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Are Rodent Models Fit For Investigation Of Human Obesity And Related Diseases
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Book Synopsis Are Rodent Models Fit for Investigation of Human Obesity and Related Diseases? by : Patrick C. Even
Download or read book Are Rodent Models Fit for Investigation of Human Obesity and Related Diseases? written by Patrick C. Even and published by Frontiers Media SA. This book was released on 2018-02-15 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: Not only developed countries, but also most developing areas of the world, have experienced a surge in obesity prevalence over recent decades. Obesity complications are now among the leading causes of premature mortality, encompassing conditions such as coronary heart disease, stroke, and type 2 diabetes. This places a heavy burden on contemporary healthcare systems. While rodent models have limitations as experimental models of human obesity-related disease, study of rats and mice either spontaneously prone - or resistant - to obesity, or genetically engineered to illuminate underlying mechanisms has yielded key information about the metabolic defects linked to obesity, and their associated diseases. This topic includes both original research studies and reviews of the use of animal studies in specific areas of obesity-related disease. Various methodological approaches are discussed, with evaluation of the extent to which use of animal models has facilitated progress, or, conversely, has proved a cul de sac in investigation of human disease mechanisms. Consideration is also given to future strategies to use such rodent models optimally to enhance comprehension and treatment of pandemic human obesity-related diseases.
Book Synopsis Are Rodent Models Fit for Investigation of Human Obesity and Related Diseases?. by :
Download or read book Are Rodent Models Fit for Investigation of Human Obesity and Related Diseases?. written by and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Not only developed countries, but also most developing areas of the world, have experienced a surge in obesity prevalence over recent decades. Obesity complications are now among the leading causes of premature mortality, encompassing conditions such as coronary heart disease, stroke, and type 2 diabetes. This places a heavy burden on contemporary healthcare systems. While rodent models have limitations as experimental models of human obesity-related disease, study of rats and mice either spontaneously prone - or resistant - to obesity, or genetically engineered to illuminate underlying mechanisms has yielded key information about the metabolic defects linked to obesity, and their associated diseases. This topic includes both original research studies and reviews of the use of animal studies in specific areas of obesity-related disease. Various methodological approaches are discussed, with evaluation of the extent to which use of animal models has facilitated progress, or, conversely, has proved a cul de sac in investigation of human disease mechanisms. Consideration is also given to future strategies to use such rodent models optimally to enhance comprehension and treatment of pandemic human obesity-related diseases.
Book Synopsis Animal Models for the Study of Human Disease by : Louise Thibault
Download or read book Animal Models for the Study of Human Disease written by Louise Thibault and published by Elsevier Inc. Chapters. This book was released on 2013-05-29 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt: This chapter aims to review literature on different aspects of obesity from fat-rich diets in non-human species. Usefulness of using small rodents in animal models to infer aspects of human obesity is discussed in terms of similarities and differences and how obesity is defined. The paradigm of using fat-rich diets in animal models of human obesity is explored according to its adequacy and dietary characteristics related to fatty acid composition. Physiological factors and mechanisms that can play a role in the development of obesity induced by a diet rich in fat are examined, namely the efficiency of nutrient utilization and the possible lack of inhibitory effect of fat on intake. The role of hormones such as leptin, ghrelin and insulin is discussed. Bevavioural mechanisms related to sensory-specific facilitation of eating with fat rich diets, altered feeding rhythmicity and learned eating are considered. The possible reversal of fat-rich diet induced obesity in animal models is explored. This chapter concludes with comments on appropriate design of animal studies and suggestions for future research.
Book Synopsis Dietary Induction Models of Nutritional Disorders in Rodents by : Jailane de Souza Aquino
Download or read book Dietary Induction Models of Nutritional Disorders in Rodents written by Jailane de Souza Aquino and published by Cambridge Scholars Publishing. This book was released on 2023-06-16 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses one of the most controversial topics in Ethics and Bioethics since the beginning of physiology and comparative anatomy, as viewed from the perspective of experienced researchers in the fields of nutrition, bioethics and translational research. The book provides up-to-date information on dietary induction models of diabetes, obesity, hypertension, dyslipidaemia and malnutrition in experimental animal models, with a focus and direction for future clinical studies in the area of health sciences. It directly describes the importance of pre-clinical studies in the construction of translational research, being useful for academic-scientific institutions, students and health professionals such as nutritionists, doctors, pharmacists, psychologists, and nurses, among others.
