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Anxiolytic Carbolines
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Book Synopsis Anxiolytic β-Carbolines by : David N. Stephens
Download or read book Anxiolytic β-Carbolines written by David N. Stephens and published by Springer Science & Business Media. This book was released on 2013-03-07 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the discovery some 15 years ago of benzodiazepine modulatory sites associated with GABA A receptors, great effort has gone into understanding their molecular pharmacology and into developing new anxiolytic drugs that interact selectively with them. Prominent in this research has beenthe discovery that ~-carbolines, a different chemical class from benzodiazepines, also act at these receptors but that their effects are sometimes quite different from those of the benzodiazepines.This book documents the latest discoveries in the molecular biology of the GABA A receptor and reveals how an integration of the results of research inmolecular biology, synthetic chemistry, biochemical and behavioral pharmacology, and clinical pharmacology has paved the way forthe development of ~-carbolines from substances inducing anxiety and convulsions to a novel therapy for anxiety states, achieving a behavioral selectivity through selective actions at subtypes of receptors.
Download or read book Anxiolytics written by Mike Briley and published by Birkhäuser. This book was released on 2012-12-06 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: For over thirty years the benzodiazepines monopolised not only the anxiolytic market but also clinical and animal research in anxiety. Indeed many animal tests developed since the 1960s have been optimised for the benzodiazepines and some programmes have even screened candidates as potential anxiolytics on their benzodiazepine-like side-effects rather than their anxiolytic activity. With the realisation of the drawbacks of the benzodiazepines, namely their potential for tolerance and dependency, there has been a renewed interest in alternative anxiolytics both from existing drugs such as the tricyclic and monoamine oxidase antidepressants and from newer agents such as buspirone. In addition anxiety is no longer considered to be a unique entity but rather an umbrella term for a series of specific anxiety disorders such as panic disorder without or with agoraphobia, generalised anxiety disorder (GAD), specific phobias, social phobias and post-traumatic stress disorder (PTSD). These new clinical categories have opened another dimension in the therapy of anxiety requiring the optimisation of treatments for different syndromes. This book is a critical review of today's anxiolytics and those that may become the anxiolytics of tomorrow. What is clear is that currently there are few clinically satisfactory alternatives to the benzodiazepines for the treatment of acute anxiety. For chronic anxiety, it is generally agreed that benzodi azepines are not the treatment of first choice. The tricyclic and monoamine oxidase antidepressants, the serotonin reuptake inhibitors and buspirone offer better solutions for chronic anxiety but they are still far from being ideal.
Book Synopsis β-Carbolines by : Keshav Lalit Ameta
Download or read book β-Carbolines written by Keshav Lalit Ameta and published by CRC Press. This book was released on 2024-11-29 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: β-Carbolines: A Privileged Scaffold for Modern Drug Discovery provides a summary of methods for the synthesis of various natural products engineered with the diverse β-carboline scaffold and their biological evaluation. β-carboline and its derivatives have generated considerable interest in recent years for their versatile properties in chemistry and pharmacology. This is due to their ability to act as agonists to benzodiazepine receptors, hydroxy serotonin receptors, and intercalate into DNA and to inhibit CDK, topisomerase, and monoamine oxidase enzymes. Their pharmacological properties include anxiolytic, hypnotic, anticonvulsant, antiviral, antiparasitic, and antimicrobial attributes. This book provides a summary of methods for the synthesis of various natural products engineered with the diverse β-carboline scaffold and their biological evaluation. Features: Focuses on the different application and therapies of β-carbolines. Provides a summary of methods for the synthesis of various natural products engineered with the diverse β-carbolines. Discusses methods of biological evaluation of β-carbolines. Explores different chemical transformations occurring with synthesis using β-carbolines. Covers both heterocyclic synthesis and multicomponent synthesis related to β-carboline. This text is key reading for researchers in medicinal chemistry and drug discovery looking to understand the broad potential of β-carbolines.
Download or read book Anxiety written by N. Sartorius and published by Taylor & Francis. This book was released on 1990 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1990. Routledge is an imprint of Taylor & Francis, an informa company.
