Autophagy Biology And Diseases

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Autophagy: Biology and Diseases

Author : Zheng-Hong Qin
Publisher : Springer Nature
ISBN 13 : 9811506027
Total Pages : 727 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Autophagy: Biology and Diseases by : Zheng-Hong Qin

Download or read book Autophagy: Biology and Diseases written by Zheng-Hong Qin and published by Springer Nature. This book was released on 2019-11-27 with total page 727 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book series consists of 3 volumes covering the basic science (Volume 1), clinical science (Volume 2) and the technology and methodology (Volume 3) of autophagy. Volume 1 focuses on the biology of autophagy, including the signaling pathways, regulating processes and biological functions. Autophagy is a fundamental physiological process in eukaryotic cells. It not only regulates normal cellular homeostasis, and organ development and function, but also plays an important role in the pathogenesis of a wide range of human diseases. Thanks to the rapid development of molecular biology and omic technologies, research on autophagy has boomed in recent decades, and more and more cellular and animal models and state-of the-art technologies are being used to shed light on the complexity of signaling networks involved in the autophagic process. Further, its involvement in biological functions and the pathogenesis of various diseases has attracted increased attention around the globe. Presenting cutting-edge knowledge, this book series is a useful reference resource for researchers and clinicians who are working on or interested in autophagy.

Autophagy: Biology and Diseases

Author : Zhiping Xie
Publisher : Springer Nature
ISBN 13 : 9811628300
Total Pages : 453 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Autophagy: Biology and Diseases by : Zhiping Xie

Download or read book Autophagy: Biology and Diseases written by Zhiping Xie and published by Springer Nature. This book was released on 2021-07-14 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book series consists of 3 volumes covering the basic science (Volume 1), clinical science (Volume 2) and the technology and methodology (Volume 3) of autophagy. Volume 3 focuses on the technical aspects of autophagy research. It is comprised of two parts. The first part discusses the basic process of autophagy, including its overall classification and individual stages in the life cycle of autophagosomes. The second part discusses the tools, strategies, and model systems in current autophagy research, including cell and animal models, detection and manipulation methods, as well as screening, genomic, proteomic and bioinformatic approaches. The book is written and edited by a team of active scientists. It is intended as a practical reference resource for interested researchers to get started on autophagy studies.

Autophagy: Biology and Diseases

Author : Weidong Le
Publisher : Springer Nature
ISBN 13 : 9811542724
Total Pages : 734 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Autophagy: Biology and Diseases by : Weidong Le

Download or read book Autophagy: Biology and Diseases written by Weidong Le and published by Springer Nature. This book was released on 2020-07-15 with total page 734 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book consists of 3 volumes: Basic Science (Volume 1), Clinical Science (Volume 2) and Technology and Methodology (Volume 3). Volume 2 focuses on the clinical aspects of autophagy research, discussing the role of autophagy in neuropsychiatric disorders, the cardiovascular, immune, digestive and endocrine systems, as well as tumors, infection, the kidney, and the respiratory and hematological systems. It also addresses autophagy-related drug development. Written and edited by a team of 90 experts, and presenting the state of the art in autophagy research, this book is a valuable reference resource for researchers and clinicians alike. It can also be used as supplementary material for graduate students majoring in biology and medicine

Autophagy in Health and Disease

Author : Beverly Rothermel
Publisher : Elsevier
ISBN 13 : 012822004X
Total Pages : 456 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Autophagy in Health and Disease by : Beverly Rothermel

Download or read book Autophagy in Health and Disease written by Beverly Rothermel and published by Elsevier. This book was released on 2021-09-22 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autophagy in Health and Disease, Second Edition provides a comprehensive overview of the process of autophagy and its impact on human physiology and pathophysiology. It expands on the scope of the first edition by covering a wider range of cell types, developmental processes, and organ systems. The second edition is an international effort by investigators from 15 different countries whose many contributions are comprised in 28 chapters organized into six sections. The first section (Chapters 1-7) covers foundational concepts, including history, trajectory of the research field, mechanisms of autophagy, and autophagy regulation. The second section (Chapters 8-11) details developmental aspects, including stem cells, embryogenesis, hematopoiesis, and paligenosis. The subsequent sections are devoted to the role of autophagy in specific organ systems involved in metabolic control and diabetes (Chapters 12-15), the cardiovascular system (Chapters 16-18), and the nervous system (Chapters 19-20). The final section (Chapters 21-28) addresses autophagy in other organ systems vital to human health and longevity. Also included are chapters on microautophagy, chaperone-mediated autophagy, and the potential for autophagy as a therapeutic target. Autophagy in Health and Disease is invaluable to anyone new to the field as well as established investigators looking for a broader understanding of autophagy from outside their specific field of study. Provides a comprehensive overview of the process of autophagy and its impact on human physiology and pathology Offers extended coverage of the mechanisms that mediate autophagy Covers the role of autophagy in stem cells and induced pluripotent stem cells, as well as the regenerative process of paligenosis Highlights important questions that remain to be addressed

