Antiviral Drugs And Interferon The Molecular Basis Of Their Activity

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Antiviral Drugs and Interferon: The Molecular Basis of Their Activity

Author : Yechiel Becker
Publisher : Springer Science & Business Media
ISBN 13 : 1461338042
Total Pages : 452 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Antiviral Drugs and Interferon: The Molecular Basis of Their Activity by : Yechiel Becker

Download or read book Antiviral Drugs and Interferon: The Molecular Basis of Their Activity written by Yechiel Becker and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on antiviral drugs and their mode of action in infected cells. in animals and in man. has led to a better understanding of the molecular pro cesses involved in virus replication. Screeninq of large numbers of natural and semisynthetic compounds resulted in the characterization of certain sub stances that had a limited efficiency as antiviral druqs. A few chemically synthesized compounds were also found to be effective as antiviral agents in the chemotherapy of human virus diseases. A major difficulty in the develop ment of effective antiviral agents has been the lack of selectivity. and toxicity for uninfected cells. of drugs that effectively inhibited virus replication in vitro. Further understanding of the molecular processes of virus replication in infected cells has resulted in the development of new antivirals directed at virus-coded enzymes or proteins. Recent studies on antivirals that are activated by the herpes simplex virus type l-coded thy midine kinase from a prod rug to an antiviral drug have opened new directions in the development of effective antiviral drugs. The present book deals with a number of antiviral drugs effective against herpes simplex viruses and provides some insight into the molecular aspects of virus replication. It also throws light on the new approaches to the development of antiviral drugs. The molecular basis of the antiviral activity of new and known drugs and their possible use in chemotherapy of viral disease are presented in this book.

Molecular Basis of Specificity in Nucleic Acid-Drug Interactions

Author : A. Pullman
Publisher : Springer Science & Business Media
ISBN 13 : 9401137285
Total Pages : 595 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis Molecular Basis of Specificity in Nucleic Acid-Drug Interactions by : A. Pullman

Download or read book Molecular Basis of Specificity in Nucleic Acid-Drug Interactions written by A. Pullman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 595 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the central problems in the study of the mechanism of DNA-ligand interactions is the existence and nature of sequence specificity with respect to the base pairs of DNA. The presence of such a specificity could be of particular significance because it might possibly mean the involvement of specific genes in the effectiveness of the different drugs. The elucidation of the factors responsible for the specificity could then be important for the development of compounds susceptible to contribute to the control of gene expression and also to the development of rationally conceived, improved new generations of effective and specific chemotherapeutic agents. Important recent achievements, experimental and theoretical, in the analysis of such sequence specificities open prospects for possible rapid progress in this field. The 23rd Jerusalem symposium was devoted to the exploration of these recent achievements in relation to many types of ligand, with special emphasis on antitumor drugs. All major types of interaction, intercalation, groove binding, covalent linking, coordination, have been considered. So was also the effect of the interaction on the structure and properties of the nucleic acids and the relationship between the interaction and biological or pharmacological activities. We feel that this Volume presents a relatively complete up-to-date account of the state of the art in this important field of research.

Antiviral Drug Development

Author : Erik De Clercq
Publisher : Springer Science & Business Media
ISBN 13 : 1468472755
Total Pages : 313 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Antiviral Drug Development by : Erik De Clercq

Download or read book Antiviral Drug Development written by Erik De Clercq and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Fields Virology: Emerging Viruses

Author : Peter M. Howley
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1975112555
Total Pages : 2597 pages
Book Rating : 4.9/5 (751 download)

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Book Synopsis Fields Virology: Emerging Viruses by : Peter M. Howley

Download or read book Fields Virology: Emerging Viruses written by Peter M. Howley and published by Lippincott Williams & Wilkins. This book was released on 2020-02-11 with total page 2597 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in four convenient volumes, Field’s Virology remains the most authoritative reference in this fast-changing field, providing definitive coverage of virology, including virus biology as well as replication and medical aspects of specific virus families. This volume of Field’s Virology: Emerging Viruses, 7th Edition covers recent changes in emerging viruses, providing new or extensively revised chapters that reflect these advances in this dynamic field.

