Antifungal Drug Discovery New Theories And New Therapies

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Antifungal Drug Discovery: New Theories and New Therapies

Author : Chaminda Jayampath Seneviratne
Publisher : Frontiers Media SA
ISBN 13 : 2889199509
Total Pages : 138 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Antifungal Drug Discovery: New Theories and New Therapies by : Chaminda Jayampath Seneviratne

Download or read book Antifungal Drug Discovery: New Theories and New Therapies written by Chaminda Jayampath Seneviratne and published by Frontiers Media SA. This book was released on 2016-09-13 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fungal infections such as candidoses can range from superficial mucous membrane infection to life-threatening systemic mycoses. Candida infections are a significant clinical problem globally due to rapid rise in compromised host populations including HIV/AIDS, organ transplant recipients and patients on chemotherapy. In addition, sharp increase in aging populations which are susceptible to fungal infections is expected in next few decades. Antifungal drugs are relatively difficult to develop compared to the antibacterial drugs owing to the eukaryotic nature of the cells. Therefore, only a handful of antifungal agents are currently available to treat the myriad of fungal infections. Moreover, rising antifungal resistance and host-related adverse reactions have limited the antifungal arsenal against fungal pathogens. In this research topic, we tried to update the theoretical aspects pertaining to the antifungal drug discovery i.e. proposed novel mechanisms, new drug targets and pathways. In addition, invited authors explored the new antifungal drugs derived from natural and synthetic sources which are currently under development. Contributors were encouraged to bring new insight into the antifungal drug discovery. We hope the reader may arrive at a general consensus on the possible strategies to combat ever increasing ubiquitous fungal infection in this new century.

Antifungal Drug Discovery: New Theories and New Therapies

Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (136 download)

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Book Synopsis Antifungal Drug Discovery: New Theories and New Therapies by :

Download or read book Antifungal Drug Discovery: New Theories and New Therapies written by and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fungal infections such as candidoses can range from superficial mucous membrane infection to life-threatening systemic mycoses. Candida infections are a significant clinical problem globally due to rapid rise in compromised host populations including HIV/AIDS, organ transplant recipients and patients on chemotherapy. In addition, sharp increase in aging populations which are susceptible to fungal infections is expected in next few decades. Antifungal drugs are relatively difficult to develop compared to the antibacterial drugs owing to the eukaryotic nature of the cells. Therefore, only a handful of antifungal agents are currently available to treat the myriad of fungal infections. Moreover, rising antifungal resistance and host-related adverse reactions have limited the antifungal arsenal against fungal pathogens. In this research topic, we tried to update the theoretical aspects pertaining to the antifungal drug discovery i.e. proposed novel mechanisms, new drug targets and pathways. In addition, invited authors explored the new antifungal drugs derived from natural and synthetic sources which are currently under development. Contributors were encouraged to bring new insight into the antifungal drug discovery. We hope the reader may arrive at a general consensus on the possible strategies to combat ever increasing ubiquitous fungal infection in this new century.

New Approaches for Antifungal Drugs

Author : FERNANDES
Publisher : Springer Science & Business Media
ISBN 13 : 148996729X
Total Pages : 211 pages
Book Rating : 4.4/5 (899 download)

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Book Synopsis New Approaches for Antifungal Drugs by : FERNANDES

Download or read book New Approaches for Antifungal Drugs written by FERNANDES and published by Springer Science & Business Media. This book was released on 2013-11-09 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt:

New Approaches for Antifungal Drugs

Author : Prabhavathi B. Fernandes
Publisher : Birkhauser
ISBN 13 : 9783764336028
Total Pages : 201 pages
Book Rating : 4.3/5 (36 download)

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Book Synopsis New Approaches for Antifungal Drugs by : Prabhavathi B. Fernandes

