Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Assessment Of Endothelial Function And Approaches To Prevent Ischemia And Reperfusion Induced Endothelial Dysfunction In Humans
Download Assessment Of Endothelial Function And Approaches To Prevent Ischemia And Reperfusion Induced Endothelial Dysfunction In Humans full books in PDF, epub, and Kindle. Read online Assessment Of Endothelial Function And Approaches To Prevent Ischemia And Reperfusion Induced Endothelial Dysfunction In Humans ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis Assessment of Endothelial Function and Approaches to Prevent Ischemia and Reperfusion-Induced Endothelial Dysfunction in Humans by : Mary Clare Luca
Download or read book Assessment of Endothelial Function and Approaches to Prevent Ischemia and Reperfusion-Induced Endothelial Dysfunction in Humans written by Mary Clare Luca and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Assessment of Endothelial Function in Humans and the Endothelial-Protective Effects of 3-hydroxy-3-methylglutaryl Coenzyme A Reductase Inhibitors by : Andrew Liuni
Download or read book Assessment of Endothelial Function in Humans and the Endothelial-Protective Effects of 3-hydroxy-3-methylglutaryl Coenzyme A Reductase Inhibitors written by Andrew Liuni and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Endothelial Dysfunction and Inflammation by : Shauna Dauphinee
Download or read book Endothelial Dysfunction and Inflammation written by Shauna Dauphinee and published by Springer Science & Business Media. This book was released on 2010-09-24 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endothelial dysfunction is broadly defined as a disruption of the balance between vasoactive mediators and a propensity towards an inflammatory state. This volume provides an overview of the fields of endothelial dysfunction and inflammation through the discussion of topics ranging from the molecular biology of activated endothelial cells to the endothelium in inflammatory disease and therapeutic approaches targeting endothelial dysfunction. Topics include: Heterogeneity of the endothelium during inflammation, oxidative stress and endothelial dysfunction, biology and regulation of nitric oxide in inflammatory pathologies, endothelial dysfunction in inflammatory diseases, such as diabetes and atherosclerosis and Clinical methods used to assess endothelial function. This book brings together basic and clinical research to assist the reader in bridging connections from bench-to-bedside. Written by expert researchers in the fields of endothelial biology, inflammation research and clinical science, it serves as a useful reference for academic and industrial researchers, clinicians, and trainees in the medical profession.
Book Synopsis Endothelial Dysfunction During Inflammation and Alloimmunity by : Olaf Penack
Download or read book Endothelial Dysfunction During Inflammation and Alloimmunity written by Olaf Penack and published by Frontiers Media SA. This book was released on 2019-04-09 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endothelial cells form the inner lining of blood and lymphatic vessels and they have frequent interactions with immune cells as well as foreign agents. Endothelial function is crucially involved in physiologic immunity at different stages including recruitment of leukocytes, angiogenesis and tissue repair. Endothelial dysfunction is a not well-defined term, it is widely used to describe the non-physiologic activity of endothelial cells. It has been suggested that endothelial dysfunction plays a role in a variety of human diseases, such as arteriosclerosis, cancer, autoimmunity and sepsis. More recently, a role of lymphatic endothelial cells as well as vascular endothelial cells in the pathophysiology of inflammation and allo-immune reactions has been suggested. Development of novel therapeutic approaches to normalize endothelial dysfunction is currently an unmet medical need. Until now, the cellular and molecular mechanisms of mutual influences between endothelial dysfunction and human diseases remain largely unexplored, constituting a frontier hindering the development of new therapies. This Research Topic aims to build a forum for a wide range of scientific studies in the fields of endothelial dysfunction during inflammatory diseases and transplantation.
Book Synopsis Endothelial Dysfunction by : Helena Lenasi
Download or read book Endothelial Dysfunction written by Helena Lenasi and published by BoD – Books on Demand. This book was released on 2018-10-24 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endothelium enables communication between blood and tissues and is actively involved in cardiovascular homeostasis. Endothelial dysfunction has been recognized as an early step in the development of cardiovascular diseases: respectively, endothelium represents a potential therapeutic niche with multiple targets. The purpose of the book is to point out some recent findings of endothelial physiology and pathophysiology emphasizing various aspects of endothelial dysfunction connected to the body's internal and external environment. While basic features of the endothelium are presented in an introductory chapter, the authors of the following 17 chapters have provided extensive insight into some selected topics of endothelial (dys)function. The book would hopefully be useful for anyone interested in recapitulating endothelial (patho)physiology and expanding knowledge of molecular mechanisms involved in endothelial dysfunction, relevant also for further clinical investigations.