Book Synopsis Anxiety and the Anxiety Disorders by : A. H. Tuma
Download or read book Anxiety and the Anxiety Disorders written by A. H. Tuma and published by Routledge. This book was released on 2019-01-22 with total page 1069 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 1980s have been called the decade of anxiety. Not only is this true of the popular press, but students of behavior and psychopathology have contributed to the rather sudden reemergence of anxiety as a respectable and fascinating field of investigation. This volume is a culmination of more than two years of planning, literature reviews, writing, conference discussions, revising of original papers, and integrating the material for final publication. It is a series of interrelated statements about research on anxiety and the anxiety disorders written by many of the leading investigators currently active in this field. First published in 1985. Routledge is an imprint of Taylor & Francis, an informa company.
Book Synopsis Behavioural Models in Psychopharmacology by : Paul Willner
Download or read book Behavioural Models in Psychopharmacology written by Paul Willner and published by Cambridge University Press. This book was released on 1991-02-21 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Behavioural models in psychopharmacology are used for different purposes. The main concern of industrial psychopharmacologists is specifically to develop new and improved drugs for the treatment of mental disorders, while basic scientists use animal models to investigate the underlying nature of such conditions. The important distinction between these different perspectives is made explicit for the first time in this book. By considering such conditions as anxiety, depression, mania and schizophrenia, feeding disorders, dementia, and drug dependence, this book provides a comprehensive and critical review of the adequacy of the behavioural procedures used by psychopharmacologists to model psychiatric disorders. Graduate students and research workers in pscyhopharmacology, from both academic and industrial spheres, as well as clinicians, will find this book of considerable interest.
Download or read book Psychopharmacology Bulletin written by and published by . This book was released on 1966 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Research Methodology in Chemical Sciences by : Tanmoy Chakraborty
Download or read book Research Methodology in Chemical Sciences written by Tanmoy Chakraborty and published by CRC Press. This book was released on 2017-03-03 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent Methodology in Chemical Sciences provides an eclectic survey of contemporary problems in experimental, theoretical, and applied chemistry. This book covers recent trends in research with the different domain of the chemical sciences. The chapters, written by knowledgeable researchers, provide different insights to the modern-day research in the domain of spectroscopy, plasma modification, and theoretical and computational analysis of chemical problems. It covers descriptions of experimental techniques, discussions on theoretical modeling, and much more.
Book Synopsis Benzodiazepine Receptor Ligands, Memory and Information Processing by : Ian Hindmarch
Download or read book Benzodiazepine Receptor Ligands, Memory and Information Processing written by Ian Hindmarch and published by Springer Science & Business Media. This book was released on 2013-03-12 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: The following papers were presented at an international workshop on benzo diazepine receptor ligands, memory and information processing, held during the 15th CINP meeting in Puerto Rico in December 1986 and organised by the editors and T. Roth. This workshop was aimed at reviewing and reflecting on past experience with benzodiazepines, evaluating the current state of knowledge of the actions of psychotropic orugs (particularly benzodiazepines, fJ-carbolines and benzodiazepine antagonists), and laying a basis of interest and speculation for future research into the potential use of these drugs in disorders of memory and information processing. There is much published material regarding the theoretical underpinnings of what psychologists call "memory", and doubtless there will be several more libraries filled with theses on the topic before a consensus is reached as regards basic definitions or even meaningful distinctions between for example, "short" and "long"-term memory - everyone has his own particular theory. The qualitative and quantitative diversity of the different approaches might seem to present an insurmountable problem for the psychologist seeking a unified conceptual framework. In practice the various theories produce a plethora of pragmatic and experimental techniques for psychopharmacologists and clinicians to use when investigating drugs with putative amnestic or promnestic properties.