Autophagy in Health and Disease

Author : Kursad Turksen
Publisher : Springer
ISBN 13 : 3319981463
Total Pages : 182 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis Autophagy in Health and Disease by : Kursad Turksen

Download or read book Autophagy in Health and Disease written by Kursad Turksen and published by Springer. This book was released on 2018-10-06 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely volume explores the impact of autophagy in various human diseases, emphasizing the cell biological aspects and focusing on therapeutic approaches to these diseases. The chapters cover autophagy and its potential applications on diseases ranging from obesity, osteoarthritis, pulmonary fibrosis, and inflammation, through ALS, Parkinson's, retinal degeneration, breast cancer, alcoholic liver disease and more. The final chapters round out the book with a discussion of autophagy in drug discovery and 'bench to bedside'. Chapters are contributed by leading authorities and describe the general concepts of autophagy in health and disease, marrying cell biology and pharmacology and covering: studies derived from preclinical experiments, manufacturing considerations,and regulatory requirements pertaining to drug discovery and manufacturing and production. This volume will be useful for basic scientists as well as already practicing clinicians and advanced graduate students.

Autophagy in Immunity and Infection

Author : Vojo Deretic
Publisher : John Wiley & Sons
ISBN 13 : 3527608540
Total Pages : 286 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Autophagy in Immunity and Infection by : Vojo Deretic

Download or read book Autophagy in Immunity and Infection written by Vojo Deretic and published by John Wiley & Sons. This book was released on 2006-08-21 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first book to cover this new topic at the interface of cell biology, immunology and infection biology offers a unique insight as to how the innate and possibly the adaptive immune system are shaped by cellular mechanisms. Following a comprehensive introduction to autophagy, the work features cellular mechanisms and medical implications, structured according to all major pathogens, while also covering emerging infectious diseases, such as tuberculosis. Edited by one of the authors of a groundbreaking paper on this topic.

Lysosomes

Author : Frederick R. Maxfield
Publisher : John Wiley & Sons
ISBN 13 : 1118978315
Total Pages : 586 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis Lysosomes by : Frederick R. Maxfield

Download or read book Lysosomes written by Frederick R. Maxfield and published by John Wiley & Sons. This book was released on 2016-06-22 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discussing recent findings, up-to-date research, and novel strategies, the book integrates perspectives from pharmacology, toxicology, and biochemistry to illustrate the potential of lysosomes in drug discovery and development. • Explores basic principles and properties of lysosomes that allow them to act as regulators of cell metabolism, therapeutic targets, and sites for activation of drug conjugates • Discusses the role of lysosomes in metabolism, drug targeting, apoptosis, cancer, aging, inflammation, autophagy, metabolism, toxicity, and membrane repair • Introduces new pathways in therapeutic development and new mechanisms in drug development

Autophagy at the Cell, Tissue and Organismal Level

Author : Eleftherios Karanasios
Publisher : Springer
ISBN 13 : 3319331450
Total Pages : 107 pages
Book Rating : 4.3/5 (193 download)

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Book Synopsis Autophagy at the Cell, Tissue and Organismal Level by : Eleftherios Karanasios

Download or read book Autophagy at the Cell, Tissue and Organismal Level written by Eleftherios Karanasios and published by Springer. This book was released on 2016-04-23 with total page 107 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an expert summary of autophagy, a relatively new but rapidly expanding field of biomedical science with important implications in health and disease. After a historical review ranging up to the identification of autophagy genes in mammals, the authors discuss the signaling pathways that regulate autophagy, the mechanism of autophagosome formation and the physiological roles of autophagy in development, ageing, neurodegeneration, immune function and cell differentiation. A comprehensive list of useful antibodies for studying autophagy compiled as a community effort is included at the end. The book is intended for newcomers to the field, as well as more experienced researchers looking for a condensed but comprehensive introduction to the physiological function and regulation of the autophagic pathway in mammalian organisms.