Book Synopsis Endothelial Dysfunction and Inflammation by : Shauna Dauphinee
Download or read book Endothelial Dysfunction and Inflammation written by Shauna Dauphinee and published by Springer. This book was released on 2010-09-16 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endothelial dysfunction is broadly defined as a disruption of the balance between vasoactive mediators and a propensity towards an inflammatory state. This volume provides an overview of the fields of endothelial dysfunction and inflammation through the discussion of topics ranging from the molecular biology of activated endothelial cells to the endothelium in inflammatory disease and therapeutic approaches targeting endothelial dysfunction. Topics include: Heterogeneity of the endothelium during inflammation, oxidative stress and endothelial dysfunction, biology and regulation of nitric oxide in inflammatory pathologies, endothelial dysfunction in inflammatory diseases, such as diabetes and atherosclerosis and Clinical methods used to assess endothelial function. This book brings together basic and clinical research to assist the reader in bridging connections from bench-to-bedside. Written by expert researchers in the fields of endothelial biology, inflammation research and clinical science, it serves as a useful reference for academic and industrial researchers, clinicians, and trainees in the medical profession.
Book Synopsis Endothelial Injury In Cardiac Transplantation by : Danny Ramzy
Download or read book Endothelial Injury In Cardiac Transplantation written by Danny Ramzy and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mechanisms of Vascular Disease by : Robert Fitridge
Download or read book Mechanisms of Vascular Disease written by Robert Fitridge and published by University of Adelaide Press. This book was released on 2011 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
Book Synopsis Endothelial Dysfunction by : Byeong Hwa Jeon
Download or read book Endothelial Dysfunction written by Byeong Hwa Jeon and published by Mdpi AG. This book was released on 2022-04-22 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dear colleagues, This Special Issue, "Endothelial Dysfunction: From Pathophysiology to Novel Therapeutic Approaches", focuses on the pathophysiology of endothelial dysfunction, new biomarkers for endothelial dysfunction related to cardiovascular disorders or tumors, and novel therapeutic approaches for endothelial dysfunctions. Vascular endothelium is an active tissue and plays a crucial role in the maintenance of vascular homeostasis. Chronic exposure to risk factors, such as hypertension, high cholesterolemia, or oxidative stress, induces endothelial dysfunctions and results in a loss of endothelial integrity, smooth muscle cell proliferation, and macrophage recruitment. The pathophysiology of endothelial dysfunction (ED) is complex and multi-factorial factors are involved, such as oxidative stress or chronic inflammation. The primary prevention of cardiovascular risk factors and endothelial dysfunctions, as well as the early detection of or molecular imaging techniques for endothelial dysfunction, helps to prevent the development of cardiovascular disorders. Novel therapeutic approaches or drug delivery systems for endothelial dysfunctions have had promising beneficial effects in preclinical or clinical levels by affecting the progression of atherosclerotic changes, tumor angiogenesis, and host-immune reactions near tumor environments.
Book Synopsis The Gastrointestinal Circulation by : Peter R. Kvietys
Download or read book The Gastrointestinal Circulation written by Peter R. Kvietys and published by Morgan & Claypool Publishers. This book was released on 2010 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt: The microcirculation of the gastrointestinal tract is under the control of both myogenic and metabolic regulatory systems. The myogenic mechanism contributes to basal vascular tone and the regulation of transmural pressure, while the metabolic mechanism is responsible for maintaining an appropriate balance between O2 demand and O2 delivery. In the postprandial state, hydrolytic products of food digestion elicit a hyperemia, which serves to meet the increased O2 demand of nutrient assimilation. Metabolically linked factors (e.g., tissue pO2, adenosine) are primarily responsible for this functional hyperemia. The fenestrated capillaries of the gastrointestinal mucosa are relatively permeable to small hydrolytic products of food digestion (e.g., glucose), yet restrict the transcapillary movement of larger molecules (e.g., albumin). This allows for the absorption of hydrolytic products of food digestion without compromising the oncotic pressure gradient governing transcapillary fluid movement and edema formation. The gastrointestinal microcirculation is also an important component of the mucosal defense system whose function is to prevent (and rapidly repair) inadvertent epithelial injury by potentially noxious constituents of chyme. Two pathological conditions in which the gastrointestinal circulation plays an important role are ischemia/reperfusion and chronic portal hypertension. Ischemia/reperfusion results in mucosal edema and disruption of the epithelium due, in part, to an inflammatory response (e.g., increase in capillary permeability to macromolecules and neutrophil infiltration). Chronic portal hypertension results in an increase in gastrointestinal blood flow due to an imbalance in vasodilator and vasoconstrictor influences on the microcirculation. Table of Contents: Introduction / Anatomy / Regulation of Vascular Tone and Oxygenation / Extrinsic Vasoregulation: Neural and Humoral / Postprandial Hyperemia / Transcapillary Solute Exchange / Transcapillary Fluid Exchange / Interaction of Capillary and Interstitial Forces / Gastrointestinal Circulation and Mucosal Defense / Gastrointestinal Circulation and Mucosal Pathology I: Ischemia/Reperfusion / Gastrointestinal Circulation and Mucosal Pathology II: Chronic Portal Hypertension / Summary and Conclusions / References / Author Biography