Download or read book New Approaches for Antifungal Drugs written by Prabhavathi B. Fernandes and published by Birkhauser. This book was released on 1992-01-01 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reviews research on the chemotherapy of fungal diseases, which has progressed at a much slower rate than that against bacterial diseases. Emphasizes the search during the past decade for selective targets of therapeutic agents, selection being the main difficulty because of the eukaryotic nature of fungi. In addition to several novel drugs, considers structures, processes, and proteins as potential targets; and new approaches such as antifungal agents from plants, and genetic methods of drug discovery. Annotation copyrighted by Book News, Inc., Portland, OR

Combating Fungal Infections

Author : Iqbal Ahmad
Publisher : Springer Science & Business Media
ISBN 13 : 364212173X
Total Pages : 539 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Combating Fungal Infections by : Iqbal Ahmad

Download or read book Combating Fungal Infections written by Iqbal Ahmad and published by Springer Science & Business Media. This book was released on 2010-08-03 with total page 539 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fungi are eukaryotic microorganisms that are closely related to humans at cellular level. Human fungal pathogens belong to various classes of fungi, mainly zygo- cetes, ascomycetes, basidiomycetes, and deuteromycetes. In recent years, fungal infections have dramatically increased as a result of improved diagnosis, high frequency of catheterization, instrumentation, etc. However, the main cause remains the increasing number of immunosuppressed patients, mostly because of HIV infection and indiscriminate usage of antineoplastic and immunosuppressive agents, broad-spectrum antibiotics and prosthetic devices, and grafts in clinical settings. Presently available means of combating fungal infections are still weak and clumsy compared to control of bacterial infection. The present scenario of antifungal therapy is still based on two classes of antifungal drugs (polyenes and azoles). These drugs are effective in many cases, but display toxicity and limited spectrum of ef?cacy. The recent trend towards emergence of drug-resistant isolates in the clinic is an additional problem. In recent years, a few new antifungal drugs have entered the clinics, but they are expected to undergo same fate as the older antifungal drugs. The application of fungal genomics offers an unparalleled opportunity to develop novel antifungal drugs. However, it is too early to expect any novel drugs, as the antifungal drug discovery program is in the stage of infancy. Interestingly, several novel antifungal drug targets have been identi?ed and validated.

Vaccines, Immunotherapy and New Antifungal Therapy Against Fungi: Updates in the New Frontier

Author : Carlos P. Taborda
Publisher : Frontiers Media SA
ISBN 13 : 2889453278
Total Pages : 185 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Vaccines, Immunotherapy and New Antifungal Therapy Against Fungi: Updates in the New Frontier by : Carlos P. Taborda

Download or read book Vaccines, Immunotherapy and New Antifungal Therapy Against Fungi: Updates in the New Frontier written by Carlos P. Taborda and published by Frontiers Media SA. This book was released on 2017-11-15 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: Invasive fungal diseases have increased many fold over the past 50 years. Current treatment regimens typically require prolonged administration of antifungal medications that can have significant toxicity. Moreover, our present potent antifungal armamentarium fails to eradicate fungal pathogens from certain compromised hosts. Additionally, invasive fungal diseases continue to have unacceptably high mortality rates. A growing body of work has focused on the utility of vaccines and/or immunotherapy as a powerful tool in combating mycoses, either for the active treatment, as an adjuvant, or in the prevention of specific fungal pathogens. Also, it is growing the interest over new drugs development as second choice for treatment when traditional chemotherapy fail. This Research Topic will detail the exciting progress in developing vaccines, immunotherapy and new drugs for fungi.

Recent Trends in Antifungal Agents and Antifungal Therapy

Author : Amit Basak
Publisher : Springer
ISBN 13 : 8132227824
Total Pages : 250 pages
Book Rating : 4.1/5 (322 download)

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Book Synopsis Recent Trends in Antifungal Agents and Antifungal Therapy by : Amit Basak