Autophagy and Signaling

Author : Esther Wong
Publisher : CRC Press
ISBN 13 : 1351646974
Total Pages : 553 pages
Book Rating : 4.3/5 (516 download)

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Book Synopsis Autophagy and Signaling by : Esther Wong

Download or read book Autophagy and Signaling written by Esther Wong and published by CRC Press. This book was released on 2017-09-18 with total page 553 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autophagy and Signaling is an up-to-date overview of the many signaling pathways regulating autophagy in response to different cellular needs. Discussion includes the status and future directions of autophagy signaling research with respect to different aspects of health and disease. These include the roles of autophagy in regulating cell fate, immune response and host defense, nutrient sensing and metabolism, neural functions and homeostasis. The mechanisms and significance of cross-talk between autophagy and other cellular processes is also explored. Lastly, alterations in autophagy observed in aging and age-related pathologies are described.

Autophagy - A Double-Edged Sword

Author : Yannick Bailly
Publisher : BoD – Books on Demand
ISBN 13 : 9535110624
Total Pages : 526 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Autophagy - A Double-Edged Sword by : Yannick Bailly

Download or read book Autophagy - A Double-Edged Sword written by Yannick Bailly and published by BoD – Books on Demand. This book was released on 2013-04-17 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: The chapters in this book review the latest advances in the molecular mechanisms of autophagy, highlighting some of the most challenging research topics. The focus is mainly on how this basic cell defense mechanism comes into play in various pathologies, including liver diseases, myopathies, infectious diseases, cancers and neurodegenerative diseases. In these diseases, the contradictory autophagy roles of cell survival versus cell death emphasize the necessity of taking into account this double-edged nature in future development of already promising, autophagy- modulating, therapies.

Autophagosome and Phagosome

Author : Vojo Deretic
Publisher : Humana Press
ISBN 13 : 9781588298539
Total Pages : 455 pages
Book Rating : 4.2/5 (985 download)

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Book Synopsis Autophagosome and Phagosome by : Vojo Deretic

Download or read book Autophagosome and Phagosome written by Vojo Deretic and published by Humana Press. This book was released on 2008-04-24 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autophagy and phagocytosis are distinct yet partially morphologically similar processes. Understanding them is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. This book presents autophagosome and phagosome methods for novices and advanced researchers alike. Comprehensive and forward-thinking, the book offers a valuable guide to both cellular processes while inciting researchers to explore their potentially important connections.

Autophagy in Current Trends in Cellular Physiology and Pathology

Author : Nikolai Gorbunov
Publisher : BoD – Books on Demand
ISBN 13 : 9535127268
Total Pages : 528 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Autophagy in Current Trends in Cellular Physiology and Pathology by : Nikolai Gorbunov

Download or read book Autophagy in Current Trends in Cellular Physiology and Pathology written by Nikolai Gorbunov and published by BoD – Books on Demand. This book was released on 2016-11-10 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autophagy in Current Trends in Cellular Physiology and Pathology is addressed to one of the fundamental molecular mechanisms - autophagy- evolutionarily adopted by cells for processing of unnecessary or malfunctioned constituents and shaping intracellular structures, adjusting them to environmental conditions, aging, disease, neoplasia, and damages over their life period. Particular attention is paid to autophagy-mediated barrier processes of selective sequestration and recycling of impaired organelles and degradation of invading microorganisms, that is, the processes sustaining intrinsic resistance to stress, tissue degeneration, toxic exposures, and infections. The presented topics encompass personal experience and visions of the chapter contributors and the editors; the book chapters include a broad analysis of literature on biology of autophagy.

Autophagy

Author : Nikolai Gorbunov
Publisher :
ISBN 13 : 9781619422667
Total Pages : 0 pages
Book Rating : 4.4/5 (226 download)

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Book Synopsis Autophagy by : Nikolai Gorbunov

Download or read book Autophagy written by Nikolai Gorbunov and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives an up-to-date overview of the biomedical aspects of autophagy research, a large interdisciplinary field emerging on intersection of (i) cell, developmental, and cancer biology, (ii) tissue remodelling and plasticity, ageing and longevity; (iii) immunology, microbiology, toxicology, and pathobiology; (iv) regenerative and adaptive biomedicine; and (v) pharmacology.