Book Synopsis Annual Reports in Medicinal Chemistry by :
Download or read book Annual Reports in Medicinal Chemistry written by and published by Academic Press. This book was released on 1983-09-01 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annual Reports in Medicinal Chemistry
Book Synopsis Foye's Principles of Medicinal Chemistry by : David A. Williams
Download or read book Foye's Principles of Medicinal Chemistry written by David A. Williams and published by Lippincott Williams & Wilkins. This book was released on 2002 with total page 1136 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive Fifth Edition has been fully revised and updated to meet the changing curricula of medicinal chemistry courses. The new emphasis is on pharmaceutical care that focuses on the patient, and on the pharmacist a therapeutic clinical consultant, rather than chemist. Approximately 45 contributors, respected in the field of pharmacy education, augment this exhaustive reference. New to this edition are chapters with standardized formats and features, such as Case Studies, Therapeutic Actions, Drug Interactions, and more. Over 700 illustrations supplement this must-have resource.
Download or read book Anxiety written by Michel Hamon and published by John Libbey Eurotext. This book was released on 1993 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although everybody had and will experience anxiety, its intensity, frequency and characteristics may vary from what can be considered as "normal" to pathological. The development of benzodiazepine as anxiolytics has been a major step firstly in therapeutics and secondly in the understanding of the associated biological mechanisms. Recently, new drugs without secondary effects of benzodiazepines have been developed. The purpose of the book was to take stock of the present knowledge: clinical aspects of pathological anxiety, neurobiological mechanisms associated with stress and anxiety, molecular targets of potent anxiolytic drugs, new issues and directions.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1994 with total page 1364 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Current Topics in Animal Learning by : Lawrence Dachowski
Download or read book Current Topics in Animal Learning written by Lawrence Dachowski and published by Psychology Press. This book was released on 2013-02-01 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, based on the Flowerree Mardi Gras Symposium at Tulane University, juxtaposes contemporary research and theory from several areas of animal learning -- learning theory, comparative cognition, animal models of human behavior, and functional neurology. Investigators pursuing these different routes often work in isolation of progress being made in, what should be, related fields. This book will acquaint students and researchers with a variety of topics, ordinarily treated separately, in a way that will stimulate integrative thinking. Cognitive interpretations of animal learning are included, as well as recent developments in conditioning theory, physiological bases of learning, animal models of human behavior problems, and psychopharmacology.
Download or read book Psychopharmacology written by Jerry Meyer and published by Oxford University Press. This book was released on 2022-05-25 with total page 841 pages. Available in PDF, EPUB and Kindle. Book excerpt: Unique in its breadth of coverage ranging from historical accounts of drug use to clinical and preclinical behavioral studies, Psychopharmacology is appropriate for undergraduates studying the relationships between the behavioral effects of psychoactive drugs and their mechanisms of action. 1. Chapter-opening vignettes foster student engagement 2. Breakout boxes present novel, and, in some cases, controversial topics for special discussion. Box themes include: History of Psychopharmacology; Pharmacology in Action; Clinical Applications; Of Special Interest; and The Cutting Edge. 3. The book is extensively illustrated with full-color photographs and line art depicting important concepts and experimental data 4. Section Summaries highlight key concepts from the section of text just read 5. Chapter-ending Recommended Readings offer suggestions for further study And the enhanced eBook provides an interactive learning pathway through the content. Meyer, Psychopharmacology and it's accompanying enhanced ebook provide engaging features like self-study questions, and clinical case studies, cutting edge research, and applied pharmacology to keep students focused on the content, while providing the scientific depth, breadth, and rigor required for the course.
Book Synopsis Recognition and Management of Anxiety Syndromes by : Hans-Ulrich Wittchen
Download or read book Recognition and Management of Anxiety Syndromes written by Hans-Ulrich Wittchen and published by . This book was released on 1998 with total page 70 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Psychopharmacology of Anxiolytics and Antidepressants by : S.E. File
Download or read book Psychopharmacology of Anxiolytics and Antidepressants written by S.E. File and published by Elsevier. This book was released on 2016-04-20 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contributed volume reviewing the clinical and animal literature related to the pharmacology of anxiety and depression. The role of the hypothalmic-pituitary-adrenal axis in anxiety and depression is reviewed as well as the response of central catecholamines to chronic stress.
