Anti Idiotype Antibodies In Cancer Treatment

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Anti-idiotype antibodies in cancer treatment

Author : Daniel Gomez
Publisher : Frontiers E-books
ISBN 13 : 2889191184
Total Pages : 88 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Anti-idiotype antibodies in cancer treatment by : Daniel Gomez

Download or read book Anti-idiotype antibodies in cancer treatment written by Daniel Gomez and published by Frontiers E-books. This book was released on with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt: Actively induced immunotherapy is one of the most promising fields in cancer research and numerous approaches are being studied to design effective cancer vaccines. Among the treatment strategies to develop an effective immune response against tumor associated antigens is the use of anti idiotype (Ab2) mAb as antigen surrogates. Several studies in animal models have demonstrated the efficacy of these vaccines for triggering the immune system to induce specific and protective immunity against tumors of different origin. In fact, anti-idiotypic mAbs have been used successfully in cancer therapeutics to overcome the poor immunogenicity of some tumor-associated antigens, in particular those of non-protein origin. In some clinical trials, including patients with different tumors, anti-Id specific humoral and/or cellular responses following immunization were associated with improved clinical outcome. This number of Frontiers will be dedicated to anti- idiotypic antibodies and their use in cancer treatment. Different article types will be considered: original contributions, case reports, methods, hypothesis and theory, reviews, historical, etc.

Safety of Biologics Therapy

Author : Brian A. Baldo
Publisher : Springer
ISBN 13 : 3319304720
Total Pages : 610 pages
Book Rating : 4.3/5 (193 download)

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Book Synopsis Safety of Biologics Therapy by : Brian A. Baldo

Download or read book Safety of Biologics Therapy written by Brian A. Baldo and published by Springer. This book was released on 2016-08-12 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: This long overdue title provides a comprehensive, up-to-date, state-of-the art review of approved biologic therapies, with coverage of mechanisms of action, Indications for therapy, immunogenicity and a detailed examination of adverse effects and safety of the many and diverse therapeutic agents presented in a total of 13 chapters. It is predicted that by 2016, biologics will make up half of the world's 20 top-selling drugs and by 2018, biologic medicine sales will account for almost half of the world's 100 biggest selling drugs. Recombinant proteins dominate the growing list of the more than 200 approved biotherapeutic agents with targeted antibodies, fusion proteins and receptors; cytokines; hormones; enzymes; proteins involved in blood-clotting, homeostasis and thrombosis; vaccines; botulinum neurotoxins; and, more recently, biosimilar preparations, comprising the majority of approved biologics. Written with clinicians, other health care professionals, and researchers in mind, Safety of Biologics Therapy examines, in a single volume, the full range of issues surrounding the safety of approved biologic therapies. A good understanding of the risks and safety issues of modern biologics therapy is increasingly being demanded of all those connected with their development, handling, prescribing, administration and subsequent patient management. In addition to being of great value to clinicians in all branches of medicine, and to nurses, pharmacists and researchers, this book will prove invaluable for students taking undergraduate and graduate courses in the above disciplines and in the biomedical sciences.

Rheumatology and Immunology Therapy

Author : Larry W. Moreland
Publisher : Springer Science & Business Media
ISBN 13 : 3540206256
Total Pages : 933 pages
Book Rating : 4.5/5 (42 download)

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Book Synopsis Rheumatology and Immunology Therapy by : Larry W. Moreland

Download or read book Rheumatology and Immunology Therapy written by Larry W. Moreland and published by Springer Science & Business Media. This book was released on 2004-07-20 with total page 933 pages. Available in PDF, EPUB and Kindle. Book excerpt: Entries in a practical A to Z Format Highly therapy-focused Uniform and clearly arranged entries for ease of reference Comprehensive information on symptoms and therapeutical possibilities of rheumatologic and musculoskeletal diseases as well as drugs Written by leading experts in the field

Tumor Immunology and Immunotherapy

Author : Robert C. Rees
Publisher : Oxford University Press, USA
ISBN 13 : 0199676860
Total Pages : 469 pages
Book Rating : 4.1/5 (996 download)

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Book Synopsis Tumor Immunology and Immunotherapy by : Robert C. Rees

Download or read book Tumor Immunology and Immunotherapy written by Robert C. Rees and published by Oxford University Press, USA. This book was released on 2014 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive account of cancer immunity and immunotherapy, examining recent results, current areas of interest and the specific issues that are affecting the research and development of vaccines. It provides insight into how these problems may be overcome as viewed by leaders in the field.

