Automation and Emerging Technology in Clinical Microbiology, An Issue of Clinics in Laboratory Medicine

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Publisher : Elsevier Health Sciences
ISBN 13 : 0323188605
Total Pages : 352 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Automation and Emerging Technology in Clinical Microbiology, An Issue of Clinics in Laboratory Medicine by : Carey-Ann D. Burnham

Download or read book Automation and Emerging Technology in Clinical Microbiology, An Issue of Clinics in Laboratory Medicine written by Carey-Ann D. Burnham and published by Elsevier Health Sciences. This book was released on 2013-09-03 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of Clinical Microbiology is evolving at a rapid pace, perhaps more so than any other arm of laboratory medicine. This can be attributed to new technology, including high throughput gene sequencing, multiplex molecular assays, rapid evolution of antimicrobial resistance, and discovery of new pathogens. In addition, modern medical procedures, such as solid organ and stem cell transplantation, have resulted in an explosion of infections with agents that historically have been considered to be of low virulence. This issue of Clinics in Laboratory Medicine will highlight some of the advances in diagnostic microbiology, including MALDI-TOF MS, pathogen discovery, and personalized antimicrobial chemotherapy. In addition, one of the papers will focus on implementation of new technologies and how to maximize patient impact of these new methods.

Advances and Trends in Clinical Microbiology: The Next 20 Years, An Issue of the Clinics in Laboratory Medicine

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Publisher : Elsevier Health Sciences
ISBN 13 : 0323682707
Total Pages : pages
Book Rating : 4.3/5 (236 download)

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Book Synopsis Advances and Trends in Clinical Microbiology: The Next 20 Years, An Issue of the Clinics in Laboratory Medicine by : James E. Kirby

Download or read book Advances and Trends in Clinical Microbiology: The Next 20 Years, An Issue of the Clinics in Laboratory Medicine written by James E. Kirby and published by Elsevier Health Sciences. This book was released on 2019-08-11 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Clinics in Laboratory Medicine, guest edited by James E. Kirby, will focus on Advances and Trends in Clinical Microbiology and take a look at the next 20 years. Topics include, but are not limited to, Rapid susceptibility testing methods; Synergy testing; Serology testing re-imagined; Total Laboratory Automation in Clinical Microbiology; MALDI-TOF; Superbugs of the Future, the Antimicrobial Laboratory Resistance Network, Partnerships between Public Health and the clinical microbiology laboratory; Next generation sequencing, from identification to susceptibility prediction; Distributed microbiology testing; Direct from Sample Identification; Biomarkers - predicting viral versus bacterial infection; PK/PD in the era of emerging multidrug-resistance; Training the next generation of clinical microbiologists; and Pictorial illustration of debate, developments, and controversy in clinical microbiology.

Current Issues in Clinical Microbiology, An Issue of the Clinics in Laboratory Medicine, E-Book

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Publisher : Elsevier Health Sciences
ISBN 13 : 0323733964
Total Pages : 257 pages
Book Rating : 4.3/5 (237 download)

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Book Synopsis Current Issues in Clinical Microbiology, An Issue of the Clinics in Laboratory Medicine, E-Book by : Nicole Pecora

Download or read book Current Issues in Clinical Microbiology, An Issue of the Clinics in Laboratory Medicine, E-Book written by Nicole Pecora and published by Elsevier Health Sciences. This book was released on 2020-11-11 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Clinics in Laboratory Medicine, guest edited by Drs. Nicole D. Pecora and Matthew Pettengill, will cover Current Issues in Clinical Microbiology. This issue is one of four selected each year by our Editor-in-Chief, Dr. Milenko Jovan Tanasijevic. Topics discussed in this issue will include: Update in Diagnostics of Bloodstream Infections, Panels and Syndromic Testing in Clinical Microbiology, Lab Consolidation and Centralization, Update in Susceptibility Testing: Phenotypic and Genotypic Methods, Genomics in the Clinical Microbiology Laboratory, Automation in the Clinical Microbiology Laboratory, Coronavirus Detection in the Clinical Microbiology Laboratory: Are We Ready for Identifying and Diagnosing a Novel Strain?, Update on Biosafety and Emerging Infections for the Clinical Microbiology Lab, Update in Clinical Mycology, Point of Care Testing in Microbiology, Pediatric Diagnostic Microbiology, Antimicrobial Stewardship: What the Clinical Laboratory Needs to Know, Fellowship Training for the Future Clinical Microbiology Laboratory Director, Update in Diagnostics/Susceptibility of Mycobacterial Diseases, Role of the Clinical Microbiology Lab in One Health, Update in Infectious Disease Diagnosis in Surgical Pathology, and more.

