biological barriers such as (i) the intestinal epithelial barrier (IEB); (ii) the gut vascular barrier (GVB) and (iii) the mucus layer. In particular, the mucus layer does not simply act as a diffusion barrier but has important dynamic functions that regulate the type of commensal bacteria residing in the inner mucus layer, enabling the passage of food and bacterial products into the gut tissue and systemic circulation. Importantly, the mucosal layer also has key immune regulatory functions. A healthy mucus structure is fundamental for promoting the presence of beneficial commensal bacteria, such as the short-chain fatty acids (SCFA)-producing bacteria which are known to promote immune tolerance. Moreover, the mucus layer contains anti-microbial peptides (AMPs) and mucins that have key immune modulatory functions. The integrated response of these combined defense systems is fundamental for containing microbes and their products within the intestine; for avoiding their systemic spread and for suppressing their capacity to activate systemic immune and autoimmune responses.

Fostering Integrity in Research

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309391253
Total Pages : 327 pages
Book Rating : 4.3/5 (93 download)

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Book Synopsis Fostering Integrity in Research by : National Academies of Sciences, Engineering, and Medicine

Download or read book Fostering Integrity in Research written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2018-01-13 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: The integrity of knowledge that emerges from research is based on individual and collective adherence to core values of objectivity, honesty, openness, fairness, accountability, and stewardship. Integrity in science means that the organizations in which research is conducted encourage those involved to exemplify these values in every step of the research process. Understanding the dynamics that support â€" or distort â€" practices that uphold the integrity of research by all participants ensures that the research enterprise advances knowledge. The 1992 report Responsible Science: Ensuring the Integrity of the Research Process evaluated issues related to scientific responsibility and the conduct of research. It provided a valuable service in describing and analyzing a very complicated set of issues, and has served as a crucial basis for thinking about research integrity for more than two decades. However, as experience has accumulated with various forms of research misconduct, detrimental research practices, and other forms of misconduct, as subsequent empirical research has revealed more about the nature of scientific misconduct, and because technological and social changes have altered the environment in which science is conducted, it is clear that the framework established more than two decades ago needs to be updated. Responsible Science served as a valuable benchmark to set the context for this most recent analysis and to help guide the committee's thought process. Fostering Integrity in Research identifies best practices in research and recommends practical options for discouraging and addressing research misconduct and detrimental research practices.

Risk, Reliability and Safety: Innovating Theory and Practice

Author : Lesley Walls
Publisher : CRC Press
ISBN 13 : 1315349167
Total Pages : 4767 pages
Book Rating : 4.3/5 (153 download)

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Book Synopsis Risk, Reliability and Safety: Innovating Theory and Practice by : Lesley Walls

Download or read book Risk, Reliability and Safety: Innovating Theory and Practice written by Lesley Walls and published by CRC Press. This book was released on 2016-11-25 with total page 4767 pages. Available in PDF, EPUB and Kindle. Book excerpt: The safe and reliable performance of many systems with which we interact daily has been achieved through the analysis and management of risk. From complex infrastructures to consumer durables, from engineering systems and technologies used in transportation, health, energy, chemical, oil, gas, aerospace, maritime, defence and other sectors, the management of risk during design, manufacture, operation and decommissioning is vital. Methods and models to support risk-informed decision-making are well established but are continually challenged by technology innovations, increasing interdependencies, and changes in societal expectations. Risk, Reliability and Safety contains papers describing innovations in theory and practice contributed to the scientific programme of the European Safety and Reliability conference (ESREL 2016), held at the University of Strathclyde in Glasgow, Scotland (25—29 September 2016). Authors include scientists, academics, practitioners, regulators and other key individuals with expertise and experience relevant to specific areas. Papers include domain specific applications as well as general modelling methods. Papers cover evaluation of contemporary solutions, exploration of future challenges, and exposition of concepts, methods and processes. Topics include human factors, occupational health and safety, dynamic and systems reliability modelling, maintenance optimisation, uncertainty analysis, resilience assessment, risk and crisis management.