Download or read book Recent Trends in Antifungal Agents and Antifungal Therapy written by Amit Basak and published by Springer. This book was released on 2016-09-21 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fungal infections have taken a new spectrum due to the increased incidence of multi-drug resistant fungal pathogens. Freedom of choice for drugs to treat fungal infections is also narrow because of lesser probability of discovering drugs that would bypass affecting human cells and target fungal cells producing fewer side effects in patients. An approach has gained prominence in research is to look for bioactive antifungal compounds from natural to synthetic sources. It is necessary to discover new classes of antifungals to control the recent emergence of multi-drug resistant fungal infections. This book proposed a details top to bottom outline of antifungal compounds derived naturally or synthetically. The details of their modifications or synthetic analogues have been described, helpful to understand the structure-activity relationship which leads to new compound development in antifungal chemotherapy. Each chapter begins with a comprehensive, top-bottom in-depth discussion of antifungal agents with updated bibliographic references. This compendium will serve as a companion not only for Scientists, Researchers, and Professors, Medical Practitioners but also a valuable reference text for the university students.

New Approaches for Antifungal Drugs

Author : B. F. Prabhavathi
Publisher :
ISBN 13 : 9781489967305
Total Pages : 212 pages
Book Rating : 4.9/5 (673 download)

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Book Synopsis New Approaches for Antifungal Drugs by : B. F. Prabhavathi

Download or read book New Approaches for Antifungal Drugs written by B. F. Prabhavathi and published by . This book was released on 2014-09-01 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Anticandidal Therapeutics

Author : Awanish Kumar
Publisher : Elsevier
ISBN 13 : 0443187452
Total Pages : 198 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Anticandidal Therapeutics by : Awanish Kumar

Download or read book Anticandidal Therapeutics written by Awanish Kumar and published by Elsevier. This book was released on 2023-01-20 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developments of antifungal agents have declined as compared to other antibiotics that have displayed a potent development with time. There is an urgent need for both prophylactic and therapeutic treatments worldwide to control the severity of infections caused by Candida. Anticandidal Therapeutics: Discovery and Development provides the readers with a compiled knowledge of the fungal human infection Candida and the development of anticandidal drugs. Anticandidal Therapeutics helps researchers form the basis for the discovery and development of novel anticandidal therapies. In 14 chapters this book provides collective information on anticandidal agents and their discovery and development with respect to major drug transporter families, different stages of anticandidal agent development, recent trends and progress in antifungal translational research, clinical studies status of anticandidal therapeutic agents, and drug repurposing for development of novel anticandidal agents. Highlights the mechanistic actions of some therapeutic agents against Candida Focuses on anticandidal agents rather than general antifungal agents Discusses the stage of development of new antifungal drugs, the repositioning of drugs, and how this could help in treatment

Oxford Textbook of Medical Mycology

Author : Christopher C. Kibbler
Publisher : Oxford University Press
ISBN 13 : 0198755384
Total Pages : 401 pages
Book Rating : 4.1/5 (987 download)

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Book Synopsis Oxford Textbook of Medical Mycology by : Christopher C. Kibbler

Download or read book Oxford Textbook of Medical Mycology written by Christopher C. Kibbler and published by Oxford University Press. This book was released on 2017-12-14 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Oxford Textbook of Medical Mycology is a comprehensive reference text which brings together the science and medicine of human fungal disease. Written by a leading group of international authors to bring a global expertise, it is divided into sections that deal with the principles of mycology, the organisms, a systems based approach to management, fungal disease in specific patient groups, diagnosis, and treatment. The detailed clinical chapters take account of recent international guidelines on the management of fungal disease. With chapters covering recent developments in taxonomy, fungal genetics and other 'omics', epidemiology, pathogenesis, and immunology, this textbook is well suited to aid both scientists and clinicians. The extensive illustrations, tables, and in-depth coverage of topics, including discussion of the non-infective aspects of allergic and toxin mediated fungal disease, are designed to aid the understanding of mechanisms and pathology, and extend the usual approach to fungal disease. This textbook is essential reading for microbiologists, research scientists, infectious diseases clinicians, respiratory physicians, and those managing immunocompromised patients. Part of the Oxford Textbook in Infectious Disease and Microbiology series, it is also a useful companion text for students and trainees looking to supplement mycology courses and microbiology training.

