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Author :
Publisher :
ISBN 13 :
Total Pages : 568 pages
Book Rating : 4.:/5 (78 download)
Download or read book ANTIBODY AS A TOOL: THE APPLICATIONS OF IMMUNOCHEMISTRY written by and published by . This book was released on 1982 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : A.M. Campbell
Publisher : Elsevier
ISBN 13 : 9780080887357
Total Pages : 426 pages
Book Rating : 4.8/5 (873 download)
Download or read book Monoclonal Antibody and Immunosensor Technology written by A.M. Campbell and published by Elsevier. This book was released on 1991-12-12 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: This highly practical book, and successor to Volume 13 in the Laboratory Techniques series, explores further and provides more comprehensive, autoritative information on the production of Mabs. Much new and illuminating material has been included covering the concepts behind the application of recombinant DNA technology and biosensor technology to monoclonal antibodies, and all the human Mab technology facilitated by PCR of antibody genes. Also included in this latest volume is a section focussing on other methods of obtaining B cell clones such as short-term culture and oncogene transformation and an interesting section on Mab patents.
Author : Pete Gagnon
Publisher : Validated Biosystems Incorporated
ISBN 13 :
Total Pages : 278 pages
Book Rating : 4.3/5 (91 download)
Download or read book Purification Tools for Monoclonal Antibodies written by Pete Gagnon and published by Validated Biosystems Incorporated. This book was released on 1996 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: Purification Tools for Monoclonal is an essential book for professionals, educators and advanced students in the field of Biotechnology. It is based on experience gained from purification process development, scale-up, and manufacture of more than 250 monoclonal-based diagnostic and therapeutic products. Ten chapters provide in-depth coverage of major separation mechanisms, process strengths, weaknesses and method development; all fully integrated with the special performance, economic and validation requirements associated with monoclonals. Covered methods include precipitation with inorganic salts, polyethylene glycol, electrolyte depletion, caprylic acid, ethacridine, chromatographic purification by size exclusion, ion exchange, hydroxyapatite, hydrophobic interaction, immobilized metal affinity, hydrophilic interaction, euglobulin adsorption, thiophilic adsorption, protein A, protein G, lectin affinity, and more. 88 figures, 29 tables.
Author : Eryl Liddell
Publisher : Garland Science
ISBN 13 : 1000141012
Total Pages : 154 pages
Book Rating : 4.0/5 (1 download)
Download or read book Antibody Technology written by Eryl Liddell and published by Garland Science. This book was released on 2020-08-26 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of antibody technology. It discusses in detail the new generation of engineered antibodies and the latest developments in immunoassay techniques and applications, as well as describing conventional methods of antibody production and use. Antibody Technology will bring the reader up-to-date with current methods, helping the reader to make informed decisions on the best approach to a given task with regard to cost, time and final application.
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309173051
Total Pages : 74 pages
Book Rating : 4.3/5 (91 download)
Download or read book Monoclonal Antibody Production written by National Research Council and published by National Academies Press. This book was released on 1999-05-06 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt: The American Anti-Vivisection Society (AAVS) petitioned the National Institutes of Health (NIH) on April 23, 1997, to prohibit the use of animals in the production of mAb. On September 18, 1997, NIH declined to prohibit the use of mice in mAb production, stating that "the ascites method of mAb production is scientifically appropriate for some research projects and cannot be replaced." On March 26, 1998, AAVS submitted a second petition, stating that "NIH failed to provide valid scientific reasons for not supporting a proposed ban." The office of the NIH director asked the National Research Council to conduct a study of methods of producing mAb. In response to that request, the Research Council appointed the Committee on Methods of Producing Monoclonal Antibodies, to act on behalf of the Institute for Laboratory Animal Research of the Commission on Life Sciences, to conduct the study. The 11 expert members of the committee had extensive experience in biomedical research, laboratory animal medicine, animal welfare, pain research, and patient advocacy (Appendix B). The committee was asked to determine whether there was a scientific necessity for the mouse ascites method; if so, whether the method caused pain or distress; and, if so, what could be done to minimize the pain or distress. The committee was also asked to comment on available in vitro methods; to suggest what acceptable scientific rationale, if any, there was for using the mouse ascites method; and to identify regulatory requirements for the continued use of the mouse ascites method. The committee held an open data-gathering meeting during which its members summarized data bearing on those questions. A 1-day workshop (Appendix A) was attended by 34 participants, 14 of whom made formal presentations. A second meeting was held to finalize the report. The present report was written on the basis of information in the literature and information presented at the meeting and the workshop.