Biological Response Modifiers — Interferons, Double-Stranded RNA and 2′,5′-Oligoadenylates

Author : W.E.G. Müller
Publisher : Springer Science & Business Media
ISBN 13 : 3642785492
Total Pages : 290 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Biological Response Modifiers — Interferons, Double-Stranded RNA and 2′,5′-Oligoadenylates by : W.E.G. Müller

Download or read book Biological Response Modifiers — Interferons, Double-Stranded RNA and 2′,5′-Oligoadenylates written by W.E.G. Müller and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological response modifiers are increasingly used in viral and cancer therapy. Since alterations of the immune system are the primary symptoms of HIV infection, especially therapies directed towards the modulation of the immune response have been under intense evaluation. This volume summarizes current knowledge of the interferon-based natural antiviral protection system including 2',5'-oligoadenylate and double-stranded RNA. It will also help to develop further a solid scientific rationale for the practical use of heterologous immunomodulators in the clinics.

Advances in Molecular Biology and Targeted Treatment for AIDS

Author : Ajit Kumar
Publisher : Springer Science & Business Media
ISBN 13 : 1468459287
Total Pages : 355 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Advances in Molecular Biology and Targeted Treatment for AIDS by : Ajit Kumar

Download or read book Advances in Molecular Biology and Targeted Treatment for AIDS written by Ajit Kumar and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the discovery of HIV-l as the etiologic agent of acquired immunodeficiency syndrome (AIDS) in the early 1980s, remarkable progress has been made in both the basic understanding of the biological processes leading to AIDS and an accelerated effort in finding new treatments. As is often the case in rapidly advancing fields, most of the scientific discussions are best handled in specialized groups. The effort to organize a meeting on advances in molecular biology and targeted treatment for AIDS was an experiment of sorts to gather experts in selected areas of overlapping interests where advances in basic biology and its application in the development of new drugs could be discussed. Of necessity, the scope of the meeting had to be limited to maintain a certain focus. Important areas of rapid development in AIDS research, such as the vaccine development, epidemiology, animal models, etc. , had to be left out for more specialized meetings. The result, from all accounts, appeared to be quite a successful gathering, which provided a forum for informal discussions among scientists from industry and academic institutions. A remarkable feature of the AIDS virus is its genetic complexity and how some of its seemingly "extra genes" manage to regulate the normal functions of the host and most importantly its immune system.

International Union of Pharmacology

Author : Paul Turner
Publisher : Springer
ISBN 13 : 1349176133
Total Pages : 376 pages
Book Rating : 4.3/5 (491 download)

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Book Synopsis International Union of Pharmacology by : Paul Turner

Download or read book International Union of Pharmacology written by Paul Turner and published by Springer. This book was released on 2015-12-31 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Clinical Aspects of Interferons

Author : Michel Revel
Publisher : Springer Science & Business Media
ISBN 13 : 1461317371
Total Pages : 377 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Clinical Aspects of Interferons by : Michel Revel

Download or read book Clinical Aspects of Interferons written by Michel Revel and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cytokines

Author : C. Bondy
Publisher : Elsevier
ISBN 13 : 9780080532646
Total Pages : 830 pages
Book Rating : 4.5/5 (326 download)

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Book Synopsis Cytokines by : C. Bondy

Download or read book Cytokines written by C. Bondy and published by Elsevier. This book was released on 1997-04-18 with total page 830 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in molecular technology in recent years has caused an amazing growth of information about intercellular peptide messengers and their receptors. The number of characterized interleukins for example numbered just three six years ago and now there are at least 16. In addition, the number of described neutrophic peptides is around 30 and the number of receptors is ever increasing. Because many of these new peptide ligands and receptors were identified by "reverse genetic" techniques the understanding of their biological roles falls behind the knowledge of their molecular structures. However a new strain of functional studies has begun and animal models are developed allowing for further research into the biological roles of these messenger peptides and their receptors. Cytokines, the theme of this volume, describes a group of proteins identified primarily within the immune and hematopoietic systems. As many cytokines as possible are included along with their receptors providing the reader with a guide to an ever-changing field of scientific research.