Book Synopsis Eat Like a Pig, Run Like a Horse by : Anastacia Marx de Salcedo
Download or read book Eat Like a Pig, Run Like a Horse written by Anastacia Marx de Salcedo and published by Simon and Schuster. This book was released on 2022-07-05 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is no magic pill. There is no perfect diet. Could it be that our underlying assumption—that what we’re eating is making us fat and sick—is just plain wrong? To address the rapid rise of “lifestyle diseases” like diabetes and heart disease, scientists have conducted a whopping 500,000 studies of diet and another 300,000 of obesity. Journalists have written close to 250 million news articles combined about these topics. Yet nothing seems to halt the epidemic. Anastacia Marx de Salcedo’s Eat Like a Pig, Run Like a Horse looks not just to data-driven science, but to animals and the natural world around us for a new approach. What she finds will transform the national debate about the root causes of our most pervasive diseases and offer hope of dramatically reducing the number who suffer—no matter what they eat. It all began with her own medical miracle—she has multiple sclerosis but has discovered that daily exercise was key to keeping it from progressing. And now, new research backs up her own experience. This revelation prompted Marx de Salcedo to ask what would happen if people with lifestyle illnesses put physical activity front and center in their daily lives? Eat Like a Pig, Run Like a Horse takes us on a fascinating journey that weaves together true confessions, mad(ish) scientists, and beguiling animal stories. Marx de Salcedo shows that we need to move beyond our current diet-focused model to a new, dynamic concept of metabolism as regulated by exercise. Suddenly the answer to good health is almost embarrassingly simple. Don’t worry about what you eat. Worry about how much you move. In a few years’ time, adhering to a finicky Keto, Paleo, low-carb, or any other special diet to stay healthy will be as antiquated as using Daffy’s Elixir or Dr. Bonker’s Celebrated Egyptian Oil—popular “medicines” from the 1800s—to cure disease. And just as the 19th-century health revolution was based on a new understanding that the true cause of malaria, tuberculosis, and cholera was microorganisms, so the coming 21st-century one will be based on our new understanding that exercise is the only way to metabolic health. Fascinating and brilliant, Eat Like a Pig, Run Like a Horse is primed to usher in that new era.
Book Synopsis Neural Control of Energy Homeostasis and Energy Homeostasis Regulation of Brain Function by : Lionel Carneiro
Download or read book Neural Control of Energy Homeostasis and Energy Homeostasis Regulation of Brain Function written by Lionel Carneiro and published by Frontiers Media SA. This book was released on 2022-04-26 with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Why We Age written by Steven N. Austad and published by Wiley. This book was released on 1999-03-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Why has the life span of the average American increased from 48 to 75 years in this century alone? . . . If the body is a machine that simply wears out, why do some cells seem immortal? . . . Is there an aging gene? And can we control it? . . . Can antioxidants and hormone therapy actually slow the aging process and extend life? Steven Austad s compelling book investigates the history, the theories, and the personalities behind the quest to understand the nature of aging. Here is hard evidence from the front lines of research that science is finally closing in on the fundamental processes of human biology and life. "Austad s book can be read with pleasure and profit by any intelligent person with a smattering of biological knowledge." Science "In this clear, engrossing overview, Austad takes the sting out of a subject that will ultimately capture us all." Publishers Weekly "Why We Age is remarkably rigorous in its analysis and thorough scope. . . . A comprehensive examination of its topic." Science Editors, Amazon.com "The problem with long life is that one keeps getting older; here s an able and clearly written summary of the latest theories on why we age and what might be done to ameliorate the process." Kirkus Reviews
Book Synopsis Human Microbiome by : Mohsin Khurshid
Download or read book Human Microbiome written by Mohsin Khurshid and published by Springer Nature. This book was released on with total page 721 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Microbiome in Human Health and Disease by : Pallaval Veera Bramhachari
Download or read book Microbiome in Human Health and Disease written by Pallaval Veera Bramhachari and published by Springer Nature. This book was released on 2021-10-18 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides an overview on how the microbiome contributes to human health and disease. The microbiome has also become a burgeoning field of research in medicine, agriculture & environment. The readers will obtain profound knowledge on the connection between intestinal microbiota and immune defense systems, medicine, agriculture & environment. The book may address several researchers, clinicians and scholars working in biomedicine, microbiology and immunology. The application of new technologies has no doubt revolutionized the research initiatives providing new insights into the dynamics of these complex microbial communities and their role in medicine, agriculture & environment shall be more emphasized. Drawing on broad range concepts of disciplines and model systems, this book primarily provides a conceptual framework for understanding these human-microbe, animal-microbe & plant-microbe, interactions while shedding critical light on the scientific challenges that lie ahead. Furthermore this book explains why microbiome research demands a creative and interdisciplinary thinking—the capacity to combine microbiology with human, animal and plant physiology, ecological theory with immunology, and evolutionary perspectives with metabolic science.This book provides an accessible and authoritative guide to the fundamental principles of microbiome science, an exciting and fast-emerging new discipline that is reshaping many aspects of the life sciences. These microbial partners can also drive ecologically important traits, from thermal tolerance to diet in a typical immune system, and have contributed to animal and plant diversification over long evolutionary timescales. Also this book explains why microbiome research presents a more complete picture of the biology of humans and other animals, and how it can deliver novel therapies for human health and new strategies.