Author : John J. Marchalonis
Publisher : John Wiley & Sons
ISBN 13 :
Total Pages : 592 pages
Book Rating : 4.3/5 (91 download)
Download or read book Antibody as a Tool written by John J. Marchalonis and published by John Wiley & Sons. This book was released on 1982 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic methods and theory; Specific applications of immunochemical and related techniques.
Author : Uwe Gottschalk
Publisher : John Wiley & Sons
ISBN 13 : 1119126932
Total Pages : 752 pages
Book Rating : 4.1/5 (191 download)
Download or read book Process Scale Purification of Antibodies written by Uwe Gottschalk and published by John Wiley & Sons. This book was released on 2017-03-07 with total page 752 pages. Available in PDF, EPUB and Kindle. Book excerpt: Promoting a continued and much-needed renaissance in biopharmaceutical manufacturing, this book covers the different strategies and assembles top-tier technology experts to address the challenges of antibody purification. • Updates existing topics and adds new ones that include purification of antibodies produced in novel production systems, novel separation technologies, novel antibody formats and alternative scaffolds, and strategies for ton-scale manufacturing • Presents new and updated discussions of different purification technologies, focusing on how they can address the capacity crunch in antibody purification • Emphasizes antibodies and innovative chromatography methods for processing
Author : William R Strohl
Publisher : Elsevier
ISBN 13 : 1908818093
Total Pages : 697 pages
Book Rating : 4.9/5 (88 download)
Download or read book Therapeutic Antibody Engineering written by William R Strohl and published by Elsevier. This book was released on 2012-10-16 with total page 697 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of antibody engineering has become a vital and integral part of making new, improved next generation therapeutic monoclonal antibodies, of which there are currently more than 300 in clinical trials across several therapeutic areas. Therapeutic antibody engineering examines all aspects of engineering monoclonal antibodies and analyses the effect that various genetic engineering approaches will have on future candidates. Chapters in the first part of the book provide an introduction to monoclonal antibodies, their discovery and development and the fundamental technologies used in their production. Following chapters cover a number of specific issues relating to different aspects of antibody engineering, including variable chain engineering, targets and mechanisms of action, classes of antibody and the use of antibody fragments, among many other topics. The last part of the book examines development issues, the interaction of human IgGs with non-human systems, and cell line development, before a conclusion looking at future issues affecting the field of therapeutic antibody engineering. Goes beyond the standard engineering issues covered by most books and delves into structure-function relationships Integration of knowledge across all areas of antibody engineering, development, and marketing Discusses how current and future genetic engineering of cell lines will pave the way for much higher productivity
Author : Pete Gagnon
Publisher : Atlasbooks Distribution
ISBN 13 : 9781616583729
Total Pages : pages
Book Rating : 4.5/5 (837 download)
Download or read book Purification Tools for Monoclonal Antibodies written by Pete Gagnon and published by Atlasbooks Distribution. This book was released on 1996 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Ten chapters provide in-depth coverage of fractionation mechanisms, process strengths, weaknesses, and method development, all integrated with the performance, economic, and regulatory requirements associated with monoclonal antibodies.
Author : A.M. Campbell
Publisher : Elsevier
ISBN 13 : 9780080858821
Total Pages : 264 pages
Book Rating : 4.8/5 (588 download)
Download or read book Monoclonal Antibody Technology: The Production and Characterization of Rodent and Human Hybridomas written by A.M. Campbell and published by Elsevier. This book was released on 2000-04-01 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains detailed, comprehensive advice on rat, mouse and human hybridoma production. It begins with a general introduction, then describes the practical applications of the technology with photographs and protocols for everything from animal dissection to epitope analysis of antigens.
