Antivirals For Pandemic Influenza

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Antivirals for Pandemic Influenza

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309118662
Total Pages : 132 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Antivirals for Pandemic Influenza by : Institute of Medicine

Download or read book Antivirals for Pandemic Influenza written by Institute of Medicine and published by National Academies Press. This book was released on 2008-07-11 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: Planning for an influenza pandemic, whether it occurs in the near or distant future, will need to take into account many constantly evolving factors. The Institute of Medicine (IOM) Committee on Implementation of Antiviral Medication Strategies for an Influenza Pandemic was asked by the Department of Health and Human Services, (DHHS) to consider best practices and policies for providing antiviral treatment and prophylaxis during a pandemic event. The committee's report, entitled Antivirals for Pandemic Influenza: Guidance on Developing a Distribution and Dispensing Program, calls for a national and public process of creating an ethical framework for antiviral use within the context of uncertainty and scarcity. It is unclear whether antivirals will work against a pandemic strain as well as they work against seasonal influenza. Also, government stockpiles may not be sufficient for all possible uses in part because antivirals are costly and public health agencies must invest in other important activities, including other medical resources for pandemic influenza. Furthermore, the report identifies the lack of a science-based advisory body to guide decision making during the pandemic, including guidance on all dimensions of antiviral dispensing (for example, prioritization, drug safety, and antiviral resistance). The report also acknowledges the need for diverse methods and sites of dispensing, and discusses their advantages and disadvantages.

Influenza Pandemic

Author : Marcia Crosse
Publisher : DIANE Publishing
ISBN 13 : 1437900062
Total Pages : 76 pages
Book Rating : 4.4/5 (379 download)

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Book Synopsis Influenza Pandemic by : Marcia Crosse

Download or read book Influenza Pandemic written by Marcia Crosse and published by DIANE Publishing. This book was released on 2008-11 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pandemic influenza poses a threat to public health at a time when the U.N.¿s World Health Organization has said that infectious diseases are spreading faster than at any time in history. The last major influenza pandemic occurred from 1918 to 1919. Estimates of deaths worldwide if a similar pandemic were to occur have ranged between 30 million and 384 million people. Individual countries and international organizations have developed and begun to implement a strategy for forestalling the onset of a pandemic. Antivirals and vaccines may help do so. This report examines: (1) constraints upon the use of antivirals and vaccines to forestall a pandemic; and (2) efforts under way to overcome these constraints. Charts and tables.

Public Engagement on Facilitating Access to Antiviral Medications and Information in an Influenza Pandemic

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309256976
Total Pages : 56 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Public Engagement on Facilitating Access to Antiviral Medications and Information in an Influenza Pandemic by : Institute of Medicine

Download or read book Public Engagement on Facilitating Access to Antiviral Medications and Information in an Influenza Pandemic written by Institute of Medicine and published by National Academies Press. This book was released on 2012-07-20 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt: Influenza pandemics overwhelm health care systems with thousands or hundreds of thousands of sick patients, as well as those worried they may be sick. In order to ensure a successful response to the patient swell caused by a pandemic, robust planning is essential to prepare for challenges public health officials may face. This includes the need to quickly distribute and dispense antiviral medications that can reduce the severity and duration of disease to large numbers of people. In response to a request from the Centers for Disease Control, the Institute of Medicine's Forum on Medical and Public Health Preparedness for Catastrophic Events held a series of workshops that explored the public's perception of how to facilitate access to antiviral medications and treatment during an influenza pandemic. To help inform potential strategies still in the development stages at the CDC, workshops were held in Fort Benton, Montana; Chattanooga, Tennessee; and Los Angeles, California during February and March 2012 to consider the usefulness of several alternative strategies of delivering antiviral medication to the public. Participants considered how the normal systems for prescribing and dispensing antiviral medications could be adjusted to ensure that the public has quick, safe, and equitable access to both potentially life-saving drugs and information about the pandemic and treatment options. This document summarizes the workshops.

Pandemic Influenza Preparedness and Response

Author : World Health Organization
Publisher : World Health Organization
ISBN 13 : 9241547685
Total Pages : 62 pages
Book Rating : 4.2/5 (415 download)

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Book Synopsis Pandemic Influenza Preparedness and Response by : World Health Organization

Download or read book Pandemic Influenza Preparedness and Response written by World Health Organization and published by World Health Organization. This book was released on 2009 with total page 62 pages. Available in PDF, EPUB and Kindle. Book excerpt: This guidance is an update of WHO global influenza preparedness plan: the role of WHO and recommendations for national measures before and during pandemics, published March 2005 (WHO/CDS/CSR/GIP/2005.5).