Antifungal Therapy

Author : Mahmoud Ghannoum
Publisher : CRC Press
ISBN 13 : 0849387868
Total Pages : 484 pages
Book Rating : 4.8/5 (493 download)

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Book Synopsis Antifungal Therapy by : Mahmoud Ghannoum

Download or read book Antifungal Therapy written by Mahmoud Ghannoum and published by CRC Press. This book was released on 2016-04-19 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: A concise one-stop-practical reference for the various physicians dealing with fungal infections, Antifungal Therapy appeals to infectious disease physicians, transplant surgeons, dermatologists, and intensivists, as well as basic scientists and pharmaceutical company researchers interested in the state of antifungal therapy. This book provides a c

Microbial Biofilms

Author : Chaminda Jayampath Seneviratne
Publisher : CRC Press
ISBN 13 : 1351646427
Total Pages : 334 pages
Book Rating : 4.3/5 (516 download)

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Book Synopsis Microbial Biofilms by : Chaminda Jayampath Seneviratne

Download or read book Microbial Biofilms written by Chaminda Jayampath Seneviratne and published by CRC Press. This book was released on 2017-07-12 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbial Biofilms: Omics Biology, Antimicrobials and Clinical Implications is a comprehensive survey of microbial biofilms and their role in human health and disease with contributions from world renowned experts in molecular microbiology, proteomics, genomics, metabolomics and infectious diseases. The book is intended to serve as a guide for students, as well as a reference for researchers, clinicians and industry professionals. The chapters cover bacterial and fungal microbiomes, and the latest omics techniques organized in a clear and up-to-date manner. One of the highlights of this book is the comprehensive information on "omics of microbial biofilms". The chapters dedicated to metagenomics, proteomics and metabolomics are designed to provide a simple and holistic review of the current knowledge and, the applications of these techniques in the field of microbial biofilms. In addition to introductory chapters on microbial biofilms and their clinical implications, subsequent chapters delve into oral biofilms, their composition, and metagenomic diversity. Thereafter, mechanisms of drug resistance in microbial biofilms are reviewed, as well as the proteomic and metabolomic characterization of this resistance. The book includes a comprehensive discussion of persister cells and host–microbial interactions on mucosal surfaces. Finally, the book concludes with a summary of novel therapeutic approaches for biofilms such as synbiotics and biogenics.

Pathogenic Yeasts

Author : Ruth Ashbee
Publisher : Springer Science & Business Media
ISBN 13 : 3642031501
Total Pages : 367 pages
Book Rating : 4.6/5 (42 download)

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Book Synopsis Pathogenic Yeasts by : Ruth Ashbee

Download or read book Pathogenic Yeasts written by Ruth Ashbee and published by Springer Science & Business Media. This book was released on 2009-10-27 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mycological studies of yeasts are entering a new phase, with the sequencing of multiple fungal genomes informing our understanding of their ability to cause disease and interact with the host. At the same time, the ongoing use of traditional methods in many clinical mycology laboratories continues to provide information for the diagnosis and treatment of patients. This volume reviews various aspects of pathogenic yeasts and what is known about their molecular and cellular biology and virulence, in addition to looking at clinical and laboratory findings. As each chapter is written by a leading expert in the field, this book summarizes in one volume much of the latest research on several pathogenic yeasts, including Candida, Cryptococcus, Malassezia and yeasts of emerging importance. The importance of laboratory diagnosis, antifungal susceptibility testing, antifungal resistance and yeast diseases in animals are reviewed.

Medicinal Plants

Author : Bassam Hassan
Publisher : BoD – Books on Demand
ISBN 13 : 1789858879
Total Pages : 194 pages
Book Rating : 4.7/5 (898 download)

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Book Synopsis Medicinal Plants by : Bassam Hassan

Download or read book Medicinal Plants written by Bassam Hassan and published by BoD – Books on Demand. This book was released on 2020-03-25 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is focused on clarifying the anticancer effects (i.e., apoptotic, antiproliferative, antimetastatic, antiangiogenic) and mechanisms of most of the medicinal plants found in the world against solid and/or hematological cancers.