Diabetes, Hematology/Coagulation in Pregnancy, An Issue of Clinics in Laboratory Medicine

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Publisher : Elsevier Health Sciences
ISBN 13 : 145577197X
Total Pages : 280 pages
Book Rating : 4.4/5 (557 download)

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Book Synopsis Diabetes, Hematology/Coagulation in Pregnancy, An Issue of Clinics in Laboratory Medicine by : Winston Campbell

Download or read book Diabetes, Hematology/Coagulation in Pregnancy, An Issue of Clinics in Laboratory Medicine written by Winston Campbell and published by Elsevier Health Sciences. This book was released on 2013-06-28 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue focuses on three disease sections: Diabetes, Hematology and Coagulation, and covers diagnostic and management issues during pregnancy of selected topics in each section. The chapters cover new concepts, evolving management and important impacts on the mother and unborn child.

Respiratory Infections, An Issue of Clinics in Laboratory Medicine,

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Publisher : Elsevier Health Sciences
ISBN 13 : 0323299423
Total Pages : 265 pages
Book Rating : 4.3/5 (232 download)

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Book Synopsis Respiratory Infections, An Issue of Clinics in Laboratory Medicine, by : Michael J. Loeffelholz

Download or read book Respiratory Infections, An Issue of Clinics in Laboratory Medicine, written by Michael J. Loeffelholz and published by Elsevier Health Sciences. This book was released on 2014-09-08 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acute respiratory infections are responsible for an estimated 4 million deaths annually worldwide, and are the leading cause of death in children younger than 5 years. Over 1 million people in the United States are hospitalized each year with pneumonia. Mycobacterium tuberculosis infects one third of world’s population. There are more than 1 million tuberculosis-related deaths worldwide each year. Emerging resistance to multiple available antimicrobial agents has hampered the ability to treat tuberculosis and hospital-acquired respiratory infections. The laboratory diagnosis of respiratory infections is an important part of patient management and treatment. In addition to culture isolation of pathogens, advances have been made in a number of non-culture methods. This issue of Clinics in Laboratory Medicinee reviews state-of-the-art laboratory diagnosis of respiratory infections, as well as the testing of susceptibility to antibiotics and antiviral agents. Among some of the respiratory infections covered are: Cystic fibrosis infections; Pertussis; Pharyngitis; Fungal infections. Among the diagnostic tests are: Interferon gamma release assays; Molecuar diagnosis of TB; Urine antigen tests and discussion of Antibiotic resistance in nosocomial respiratory infections.

Molecular Pathology: An Update, An Issue of the Clinics in Laboratory Medicine, Ebook

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Publisher : Elsevier Health Sciences
ISBN 13 : 0323610730
Total Pages : 249 pages
Book Rating : 4.3/5 (236 download)

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Book Synopsis Molecular Pathology: An Update, An Issue of the Clinics in Laboratory Medicine, Ebook by : Martin H. Bluth

