Animals And Bioterrorism

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Animal Models for Assessing Countermeasures to Bioterrorism Agents

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309219094
Total Pages : 152 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Animal Models for Assessing Countermeasures to Bioterrorism Agents by : National Research Council

Download or read book Animal Models for Assessing Countermeasures to Bioterrorism Agents written by National Research Council and published by National Academies Press. This book was released on 2012-01-09 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Transformational Medical Technologies (TMT) has been a unique component of the U.S. Department of Defense (DoD) medical biodefense efforts since 2006. Its mission is to advance countermeasure research and development in support of the broader goal of the DoD to protect warfighters from emerging infectious diseases and future genetically engineered biological weapons. The TMT, using advanced science and technology approaches, focused on the development of roadspectrum countermeasures that target common host and pathogen pathways or enhance the host's immune response. Many of these pathogens are lethal or cause such debilitating diseases in humans that it is ethically inappropriate to test the efficacy of these countermeasures in human volunteers. In lieu of human participants, these products may be tested in animals and approved for human use under the provisions of the Food and Drug Administration (FDA)'s 2002 Animal Rule. The reliance on animal models for the development and licensure of medical countermeasures against biothreats is challenging for a number of reasons. The ad hoc Committee on Animal Models for Assessing Countermeasures to Bioterrorism Agents prepared a consensus report that would address the challenges stemming from developing and testing medical countermeasures against biothreat agents in animal models. Animal Models for Assessing Countermeasures to Bioterrorism Agents evaluates how well the existing TMT-employed or candidate animal models reflect the pathophysiology, clinical picture, and treatment of human disease as related to the agents of interest. The report addresses the process and/or feasibility of developing new animal models for critical biodefense research, placing emphasis on the need for a robust and expeditious validation process in terms of the FDA's Animal Rule. The report also evaluates alternatives to the use of animal models based on the premise of the Three Rs.

Overcoming Challenges to Develop Countermeasures Against Aerosolized Bioterrorism Agents

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309102111
Total Pages : 87 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Overcoming Challenges to Develop Countermeasures Against Aerosolized Bioterrorism Agents by : National Research Council

Download or read book Overcoming Challenges to Develop Countermeasures Against Aerosolized Bioterrorism Agents written by National Research Council and published by National Academies Press. This book was released on 2006-09-07 with total page 87 pages. Available in PDF, EPUB and Kindle. Book excerpt: The National Institute of Allergy and Infectious Diseases (NIAID) gives the highest priority to developing countermeasures against bioterrorism agents that are highly infective when dispersed in aerosol form. Developing drugs to prevent or treat illnesses caused by bioterrorism agents requires testing their effectiveness in animals since human clinical trials would be unethical. At the request of NIAID, the National Academies conducted a study to examine how such testing could be improved. Overcoming Challenges to Develop Countermeasures Against Aerosolized Bioterrorism Agents provides recommendations to researchers on selecting the kinds of animal models, aerosol generators, and bioterrorism agent doses that would produce conditions that most closely mimic the disease process in humans. It also urges researchers to fully document experimental parameters in the literature so that studies can be reproduced and compared. The book recommends that all unclassified data on bioterrorism agent studies-including unclassified, unpublished data from U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID)-be published in the open literature. The book also calls on the U.S. Food and Drug Administration to improve the process by which bioterrorism countermeasures are approved based on the results of animal studies.

Countering Agricultural Bioterrorism

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 9780309085458
Total Pages : 196 pages
Book Rating : 4.0/5 (854 download)

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Book Synopsis Countering Agricultural Bioterrorism by : National Research Council

Download or read book Countering Agricultural Bioterrorism written by National Research Council and published by National Academies Press. This book was released on 2003-05-30 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Public confidence in the security of the US food and fiber system has been sustained by the quality, variety, abundance, and affordability of agricultural products in the United States. Although the system in place to defend against unintentional threats to agriculture has weaknesses and needs, the demonstrated ability of the system to resolve, accommodate, or manage critical food safety problems, temporary shortages of some commodities, plant and animal infestations and diseases, and natural disasters indicates that, in general, such confidence has been warranted. However, over the last several years, there has been recognition of the possibility and consequences of intentional threats directed at US agriculture. Such attacks could come from foreign or domestic terrorists and use biological, chemical, or radiological agents. They could be directed at the pre harvest (live plant and live animal) or post harvest (processing and distribution) stages of food and fiber production. Countering Agricultural Bioterrorism asseses the vulnerability of US agriculture to intentional threats and provides recommendations needed to strengthen and adapt the US system for defense against biological threats to agriculture.

