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Animal Models And Experimental Research In Medicine
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Book Synopsis Use of Laboratory Animals in Biomedical and Behavioral Research by : National Research Council
Download or read book Use of Laboratory Animals in Biomedical and Behavioral Research written by National Research Council and published by National Academies Press. This book was released on 1988-02-01 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific experiments using animals have contributed significantly to the improvement of human health. Animal experiments were crucial to the conquest of polio, for example, and they will undoubtedly be one of the keystones in AIDS research. However, some persons believe that the cost to the animals is often high. Authored by a committee of experts from various fields, this book discusses the benefits that have resulted from animal research, the scope of animal research today, the concerns of advocates of animal welfare, and the prospects for finding alternatives to animal use. The authors conclude with specific recommendations for more consistent government action.
Book Synopsis Animal Models and Experimental Research in Medicine by : Mahmut Karapehlivan
Download or read book Animal Models and Experimental Research in Medicine written by Mahmut Karapehlivan and published by BoD – Books on Demand. This book was released on 2023-04-05 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of experimental animals is quite common in medical research, especially for pharmaceutical developments and molecular pathway studies. Considering the effects of therapeutic agents used in the treatment of tissues and systems, it becomes clear how important experimental animals and the models developed on them are in research. The benefits of using animals for disease models include accessibility, applicability, and affordability. Most importantly, they have proven to be successful in the prevention, diagnosis, and treatment of many diseases. This book provides a comprehensive overview of the use of animal models for amyotrophic lateral sclerosis, hepatotoxicity, liver fibrosis/cirrhosis, visceral hyperalgesia, female reproduction, and more.
Book Synopsis Animal Models and Experimental Research in Medicine by : Manoj Shah
Download or read book Animal Models and Experimental Research in Medicine written by Manoj Shah and published by . This book was released on 2023-07-13 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Sourcebook of Models for Biomedical Research by : P. Michael Conn
Download or read book Sourcebook of Models for Biomedical Research written by P. Michael Conn and published by Springer Science & Business Media. This book was released on 2008-03-07 with total page 756 pages. Available in PDF, EPUB and Kindle. Book excerpt: The collection of systems represented in this volume is a unique effort to reflect the diversity and utility of models used in biomedicine. That utility is based on the consideration that observations made in particular organisms will provide insight into the workings of other, more complex systems. This volume is therefore a comprehensive and extensive collection of these important medical parallels.
Book Synopsis Improving the Utility and Translation of Animal Models for Nervous System Disorders by : Institute of Medicine
Download or read book Improving the Utility and Translation of Animal Models for Nervous System Disorders written by Institute of Medicine and published by National Academies Press. This book was released on 2013-04-25 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nervous system diseases and disorders are highly prevalent and substantially contribute to the overall disease burden. Despite significant information provided by the use of animal models in the understanding of the biology of nervous system disorders and the development of therapeutics; limitations have also been identified. Treatment options that are high in efficacy and low in side effects are still lacking for many diseases and, in some cases are nonexistent. A particular problem in drug development is the high rate of attrition in Phase II and III clinical trials. Why do many therapeutics show promise in preclinical animal models but then fail to elicit predicted effects when tested in humans? On March 28 and 29, 2012, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened the workshop "Improving Translation of Animal Models for Nervous System Disorders" to discuss potential opportunities for maximizing the translation of new therapies from animal models to clinical practice. The primary focus of the workshop was to examine mechanisms for increasing the efficiency of translational neuroscience research through discussions about how and when to use animal models most effectively and then best approaches for the interpretation of the data collected. Specifically, the workshop objectives were to: discuss key issues that contribute to poor translation of animal models in nervous system disorders, examine case studies that highlight successes and failures in the development and application of animal models, consider strategies to increase the scientific rigor of preclinical efficacy testing, explore the benefits and challenges to developing standardized animal and behavioral models. Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary also identifies methods to facilitate development of corresponding animal and clinical endpoints, indentifies methods that would maximize bidirectional translation between basic and clinical research and determines the next steps that will be critical for improvement of the development and testing of animal models of disorders of the nervous system.
Book Synopsis Using Animal Models in Biomedical Research by : Pierce K. H. Chow
Download or read book Using Animal Models in Biomedical Research written by Pierce K. H. Chow and published by World Scientific. This book was released on 2008 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal models play crucial roles in the continuum of experimental activities that make up biomedical research. This book fills this gap in knowledge and provides material not easily sourced by the average biomedical researcher, such as current information biosafety, animal protocal design and histological-pathological support.