Immunoglobulin Idiotypes

Author : Charles Janeway
Publisher :
ISBN 13 :
Total Pages : 952 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Immunoglobulin Idiotypes by : Charles Janeway

Download or read book Immunoglobulin Idiotypes written by Charles Janeway and published by . This book was released on 1981 with total page 952 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Biological Application of Anti-Idiotypes

Author : Constantin A. Bona
Publisher : CRC Press
ISBN 13 : 1351078674
Total Pages : 194 pages
Book Rating : 4.3/5 (51 download)

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Book Synopsis Biological Application of Anti-Idiotypes by : Constantin A. Bona

Download or read book Biological Application of Anti-Idiotypes written by Constantin A. Bona and published by CRC Press. This book was released on 2018-01-18 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of this book is to present findings which are supportive of the concept that the words of the idiotype dictionary and likewise self-recognition are essential for communication between lymphocyte clones while some unfaithful ( infidel ) copies of the words contained in the idiotype dictionary perhaps play a role in the functional regulation of nonlymphoid cells.

Idiotypes in Medicine: Autoimmunity, Infection and Cancer

Author : R.C. Kennedy
Publisher : Elsevier
ISBN 13 : 9780080534435
Total Pages : 540 pages
Book Rating : 4.5/5 (344 download)

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Book Synopsis Idiotypes in Medicine: Autoimmunity, Infection and Cancer by : R.C. Kennedy

Download or read book Idiotypes in Medicine: Autoimmunity, Infection and Cancer written by R.C. Kennedy and published by Elsevier. This book was released on 1997-11-19 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the most comprehensive review of the idiotypic network available. All the current knowledge of idiotypes of the various antibodies is incorporated in this volume. The pathogenic role of idiotypes in autoimmunity and cancer is reviewed in depth. The therapeutic part focusses on harnessing anti-idiotypes for treating autoimmunological disorders, and on the employment of idiotypes for vaccines in cancer and infectious diseases, as well as explaining the manipulation of the idiotypic network in autoimmunity and cancer idiotypes and vaccines.

Adverse Reactions to Biologics

Author : L. Puig
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318061018
Total Pages : 120 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis Adverse Reactions to Biologics by : L. Puig

Download or read book Adverse Reactions to Biologics written by L. Puig and published by Karger Medical and Scientific Publishers. This book was released on 2017-11-07 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: In many areas of medicine physicians still face the great challenge of finding therapies that will meet the patients’ needs. In dermatology the challenge has arisen on multiple fronts through advances in the understanding of the immunopathogenesis of many inflammatory and malignant cutaneous disorders. Breakthroughs, combined with significant developments in targeted immunotherapy, have resulted in improved outcomes as these newer therapies are being used for both approved indications and as off-label therapies for various chronic inflammatory skin disorders and many forms of skin cancer. In the expectation that by truly understanding the safety profile of these targeted therapies patients’ outcomes will be significantly improved, this book offers insights into topics such as adverse reactions, infectious complications and the perioperative use of biologics in psoriasis, immunogenicity of biologic therapies, paradoxical reactions, safety of biologics used to treat autoimmune bullous diseases and primary cutaneous lymphomas, adverse reactions and skin manifestations of therapies targeting melanoma and non-melanoma skin cancer and other neoplastic diseases. Eminent researchers with extensive clinical experience have contributed to this publication, providing an in-depth overview of the latest knowledge in this field.

Anti-Idiotypic Vaccines

Author : Pierre-Andre Cazenave
Publisher : Springer Science & Business Media
ISBN 13 : 1461229928
Total Pages : 152 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis Anti-Idiotypic Vaccines by : Pierre-Andre Cazenave

Download or read book Anti-Idiotypic Vaccines written by Pierre-Andre Cazenave and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vaccines have historically been considered to be the most cost-effective method for preventing communicable diseases. It was a vaccine~hat enabled global eradication of the dreaded disease smallpox. Mass immunization of children forms the anchor of the strategy of the World Health Organization (WHO) to attain "health for all" status by the year 2000. Vaccinology is undergoing a dimensional change with the advances that have taken place in immunology and genetic engineering. Vaccines that confer short or inadequate immunity or that have side effects are being replaced by better vaccines. New vaccines are being developed for a variety of maladies. Monoclonal antibodies and T cell clones have been employed to delineate the immunodeterminants on microbes, an approach elegantly complemented by computer graphics and molecular imaging techniques. Possibilities have opened for obtaining hitherto scarce antigens of parasites by the DNA recombinant route. Better appreciation of the idiotypic network has aroused research on anti-idiotypic vaccines. Solid-phase synthesis of peptides is leading to an array of synthetic vaccines, an approach that is expected to attain its full potential once the sequences activating suppressor cells are discovered and the rules for presentation of antigens to T and B cells are better worked out. A new breed of vaccines is on the horizon that seeks to control fertility.

Encyclopedia of Cancer

Author : Manfred Schwab
Publisher : Springer Science & Business Media
ISBN 13 : 3540368477
Total Pages : 3307 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Encyclopedia of Cancer by : Manfred Schwab

Download or read book Encyclopedia of Cancer written by Manfred Schwab and published by Springer Science & Business Media. This book was released on 2008-09-23 with total page 3307 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.