Animals and Bioterrorism

Author : University of Minnesota. College of Veterinary Medicine
Publisher :
ISBN 13 :
Total Pages : 66 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Animals and Bioterrorism by : University of Minnesota. College of Veterinary Medicine

Download or read book Animals and Bioterrorism written by University of Minnesota. College of Veterinary Medicine and published by . This book was released on 2001 with total page 66 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Anthrax in Humans and Animals

Author : World Health Organization
Publisher : World Health Organization
ISBN 13 : 9241547537
Total Pages : 219 pages
Book Rating : 4.2/5 (415 download)

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Book Synopsis Anthrax in Humans and Animals by : World Health Organization

Download or read book Anthrax in Humans and Animals written by World Health Organization and published by World Health Organization. This book was released on 2008 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fourth edition of the anthrax guidelines encompasses a systematic review of the extensive new scientific literature and relevant publications up to end 2007 including all the new information that emerged in the 3-4 years after the anthrax letter events. This updated edition provides information on the disease and its importance, its etiology and ecology, and offers guidance on the detection, diagnostic, epidemiology, disinfection and decontamination, treatment and prophylaxis procedures, as well as control and surveillance processes for anthrax in humans and animals. With two rounds of a rigorous peer-review process, it is a relevant source of information for the management of anthrax in humans and animals.

Guidelines for the Humane Transportation of Research Animals

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 030916477X
Total Pages : 164 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Guidelines for the Humane Transportation of Research Animals by : National Research Council

Download or read book Guidelines for the Humane Transportation of Research Animals written by National Research Council and published by National Academies Press. This book was released on 2006-07-14 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: Arranging the transportation of animals at research facilities is often an ordeal. There is a confusing patchwork of local, national, and international regulations; a perceived lack of high-quality shipping services; a dearth of science-based good practices; and a lack of biosafety standards. It's a challenge â€"and an impediment to biomedical research. Guidelines for the Humane Transportation of Research Animals identifies the current problems encountered in the transportation of research animals and offers recommendations aimed at local and federal officials to rectify these problems. This book also includes a set of good practices based on the extensive body of literature on transportation of agricultural animals, universal concepts of physiology, and a scientific understanding of species-specific needs and differences. Good practices were developed by the committee to address thermal environment, space requirements, food and water requirements, social interaction, monitoring of transportation, emergency procedures, personnel training, and biosecurity. Guidelines for the Humane Transportation of Research Animals is an essential guide for all researchers, animal care technicians, facilities managers, administrators, and animal care and use committees at research institutions.

Biological Disasters of Animal Origin

Author : Martin E. Hugh-Jones
Publisher : Office International Des Epizooties
ISBN 13 : 9789290446613
Total Pages : 461 pages
Book Rating : 4.4/5 (466 download)

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Book Synopsis Biological Disasters of Animal Origin by : Martin E. Hugh-Jones

Download or read book Biological Disasters of Animal Origin written by Martin E. Hugh-Jones and published by Office International Des Epizooties. This book was released on 2006 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Bioterrorism Agents

Author : Jacob Casper
Publisher :
ISBN 13 :
Total Pages : 100 pages
Book Rating : 4.:/5 (487 download)

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Book Synopsis Bioterrorism Agents by : Jacob Casper

Download or read book Bioterrorism Agents written by Jacob Casper and published by . This book was released on 2001 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Biosecurity and Bioterrorism

Author : Jeffrey Ryan
Publisher : Butterworth-Heinemann
ISBN 13 : 0128020571
Total Pages : 394 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Biosecurity and Bioterrorism by : Jeffrey Ryan

Download or read book Biosecurity and Bioterrorism written by Jeffrey Ryan and published by Butterworth-Heinemann. This book was released on 2016-02-18 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biosecurity and Bioterrorism, Second Edition, takes a holistic approach to biosecurity, with coverage of pathogens, prevention, and response methodology. It addresses these hazards in the context of vulnerability assessments and the planning strategies government and industry can use to prepare for and respond to such events. The book is organized into four thematic sections: Part I provides a conceptual understanding of biowarfare, bioterrorism and the laws we have to counteract this; Part II investigates known bioagents and the threat from emerging diseases; Part III focuses on agricultural terrorism and food security; and Part IV outlines international, US, and local initiatives for biodefense and biosecurity. Case studies illustrate biodefense against both intentional terrorism and natural outbreaks. - Covers emerging threats of pandemic influenza, antibiotic resistant strains of bacterial pathogens, and severe respiratory diseases caused by novel viruses - Offers increased international coverage, including initiatives to counter biological weapons and threats, and food security - Updated throughout with latest protocols for dealing with biological threats and new case studies - Includes online instructor ancillaries - PowerPoint lecture slides, test questions, and an instructor manual, for increased classroom functionality