Book Synopsis The Endothelial Response to Injury by : Mitesh Vallabh Badiwala
Download or read book The Endothelial Response to Injury written by Mitesh Vallabh Badiwala and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Endothelial Dysfunction in Hypercholesterolemia and Obesity by : Poay Sian Lee
Download or read book Endothelial Dysfunction in Hypercholesterolemia and Obesity written by Poay Sian Lee and published by . This book was released on 2012 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis addresses endothelial pathologies in early cardiovascular disease. It examines risk factors such as hypercholesterolemia and obesity and explores adjunct treatment strategies and novel biomarkers. As well a comprehensive assessment of novel methodologies to assess endothelial function in man and patients with cardiovascular disease was undertaken. Patients with hypercholesterolemia are regularly treated with statins which effectively, and with minimal side effects, lower low density lipoprotein (LDL) cholesterol by 18-55% (Ballantyne, 2007). However, despite the efficacy of statin therapy, the majority of patients with hypercholesterolemia remain at higher risk of developing cardiovascular disease than healthy individuals (GISSI-HF Investigators 2008). Omega-3 fatty acids, members of the polyunsaturated fatty acids (PUFAs) family, have been demonstrated to be effective in reducing triglyceride levels and blood pressure (Lungershausen et al., 1994). Omega-6 fatty acids, on the other hand, have opposing actions (Dubnov & Berry 2004). Little, however, is known about the influence of the ratio of omega-6:omega-3 PUFAs. In Chapter 2, a dietary intervention examining the effects of altering omega-6:omega-3 PUFAs ratio on vascular health in patients on statins was conducted. We were primarily interested as to whether the introduction of a diet rich in PUFAs could improve vascular health in patients already on standard clinical care. A secondary interest was to study whether a low or high omega-6:omega-3 PUFAs ratio diet was more efficacious. We found that the diet interventions improved endothelial function and blood pressure but neither high nor low omega-6:omega-3 PUFAs ratio was better than the other. Obesity is the leading preventable cause of death worldwide, contributing to the likelihood of cardiovascular disease and type II diabetes. Cardiovascular risk factors are associated with decreased levels of circulating endothelial progenitor cells (EPCs), marked by combinations of CD133, CD34, CD117 and KDR markers in flow cytometry (Muller-Ehmsen et al., 2008) and increased intima-media thickness (IMT) (Lorenz et al., 2010). Weight reduction has been associated with reduction in cardiovascular risk factors (Karason et al., 1999; Muller-Ehmsen et al., 2008). In Muller-Ehmsen's study, the participants only underwent dietary intervention plus physical activity for six months and no study was performed to examine the function of EPCs in these subjects. In contrast, there was evidence of increased EPCs (colony forming units - a measure of EPC function) and increased IMT in the severely obese cohort in our study, which weight reduction had no impact on. Endothelial dysfunction, defined as decreased bioavailability of nitric oxide (NO), is an early manifestation in atherosclerosis (Kuvin et al., 2003). The evaluation of endothelial function in vivo is therefore commonly used to identify individuals at high risk for atherosclerosis, as well as for risk stratification of patients with established coronary artery disease (CAD) (Tousoulis et al., 2005). Several invasive and non-invasive techniques have been developed to evaluate endothelial function. Non-invasive techniques are clearly more advantageous in the clinical setting. Methodologies using flow-mediated dilation (FMD) assessed by Doppler and strain-gauge plethysmography are commonly used in human experimental research studies while the FDA approved EndoPAT-2000, a novel technique is arguably yet to be validated. In Chapter 5, we compared the assessment of endothelial function using this methodology against the other two better established methods in both healthy individuals and patients at high cardiovascular risk. We found evidence of endothelial dysfunction in the high cardiovascular risk group using all three techniques. However, while the correlation between both the established techniques were significant, neither correlated with assessment using the EndoPAT-2000. It is concluded that assessment of function using the EndoPAT-2000 requires further validation in this and other populations.