Autophagy in Disease and Clinical Applications, Part C

Author : Daniel Klionsky
Publisher : Academic Press
ISBN 13 : 0080958486
Total Pages : 550 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Autophagy in Disease and Clinical Applications, Part C by : Daniel Klionsky

Download or read book Autophagy in Disease and Clinical Applications, Part C written by Daniel Klionsky and published by Academic Press. This book was released on 2009-03-10 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: The third and final installment of Daniel J. Klionsky's new three-volume treatment of autophagy, this volume focuses on monitoring autophagy with regard to disease connections, and presents methods that can be used to analyze autophagy in clinical samples. Edited by one of the leading authorities in the field, this volume and its companion volumes, Autophagy: Lower Eukaryotes and Autophagy in Mammalian Systems, provide a comprehensive overview of the techniques involved in studying autophagy in eukaryotes and simple animal systems, mammalian cells and non-human animals, and humans. Particularly in times of stress, like starvation and disease, higher organisms have an internal mechanism in their cells for chewing up and recycling parts of themselves. The process of internal “house cleaning in the cell is called autophagy – literally self-eating. In the future, research in this field will help to design clinical approaches that can turn on autophagy and halt tumor growth. Provides an overview of autophagy in regards to humans, specifically regarding disease connections and clinical samples Includes methods to evaluate the role of autophagy in the drug-induced cell death of cancer cells in culture Presents reliable methods that, in this relatively new field, allow the reader to find appropriate techniques to identify, monitor, and quantify autophagic processes

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

Author : M. A. Hayat
Publisher : Elsevier
ISBN 13 : 0124115144
Total Pages : 435 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging by : M. A. Hayat

Download or read book Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging written by M. A. Hayat and published by Elsevier. This book was released on 2013-09-03 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is a complete, authoritative examination of the role of autophagy in health and disease. Understanding this phenomenon is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward thinking, this four-volume work offers a valuable guide to cellular processes while encouraging researchers to explore their potentially important connections. Understanding the role of autophagy is critical, considering its association with numerous biological processes, including cellular development and differentiation, cancer (both antitumor and protumor functions), immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases. Cell homeostasis is achieved by balancing biosynthesis and cellular turnover. In spite of the increasing importance of autophagy in various pathophysiological conditions mentioned above, this process remains underestimated and overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these and other diseases (e.g., autoimmune disease) remains poorly understood. This work will broaden the knowledge base of academic and clinical professors, post-doctoral fellows, graduate and medical students regarding this vital biological process. Volumes in the Series

Autophagy

Author : Nikolaĭ Vasilʹevich Gorbunov
Publisher : Nova Science Publishers
ISBN 13 : 9781619422810
Total Pages : 379 pages
Book Rating : 4.4/5 (228 download)

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Book Synopsis Autophagy by : Nikolaĭ Vasilʹevich Gorbunov

Download or read book Autophagy written by Nikolaĭ Vasilʹevich Gorbunov and published by Nova Science Publishers. This book was released on 2012-08-01 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives an up-to-date overview of the biomedical aspects of autophagy research, a large interdisciplinary field emerging on intersection of (i) cell, developmental, and cancer biology, (ii) tissue remodeling and plasticity, aging and longevity; (iii) immunology, microbiology, toxicology, and pathobiology; (iv) regenerative and adaptive biomedicine; and (v) pharmacology.

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

Author : M. A. Hayat
Publisher : Academic Press
ISBN 13 : 0128010541
Total Pages : 339 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging by : M. A. Hayat

Download or read book Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging written by M. A. Hayat and published by Academic Press. This book was released on 2014-09-26 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and up-to-date, this book offers a valuable guide to these cellular processes whilst inciting researchers to explore their potentially important connections. Volume 5 comprehensively describes the role of autophagy in human diseases, delivering coverage of the antitumor and protumor roles of autophagy; the therapeutic inhibition of autophagy in cancer; and the duality of autophagy’s effects in various cardiovascular, metabolic, and neurodegenerative disorders. In spite of the increasing importance of autophagy in the various pathophysiological conditions mentioned above, this process remains underestimated and overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these and other diseases remains poorly understood. This book is an asset to newcomers as a concise overview of the diverse disease implications of autophagy, while serving as an excellent reference for more experienced scientists and clinicians looking to update their knowledge. Volumes in the Series