Business Ethics

Author : Mark S. Schwartz
Publisher : John Wiley & Sons
ISBN 13 : 1118393430
Total Pages : 324 pages
Book Rating : 4.1/5 (183 download)

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Book Synopsis Business Ethics by : Mark S. Schwartz

Download or read book Business Ethics written by Mark S. Schwartz and published by John Wiley & Sons. This book was released on 2017-05-01 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Business Ethics: An Ethical Decision-Making Approach presents a practical decision-making framework to aid in the identification, understanding, and resolution of complex ethical dilemmas in the workplace. Focuses exclusively on three basic aspects of ethical decision making and behavior—how it actually takes place, how it should take place, and how it can be improved Uses real-life examples of moral temptations and personal ethical dilemmas faced by employees and managers Discusses the biases, psychological tendencies, moral rationalizations, and impact of self-interest as impediments to proper ethical decision making Includes relevant examples of ethical misconduct and scandals appearing in the news media

Well Control for Completions and Interventions

Author : Howard Crumpton
Publisher : Gulf Professional Publishing
ISBN 13 : 0081022875
Total Pages : 828 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Well Control for Completions and Interventions by : Howard Crumpton

Download or read book Well Control for Completions and Interventions written by Howard Crumpton and published by Gulf Professional Publishing. This book was released on 2018-04-04 with total page 828 pages. Available in PDF, EPUB and Kindle. Book excerpt: Well Control for Completions and Interventions explores the standards that ensure safe and efficient production flow, well integrity and well control for oil rigs, focusing on the post-Macondo environment where tighter regulations and new standards are in place worldwide. Too many training facilities currently focus only on the drilling side of the well's cycle when teaching well control, hence the need for this informative guide on the topic. This long-awaited manual for engineers and managers involved in the well completion and intervention side of a well's life covers the fundamentals of design, equipment and completion fluids. In addition, the book covers more important and distinguishing components, such as well barriers and integrity envelopes, well kill methods specific to well completion, and other forms of operations that involve completion, like pumping and stimulation (including hydraulic fracturing and shale), coiled tubing, wireline, and subsea intervention. - Provides a training guide focused on well completion and intervention - Includes coverage of subsea and fracturing operations - Presents proper well kill procedures - Allows readers to quickly get up-to-speed on today's regulations post-Macondo for well integrity, barrier management and other critical operation components

CMOS Past, Present and Future

Author : Henry Radamson
Publisher : Woodhead Publishing
ISBN 13 : 0081021402
Total Pages : 280 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis CMOS Past, Present and Future by : Henry Radamson

Download or read book CMOS Past, Present and Future written by Henry Radamson and published by Woodhead Publishing. This book was released on 2018-04-03 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: CMOS Past, Present and Future provides insight from the basics, to the state-of-the-art of CMOS processing and electrical characterization, including the integration of Group IV semiconductors-based photonics. The book goes into the pitfalls and opportunities associated with the use of hetero-epitaxy on silicon with strain engineering and the integration of photonics and high-mobility channels on a silicon platform. It begins with the basic definitions and equations, but extends to present technologies and challenges, creating a roadmap on the origins of the technology and its evolution to the present, along with a vision for future trends. The book examines the challenges and opportunities that materials beyond silicon provide, including a close look at high-k materials and metal gate, strain engineering, channel material and mobility, and contacts. The book's key approach is on characterizations, device processing and electrical measurements. - Addresses challenges and opportunities for the use of CMOS - Covers the latest methods of strain engineering, materials integration to increase mobility, nano-scaled transistor processing, and integration of CMOS with photonic components - Provides a look at the evolution of CMOS technology, including the origins of the technology, current status and future possibilities

Driving Continuous Process Safety Improvement From Investigated Incidents

Author : CCPS (Center for Chemical Process Safety)
Publisher : John Wiley & Sons
ISBN 13 : 1119768683
Total Pages : 288 pages
Book Rating : 4.1/5 (197 download)

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Book Synopsis Driving Continuous Process Safety Improvement From Investigated Incidents by : CCPS (Center for Chemical Process Safety)

