Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Antioxidant Function Of Coenzyme Q And The Role Of The Abc1 Coq8 Gene In Coenzyme Q Biosynthesis In The Yeast Saccharomyces Cerevisiae
Download Antioxidant Function Of Coenzyme Q And The Role Of The Abc1 Coq8 Gene In Coenzyme Q Biosynthesis In The Yeast Saccharomyces Cerevisiae full books in PDF, epub, and Kindle. Read online Antioxidant Function Of Coenzyme Q And The Role Of The Abc1 Coq8 Gene In Coenzyme Q Biosynthesis In The Yeast Saccharomyces Cerevisiae ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis Antioxidant Function of Coenzyme Q and the Role of the ABC1/COQ8 Gene in Coenzyme Q Biosynthesis in the Yeast Saccharomyces Cerevisiae by : Thai Quoc Do
Download or read book Antioxidant Function of Coenzyme Q and the Role of the ABC1/COQ8 Gene in Coenzyme Q Biosynthesis in the Yeast Saccharomyces Cerevisiae written by Thai Quoc Do and published by . This book was released on 2002 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Roles of the Coq10 Chaperone Protein, Cardiolipin, and Endoplasmic Reticulum-mitochondria Contact Sites in Coenzyme Q Biosynthesis and Function by : Hui Su Tsui
Download or read book The Roles of the Coq10 Chaperone Protein, Cardiolipin, and Endoplasmic Reticulum-mitochondria Contact Sites in Coenzyme Q Biosynthesis and Function written by Hui Su Tsui and published by . This book was released on 2019 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Coenzyme Q (CoQ) is an essential lipid molecule for cellular bioenergetics, cellular antioxidant defense, and is a co-factor for enzymes participating in fatty acid -oxidation and pyrimidine biosynthesis. The biosynthetic machinery of CoQ consists of a cohort of Coq polypeptides that are organized in a multi-subunit complex known as the CoQ synthome, residing on the mitochondrial inner membrane. Although CoQ is almost exclusively produced inside the mitochondria, it exists in most cellular membranes. The hydrophobicity of CoQ, especially CoQ isoforms with long polyisoprenyl tail prevents CoQ from being distributed to cellular membranes via diffusion. Thus, protein complexes localized at the membrane contact sites between two organelles, and lipid-binding chaperones play important roles redistributing CoQ and escorting CoQ from place where it is being synthesized to places where it functions. My research uses Saccharomyces cerevisiae (hereafter termed "yeast") as the model organism because many of the enzymes involved in the yeast CoQ biosynthesis are conserved in humans. Additionally, the ability of yeast cells to survive by fermentation allows genetic manipulation of genes that are essential for respiratory growth. Chapter 1 provides an overview of the biosynthesis of CoQ in both yeast and human cells, and highlights the functional conservation of many of the enzymes involved in the CoQ production. Chapter 2 focuses on the biochemical characterization of two human steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain proteins, COQ10A and COQ10B. These two human COQ10 paralogs are co-orthologous to yeast Coq10, which is essential for CoQ function and is required for efficient de novo CoQ biosynthesis. Expression of either one of the two human COQ10 paralogs restores CoQ function in yeast coq10 deletion mutant, but neither is able to restore de novo CoQ production. This result implies divergent functions of yeast Coq10 and its human COQ10 co-orthologs for CoQ production, and the existence of a second protein that needs to function concurrently with Coq10 for efficient CoQ biosynthesis in yeast. Chapter 3 explores CoQ biosynthesis in yeast mutants lacking the endoplasmic reticulum (ER)-mitochondria encounter structure (ERMES) complex at the ER and mitochondria membrane contact sites. In collaboration with Dr. Maya Schuldiner's lab, we found that the de novo production and distribution of CoQ in the ERMES deletion mutants are distorted due to the destabilization of the CoQ synthome in the absence of ERMES complex. Fluorescent microcopy data suggests close proximity of the CoQ synthome and the ERMES complex, implying a spatially