Download or read book Molecular Pathology: An Update, An Issue of the Clinics in Laboratory Medicine, Ebook written by Martin H. Bluth and published by Elsevier Health Sciences. This book was released on 2018-05-23 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated issue of Clinics in Laboratory Medicine, edited by Martin H. Bluth, will focus on Molecular Pathology. Topics include, but are not limited to, The Impact of Molecular Pathology on the Practice of Pathology; Molecular pathology techniques; Clinical Implication of MicroRNAs in Molecular Pathology; Diagnostic Molecular Microbiology; Molecular Pathology in Transfusion Medicine; Molecular Diagnosis of Hematopoietic Neoplasms; Molecular Diagnostics in Colorectal Carcinoma; Molecular Diagnostics in the Neoplasms of Small Intestine and Appendix; Molecular Diagnostics in Esophageal and Gastric Neoplasms; Molecular Diagnostics in the Neoplasms of the Pancreas, Liver, Gall Bladder, and Extrahepatic Biliary Tract; Current Applications of Molecular Genetic Technologies to the Diagnosis and Treatment of Cutaneous Melanocytic Neoplasms; Breast Carcinoma; and Gynecologic Cancers.

Cardiac Markers, An Issue of Clinics in Laboratory Medicine, E-Book

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Publisher : Elsevier Health Sciences
ISBN 13 : 0323287115
Total Pages : 209 pages
Book Rating : 4.3/5 (232 download)

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Book Synopsis Cardiac Markers, An Issue of Clinics in Laboratory Medicine, E-Book by : Kent Balanis Lewandrowski

Download or read book Cardiac Markers, An Issue of Clinics in Laboratory Medicine, E-Book written by Kent Balanis Lewandrowski and published by Elsevier Health Sciences. This book was released on 2014-02-15 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topics in this clinically focused publication devoted to Cardiac Markers include: Overview of cardiac markers in heart disease; Methodologies for measurement of cardiac markers; Natriuretic peptides in HF and ACS; Tropoinins and high sensitivity troponins; Point-of-care testing for cardiac markers; ST-2 and galectin 3 in patients with heart failure; Cardiac markers following heart surgery and percutaneous coronary intervention; Cholesterol, lipoproteins, high sensitivity CRP and other risk factors for atherosclerosis; Myocarditis and cardiac transplant and rejection; New molecular genetic tests in the diagnosis of heart disease; Biomarkers for cholesterol balance.

Infectious Disease Epidemiology

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Publisher : Oxford University Press
ISBN 13 : 0191030554
Total Pages : 416 pages
Book Rating : 4.1/5 (91 download)

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Book Synopsis Infectious Disease Epidemiology by : Ibrahim Abubakar

Download or read book Infectious Disease Epidemiology written by Ibrahim Abubakar and published by Oxford University Press. This book was released on 2016-04-07 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infectious Disease Epidemiology is a concise reference guide which provides trainees and practicing epidemiologists with the information that they need to understand the basic concepts necessary for working in this specialist area. Divided into two sections, part one comprehensively covers the basic principles and methods relevant to the study of infectious disease epidemiology. It is organised in order of increasing complexity, ranging from a general introduction to subjects such as mathematical modelling and sero-epidemiology. Part two examines key major infectious diseases that are of global significance. Grouped by their route of transmission for ease of reference, they include diseases that present a particular burden or a high potential for causing mortality. This practical guide will be essential reading for postgraduate students in infectious disease epidemiology, health protection trainees, and practicing epidemiologists.

Quality Control in the age of Risk Management, An Issue of Clinics in Laboratory Medicine

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Publisher : Elsevier Health Sciences
ISBN 13 : 1455772313
Total Pages : 220 pages
Book Rating : 4.4/5 (557 download)

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Book Synopsis Quality Control in the age of Risk Management, An Issue of Clinics in Laboratory Medicine by : James O. Westgard