The Threat of Pandemic Influenza

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309095042
Total Pages : 431 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis The Threat of Pandemic Influenza by : Institute of Medicine

Download or read book The Threat of Pandemic Influenza written by Institute of Medicine and published by National Academies Press. This book was released on 2005-04-09 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Public health officials and organizations around the world remain on high alert because of increasing concerns about the prospect of an influenza pandemic, which many experts believe to be inevitable. Moreover, recent problems with the availability and strain-specificity of vaccine for annual flu epidemics in some countries and the rise of pandemic strains of avian flu in disparate geographic regions have alarmed experts about the world's ability to prevent or contain a human pandemic. The workshop summary, The Threat of Pandemic Influenza: Are We Ready? addresses these urgent concerns. The report describes what steps the United States and other countries have taken thus far to prepare for the next outbreak of "killer flu." It also looks at gaps in readiness, including hospitals' inability to absorb a surge of patients and many nations' incapacity to monitor and detect flu outbreaks. The report points to the need for international agreements to share flu vaccine and antiviral stockpiles to ensure that the 88 percent of nations that cannot manufacture or stockpile these products have access to them. It chronicles the toll of the H5N1 strain of avian flu currently circulating among poultry in many parts of Asia, which now accounts for the culling of millions of birds and the death of at least 50 persons. And it compares the costs of preparations with the costs of illness and death that could arise during an outbreak.

National Strategy for Pandemic Influenza

Author :
Publisher : Executive Office of the President
ISBN 13 :
Total Pages : 246 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis National Strategy for Pandemic Influenza by :

Download or read book National Strategy for Pandemic Influenza written by and published by Executive Office of the President. This book was released on 2006 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Implementation Plan for the National Strategy for Pandemic Influenza clarifies the roles and responsibilities of governmental and non-governmental entities, including Federal, State, local, and tribal authorities and regional, national, and international stakeholders, and provides preparedness guidance for all segments of society.

Combating the Threat of Pandemic Influenza

Author : Paul F. Torrence
Publisher : John Wiley & Sons
ISBN 13 : 0470179708
Total Pages : 308 pages
Book Rating : 4.4/5 (71 download)

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Book Synopsis Combating the Threat of Pandemic Influenza by : Paul F. Torrence

Download or read book Combating the Threat of Pandemic Influenza written by Paul F. Torrence and published by John Wiley & Sons. This book was released on 2007-09-28 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug discovery for influenza antivirals Priorities for combating pandemic influenza include rapid detection and identification, the quick administration of available drugs to treat the infection, the development of new antivirals, and the development of vaccines. Since lead-time may be required to produce an effective vaccine, antivirals would serve as a key first line of defense in containing an outbreak. Diverse antivirals, acting through different mechanisms, would help stay the development of resistant viruses. Thus, drug discovery for influenza antivirals is an important public health–related endeavor. With chapters contributed by leading international specialists, this guide gets readers up to speed on the latest advances and technologies in diverse approaches to drug discovery, covering: Existing antivirals, including broadly effective anti-respiratory virus agents The development of high-throughput screening assays IFN resistance The development of nucleic acid–based antiviral drugs Antiviral RNAi strategies targeting influenza virus Other promising antiviral drug discovery strategies Combating the Threat of Pandemic Influenza: Drug Discovery Approaches consolidates the latest information on diverse approaches into one comprehensive resource. It is an invaluable, hands-on reference for researchers in medicinal chemistry, pharmaceutical chemistry, drug discovery, biochemistry, virology, microbiology, and public health.