Book Synopsis PanVascular Medicine by : Peter Lanzer
Download or read book PanVascular Medicine written by Peter Lanzer and published by Springer. This book was released on 2015-03-30 with total page 5004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vascular management and care has become a truly multidisciplinary enterprise as the number of specialists involved in the treatment of patients with vascular diseases has steadily increased. While in the past, treatments were delivered by individual specialists, in the twenty-first century a team approach is without doubt the most effective strategy. In order to promote professional excellence in this dynamic and rapidly evolving field, a shared knowledge base and interdisciplinary standards need to be established. Pan Vascular Medicine, 2nd edition has been designed to offer such an interdisciplinary platform, providing vascular specialists with state-of-the art descriptive and procedural knowledge. Basic science, diagnostics, and therapy are all comprehensively covered. In a series of succinct, clearly written chapters, renowned specialists introduce and comment on the current international guidelines and present up-to-date reviews of all aspects of vascular care.
Book Synopsis Cardiovascular Disability by : Institute of Medicine
Download or read book Cardiovascular Disability written by Institute of Medicine and published by National Academies Press. This book was released on 2010-12-04 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Social Security Administration (SSA) uses a screening tool called the Listing of Impairments to identify claimants who are so severely impaired that they cannot work at all and thus immediately qualify for benefits. In this report, the IOM makes several recommendations for improving SSA's capacity to determine disability benefits more quickly and efficiently using the Listings.
Book Synopsis Coronary Microvascular Dysfunction by : Filippo Crea
Download or read book Coronary Microvascular Dysfunction written by Filippo Crea and published by Springer Science & Business Media. This book was released on 2013-08-15 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past two decades a number of studies have shown that abnormalities in the function and structure of coronary microcirculation can be detected in several cardiovascular diseases. On the basis of the clinical setting in which it occurs, coronary microvascular dysfunction (CMD) can be classified into four types: CMD in the absence of any other cardiac disease; CMD in myocardial diseases; CMD in obstructive epicardial coronary artery disease; and iatrogenic CMD. In some instances CMD represents an epiphenomenon, whereas in others it represents an important marker of risk or may contribute to the pathogenesis of myocardial ischemia, thus becoming a possible therapeutic target. This book provides an update on coronary physiology and a systematic assessment of microvascular abnormalities in cardiovascular diseases, in the hope that it will assist clinicians in prevention, detection and management of CMD in their everyday activity.
Book Synopsis Coronary Microvascular Obstruction in Acute Myocardial Infarction by : Giampaolo Niccoli
Download or read book Coronary Microvascular Obstruction in Acute Myocardial Infarction written by Giampaolo Niccoli and published by Academic Press. This book was released on 2018-07-07 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: Coronary Microvascular Obstruction in Acute Myocardial Infarction: From Mechanisms to Treatment provides a comprehensive understanding of the phenomenon of coronary microvascular obstruction (CMVO) that is the main limitation of reperfusion therapies in ST-elevation myocardial infarction. It provides in-depth coverage of the phenomenon of CMVO which heavily affects prognosis by increasing the risk of death and heart failure at follow-up. A first of its kind reference dedicated solely to this topic, it is appropriate for a wide audience, from researchers, to those who aid in the management, prevention and treatment of CMVO. Provides in-depth coverage of coronary microvascular obstruction (CMVO), spanning research, management, prevention and treatment Includes the most up-to-date information on CMVO as presented from top experts around the word Provides access to a companion website with extra material, including tables, additional references and instructional videos Gives extensive coverage on how to measure CMVO, including in-depth indexes that can be used to detect and quantify the phenomenon
Book Synopsis Trauma Induced Coagulopathy by : Hunter B. Moore
Download or read book Trauma Induced Coagulopathy written by Hunter B. Moore and published by Springer Nature. This book was released on 2020-10-12 with total page 802 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first edition of this publication was aimed at defining the current concepts of trauma induced coagulopathy by critically analyzing the most up-to-date studies from a clinical and basic science perspective. It served as a reference source for any clinician interested in reviewing the pathophysiology, diagnosis, and management of the coagulopathic trauma patient, and the data that supports it. By meticulously describing the methodology of most traditional as well as state of the art coagulation assays the reader is provided with a full understanding of the tests that are used to study trauma induced coagulopathy. With the growing interest in understanding and managing coagulation in trauma, this second edition has been expanded to 46 chapters from its original 35 to incorporate the massive global efforts in understanding, diagnosing, and treating trauma induced coagulopathy. The evolving use of blood products as well as recently introduced hemostatic medications is reviewed in detail. The text provides therapeutic strategies to treat specific coagulation abnormalities following severe injury, which goes beyond the first edition that largely was based on describing the mechanisms causing coagulation abnormalities. Trauma Induced Coagulopathy 2nd Edition is a valuable reference to clinicians that are faced with specific clinical challenges when managing coagulopathy.