Monoclonal Antibody Therapy of Human Cancer

Author : Kenneth A. Foon
Publisher : Springer Science & Business Media
ISBN 13 : 1461326273
Total Pages : 171 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Monoclonal Antibody Therapy of Human Cancer by : Kenneth A. Foon

Download or read book Monoclonal Antibody Therapy of Human Cancer written by Kenneth A. Foon and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: KENNETH A. FOON and ALTON C. MORGAN, JR. Passive immunotherapy using heteroantisera for the treatment of cancer in animals and humans has been studied for over 50 years. Attempts have been made to treat animal tumors with sera from immunized syngeneic, allogeneic, or xenogeneic animals. A number of studies of passive immunotherapy using heterologous antisera in humans have also been performed. These studies have generally been attempted in patients with large tumor burdens, and as would be expected, results have been transient at best. A wide variety of solid tumors as well as leukemias and lym phomas have been treated with antisera raised in sheep, horses, rabbits, and goats. Problems such as anaphylaxis, serum sick ness, and severe cytopenias have been encountered with these antisera. There are a number of potential mechanisms by which unconju gated antibodies might be cytotoxic to tumor cells. Antibodies bound to the cell surface membrane of tumor cells may lead to cell lysis by complement-dependent or antibody-dependent cellu lar cytotoxicity. Circulating tumor cells bound by antibody may be more susceptible to phagocytosis by the reticuloendothelial system. Antibody bound to the cell surface membrane of tumor cells may enhance immunogenicity of the tumor cell leading to activation of the host's immune system.

Maternal Fetal Transmission of Human Viruses and their Influence on Tumorigenesis

Author : György Berencsi III
Publisher : Springer Science & Business Media
ISBN 13 : 9400742169
Total Pages : 467 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Maternal Fetal Transmission of Human Viruses and their Influence on Tumorigenesis by : György Berencsi III

Download or read book Maternal Fetal Transmission of Human Viruses and their Influence on Tumorigenesis written by György Berencsi III and published by Springer Science & Business Media. This book was released on 2012-04-05 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human foetus is separated from the maternal blood by the syncytiotrophoblast induced by endogeneous human retrovirus-encoded proteins. This barrier is a highly developed one, which suppors apical-basolateral transport of maternal idiotype and anti-idiotype IgG, IgG-virus complexes. The selective maternal-fetal transport of epitope- and paratope-bearing entities can influence the developping fetal immune system during pregnancy. The bidirectional maternal-fetal transfer of cells are of even more importance during pregnancy. Maternal cells with latent viruses transport viruses without impairment of fetal development. Cells with premaligant and malignant genetic transformation are also transported to the fetus. Fetal and neonatal tumours are initiated by such cells in spite of the antitumour potential of fetal organism. On the contary, the fetal cells repair maternal tissue injouries and survive in the organisms of the recipients for decades. These possess new consequences for the neonatal immunity and organ transplatation surgery.

Encyclopedic Reference of Immunotoxicology

Author : Hans-Werner Vohr
Publisher : Springer
ISBN 13 : 9783540441724
Total Pages : 0 pages
Book Rating : 4.4/5 (417 download)

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Book Synopsis Encyclopedic Reference of Immunotoxicology by : Hans-Werner Vohr

Download or read book Encyclopedic Reference of Immunotoxicology written by Hans-Werner Vohr and published by Springer. This book was released on 2005-06-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work provides rapid access to focused information on topics of Immunotoxicology not only for scientists and those dealing with laboratory aspects but also for lecturers and advanced students. Over 200 contributing authors – including many of the world’s top specialists – have contributed full essays on all relevant topics, supplemented by keyword definitions of related terms. Full essays are structured uniformly to provide reader-friendly information on all aspects of Immunotoxicology, including methods of testing and analysis, characteristics of substances, the regulatory environment and the relevance of these to humans. The single A–Z format of both types of entry makes this reference book very easy to use. The Encyclopedic Reference of Immunotoxicology is intended to be a comprehensive work of reference which will provide easy access to relevant information in the fast-growing field of Immunotoxicology.