Book Synopsis Animal Models in Experimental Medicine by : Faris Q. Alenzi
Download or read book Animal Models in Experimental Medicine written by Faris Q. Alenzi and published by Bentham Science Publishers. This book was released on with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference presents information about models utilized in experimental medicine and pharmaceutical research and development for several human diseases. Written by experts in immunology, cancer biology and pharmacology, the book provides readers with handy notes and updated data on animal models that are critical to research planning and lab execution. The main feature of the book is a set of 12 structured chapters that focus on a specific disease such as cancer, infectious diseases, autism, autoimmune diseases, Alzheimer’s disease and anemia. The contributors have gathered information on a wide range of genetic and physiological animal models that are employed in research with comparative charts that highlight their main differences. The book also includes chapters for special topics like food allergies and dentistry. Additional features of the book are an explanation of disease mechanisms that give an easy understanding, notes for idiopathic models and specific clinical conditions, and a list of references for advanced readers. Animal Models In Experimental Medicine is essential reading for scholars, graduate students and senior researchers in life sciences and clinical medicine. It also serves as a resource for professionals involved in bench-to-bedside pharmaceutical projects. Readership Scholars, graduate students and senior researchers in life sciences and clinical medicine; professionals involved in bench-to-bedside pharmaceutical projects.
Book Synopsis Animal Models in Medicine and Biology by : Eva Tvrdá
Download or read book Animal Models in Medicine and Biology written by Eva Tvrdá and published by BoD – Books on Demand. This book was released on 2020-04-08 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thanks to animal models, our knowledge of biology and medicine has increased enormously over the past decades, leading to significant breakthroughs that have had a direct impact on the prevention, management and treatment of a wide array of diseases.This book presents a comprehensive reference that reflects the latest scientific research being done in a variety of medical and biological fields utilizing animal models. Chapters on Drosophila, rat, pig, rabbit, and other animal models reflect frontier research in neurology, psychiatry, cardiology, musculoskeletal disorders, reproduction, chronic diseases, epidemiology, and pain and inflammation management. Animal Models in Medicine and Biology offers scientists, clinicians, researchers and students invaluable insights into a wide range of issues at the forefront of medical and biological progress.
Author :National Academies of Sciences, Engineering, and Medicine Publisher :National Academies Press ISBN 13 :0309471192 Total Pages :139 pages Book Rating :4.3/5 (94 download)
Book Synopsis Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine by : National Academies of Sciences, Engineering, and Medicine
Download or read book Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2018-05-29 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt: Precision medicine is focused on the individual and will require the rapid and accurate identification and prioritization of causative factors of disease. To move forward and accelerate the delivery of the anticipated benefits of precision medicine, developing predictable, reproducible, and reliable animal models will be essential. In order to explore the topic of animal-based research and its relevance to precision medicine, the National Academies of Sciences, Engineering, and Medicine convened a 2-day workshop on October 5 and 6, 2017. The workshop was designed to focus on the development, implementation, and interpretation of model organisms to advance and accelerate the field of precision medicine. Participants examined the extent to which next-generation animal models, designed using patient data and phenotyping platforms targeted to reveal and inform disease mechanisms, will be essential to the successful implementation of precision medicine. This publication summarizes the presentations and discussions from the workshop.
Book Synopsis Comparative Physiology, Natural Animal Models And Clinical Medicine: Insights Into Clinical Medicine From Animal Adaptations by : Michael Alan Singer
Download or read book Comparative Physiology, Natural Animal Models And Clinical Medicine: Insights Into Clinical Medicine From Animal Adaptations written by Michael Alan Singer and published by World Scientific. This book was released on 2007-07-27 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes a novel and unique approach to the treatment of human diseases based on the study of natural animal models. A natural animal model is defined as an animal group or species that possesses a set of biochemical/physiological characteristics which are natural and adaptive for that animal, but are quite abnormal for humans. For example, how is it that birds can tolerate blood glucose concentrations which in humans are associated with diabetes. The natural animal model is living proof that a biological answer to this question is available. By studying natural animal models, we can gain valuable insights into the treatment of various human clinical disorders. Covering a wide range of disorders, this book describes in detail how medical scientists can take advantage of all the “research” that nature has already performed over billions of years in biological problem solving through extensive animal design testing and selection./a
Author :National Academies of Sciences, Engineering, and Medicine Publisher :National Academies Press ISBN 13 :0309463912 Total Pages :115 pages Book Rating :4.3/5 (94 download)
Book Synopsis Animal Models for Microbiome Research by : National Academies of Sciences, Engineering, and Medicine
Download or read book Animal Models for Microbiome Research written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2018-04-23 with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt: The surface of the human body and its mucous membranes are heavily colonized by microorganisms. Our understanding of the contributions that complex microbial communities make to health and disease is advancing rapidly. Most microbiome research to date has focused on the mouse as a model organism for delineating the mechanisms that shape the assembly and dynamic operations of microbial communities. However, the mouse is not a perfect surrogate for studying different aspects of the microbiome and how it responds to various environmental and host stimuli, and as a result, researchers have been conducting microbiome studies in other animals. To examine the different animal models researchers employ in microbiome studies and to better understand the strengths and weaknesses of each of these model organisms as they relate to human and nonhuman health and disease, the Roundtable on Science and Welfare in Laboratory Animal Use of the National Academies of Sciences, Engineering, and Medicine convened a workshop in December 2016. The workshop participants explored how to improve the depth and breadth of analysis of microbial communities using various model organisms, the challenges of standardization and biological variability that are inherent in gnotobiotic animal-based research, the predictability and translatability of preclinical studies to humans, and strategies for expanding the infrastructure and tools for conducting studies in these types of models. This publication summarizes the presentations and discussions from the workshop.