Antiviral Drug Discovery and Development

Author : Xinyong Liu
Publisher : Springer Nature
ISBN 13 : 9811602670
Total Pages : 357 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Antiviral Drug Discovery and Development by : Xinyong Liu

Download or read book Antiviral Drug Discovery and Development written by Xinyong Liu and published by Springer Nature. This book was released on 2021-07-13 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes state-of-the-art antiviral drug design and discovery approaches starting from natural products to de novo design, and provides a timely update on recently approved antiviral drugs and compounds in advanced clinical development. Special attention is paid to viral infections with a high impact on the world population or highly relevant from the public health perspective (HIV, hepatitis C, influenza virus, etc.). In these chapters, limitations associated with adverse effects and emergence of drug resistance are discussed in detail. In addition to classical antiviral strategies, chapters will be dedicated to discuss the non-classical drug development strategies to block viral infection, for instance, allosteric inhibitors, covalent antiviral agents, or antiviral compounds targeting protein–protein interactions. Finally, current prospects for producing broad-spectrum antiviral inhibitors will be also addressed. The book is distinctive in providing the most recent update in the rapidly evolving field of antiviral therapeutics. Authoritative reviews are written by international scientists well known for their contributions in their topics of research, which makes this book suitable for researchers not only within the antiviral research community but also attractive to a broad audience in the drug discovery field. This book covers molecular structures and biochemical mechanisms mediating the antiviral effects, while discussing various ligand design strategies, which include traditional medicinal chemistry, computational chemistry, and chemical biology approaches. The book provides a comprehensive review of antiviral drug discovery and development approaches, particularly focusing on current innovations and future trends.

Influenza pandemic

Author : United States. Government Accountability Office
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (765 download)

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Book Synopsis Influenza pandemic by : United States. Government Accountability Office

Download or read book Influenza pandemic written by United States. Government Accountability Office and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Crisis and Emergency Risk Communication

Author : Barbara Reynolds
Publisher : CreateSpace
ISBN 13 : 9781470193294
Total Pages : 278 pages
Book Rating : 4.1/5 (932 download)

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Book Synopsis Crisis and Emergency Risk Communication by : Barbara Reynolds

Download or read book Crisis and Emergency Risk Communication written by Barbara Reynolds and published by CreateSpace. This book was released on 2011-09-05 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: Originally designed for communicating public health information associated with communicable diseases, this book covers essential topics concerning media relations for public and private sector public information officers. Topics include: Introduction to Crisis and Emergency Risk Communication-Types of crisis and communications during a crisis, the risk of disaster, emergency/crisis/risk communications, the crisis communications lifecycle-pre-crisis phase, initial phase, crisis maintenance, resolution, and evaluation. Psychology of a Crisis-Human behavior in an emergency, decision making, perception of risk, facts to consider about human psychology in a crisis, and how to communicate effectively in a crisis. The Crisis Communication Plan-Developing an emergency/crisis communication plan, Information verification and clearance/approval procedures, agreements on information release authorities (who releases what/when/how, procedures to secure needed resources (space, equipment, people) to operate the public information. The nine steps of crisis response. Surviving the first 48 hours of an emergency: Be first, be right, be credible. The Role of the Spokesperson- The role of the spokesperson in an emergency, what makes a good spokesperson, general recommendations for spokespersons in all settings, pitfalls for spokespersons during an emergency, when emotions and accusations run high in an emergency public meeting, what spokespersons should know when talking through the media, general media interview pitfalls, media opportunity or press conference tips, counters to electronic media interview techniques, radio interview tips, television interview tips, what to wear on television, assessing your communication skills and habits, facial expressions, voice cues, body positions and movements, and effective nonverbal communication. Working With the Media- Think local media first, what do reporters want, getting emergency information to the media, the press conference or media opportunity, telephone news conferences/Web casts, commercial press release services, E-mail listservs and broadcast faxes, Web sites/video streaming, and responding to media calls. Writing For the Media During a Crisis- What your media release should include, press statements are not press releases, media factsheets/backgrounders, visuals, video press releases, and B-roll. Press Conferences- Where to hold the press conference, whom to invite, how and when to invite the media, how to conduct the media opportunity, using visuals and handouts.