Plant-Derived Antimycotics

Author : M.k. Rai
Publisher : CRC Press
ISBN 13 : 9781560229278
Total Pages : 622 pages
Book Rating : 4.2/5 (292 download)

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Book Synopsis Plant-Derived Antimycotics by : M.k. Rai

Download or read book Plant-Derived Antimycotics written by M.k. Rai and published by CRC Press. This book was released on 2003-05-29 with total page 622 pages. Available in PDF, EPUB and Kindle. Book excerpt: An important overview of the state of the art in naturally occurring antimycotics! Here is a comprehensive and innovative examination of the antimycotic potential of essential plant oils and extracts against fungal infections affecting humans, animals, plants, and foodstuffs. Plant-Derived Antimycotics emphasizes the antimycotic activity of plants found in Central America, India, Nepal, Fiji, and China--areas rich in phyto-diversity and traditional botanical/medical knowledge. From editor M.K. Rai: “Since the inception of human civilization men have been using herbs against various mycotic infections. In the recent past, several antimycotic agents have been introduced into the market due to their rapid curative properties. Still, the quest for new antifungal agents of a fungicidal rather than fungistatic nature continues. Furthermore, there has been a dramatic increase in the new spectrum of fungal infections known as opportunistic fungal pathogens. Consequently, plant-derived antimycotics are gaining importance, being natural, cheaper, safer, eco-friendly, and within the reach of the common man.” With a distinguished list of contributors from around the world, Plant-Derived Antimycotics explores: antifungal compounds that strengthen plant-defense systems traditional herbs that have revealed their antifungal properties newer, faster methods of screening and evaluating antifungal drugs natural antimycotics derived from plants in Croatia, South America, South Africa, China, India, and Fiji the mechanism of herbal antimycotic action the diversity of antimycotic efficacy in Asteraceous and Meliaceous plants new bioactive antifungal molecules Plant-Derived Antimycotics is an essential reference for pharmacologists, microbiologists, clinical mycologists, oncologists, immunologists, drug manufacturers, botanists and ethnobotanists, phytochemists, herbalists, and everyone searching for a natural remedy for the new spectrum of opportunistic fungal infections generated by the immunocompromising difficulties encountered by AIDS and cancer patients. Color illustrations, photographs, charts, tables, and graphs make the information easier to absorb and understand.

Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts

Author :
Publisher :
ISBN 13 : 9781562384692
Total Pages : 30 pages
Book Rating : 4.3/5 (846 download)

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Book Synopsis Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts by :

Download or read book Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts written by and published by . This book was released on 2002 with total page 30 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Antimicrobial Pharmacodynamics in Theory and Clinical Practice

Author : Nightingale
Publisher : CRC Press
ISBN 13 : 082474182X
Total Pages : 427 pages
Book Rating : 4.8/5 (247 download)

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Book Synopsis Antimicrobial Pharmacodynamics in Theory and Clinical Practice by : Nightingale

Download or read book Antimicrobial Pharmacodynamics in Theory and Clinical Practice written by Nightingale and published by CRC Press. This book was released on 2001-09-25 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: This up-to-the-minute reference explores the pharmacodynamics of antimicrobials as well as the absorption, distribution, metabolism, and elimination of the major classes of antimicrobials-covering new agents such as ketolide antibiotics and highlighting the pharmacodynamic relationship between drug concentration and antimicrobial activity, as well as the relationship of pharmacodynamics to bacterial resistance. Contains specific examples and practical applications for the design of effective dosing regimens! Written by recognized experts in the field, Antimicrobial Pharmacodynamics in Theory and Clinical Practice describes the pharmacodynamic properties of all major classes of antibiotics parameters for microbiological activity of antimicrobial agents such as minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) serum/tissue protein binding and penetration rates differences between in vivo and in vitro postantibiotic effects (PAE) and more! With nearly 1000 references, tables, drawings, and illustrations, Antimicrobial Pharmacodynamics in Theory and Clinical Practice is a state-of-the-art reference for infectious disease specialists, pulmonologists, pharmacists, pharmacologists, microbiologists, biological chemists, epidemiologists, internists, and students in these disciplines.