Book Synopsis Science, Medicine, and Animals by : National Research Council
Download or read book Science, Medicine, and Animals written by National Research Council and published by National Academies Press. This book was released on 2004-11-21 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt: Science, Medicine, and Animals explains the role that animals play in biomedical research and the ways in which scientists, governments, and citizens have tried to balance the experimental use of animals with a concern for all living creatures. An accompanying Teacher's Guide is available to help teachers of middle and high school students use Science, Medicine, and Animals in the classroom. As students examine the issues in Science, Medicine, and Animals, they will gain a greater understanding of the goals of biomedical research and the real-world practice of the scientific method in general. Science, Medicine, and Animals and the Teacher's Guide were written by the Institute for Laboratory Animal Research and published by the National Research Council of the National Academies. The report was reviewed by a committee made up of experts and scholars with diverse perspectives, including members of the U.S. Department of Agriculture, National Institutes of Health, the Humane Society of the United States, and the American Society for the Prevention of Cruelty to Animals. The Teacher's Guide was reviewed by members of the National Academies' Teacher Associates Network. Science, Medicine, and Animals is recommended by the National Science Teacher's Association.
Book Synopsis Experimental Design and Reproducibility in Preclinical Animal Studies by : José M. Sánchez Morgado
Download or read book Experimental Design and Reproducibility in Preclinical Animal Studies written by José M. Sánchez Morgado and published by Springer Nature. This book was released on 2021-08-31 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: This highly-readable text provides grounds on how to plan and conduct animal experiments that can be reproduced by others. The book touches on factors that may impact the reproducibility of animal studies including: the animal genetic background, the animal microbial flora, environmental and physiological variables affecting the animal, animal welfare, statistics and experimental design, systematic reviews of animal studies, and the publishing process. The book addresses advanced undergraduates, graduate students and all scientists working with animals.
Book Synopsis Animal Models in Biomedical Research by : Cynthia Petrie Smith
Download or read book Animal Models in Biomedical Research written by Cynthia Petrie Smith and published by . This book was released on 1991 with total page 66 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis What Will We Do If We Don't Experiment on Animals? by : Jean Swingle Greek
Download or read book What Will We Do If We Don't Experiment on Animals? written by Jean Swingle Greek and published by Trafford Publishing. This book was released on 2004 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drs. Greek have written 2 books on why using animals as models for humans is not the best way to conduct medical research and drug testing. During their lectures and debates, the most commonly asked question was, "Well. What will we use if we don't use animals?" What Will We Do If We Don't Experiment On Animals? Medical Research for the Twenty-first Century is the answer to that question. Drs. Greek explain briefly why one species cannot predict drug response for another and describe what research and testing methods should be used today instead of animals. They also describe where our biomedical research dollars should be spent if we are to have cures for cancer, AIDS, and Alzheimer's. This book will appeal to science-trained and general audiences, animal lovers and science readers, public policy analysts, students, patients and patient support groups, and government watchdog groups. What Will We Do If We Don't Experiment On Animals? Medical Research for the Twenty-first Century takes medical research out of the nineteenth and into the 21st century.
Book Synopsis Experimental Animal Models of Human Diseases by : Bartholomew Ibeh
Download or read book Experimental Animal Models of Human Diseases written by Bartholomew Ibeh and published by BoD – Books on Demand. This book was released on 2018-05-23 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: The world has recorded losses in terms of human life as well as extensive time spent in experimentation with development of new drugs, elucidation of disease mechanism(s), and therapeutic agent discovery. Ethical and legal issues cojoin in slowing down scientific discoveries in medicine and biology. The past two (2) decades, therefore, have seen tremendous attempts that largely are successful in developing animal models with the characteristics of mimicking, approximating, or expressing transplanted human organs/tissues. These models or rather approaches seem to be fast, cost-effective, and easy to maintain compared to primates. This book is a collection of expert essays on animal models of human diseases of global interest. A visible objective of the book is to provide real-time experimental approach to scientists, clinicians, ethicists, medicolegal/medical jurisprudence workers, immunologists, postgraduate students, and vaccinologists and informative and multidisciplinary approach for the identification of new therapeutic targets and biomarkers using animal models as well as investigating the pathogenesis and therapeutic strategies of human diseases. An increased understanding of the genetic, molecular, and cellular mechanisms responsible for the development of human diseases has laid out the foundation for the development of rational therapies mainly with animal models.
Download or read book Specious Science written by C. Ray Greek and published by A&C Black. This book was released on 2002-01-01 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Builds on the message of Sacred Cows and Golden Geese to understand why medical research on animals really harms humans.