Download or read book Quality Control in the age of Risk Management, An Issue of Clinics in Laboratory Medicine written by James O. Westgard and published by Elsevier Health Sciences. This book was released on 2013-03-28 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: In October of 2011, CLSI published a new guideline EP23A on “Laboratory Quality Control Based on Risk Management. In March, 2012, CMS announced its intention to incorporate key concepts from EP23A into its Interpretative Guidelines and QC policy for “Individualized Quality Control Plans. Thus begins a new era of Quality Control in the Age of Risk Management. This issue is intended to help laboratories with the transition between traditional QC practices and the new risk management approach. Laboratories face a steep learning curve to apply risk analysis for identifying and prioritizing failure-modes, developing and implementing control mechanisms to detect those failure-modes, and assessing the acceptability of the residual risks that exist after implementation of a QC Plan. One of the main benefits of the new risk analysis based QC Plans should be an integration of all the control mechanisms that are needed to monitor the total testing process, including pre-analytic, analytic, and post-analytic controls. One of the main risks of the new approach is an expectation that Statistical QC is no longer important, even though SQC still remains the most useful and flexible approach for monitoring the quality of the analytic process. The key to the future is the successful integration of all these control mechanisms to provide a cost-effective quality system that monitors all phases of the total testing process. This issue should help laboratories understand the evolution of QC practices to include risk management, but also to recognize the need to maintain traditional techniques such as Statistical QC, especially during the transition to well-designed and carefully-validated QC Plans. Risk analysis may be risky business unless laboratories proceed carefully and cautiously.

Clinical Decision Support: Tools, Strategies, and Emerging Technologies, An Issue of the Clinics in Laboratory Medicine

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Publisher : Elsevier Health Sciences
ISBN 13 : 0323681166
Total Pages : pages
Book Rating : 4.3/5 (236 download)

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Book Synopsis Clinical Decision Support: Tools, Strategies, and Emerging Technologies, An Issue of the Clinics in Laboratory Medicine by : Anand S Dighe

Download or read book Clinical Decision Support: Tools, Strategies, and Emerging Technologies, An Issue of the Clinics in Laboratory Medicine written by Anand S Dighe and published by Elsevier Health Sciences. This book was released on 2019-05-08 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Clinics in Laboratory Medicine, Guest Edited by Dr. Anand S. Dighe, will focus on Clinical Decision Support, including tools, strategies, and emerging technologies. This issue is one of four issues selected per year by the series Consulting Editor, Milenko Jovan Tanasijevic. Topics include, but are not limited to, The Laboratory’s Role in Clinical Decision Support, Integrating Decision Support into a Utilization Management Program, Decision Support Tools within the Electronic Health Record, Decision Support to Enhance Automated Testing and Laboratory Workflow, Laboratory-based CDS programs, Decision Support in Blood Banking, Decision Support in Molecular Pathology, A Computational Perspective on Decision Support, Emerging Decision Support Techniques, Decision Support and Patient Safety, Decision Support from a Reference laboratory perspective, and Training Aspects of Laboratory Based Decision Support.

Clinical Pathology, An Issue of the Clinics in Laboratory Medicine E-Book

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Publisher : Elsevier Health Sciences
ISBN 13 : 0323641040
Total Pages : pages
Book Rating : 4.3/5 (236 download)

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Book Synopsis Clinical Pathology, An Issue of the Clinics in Laboratory Medicine E-Book by : Geza S Bodor

Download or read book Clinical Pathology, An Issue of the Clinics in Laboratory Medicine E-Book written by Geza S Bodor and published by Elsevier Health Sciences. This book was released on 2018-08-19 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Clinics in Laboratory Medicine will focus on Clinical Pathology and is edited by Geza S. Bodor. Topics include, but are not limited to, Steroid measurement / Salivary cortisol measurement, Protein testing by LCMSMS, LCMSMS in the Clinical Laboratory, Laboratory Standards for Clinical LCMSMS, The need to teach LCMSMS to clinical laboratory scientists, MALDI-TOF in the clinical laboratory, MALDI TOF MS in the clinical microbiology laboratory, LCMSMS method development consideration in clinical laboratory practice, Cancer diagnosis using mass spectrometry, Adulteration and LCMSMS drug testing, Diagnosis of inherited metabolic disorders using LCMSMS, Harmonization of LCMSMS protein assays, Vitamin D testing by LCMSMS versus by immunoassay, Pain management testing by LCMSMS, and Development of FDA approved clinical mass spectrometer.