coordinated regulation of CoQ biosynthesis and distribution by two closely apposed organelles. Chapter 4 examines the antioxidant property of CoQ. In collaboration with Dr. Anne Murphy's lab and Dr. Mikhail Shchepinov from Retrotope, Inc., We showed that the yeast CoQ-less mutants are exquisitely sensitive to polyunsaturated fatty acid (PUFA)-induced lipid peroxidation, and these CoQ-less mutants can be protected from oxidative damage by substituting the exogenously supplied PUFA with isotope-reinforced PUFA with its bis-allylic hydrogen replaced with deuterium atom. Chapter 5 studies CoQ biosynthesis and CoQ synthome assembly in yeast mutants that have defects in cardiolipin biosynthesis and remodeling. Cardiolipin (CL) is a unique phospholipid that is found exclusively within the mitochondrial membranes. In yeast, unmodified CL functions almost identically to remodeled CL, and the CL remodeling process is thought to remove and repair damaged CL. The yeast mutants with defects in CL biosynthesis and remodeling synthesize CoQ less efficiently, despite that the CoQ synthome assembly is only marginally affected. Last but not least, Chapter 6 describes efforts made towards characterizing the biological function of Coq10 with preliminary data collected with help from Kate Liu, Dr. Dyna Shirasaki, Dr. Frederik Lermyte, Dr. Brendan Amer, and Alice Hsu. Collectively, my work explores the biosynthesis and molecular functions of CoQ, and provides new insight into the regulation of CoQ production.
Book Synopsis The Fourth Conference of the International Coenzyme Q10 Association by : G. P. Littarru
Download or read book The Fourth Conference of the International Coenzyme Q10 Association written by G. P. Littarru and published by IOS Press. This book was released on 2006-07 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on coenzyme Q, this book includes topics spanning from biochemical aspects to biomedical implications and clinical use of CoQ10. It addresses the antioxidant aspects as well as the non-mitochondrial electron transport systems, and investigates coenzyme Q biosynthesis in yeast and in Caenorhabditis elegans.
Book Synopsis Coenzyme Q in Aging by : Guillermo López Lluch
Download or read book Coenzyme Q in Aging written by Guillermo López Lluch and published by Springer. This book was released on 2021-08-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a comprehensive exploration of research on the essential relationship of the coenzyme Q10 and the process of aging in living organisms. CoQ10 is an important factor in two main aspects of cell physiology: bioenergetics and antioxidant protection. While primary deficiency of CoQ10 is associated with severe and lethal disease, secondary deficiency can be associated with the progression of mitochondrial dysfunction linked to the lessening of biological activities during aging. The book is organized in four sections. The first offers an overview of the function of CoQ10, highlighting the two main functions of CoQ10 in cells: its essential role as electron transport chain member in mitochondria, and the protection of cell membranes against oxidation as one of the main endogenous-synthesized antioxidants. The second section covers research on Coenzyme 10. Topics include studies involving invertebrate models, mammal studies and the influence of CoQ on longevity. Also covered is research involving the role of CoQ in senescence-accelerated mice. Section three examines the effects of reduced CoQ in human aging, as evident in mitochondrial dysfunction, metabolic syndrome, neurodegenerative disorders, immunosenescence and fertility and reproduction. The final section, Prolongevity effectors and Coenzyme Q, explores research into slowing or stopping the aging process. Coverage includes strategies including calorie restriction, and modulation of CoQ10 levels by induction of synthesis or by supplementation. Coenzyme Q in Aging benefits a broad readership of researchers, clinicians, educators and students interested in the biochemical and physiological effects of coenzyme Q and the importance of this molecule in aging process.