Flu

Author : Gina Kolata
Publisher : Farrar, Straus and Giroux
ISBN 13 : 1429979356
Total Pages : 378 pages
Book Rating : 4.4/5 (299 download)

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Book Synopsis Flu by : Gina Kolata

Download or read book Flu written by Gina Kolata and published by Farrar, Straus and Giroux. This book was released on 2011-04-01 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: Veteran journalist Gina Kolata's Flu: The Story of the Great Influenza Pandemic of 1918 and the Search for the Virus That Caused It presents a fascinating look at true story of the world's deadliest disease. In 1918, the Great Flu Epidemic felled the young and healthy virtually overnight. An estimated forty million people died as the epidemic raged. Children were left orphaned and families were devastated. As many American soldiers were killed by the 1918 flu as were killed in battle during World War I. And no area of the globe was safe. Eskimos living in remote outposts in the frozen tundra were sickened and killed by the flu in such numbers that entire villages were wiped out. Scientists have recently rediscovered shards of the flu virus frozen in Alaska and preserved in scraps of tissue in a government warehouse. Gina Kolata, an acclaimed reporter for The New York Times, unravels the mystery of this lethal virus with the high drama of a great adventure story. Delving into the history of the flu and previous epidemics, detailing the science and the latest understanding of this mortal disease, Kolata addresses the prospects for a great epidemic recurring, and, most important, what can be done to prevent it.

New Drug Development for Known and Emerging Viruses

Author : Helga Rübsamen-Schaeff
Publisher : John Wiley & Sons
ISBN 13 : 3527343377
Total Pages : 530 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis New Drug Development for Known and Emerging Viruses by : Helga Rübsamen-Schaeff

Download or read book New Drug Development for Known and Emerging Viruses written by Helga Rübsamen-Schaeff and published by John Wiley & Sons. This book was released on 2022-01-31 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discusses how to fight Ebola, SARS Corona, and other known or emerging human viruses by building on the successes in antiviral therapy of the past decades Written by leading medicinal chemists from academia and industry, this book discusses the entire field of antiviral drug discovery and development from a medicinal chemistry perspective, focusing on antiviral drugs, targets, and viral disease mechanisms. It provides an outlook on emerging pathogens such as Ebola, Zika, West Nile, Lassa, and includes a chapter on SARS Coronoavirus-2 causing the present pandemic. New Drug Development for Known and Emerging Viruses describes the discovery and development process for antiviral agents for different classes of viruses and targets based on the experiences from the nine human viruses for which approved drugs are on the market (HIV, HCV, Influenza, RSV, HBV, HPV, HCMV, HSV, and VZV). It covers the properties and potential of 20 classes of currently approved antivirals, including combination drugs, and looks at novel antiviral strategies against emerging viruses. Covers the entire field of antiviral drug discovery and development Addresses the need for antiviral drugs to combat major health threats such as Ebola, Zika, West Nile, and SARS Coronavirus-2 Summarizes the successes of the past 15 years in developing ground-breaking medicines against 9 major human viruses, both from the medicinal chemistry and the pharmacological angle Discusses practical and strategic challenges in the drug discovery and development process, including screening technologies, latency, and toxicity issues New Developments in Antiviral Drugs is an important book for medicinal chemists, pharmaceutical chemists, virologists, and epidemiologists, and will be of great interest to those in the pharmaceutical industry and public health agencies.

National Strategy for Pandemic Influenza

Author : Homeland Security Council (U.S.)
Publisher : International Medical Publishing
ISBN 13 : 9781588088895
Total Pages : 0 pages
Book Rating : 4.0/5 (888 download)

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Book Synopsis National Strategy for Pandemic Influenza by : Homeland Security Council (U.S.)

Download or read book National Strategy for Pandemic Influenza written by Homeland Security Council (U.S.) and published by International Medical Publishing. This book was released on 2006 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Implementation Plan clarifies the roles and responsibilities of governmental and non-governmental entities, including Federal, State, local, and tribal authorities and regional, national, and international stakeholders, and provides preparedness guidance for all segments of society.--Preface.

Antiviral Drug Resistance

Author : Douglas D. Richman
Publisher : Wiley
ISBN 13 : 9780471961208
Total Pages : 324 pages
Book Rating : 4.9/5 (612 download)

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Book Synopsis Antiviral Drug Resistance by : Douglas D. Richman

Download or read book Antiviral Drug Resistance written by Douglas D. Richman and published by Wiley. This book was released on 1996-12-02 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of antiviral drug resistance has provided important insights into the structure of virus enzymes, the functions of certain genes, mechanisms of action of antiviral drugs, the design of new antiviral compounds and the pathogenesis of viral diseases. The emergence of resistant strains must be explored at all stages of drug development: during the preclinical evaluation of candidate compounds; during the early clinical evaluation of new drugs; and as part of epidemiological surveillance for the prevalence of resistance during use of approved treatments. Accumulating understanding of antiviral drug resistance thus reflects progress in the chemotherapy of viral infection. Antiviral Drug Resistance provides state-of-the-art coverage of the basic and clinical aspects of this subject. It deals with the basic science, including the mechanisms of drug resistance and drug action, genetics of drug resistance, cross resistance, and X-ray crystallographic structural aspects of resistance, as well as the clinical aspects, including issues of assay of susceptibility of clinical isolates, descriptive aspects of emergence of reduced susceptibility, and clinical significance and impact of resistance. As such this unique volume will be essential to basic researchers in drug discovery and viral pathogenesis, as well as clinicians involved in antiviral chemotherapy.