Current Issues in Clinical Microbiology, An Issue of the Clinics in Laboratory Medicine

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Publisher : Elsevier
ISBN 13 : 9780323733953
Total Pages : 240 pages
Book Rating : 4.7/5 (339 download)

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Book Synopsis Current Issues in Clinical Microbiology, An Issue of the Clinics in Laboratory Medicine by : Nicole Pecora

Download or read book Current Issues in Clinical Microbiology, An Issue of the Clinics in Laboratory Medicine written by Nicole Pecora and published by Elsevier. This book was released on 2020-12-28 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Clinics in Laboratory Medicine, guest edited by Drs. Nicole D. Pecora and Matthew Pettengill, will cover Current Issues in Clinical Microbiology. This issue is one of four selected each year by our Editor-in-Chief, Dr. Milenko Jovan Tanasijevic. Topics discussed in this issue will include: Update in Diagnostics of Bloodstream Infections, Panels and Syndromic Testing in Clinical Microbiology, Lab Consolidation and Centralization, Update in Susceptibility Testing: Phenotypic and Genotypic Methods, Genomics in the Clinical Microbiology Laboratory, Automation in the Clinical Microbiology Laboratory, Coronavirus Detection in the Clinical Microbiology Laboratory: Are We Ready for Identifying and Diagnosing a Novel Strain?, Update on Biosafety and Emerging Infections for the Clinical Microbiology Lab, Update in Clinical Mycology, Point of Care Testing in Microbiology, Pediatric Diagnostic Microbiology, Antimicrobial Stewardship: What the Clinical Laboratory Needs to Know, Fellowship Training for the Future Clinical Microbiology Laboratory Director, Update in Diagnostics/Susceptibility of Mycobacterial Diseases, Role of the Clinical Microbiology Lab in One Health, Update in Infectious Disease Diagnosis in Surgical Pathology, and more.

Bailey & Scott's Diagnostic Microbiology - E-Book

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Publisher : Elsevier Health Sciences
ISBN 13 : 0323428924
Total Pages : 1136 pages
Book Rating : 4.3/5 (234 download)

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Book Synopsis Bailey & Scott's Diagnostic Microbiology - E-Book by : Patricia Tille

Download or read book Bailey & Scott's Diagnostic Microbiology - E-Book written by Patricia Tille and published by Elsevier Health Sciences. This book was released on 2015-12-28 with total page 1136 pages. Available in PDF, EPUB and Kindle. Book excerpt: Perfect your lab skills with the gold standard in microbiology! Serving as both the #1 bench reference for practicing microbiologists and as a favorite text for students in clinical laboratory science programs, Bailey & Scott’s Diagnostic Microbiology, 14th Edition covers all the topical information and critical thinking practice you need for effective laboratory testing. This new edition also features hundreds step-by-step procedures, updated visuals, new case studies, and new material on the latest trends and equipment in clinical microbiology — including automation, automated streaking, MALDI-TOF, and incubator microscopes. It’s everything you need to get quality lab results in class and in clinical practice! More than 800 detailed, full-color illustrations aid comprehension and help in visualizing concepts. Expanded sections on parasitology, mycology, and virology eliminate the need to purchase separate books on this material. General and Species boxes in the organism chapters highlight the important topics that will be discussed in the chapter. Case studies provide the opportunity to apply information to a variety of diagnostic scenarios, and help improve decision-making and critical thinking skills. Hands-on procedures include step-by-step instructions, full-color photos, and expected results. A glossary of terms is found at the back of the book for quick reference. Learning objectives begin each chapter, offering a measurable outcome to achieve by the completing the material. Learning resources on the Evolve companion website enhance learning with review questions and procedures. NEW! Coverage of automation, automated streaking, MALDI-TOF, and incubator microscopes keeps you in the know on these progressing topics. NEW! Updated images provide a more vivid look into book content and reflect the latest procedures. NEW! Thoroughly reviewed and updated chapters equip you with the most current information. NEW! Significant lab manual improvements provide an excellent learning resource at no extra cost. NEW! 10 extra case studies on the Evolve companion website offer more opportunities to improve critical thinking skills.