Bioterrorism and Infectious Agents

Author : I.W. Fong
Publisher : Springer Science & Business Media
ISBN 13 : 1441912665
Total Pages : 284 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Bioterrorism and Infectious Agents by : I.W. Fong

Download or read book Bioterrorism and Infectious Agents written by I.W. Fong and published by Springer Science & Business Media. This book was released on 2010-03-18 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Compiled by two leading experts in the field, this volume provides a concise, timely, and authoritative review of some of the most problematic infections of the new century. It presents issues and new ideas for preventing and controlling infectious diseases.

The Arenaviridae

Author : Maria S. Salvato
Publisher : Springer Science & Business Media
ISBN 13 : 1461530288
Total Pages : 417 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis The Arenaviridae by : Maria S. Salvato

Download or read book The Arenaviridae written by Maria S. Salvato and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this volume, a distinguished international group of contributors present the latest molecular, organismal, and epidemiological research on arenaviruses. Their work will broaden both the clinician's and the researcher's knowledge of basic mechanisms of immunological tolerance, viral immunosuppression, the nature of protective immune responses to vaccination, and viral effects on cell functions.

Bioterrorism

Author : Lawrence J. Dyckman
Publisher :
ISBN 13 :
Total Pages : 24 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis Bioterrorism by : Lawrence J. Dyckman

Download or read book Bioterrorism written by Lawrence J. Dyckman and published by . This book was released on 2003 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Defence Against Bioterrorism

Author : Vladan Radosavljevic
Publisher : Springer
ISBN 13 : 9402412638
Total Pages : 272 pages
Book Rating : 4.4/5 (24 download)

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Book Synopsis Defence Against Bioterrorism by : Vladan Radosavljevic

Download or read book Defence Against Bioterrorism written by Vladan Radosavljevic and published by Springer. This book was released on 2018-03-22 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is based on a multidisciplinary approach towards biological and chemical threats that can, and have been previously used in bioterrorism attacks around the globe. Current knowledge and evidence-based principles from the fields of synthetic biology, microbiology, plant biology, chemistry, food science, forensics, tactics, infective medicine, psychology and others are compiled to address numerous aspects and the complexity of bioterrorism attacks. The main focus is on biological threats, especially in the context of synthetic biology and its emerging findings that can be observed as possible threat and tool. The book examines microorganisms and their possible use in forensics, i.e. as possible detection tool that could enable fast and precise detection of possible treats. A number of plant derived components are also discussed as possible agents in bioterrorism attacks, and in relation to infectious disease pathology. Another integral part is food safety, especially in terms of large food supply chains, like airline caterings, institutionalized kitchens etc. Food can be observed as a possible mean of delivery of various agents (biological and chemical) for bioterrorism attacks. Steps on how to recognize specific critical points in a food supply chain, along with proposed corrective activities are discussed. Examples from around the globe, along with the methodological approach on how to differentiate bioterrorism attacks from other epidemics are provided. However, epidemics are also discussed in the context of migrations, with the special emphasis on the current refugee migrations that affect not only Europe, but also the United States. The book will be of interest to experts from various fields of science as well as professionals working in the field. The book encompasses examples and tools developed for easier, more specific, and faster detection of possible bioterrorism treats, along with proposed actions for some aspects of a bioterrorism attack.

Handbook on Biological Warfare Preparedness

Author : S.J.S. Flora
Publisher : Academic Press
ISBN 13 : 012812055X
Total Pages : 308 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Handbook on Biological Warfare Preparedness by : S.J.S. Flora

Download or read book Handbook on Biological Warfare Preparedness written by S.J.S. Flora and published by Academic Press. This book was released on 2019-10-05 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook on Biological Warfare Preparedness provides detailed information on biological warfare agents and their mode of transmission and spread. In addition, it explains methods of detection and medical countermeasures, including vaccine and post-exposure therapeutics, with specific sections detailing diseases, their transmission, clinical signs and symptoms, diagnosis, treatment, vaccines, prevention and management. This book is useful reading for researchers and advanced students in toxicology, but it will also prove helpful for medical students, civil administration, medical doctors, first responders and security forces. As the highly unpredictable nature of any event involving biological warfare agents has given rise to the need for the rapid development of accurate detection systems, this book is a timely resource on the topic. - Introduces different bacterial and viral agents, including Ebola and other emerging threats and toxins - Discusses medical countermeasures, including vaccines and post-exposure therapeutics - Includes a comprehensive review of current methods of detection