John R. La Montagne Memorial Symposium on Pandemic Influenza Research

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309097312
Total Pages : 214 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis John R. La Montagne Memorial Symposium on Pandemic Influenza Research by : Institute of Medicine

Download or read book John R. La Montagne Memorial Symposium on Pandemic Influenza Research written by Institute of Medicine and published by National Academies Press. This book was released on 2005-11-06 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Institute of Medicine (IOM) of the National Academies of Science held a symposium, in memory of Dr. John R. La Montagne on April 4-5, 2005, to discuss the current state of the art of research on pandemic influenza and to identify gaps in research. The symposium serves as a first step of discussion towards a combined and coordinated research effort among Department of Health and Human Services agencies, other governmental agencies, international partners and the private sector. The statement of task that guided the Symposium agenda included these specific questions: What is the current state of the science on pandemic influenza research? What are the pressing unmet scientific questions and technical issues? What administrative, logistic or legal impediments exist that block progress towards the development of interventions to respond to pandemic influenza? How can collaboration among Global health Security Action Group nations be strengthened to address unmet scientific questions and technical issues related to research on pandemic influenza? What do experts believe are the most important next steps to take to advance research on pandemic influenza? The Proceedings of the John La Montagne Memorial Symposium on Pandemic Influenza Research Gaps represents a slightly edited transcript of the plenary presentations, rapporteur presentations, plenary discussion and presentation slides. This document contains the Symposium agenda, short biographies of plenary speakers, and provides a list of individuals who attended the symposium.

Pandemic Influenza

Author : Jonathan Van-Tam
Publisher : CABI
ISBN 13 : 9781845938604
Total Pages : 258 pages
Book Rating : 4.9/5 (386 download)

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Book Synopsis Pandemic Influenza by : Jonathan Van-Tam

Download or read book Pandemic Influenza written by Jonathan Van-Tam and published by CABI. This book was released on 2012 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: With a strong emphasis on practicality, this book offers comprehensive coverage of the science and operational application of influenza epidemiology, virology and immunology, as well as vaccinology, pharmaceutical and public health measures, biomathematical modelling, policy issues and ethics. Each chapter raises key questions and answers them in clear and concise sections, detailing relevant modelling studies and further reading. This new 2nd Edition is comprehensively updated and includes:* major lessons from the 2009-10 pandemic* new contributions on surveillance, International Health Regul.

Operations Research and Health Care

Author : Margaret L. Brandeau
Publisher : Springer Science & Business Media
ISBN 13 : 1402080662
Total Pages : 870 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Operations Research and Health Care by : Margaret L. Brandeau

Download or read book Operations Research and Health Care written by Margaret L. Brandeau and published by Springer Science & Business Media. This book was released on 2006-04-04 with total page 870 pages. Available in PDF, EPUB and Kindle. Book excerpt: In both rich and poor nations, public resources for health care are inadequate to meet demand. Policy makers and health care providers must determine how to provide the most effective health care to citizens using the limited resources that are available. This chapter describes current and future challenges in the delivery of health care, and outlines the role that operations research (OR) models can play in helping to solve those problems. The chapter concludes with an overview of this book – its intended audience, the areas covered, and a description of the subsequent chapters. KEY WORDS Health care delivery, Health care planning HEALTH CARE DELIVERY: PROBLEMS AND CHALLENGES 3 1.1 WORLDWIDE HEALTH: THE PAST 50 YEARS Human health has improved significantly in the last 50 years. In 1950, global life expectancy was 46 years [1]. That figure rose to 61 years by 1980 and to 67 years by 1998 [2]. Much of these gains occurred in low- and middle-income countries, and were due in large part to improved nutrition and sanitation, medical innovations, and improvements in public health infrastructure.