Artificial Intelligence in the Clinical Laboratory: Current Practice and Emerging Opportunities, An Issue of the Clinics in Laboratory Medicine, E-Book

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Publisher : Elsevier Health Sciences
ISBN 13 : 0323939848
Total Pages : 161 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Artificial Intelligence in the Clinical Laboratory: Current Practice and Emerging Opportunities, An Issue of the Clinics in Laboratory Medicine, E-Book by : Jason Baron

Download or read book Artificial Intelligence in the Clinical Laboratory: Current Practice and Emerging Opportunities, An Issue of the Clinics in Laboratory Medicine, E-Book written by Jason Baron and published by Elsevier Health Sciences. This book was released on 2023-02-10 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue, guest editors bring their considerable expertise to this important topic. Provides in-depth reviews on the latest updates in the field, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize

Emerging Pathogens, An Issue of Clinics in Laboratory Medicine, E-Book

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Publisher : Elsevier Health Sciences
ISBN 13 : 0323530168
Total Pages : pages
Book Rating : 4.3/5 (235 download)

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Book Synopsis Emerging Pathogens, An Issue of Clinics in Laboratory Medicine, E-Book by : Nahed Ismail

Download or read book Emerging Pathogens, An Issue of Clinics in Laboratory Medicine, E-Book written by Nahed Ismail and published by Elsevier Health Sciences. This book was released on 2017-06-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Clinics in Laboratory Medicine, edited by Drs. Nahed Ismail, A. William Pasculle, and James Snyder, will cover a wide variety of Emerging Pathogens. Topics covered in this issue include, but are not limited to West Nile Virus; Zika Virus; Ebola and Marburg Heamorrhagic Fever; Rift Valley Fever; Carbapenem Resistant Enterobacteriacae; Closteridium Difficuile; and Chikungunya, among others.

Current and Emerging Technologies for the Diagnosis of Microbial Infections

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Author :
Publisher : Academic Press
ISBN 13 : 0128033312
Total Pages : 634 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Current and Emerging Technologies for the Diagnosis of Microbial Infections by :

Download or read book Current and Emerging Technologies for the Diagnosis of Microbial Infections written by and published by Academic Press. This book was released on 2015-11-23 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current and Emerging Technologies in Microbial Diagnostics, the latest volume in the Methods in Microbiology series, provides comprehensive, cutting-edge reviews of current and emerging technologies in the field of clinical microbiology. The book features a wide variety of state-of-the art methods and techniques for the diagnosis and management of microbial infections, with chapters authored by internationally renowned experts. This volume focuses on current techniques, such as MALDI-TOF mass spectroscopy and molecular diagnostics, along with newly emerging technologies such as host-based diagnostics and next generation sequencing. Written by recognized leaders and experts in the field Provides a comprehensive and cutting-edge review of current and emerging technologies in the field of clinical microbiology, including discussions of current techniques such as MALDI-TOF mass spectroscopy and molecular diagnostics Includes a broad range and breadth of techniques covered Presents discussions on newly emerging technologies such as host-based diagnostics and next generation sequencing

Automation In Clinical Microbiology

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Author :
Publisher : CRC Press
ISBN 13 : 1351086898
Total Pages : 382 pages
Book Rating : 4.3/5 (51 download)

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Book Synopsis Automation In Clinical Microbiology by : James Wallace Jorgenson

Download or read book Automation In Clinical Microbiology written by James Wallace Jorgenson and published by CRC Press. This book was released on 2018-01-18 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: The chapters of this book describe numerous successful examples of automation in microbiology, e.g., radiometric detection of bacteremia, instruments for detection of bacteriuria, machines for organism identification and susceptibility testing, and automated antigen and antibody measurement systems. In addition, there are discussions of exciting but not yet proven methodologies such as chromatography, flow cytometry, and other applications of radiometry. There are also important discussions regarding improved means of data communication and ways to improve the clinician‘s use of test results. Lastly, there are candid assessments of the best and worst aspects of the current spectrum of automated instruments for microbiology. It is hoped that the reader of this volume will be left with a feeling of excitement at the possibilities that lie ahead for application of instrument techniques in the diagnosis of infectious diseases.