Progress in Nucleic Acid Research and Molecular Biology

Author :
Publisher : Academic Press
ISBN 13 : 9780080863214
Total Pages : 311 pages
Book Rating : 4.8/5 (632 download)

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Book Synopsis Progress in Nucleic Acid Research and Molecular Biology by :

Download or read book Progress in Nucleic Acid Research and Molecular Biology written by and published by Academic Press. This book was released on 1986-11-06 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in Nucleic Acid Research and Molecular Biology

Scientific Directory and Annual Bibliography

Author : National Institutes of Health (U.S.)
Publisher :
ISBN 13 :
Total Pages : 628 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Scientific Directory and Annual Bibliography by : National Institutes of Health (U.S.)

Download or read book Scientific Directory and Annual Bibliography written by National Institutes of Health (U.S.) and published by . This book was released on 1985 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: Each issue lists papers published during the preceding year.

Advances in Antiviral Drug Design

Author : E. De Clercq
Publisher : Elsevier
ISBN 13 : 9780080526034
Total Pages : 233 pages
Book Rating : 4.5/5 (26 download)

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Book Synopsis Advances in Antiviral Drug Design by : E. De Clercq

Download or read book Advances in Antiviral Drug Design written by E. De Clercq and published by Elsevier. This book was released on 1996-04-23 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of the series on Advances in Antiviral Drug Design is to regularly review the "state of the art" on emerging new developments in the antiviral drug research field, thereby spanning the conceptual design and chemical synthesis of new antiviral compounds, their structure-activity relationship, mechanism and target(s) of action, pharmacological behavior, antiviral activity spectrum, and therapeutic potential for clinical use. Volume 2 begins with a description of the antiviral potential of antisense oligonucleotides by J. Temsamani and S. Agrawal. According to the aims of the anitsense technology, these oligonucleotides should be targeted at specific viral antisense technology, these oligonucleotides should be targeted at specific viral mRNA sequences so that translation to the virus-specified proteins is blocked; this has been achieved for a number of oligomers, some of which are now in clinical trials for the treatment of HIV, HCMV, and human papilloma virus (HPV) infections. Then C.-S. Yuan, S. Liu, S.F. Wnuk, M.J. Robins and R.T. Borchardt assess the role of S-adenosylhornocysteine (AdoHcy) hydrolase as target for the design of antiviral agents with broad-spectrum antiviral activity. This is followed by an in-depth account on the design and synthesis of a number of first-, second- and third-generation AdoHcy hydrolase inhibitors and their mode of action at the enzyme level. V.E. Marquez provides a comprehensive description of the various carbocyclic (carba) nucleosides that have been synthesized and evaluated for antiviral activity. Although the number and diversity of the carba-nucleosides that have been found to be antivirally active (or inactive) is astonishingly high, there is no limit to further expansion of this fascinating class of molecules. For the various nucleoside analogues that have to be intracellularly phosphorylated to the 5'-triphosphate stage, to interact with their target enzyme (i.e., herpesviral DNA polymerase or retroviral revers transcriptase) the first phosphorylation step is often the rate-limiting step, and thus various strategies are envisaged by C. Perigoud, J.-L. Girardet, G. Gosselin and J.-L. Bach on how to bypass this initial phosphorylation and to deliver the nucleoside 5'-monophophate directly inside the cells. The HIV protease has been considered as a paradigm for rational drug design. The enzyme is among the best understood in terms of both structure and action, and because of its crucial role in the maturation of HIV, it has been vigorously pursued as a target for anti-HIV chemotherapy. In their comprehensive review of the multidisciplinary approach towards the development of HIV protease inhibitors A.G. Tomasselli, S. Thaisrivongs and R.L. Heinrikson highlight those protease inhibitors which have been brought forward to clinical trials.

Programmed Cell Death in Tumours and Tissues

Author : I.D. Bowen
Publisher : Springer Science & Business Media
ISBN 13 : 9780412279706
Total Pages : 284 pages
Book Rating : 4.2/5 (797 download)

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Book Synopsis Programmed Cell Death in Tumours and Tissues by : I.D. Bowen

Download or read book Programmed Cell Death in Tumours and Tissues written by I.D. Bowen and published by Springer Science & Business Media. This book was released on 1990-07-31 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recently there have been many advances in the understanding of the genetic basis of development and regular breakthroughs are being made in the field of tumour cell targeting. Both these areas of research are coming together in terms of their perception of programmed cell death.