Book Synopsis Dissertation Abstracts International by :
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2002 with total page 756 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Coenzyme Q Biosynthesis in Saccharomyces Cerevisiae by : Peter Kai Chong Gin
Download or read book Coenzyme Q Biosynthesis in Saccharomyces Cerevisiae written by Peter Kai Chong Gin and published by . This book was released on 2005 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis American Doctoral Dissertations by :
Download or read book American Doctoral Dissertations written by and published by . This book was released on 2001 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Journal of Bioscience and Bioengineering by :
Download or read book Journal of Bioscience and Bioengineering written by and published by . This book was released on 2002 with total page 744 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Membrane Protein Purification and Crystallization by : Carola Hunte
Download or read book Membrane Protein Purification and Crystallization written by Carola Hunte and published by Elsevier. This book was released on 2003-01-05 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition of Membrane Protein Purification and Crystallization, A Practical Guide is written for bench scientists working in the fields of biochemistry, biology, and proteomic research. This guide presents isolation and crystallization techniques in a concise form, emphasizing the critical aspects unique to membrane proteins. It explains the principles of the methods and provides protocols of general use, permitting researchers and students new to this area to adapt these techniques to their particular needs. This edition is not only an update but is comprised mainly of new contributions. It is the first monograph compiling the essential approaches for membrane protein crystallization, and emphasizes recent progress in production and purification of recombinant membrane proteins. Provides general guidelines and strategies for isolation and crystallization of membrane proteins Gives detailed protocols that have wide application, and low specialized equipment needs Emphasizes recent progress in production and purification of recombinant membrane proteins, especially of histidine-tagged and other affinity-epitope-tagged proteins Summarizes recent developments of Blue-Native PAGE, a high resolution separation technique, which is independent of the use of recombinant techniques, and is especially suited for proteomic analyses of membrane protein complexes Gives detailed protocols for membrane protein crystallization, and describes the production and use of antibody fragments for high resolution crystallization Presents a comprehensive guide to 2D-crystallization of membrane proteins
Book Synopsis Microbial Respiration by : Walter P. Hempfling
Download or read book Microbial Respiration written by Walter P. Hempfling and published by Hutchinson Ross Publishing Company. This book was released on 1979 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Coenzyme Q written by Giorgio Lenaz and published by John Wiley & Sons. This book was released on 1985 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is becoming increasingly apparent that Coenzyme Q (Ubiquinone) is a major component of the electron transfer chains within aerobic micro-oganisms, photo-synthetic micro-organisms and mitochondria of eukaryotes. In particular, the proposal by Nobel laureate, Peter Mitchell, that Coenzyme Q possibly acts as a proton translocator within a proton motive Q-cycle, thus establishing an electrochemical membrane potential which in turn drives ATP synthesis, has received wide attention. This exhaustive, inter-disciplinary study discusses Ubiquinone's chemical and physical properties, metabolism, and function in different organisms.
Download or read book Coenzyme Q written by Valerian E. Kagan and published by CRC Press. This book was released on 2000-08-30 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since its discovery in 1957, Coenzyme Q has piqued the interest of scientists from a wide range of disciplines because of its bioenergetics, vitamin-like behavior, and interactions with antioxidant vitamins E and C. Coenzyme Q: Molecular Mechanisms in Health and Disease is a comprehensive treatise on this often-studied coenzyme. International exper
Book Synopsis Nonvesicular Transport by : Stephen S. Rothman
Download or read book Nonvesicular Transport written by Stephen S. Rothman and published by Wiley-Interscience. This book was released on 1985 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a range of articles on varied topics that consider evidence for the existence of nonvesicular transport for processes that have generally been considered to be carried out by means of vesicle mechanisms, particularly for the movement of proteins and neurotransmitters across membranes. The contributors base their hypotheses on knowledge of the kinetic, thermodynamic, and compartmental characteristics of a process in real space-time, independent of specific models that attempt to explain it.