Download or read book Driving Continuous Process Safety Improvement From Investigated Incidents written by CCPS (Center for Chemical Process Safety) and published by John Wiley & Sons. This book was released on 2021-04-13 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: New perspectives on how to successfully drive changes in companies’ process safety management systems Simply learning from process safety incidents has proven to be insufficient to drive performance improvements. To truly change, organizations must seek out & embed learnings in their programs & systems. This book picks up from previous CCPS books, Incidents That Define Process Safety and Investigating Process Safety Incidents. This important book: Offers guidelines for improving process safety performance by embedding the lessons learned from publicly available investigations Recommends a continuous improvement learning model focused on organizational learning Provides examples for using the model’s techniques to drive continuous improvements Contains an index of more than 400 investigated incidents and introduces the concept of Drilldown to help find lessons that might not have been mentioned before. Written for safety professionals and process safety consultants, Driving Continuous Process Safety Improvement from Investigated Incidents is a hands-on guide for adopting a model for successfully driving the learnings from process safety incident investigations.

Dietary Polyphenols for Improving Gut Health: Volume 2

Author : Kai Wang
Publisher : Frontiers Media SA
ISBN 13 : 2832511244
Total Pages : 218 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Dietary Polyphenols for Improving Gut Health: Volume 2 by : Kai Wang

Download or read book Dietary Polyphenols for Improving Gut Health: Volume 2 written by Kai Wang and published by Frontiers Media SA. This book was released on 2023-01-10 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt:

International Containment Technology Conference

Author :
Publisher :
ISBN 13 :
Total Pages : 1168 pages
Book Rating : 4.3/5 (121 download)

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Book Synopsis International Containment Technology Conference by :

Download or read book International Containment Technology Conference written by and published by . This book was released on 1997 with total page 1168 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Vascular Hyperpermeability

Author : Binu Tharakan
Publisher : Springer Nature
ISBN 13 : 1071634291
Total Pages : 266 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Vascular Hyperpermeability by : Binu Tharakan

Download or read book Vascular Hyperpermeability written by Binu Tharakan and published by Springer Nature. This book was released on 2023-09-30 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on the latest research methods and techniques used by researchers to study vascular permeability/hyperpermeability in a science laboratory setting. The chapters in this book cover topics such as determination of solute permeability of microvascular endothelial cell monolayers in vitro; evaluation of barrier integrity used in a two-layered microfluidic device mimicking the blood-brain barrier; isolation and culture of human umbilical vein endothelial cells; measurement of blood-brain barrier hyperpermeability using Evans Blue extravasation assay; lymphatic vascular permeability determined from direct measurements of solute flux; intravital imaging of leukocyte-endothelial interaction by intravital multiphoton microscopy; and evaluation of tight junction integrity in brain endothelial cells using confocal microscopy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, Vascular Hyperpermeability: Methods and Protocols is a valuable resource that will aid novice researchers with creating new and affordable research projects, and for expert researchers to initiate new strategies and collaborations in their ongoing programs.

The Mechanical Behavior of Salt – Understanding of THMC Processes in Salt

Author : Manfred Wallner
Publisher : CRC Press
ISBN 13 : 1351377167
Total Pages : 453 pages
Book Rating : 4.3/5 (513 download)

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Book Synopsis The Mechanical Behavior of Salt – Understanding of THMC Processes in Salt by : Manfred Wallner

Download or read book The Mechanical Behavior of Salt – Understanding of THMC Processes in Salt written by Manfred Wallner and published by CRC Press. This book was released on 2017-12-14 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: A unique opportunity to review the latest progress in an expanding area of interest: the Mechanical Behaviour of Salt. These Proceedings include over fifty papers and summaries describing the latest findings in ongoing studies from a number of research groups. For the 2007 conference, there was a particular focus on the understanding of thermal, mechanical, hydraulic and chemical coupled processes (THMC). Such processes are of specific interest when considering advanced problems in waste disposal, storage and mining. The book includes a number of themes: - laboratory and in-situ investigations modelling, e.g. derivation of constitutive equations - numerical computations and prediction of long-term behaviour - THMC processes in mining projects, storage and permanent disposal - case studies - geology - mining and storage applications and abandonment The International Conferences on the Mechanical Behaviour of Salt have a long tradition, being initiated in 1981 at The Pennsylvania State University, USA. The present conference, the sixth of the series, took place in Hannover, Germany, in May 2007. The conference brought together mining engineers, researchers, and university professors interested in the mechanical behaviour of salt, mostly from Europe and beyond.