Herpesviruses, the Immune System, and AIDS

Author : Yechiel Becker
Publisher : Springer Science & Business Media
ISBN 13 : 1461315077
Total Pages : 385 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Herpesviruses, the Immune System, and AIDS by : Yechiel Becker

Download or read book Herpesviruses, the Immune System, and AIDS written by Yechiel Becker and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Maedi-Visna and Related Diseases

Author : G. Pétursson
Publisher : Springer Science & Business Media
ISBN 13 : 1461316138
Total Pages : 192 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Maedi-Visna and Related Diseases by : G. Pétursson

Download or read book Maedi-Visna and Related Diseases written by G. Pétursson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: G. Petursson and Rikke Hoff-J0rgensen The concept of slow viral infections was first put forward in 1954 by Dr. Bjorn Sigurdsson, an Icelandic physician who had been studying some sheep diseases which were introduced into Iceland with the importation of a foreign breed of sheep in 1933. Sigurdsson's main criteria for defining slow infec tions were a very long initial period without clinical signs lasting months or even years following infection and a rather regular protracted, progres sive course, once clinical symptoms had appeared, usually ending in serious disease or death. Sigurdsson included in this list of slow infections maedi -visna, infectious adenomatosis of sheep, scrapie in sheep, Bittner's mam mary carcinoma and Gross' leukemia in mice. All of these diseases, except scrapie, are caused by retroviruses. The characteristics of slow infections as described above are of prac tical importance for epidemiology, diagnosis and control of these diseases. For many years the slow infections remained primarily a veterinary problem, mainly affecting sheep and goats in certain countries. In recent years, how ever, the human immunodeficiency virus (HIV) causing acquired immunodefici ency syndrome (AIDS), has suddenly appeared in many countries of the world and brought the slow infection concept forcefully to the attention of the medical profession. The disease problems and the economic effects of slow infections of sheep and goats are increasingly recognized in various coun tries. For the reasons stated above we feel that this book should be useful for veterinarians and physicians alike.

Herpesvirus Diseases of Cattle, Horses, and Pigs

Author : G. Wittmann
Publisher : Springer Science & Business Media
ISBN 13 : 1461315875
Total Pages : 355 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Herpesvirus Diseases of Cattle, Horses, and Pigs by : G. Wittmann

Download or read book Herpesvirus Diseases of Cattle, Horses, and Pigs written by G. Wittmann and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Newcastle Disease

Author : D. J. Alexander
Publisher : Springer Science & Business Media
ISBN 13 : 1461317592
Total Pages : 390 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Newcastle Disease by : D. J. Alexander

Download or read book Newcastle Disease written by D. J. Alexander and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most of the chapters of this book were written during 1987 which was the Diamond Jubilee year of the publication of the first reports of Newcastle disease in 1927. During the intervening years the nature of the Poultry Industry throughout the World has changed, or is in the process of changing, dramatically from one based on small village or farm flocks, frequently kept as a sideline, to an industry based on large flocks, sometimes consisting of hundreds of thousands of birds, run by multinational companies. To all these flocks, both large and small, Newcastle disease poses a considerable threat to their well-being and profitability and it is not unreasonable to state that hardly a single commercial flock of poultry is raised in the world without Newcastle disease having some effect due to actual disease, prophylactic vaccination or restrictions placed on rearing, movement, processing, sale or export of birds and products. In addition, recent years have produced developments in virology and associated biological technology which would have been unbelievable when Newcastle disease virus was first isolated. The economic importance of Newcastle disease virus and its use as a laboratory model has meant that major advances have been quickly applied to the field situation whenever possible and, as a result, a much fuller understanding, not only of the biochemistry and basic virology of the virus but also the ecology, epizootiology, antigenicity, immunology and other important aspects in the control of the disease has been achieved.