The United States and Biological Warfare

Author : Stephen Endicott
Publisher : Indiana University Press
ISBN 13 : 9780253334725
Total Pages : 320 pages
Book Rating : 4.3/5 (347 download)

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Book Synopsis The United States and Biological Warfare by : Stephen Endicott

Download or read book The United States and Biological Warfare written by Stephen Endicott and published by Indiana University Press. This book was released on 1998-11-22 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: The United States and Biological Warfare] is a major contribution to our understanding of the past involvement by the US and Japanese governments with BW, with important, crucial implications for the future.... Pieces of this story, including the Korean War allegations, have been told before, but never so authoritatively, and with such a convincing foundation in historical research.... This is a brave and significant scholarly contribution on a matter of great importance to the future of humanity. --Richard Falk, Albert G. Milbank Professor of International Law and Practice, Princeton University The United States and Biological Warfare argues persuasively that the United States experimented with and deployed biological weapons during the Korean War. Endicott and Hagerman explore the political and moral dimensions of this issue, asking what restraints were applied or forgotten in those years of ideological and political passion and military crisis. For the first time, there is hard evidence that the United States lied both to Congress and the American public in saying that the American biological warfare program was purely defensive and for retaliation only. The truth is that a large and sophisticated biological weapons system was developed as an offensive weapon of opportunity in the post-World War II years. From newly declassified American, Canadian, and British documents, and with the cooperation of the Chinese Central Archives in giving the authors the first access by foreigners to relevant classified documents, Endicott and Hagerman have been able to tell the previously hidden story of the extension of the limits of modern war to include the use of medical science, the most morally laden of sciences with respect to the sanctity of human life. They show how the germ warfare program developed collaboratively by Great Britain, Canada, and the United States during the Second World War, together with information gathered from the Japanese at the end of World War II about their biological warfare technology, was incorporated into an ongoing development program in the United States. Startling evidence from both Chinese and American sources is presented to make the case. An important book for anyone interested in the history and morality of modern warfare.

Bioterrorism and Biocrimes

Author : W. Seth Carus
Publisher : The Minerva Group, Inc.
ISBN 13 : 9781410100238
Total Pages : 224 pages
Book Rating : 4.1/5 (2 download)

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Book Synopsis Bioterrorism and Biocrimes by : W. Seth Carus

Download or read book Bioterrorism and Biocrimes written by W. Seth Carus and published by The Minerva Group, Inc.. This book was released on 2002 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: The working paper is divided into two main parts. The first part is a descriptive analysis of the illicit use of biological agents by criminals and terrorists. It draws on a series of case studies documented in the second part. The case studies describe every instance identifiable in open source materials in which a perpetrator used, acquired, or threatened to use a biological agent. While the inventory of cases is clearly incomplete, it provides an empirical basis for addressing a number of important questions relating to both biocrimes and bioterrorism. This material should enable policymakers concerned with bioterrorism to make more informed decisions. In the course of this project, the author has researched over 270 alleged cases involving biological agents. This includes all incidents found in open sources that allegedly occurred during the 20th Century. While the list is certainly not complete, it provides the most comprehensive existing unclassified coverage of instances of illicit use of biological agents.

A Short History of Biological Warfare

Author : W. Seth Carus
Publisher : Government Printing Office
ISBN 13 : 9780160941481
Total Pages : 80 pages
Book Rating : 4.9/5 (414 download)

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Book Synopsis A Short History of Biological Warfare by : W. Seth Carus

Download or read book A Short History of Biological Warfare written by W. Seth Carus and published by Government Printing Office. This book was released on 2017-08-03 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication gives a history of biological warfare (BW) from the prehistoric period through the present, with a section on the future of BW. The publication relies on works by historians who used primary sources dealing with BW. In-depth definitions of biological agents, biological weapons, and biological warfare (BW) are included, as well as an appendix of further reading on the subject. Related items: Arms & Weapons publications can be found here: https://bookstore.gpo.gov/catalog/arms-weapons Hazardous Materials (HAZMAT & CBRNE) publications can be found here: https://bookstore.gpo.gov/catalog/hazardous-materials-hazmat-cbrne