Book Synopsis Weight Management by : Institute of Medicine
Download or read book Weight Management written by Institute of Medicine and published by National Academies Press. This book was released on 2003-12-01 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: The primary purpose of fitness and body composition standards in the U.S. Armed Forces has always been to select individuals best suited to the physical demands of military service, based on the assumption that proper body weight and composition supports good health, physical fitness, and appropriate military appearance. The current epidemic of overweight and obesity in the United States affects the military services. The pool of available recruits is reduced because of failure to meet body composition standards for entry into the services and a high percentage of individuals exceeding military weight-for-height standards at the time of entry into the service leave the military before completing their term of enlistment. To aid in developing strategies for prevention and remediation of overweight in military personnel, the U.S. Army Medical Research and Materiel Command requested the Committee on Military Nutrition Research to review the scientific evidence for: factors that influence body weight, optimal components of a weight loss and weight maintenance program, and the role of gender, age, and ethnicity in weight management.
Book Synopsis The Surgeon General's Call to Action to Prevent and Decrease Overweight and Obesity by :
Download or read book The Surgeon General's Call to Action to Prevent and Decrease Overweight and Obesity written by and published by Office of the Surgeon General. This book was released on 2001 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt: Promotes the recognition, treatment, and prevention of conditions of overweight and obesity in the United States.
Book Synopsis The Nature of Nutrition by : Stephen J. Simpson
Download or read book The Nature of Nutrition written by Stephen J. Simpson and published by Princeton University Press. This book was released on 2012-07-22 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nutrition has long been considered more the domain of medicine and agriculture than of the biological sciences, yet it touches and shapes all aspects of the natural world. The need for nutrients determines whether wild animals thrive, how populations evolve and decline, and how ecological communities are structured. 'The Nature of Nutrition' addresses nutrition's enormously complex role in biology, both at the level of individual organisms and in their broader ecological interactions.
Author :Expert Panel on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults (U.S.) Publisher : ISBN 13 : Total Pages :306 pages Book Rating :4.:/5 (319 download)
Book Synopsis Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults by : Expert Panel on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults (U.S.)
Download or read book Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults written by Expert Panel on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults (U.S.) and published by . This book was released on 1998 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of evidence-based recommendations -- Introduction -- Overweight and obesity: background -- Examination of randomized controlled trial evidence -- Treatment guidelines -- Summary of recommendations -- Future research.
Book Synopsis Cells and Materials for Disease Modeling and Regenerative Medicine by : Ander Abarrategi
Download or read book Cells and Materials for Disease Modeling and Regenerative Medicine written by Ander Abarrategi and published by MDPI. This book was released on 2021-05-05 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Materials science and engineering are strongly developing tools with increasing impact in the biotechnological and biomedical areas. Interestingly, research in molecular and cellular biology is often at the core of the design and development of materials-based approaches, providing biological rationale. Focused on research relying on biology–materials interaction, IJMS launched a Special Issue named “Cells and Materials for Disease Modeling and Regenerative Medicine”. The aim of the Special Issue was to generate a compilation of in vitro and in vivo strategies based on cell–material interactions. This book compiles the papers published in that Special Issue and includes a selection of six original scientific experimental articles and six comprehensive reviews. We are convinced that this collection of articles shows representative examples of the state of the art in the field, unveiling the relevance of materials research in generating new regenerative medicine and disease modeling approaches.
Book Synopsis Diet and Health by : National Research Council
Download or read book Diet and Health written by National Research Council and published by National Academies Press. This book was released on 1989-01-01 with total page 765 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diet and Health examines the many complex issues concerning diet and its role in increasing or decreasing the risk of chronic disease. It proposes dietary recommendations for reducing the risk of the major diseases and causes of death today: atherosclerotic cardiovascular diseases (including heart attack and stroke), cancer, high blood pressure, obesity, osteoporosis, diabetes mellitus, liver disease, and dental caries.
Book Synopsis Animal Models for the Study of Human Disease by : P. Michael Conn
Download or read book Animal Models for the Study of Human Disease written by P. Michael Conn and published by Academic Press. This book was released on 2013-05-29 with total page 1109 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse. - Organized by disease orientation for ease of searchability - Provides information on locating resources, animal alternatives and animal ethics - Covers a broad range of animal models used in research for human disease
Book Synopsis Animal Models for the Study of Human Disease by : Heather A. Lawson
Download or read book Animal Models for the Study of Human Disease written by Heather A. Lawson and published by Elsevier Inc. Chapters. This book was released on 2013-05-29 with total page 62 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolic syndrome (MetS) is a clustering of metabolic complications representing a pre-morbid condition that is a substantial public health burden. Animal models provide an opportunity to examine correlations among different metabolic parameters to understand why metabolic complications sometimes cluster and sometimes do not. This chapter provides an overview of animal models of MetS that are used to understand etiology and pathophysiology, with a focus on methods of identifying and testing candidate genes with the aim of translating results to human studies. Genetic, epigenetic, environmental, and gene by environmental methods and results are discussed along with important lessons learned. Rodent models are the most frequently used, however other animal models including dogs, pigs, sheep, and non-human primates have contributed to our understanding of MetS and each are discussed. Additionally, animal models used to test physiological hypotheses are reviewed along with their potential to illuminate DNA sequence–metabolic function relationships to inform therapies.