Author : Mats Ohlin
Publisher :
ISBN 13 :
Total Pages : 206 pages
Book Rating : 4.3/5 (91 download)
Download or read book Human Monoclonal Antibody Technology written by Mats Ohlin and published by . This book was released on 1992 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Martin Rosenberg
Publisher : Springer Science & Business Media
ISBN 13 : 3642784321
Total Pages : 414 pages
Book Rating : 4.6/5 (427 download)
Download or read book The Pharmacology of Monoclonal Antibodies written by Martin Rosenberg and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: A sample of the most exciting developments in the cloning, manipulation, expression and application of genetically-engineered monoclonal antibodies. This rapidly-evolving field has witnessed the PCR combinatorial cloning of vast immunological diversity, in vitro mutagenesis of MAbs, MAbs created by transgenic animals, novel expression systems in plants, animals and lower systems, as well as a rich variety of genetically modified MAbs as potential therapeutic agents. Leading scientists from academia and industry present their own findings as well as short reviews of these research areas.
Author : Zhiqiang An
Publisher : John Wiley & Sons
ISBN 13 : 1118210263
Total Pages : 932 pages
Book Rating : 4.1/5 (182 download)
Download or read book Therapeutic Monoclonal Antibodies written by Zhiqiang An and published by John Wiley & Sons. This book was released on 2011-09-20 with total page 932 pages. Available in PDF, EPUB and Kindle. Book excerpt: 70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies. First book to address the discovery and development of antibody therapeutics in their entirety. Most chapters contain experimental data to illustrate the principles described in them. Authors provide detailed methodologies that readers can take away with them and use in their own laboratories.
Author : Gabriele Proetzel
Publisher : Humana Press
ISBN 13 : 9781617799303
Total Pages : 325 pages
Book Rating : 4.7/5 (993 download)
Download or read book Antibody Methods and Protocols written by Gabriele Proetzel and published by Humana Press. This book was released on 2012-06-24 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rapidly growing field of antibody research is the result of many advancing technologies allowing current developments to take advantage of molecular engineering to create tailor-made antibodies. Antibody Methods and Protocols attempts to provide insight into the generation of antibodies using in vitro and in vivo approaches, as well as technical aspects for screening, analysis, and modification of antibodies and antibody fragments. The detailed volume is focused on basic protocols for isolating antibodies and, at the same time, it selects a range of specific areas with the aim of providing guides for the overall process of antibody isolation and characterization as well as protocols for enhancing classical antibodies and antibody fragments. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and easy to use, Antibody Methods and Protocols provides a broad and useful background to support ongoing efforts by novices and experts alike and encourages the development of new imaginative approaches to this vital area of study.
Author : Ailsa M. Campbell
Publisher :
ISBN 13 : 9780720442007
Total Pages : 427 pages
Book Rating : 4.4/5 (42 download)
Download or read book Monoclonal Antibody and Immunosensor Technology written by Ailsa M. Campbell and published by . This book was released on 1991 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Roland E. Kontermann
Publisher : Springer Science & Business Media
ISBN 13 : 3642011446
Total Pages : 770 pages
Book Rating : 4.6/5 (42 download)
Download or read book Antibody Engineering Volume 1 written by Roland E. Kontermann and published by Springer Science & Business Media. This book was released on 2010-03-10 with total page 770 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antibodies are indispensable tools for research, diagnosis, and therapy. Recombinant approaches allow the modification and improvement of nearly all antibody properties, such as affinity, valency, specificity, stability, serum half-life, effector functions, and immunogenicity. "Antibody Engineering" provides a comprehensive toolbox covering the well-established basics but also many exciting new techniques. The protocols reflect the latest "hands on" knowledge of key laboratories in this still fast-moving field. Newcomers will benefit from the proven step-by-step protocols, which include helpful practical advice; experienced antibody engineers will appreciate the new ideas and approaches. The book is an invaluable resource for all those engaged in antibody research and development.
Author : Clive R. Wood
Publisher : World Scientific
ISBN 13 : 1848166281
Total Pages : 490 pages
Book Rating : 4.8/5 (481 download)
Download or read book Antibody Drug Discovery written by Clive R. Wood and published by World Scientific. This book was released on 2012 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antibody-based therapeutics are a central driver of the success of biopharmaceuticals. The discovery technology of this field is isolated to a limited number of centers of excellence in industry and academia. The objective of this volume is to provide a series of guides to those evaluating and preparing to enter particular areas within the field. Each chapter is written with a historical perspective that sets into context the significance of the key developments, and with the provision of “points to consider” for the reader as a value-added feature of the volume. All contributors are experts in their fields and have played pivotal roles in the creation of the technology.