Book Synopsis Photosynthetic Carbon Assimilation by : H. W. Siegelman
Download or read book Photosynthetic Carbon Assimilation written by H. W. Siegelman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: The photosynthetic fixation of carbon dioxide into organic compounds is mediated by the enzyme ribulose 1,S-bisphosphate (RuBP) carboxylase. The diversity of current research on this protein attests to its central role in biomass productivity, and suggests the importance of a timely and broadly based review. This Symposium was the first devoted exclusively to RuBP carboxylase and was attended by agronomists, plant physiologists, biochemists, molecular biologists, and crystallographers. Special efforts were made to involve young scientists in addition to established investigators. It is a pleasure to acknowledge financial support provided by the Department of Energy, the United States Department of Agricul ture, and the National Science Foundation, and the valued assistance of agency representatives, Drs. Joe Key, Robert Rabson, Elijah Romanoff, and Donald Senich. Thanks are due to Mrs. Margaret Dienes, without whose editorial skills this volume could not have been produced, and to Mrs. Helen Kondratuk as Symposium Coordinator. Finally, we wish to record our indebtedness to Dr. Alexander Hollaender for his tireless efforts in support of all aspects of this Symposium.
Book Synopsis Hydrogen Peroxide and Cell Signaling, Part A by :
Download or read book Hydrogen Peroxide and Cell Signaling, Part A written by and published by Academic Press. This book was released on 2013-06-19 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This is the first of three volumes on hydrogen peroxide and cell signaling, and includes chapters on such topics as photooxidation of amplex red to resorufin, boronate-based fluorescent probes, and visualization of intracellular hydrogen peroxide with HyPer. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers hydrogen peroxide and cell signaling Contains chapters on such topics as photooxidation of amplex red to resorufin, boronate-based fluorescent probes, and visualization of intracellular hydrogen peroxide with HyPer
Book Synopsis The Chlamydomonas Sourcebook: Introduction to Chlamydomonas and Its Laboratory Use by : Elizabeth H. Harris
Download or read book The Chlamydomonas Sourcebook: Introduction to Chlamydomonas and Its Laboratory Use written by Elizabeth H. Harris and published by Academic Press. This book was released on 2009-03-07 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Harris has played a major role in the development of this organism as a model system. Her previous version of the Chlamydomonas Sourcebook which published in 1989, has been a classic in the field and is considered required reading for anyone working with this organism. This latest edition has been expanded to include three volumes providing molecular techniques, analysis of the recently sequenced genome, and reviews of the current status of the diverse fields in which Chlamydomonas is used as a model organism. Methods for Chlamydomonas research and best practices for applications in research, including methods for culture, preservation of cultures, preparation of media, lists of inhibitors and other additives to culture media, are included. Additions to this volume also include help with common laboratory problems such as contamination, student demonstrations, and properties of particular strains and mutants. This volume is part of a 3-Volume Set (ISBN: 978-0-12-370873-1) and is also sold individually. Expanded revision of gold standard reference Includes latest advances in research, including completion of the genome Provides broad perspective with studies in cell and molecular biology, genetics, plant physiology and related fields Available as part of a 3-Volume Set or sold individually
Book Synopsis Regulation of HMG-CoA Reductase by : Benjamin Preiss
Download or read book Regulation of HMG-CoA Reductase written by Benjamin Preiss and published by Elsevier. This book was released on 2012-12-02 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulation of HMG-CoA Reductase is a nine-chapter text that focuses on the research developments in the regulation of HMG-CoA reductase enzyme and cholesterol biosynthesis. This book deals first with the role of cholesterol in the regulation of its own biosynthesis and the work involving compactin and related competitive inhibitors of HMG-CoA reductase. The subsequent chapters examine the reversible phosphorylation of HMG-CoA reductase in hormonal and other short-term physiological changes and the structure and properties of the enzyme, including evidence for modulation of enzyme activity and structure unrelated to phosphorylation. These topics are followed by discussions on the regulation of reductase in the biosynthesis of ubiquinone, dolichols, and isopentenyl-tRNA and the regulation of reductase activity in extrahepatic tissues. This text further explores the contributions made through the use of cultured cells and their genetic manipulation, with emphasis on the great potential of this approach. The concluding chapters address the status of the low-density lipoprotein pathway and related mechanisms. These chapters also consider the regulation of human hepatic HMG-CoA reductase and the special problems inherent in work with human tissues. Enzyme scientists and researchers and graduate students will find this book invaluable.