The Blood Brain Barrier and Inflammation

Author : Ruth Lyck
Publisher : Springer
ISBN 13 : 3319455141
Total Pages : 288 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis The Blood Brain Barrier and Inflammation by : Ruth Lyck

Download or read book The Blood Brain Barrier and Inflammation written by Ruth Lyck and published by Springer. This book was released on 2017-03-29 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: This PIR volume presents a comprehensive collection of reviews that focus on the role of the blood-brain barrier (BBB) during steady-state and inflamed conditions. Within the central nervous system (CNS) the constantly changing bloodstream is strictly separated from the CNS parenchyma by the BBB. However, viruses, bacteria, parasites and auto-aggressive immune cells can penetrate the barrier and significantly contribute to CNS inflammation. The BBB can actively contribute to neuroinflammation by presentation of chemokines, expression of cell adhesion molecules and alterations of barrier properties. As such, understanding the role of the BBB under healthy and pathological conditions is essential to the development of new drugs to efficiently combat inflammatory diseases of the CNS.

Physiology, Pharmacology and Pathology of the Blood-Brain Barrier

Author : Zameel Cader
Publisher : Springer Nature
ISBN 13 : 3030996549
Total Pages : 362 pages
Book Rating : 4.0/5 (39 download)

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Book Synopsis Physiology, Pharmacology and Pathology of the Blood-Brain Barrier by : Zameel Cader

Download or read book Physiology, Pharmacology and Pathology of the Blood-Brain Barrier written by Zameel Cader and published by Springer Nature. This book was released on 2022-06-13 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a comprehensive collection of current knowledge and leading research about the blood-brain barrier. The chapters are organized in four main parts providing basic information and novel insights about the physiology of the blood-brain barrier, the challenges related to finding and developing drugs crossing the blood-brain barrier, experimental methods to study the blood-brain barrier and the role of the blood-brain barrier in disease mechanisms and its consequences for drug development. In the first part the readers will discover the structure, function and developmental aspects of the blood-brain barrier and gain novel insights into the complexity and functionality of the neurovascular unit and energy metabolism of brain endothelial cells. Chapters of the second part focus on translational challenges from the bench to the bedside in CNS drug development, shed light on the importance to understand the brain distribution of drugs related to their efficacy, elaborate on general pharmacokinetic considerations for CNS drugs and introduce current and novel drug delivery strategies to overcome the blood-brain barrier. The experimental part of the book covers mathematical and in vitro models as well as animal and human methods in blood-brain barrier research. Specific emphasis is set on the description of the methods, the role of species differences for data interpretation, novel human models based on stem cells with the potential for personalized medicine and technical considerations and tips helpful for readers interested in working with these models. In the fourth part particular attentions is given to the blood-brain barrier, its changes and participation during disease progression. Chapters summarize alterations of the blood-brain barrier that are present in common disorders such as Alzheimer’s disease, multiple sclerosis, stroke, traumatic brain injury, epilepsy and brain tumors. Present therapies will be discussed and the consequences for novel treatment approaches that need to bypass the blood-brain-barrier will be explored. In addition, experts discuss the question in how far changes at the blood-brain barrier are causally linked to disease progressions and consequently could serve as therapeutic targets. This collection is designed to appeal to a wide readership from students through basic and applied scientist to pharmacologists, medical doctors and stakeholders from the pharmaceutical industry and regulatory affairs. Due its comprehensive content the book has the potential to become a standard work in the field of blood-brain barrier research.