The Mosaic of Autoimmunity

Author : Yehuda Shoenfeld
Publisher : Elsevier Science Limited
ISBN 13 : 9780444811844
Total Pages : 523 pages
Book Rating : 4.8/5 (118 download)

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Book Synopsis The Mosaic of Autoimmunity by : Yehuda Shoenfeld

Download or read book The Mosaic of Autoimmunity written by Yehuda Shoenfeld and published by Elsevier Science Limited. This book was released on 1989 with total page 523 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively sets out the common aetiopathogenetic mechanisms shared by many, apparently diverse, diseases of the immune system. Unlike most other texts it does not emphasise the differences between autoimmune diseases, but establishes their many common links including hormonal effects, dietary and immunogenetic influences, complement deficiencies and environmental factors. Special attention is given to the effects of ageing and the relationship with malignancies. The scope of the book is very broad so as to cover the integration of the many diverse components which interact to cause autoimmunity, and it contains many 1988 and 1989 references and over 100 figures and tables, offering an attractive, up-to-date guide to modern concepts. It will greatly assist immunologists wishing to enter the field of autoimmunity, and will serve as an invaluable reference work for those already working in it.

Frontiers in Oncology: Quarterly Highlights. Quarter 1 2019

Author : Giuseppe Giaccone
Publisher : Frontiers Media SA
ISBN 13 : 288945939X
Total Pages : 213 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Frontiers in Oncology: Quarterly Highlights. Quarter 1 2019 by : Giuseppe Giaccone

Download or read book Frontiers in Oncology: Quarterly Highlights. Quarter 1 2019 written by Giuseppe Giaccone and published by Frontiers Media SA. This book was released on 2019-07-01 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: Foreword from the Field Chief Editor, Giuseppe Giaccone Once again Frontiers in Oncology has started the year on a positive note, breaking previous records for submissions and publications, as well as the number of Research Topic article collections posted. The journal continues to grow in size, adding an 18th section focusing on Cancer Metabolism, led by Michael Lisanti and Ubaldo Martinez-Outschoorn, and has brought on a total of five new Chief Editors. Here, introducing Frontiers in Oncology: Quarterly Highlights, we feature a collection of carefully selected articles published during the first quarter of 2019 across the different sections. With a record number of papers to choose from, the papers enclosed in this Special Edition highlight some of the recent advances across the different disciplines. With an array of papers looking at everything from translational research to association studies and clinical trial results, Frontiers in Oncology continues to publish high-quality research from researchers around the world. Many of the recently posted Research Topics in the journal focus on early diagnosis and prevention, as well as the importance of survivorship studies and outcomes of cancer treatment. Consideration of such aspects of cancer research and treatment is pivotal in the global effort towards increased survival rates and improved quality of life. With ASCO 2019 marking the end of Q1 and the transition into Q2, the journal looks forward to the rest of the year, and continuing to play an active role in the research community. Giuseppe Giaccone

Immunoassay

Author : Eleftherios P. Diamandis
Publisher : Academic Press
ISBN 13 : 9780080534503
Total Pages : 579 pages
Book Rating : 4.5/5 (345 download)

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Book Synopsis Immunoassay by : Eleftherios P. Diamandis

Download or read book Immunoassay written by Eleftherios P. Diamandis and published by Academic Press. This book was released on 1996-06-21 with total page 579 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunoassays are among the most powerful and sensitive technologies now available for patient diagnosis and monitoring. This book is an indispensable guide to information on the theory and practice of immunoassays. It discusses the scientific basis of these technologies in a logical, organized, and heuristic manner and provides protocols for specific assays. The contents of this unique book are balanced among theory, practical issues, quality control, automation, and subspecialty areas, making it ideal for health science students, laboratory scientists, and clinicians. Presents up-to-date information Provides extensive cross-referencing Covers theory and practice in full detail Written by leading authorities

IASLC Thoracic Oncology E-Book

Author : Harvey Pass
Publisher : Elsevier Health Sciences
ISBN 13 : 0323527841
Total Pages : 960 pages
Book Rating : 4.3/5 (235 download)

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Book Synopsis IASLC Thoracic Oncology E-Book by : Harvey Pass

Download or read book IASLC Thoracic Oncology E-Book written by Harvey Pass and published by Elsevier Health Sciences. This book was released on 2017-04-21 with total page 960 pages. Available in PDF, EPUB and Kindle. Book excerpt: Global experts, in conjunction with the International Association for the Study of Lung Cancer, bring you up to date with today’s best approaches to lung cancer diagnosis, treatment, and follow-up. IASLC Thoracic Oncology, 2nd Edition, keeps you abreast of the entire scope of this fast-changing field, from epidemiology to diagnosis to treatment to advocacy. Written in a straightforward, practical style for the busy clinician, this comprehensive, multidisciplinary title is a must-have for anyone involved in the care of patients with lung cancer and other thoracic malignancies. Offers practical, relevant coverage of basic science, epidemiology, pulmonology, medical and radiation oncology, surgery, pathology, palliative care, nursing, and advocacy. Provides authoritative guidance from the IASLC – the only global organization dedicated to the study of lung cancer. Includes new content on molecular testing, immunotherapy, early detection, staging and the IASLC staging system, surgical resection for stage I and stage II lung cancer, and stem cells in lung cancer. Features a new full-color design throughout, as well as updated diagnostic algorithms.