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Analysis Of Randomized Experiments With Missing Data
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Book Synopsis Analysis of Randomized Experiments with Missing Data by :
Download or read book Analysis of Randomized Experiments with Missing Data written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Resources for the Future (RFF), located in Washington, D.C., offers the full text of the May 2000 discussion paper entitled "The Analysis of Randomized Experiments with Missing Data," written by Guido W. Imbens and William A. Pizer. The text is available in PDF format. The authors provide an alternative to the missing at random model (MAR), which is both consistent with the data and preserves the satisfaction of MAR.
Book Synopsis Nonparametric Analysis of Randomized Experiments with Missing Covariate and Outcome Data by : Joel L. Horowitz
Download or read book Nonparametric Analysis of Randomized Experiments with Missing Covariate and Outcome Data written by Joel L. Horowitz and published by . This book was released on 1997 with total page 34 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Statistical Analysis of Randomized Experiments with Nonignorable Missing Binary Outcomes by : Kosuke Imai
Download or read book Statistical Analysis of Randomized Experiments with Nonignorable Missing Binary Outcomes written by Kosuke Imai and published by . This book was released on 2007 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Missing data are frequently encountered in the statistical analysis of randomized experiments. In this paper, I propose statistical methods that can be used to analyze randomized experiments with a nonignorable missing binary outcome where the missing-data mechanism may depend on the unobserved values of the outcome variable itself. I first introduce an identification strategy for the average treatment effect and compare it with the existing alternative approaches in the literature. I then derive the maximum likelihood estimator and its asymptotic properties, and discuss possible estimation methods. Furthermore, since the proposed identification assumption is not directly verifiable from the data, I show how to conduct a sensitivity analysis based on the parameterization that links the key identification assumption with the causal quantities of interest. Then, the proposed methodology is extended to the analysis of randomized experiments with noncompliance. Although the method introduced in this paper may not directly apply to randomized experiments with non-binary outcomes, I briefly discuss possible identification strategies in more general situations. Finally, I apply the proposed methodology to analyze data from the German election experiment and the influenza vaccination study, which originally motivated the methodological problems addressed in this paper.
Book Synopsis Randomized Experiments for Planning and Evaluation by : Robert F. Boruch
Download or read book Randomized Experiments for Planning and Evaluation written by Robert F. Boruch and published by SAGE. This book was released on 1997 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Boruch untangles the complexities of randomized field experiments, exploring the criteria for deciding whether a programme has worked or not, standards used to judge the ethcial propriety of the experiments and baseline measures.
Book Synopsis Quasi-Experimentation by : Charles S. Reichardt
Download or read book Quasi-Experimentation written by Charles S. Reichardt and published by Guilford Publications. This book was released on 2019-09-02 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Featuring engaging examples from diverse disciplines, this book explains how to use modern approaches to quasi-experimentation to derive credible estimates of treatment effects under the demanding constraints of field settings. Foremost expert Charles S. Reichardt provides an in-depth examination of the design and statistical analysis of pretest-posttest, nonequivalent groups, regression discontinuity, and interrupted time-series designs. He details their relative strengths and weaknesses and offers practical advice about their use. Reichardt compares quasi-experiments to randomized experiments and discusses when and why the former might be a better choice. Modern moethods for elaborating a research design to remove bias from estimates of treatment effects are described, as are tactics for dealing with missing data and noncompliance with treatment assignment. Throughout, mathematical equations are translated into words to enhance accessibility.
Book Synopsis Flexible Imputation of Missing Data, Second Edition by : Stef van Buuren
Download or read book Flexible Imputation of Missing Data, Second Edition written by Stef van Buuren and published by CRC Press. This book was released on 2018-07-17 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Missing data pose challenges to real-life data analysis. Simple ad-hoc fixes, like deletion or mean imputation, only work under highly restrictive conditions, which are often not met in practice. Multiple imputation replaces each missing value by multiple plausible values. The variability between these replacements reflects our ignorance of the true (but missing) value. Each of the completed data set is then analyzed by standard methods, and the results are pooled to obtain unbiased estimates with correct confidence intervals. Multiple imputation is a general approach that also inspires novel solutions to old problems by reformulating the task at hand as a missing-data problem. This is the second edition of a popular book on multiple imputation, focused on explaining the application of methods through detailed worked examples using the MICE package as developed by the author. This new edition incorporates the recent developments in this fast-moving field. This class-tested book avoids mathematical and technical details as much as possible: formulas are accompanied by verbal statements that explain the formula in accessible terms. The book sharpens the reader’s intuition on how to think about missing data, and provides all the tools needed to execute a well-grounded quantitative analysis in the presence of missing data.
Book Synopsis The Prevention and Treatment of Missing Data in Clinical Trials by : National Research Council
Download or read book The Prevention and Treatment of Missing Data in Clinical Trials written by National Research Council and published by National Academies Press. This book was released on 2010-12-21 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: Randomized clinical trials are the primary tool for evaluating new medical interventions. Randomization provides for a fair comparison between treatment and control groups, balancing out, on average, distributions of known and unknown factors among the participants. Unfortunately, these studies often lack a substantial percentage of data. This missing data reduces the benefit provided by the randomization and introduces potential biases in the comparison of the treatment groups. Missing data can arise for a variety of reasons, including the inability or unwillingness of participants to meet appointments for evaluation. And in some studies, some or all of data collection ceases when participants discontinue study treatment. Existing guidelines for the design and conduct of clinical trials, and the analysis of the resulting data, provide only limited advice on how to handle missing data. Thus, approaches to the analysis of data with an appreciable amount of missing values tend to be ad hoc and variable. The Prevention and Treatment of Missing Data in Clinical Trials concludes that a more principled approach to design and analysis in the presence of missing data is both needed and possible. Such an approach needs to focus on two critical elements: (1) careful design and conduct to limit the amount and impact of missing data and (2) analysis that makes full use of information on all randomized participants and is based on careful attention to the assumptions about the nature of the missing data underlying estimates of treatment effects. In addition to the highest priority recommendations, the book offers more detailed recommendations on the conduct of clinical trials and techniques for analysis of trial data.
Book Synopsis Identification Problems in the Social Sciences by : Charles F. Manski
Download or read book Identification Problems in the Social Sciences written by Charles F. Manski and published by Harvard University Press. This book was released on 1995 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: The author draws on examples from a range of disciplines to provide social and behavioural scientists with a toolkit for finding bounds when predicting behaviours based upon nonexperimental and experimental data.
Book Synopsis Secondary Analysis of Electronic Health Records by : MIT Critical Data
Download or read book Secondary Analysis of Electronic Health Records written by MIT Critical Data and published by Springer. This book was released on 2016-09-09 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book trains the next generation of scientists representing different disciplines to leverage the data generated during routine patient care. It formulates a more complete lexicon of evidence-based recommendations and support shared, ethical decision making by doctors with their patients. Diagnostic and therapeutic technologies continue to evolve rapidly, and both individual practitioners and clinical teams face increasingly complex ethical decisions. Unfortunately, the current state of medical knowledge does not provide the guidance to make the majority of clinical decisions on the basis of evidence. The present research infrastructure is inefficient and frequently produces unreliable results that cannot be replicated. Even randomized controlled trials (RCTs), the traditional gold standards of the research reliability hierarchy, are not without limitations. They can be costly, labor intensive, and slow, and can return results that are seldom generalizable to every patient population. Furthermore, many pertinent but unresolved clinical and medical systems issues do not seem to have attracted the interest of the research enterprise, which has come to focus instead on cellular and molecular investigations and single-agent (e.g., a drug or device) effects. For clinicians, the end result is a bit of a “data desert” when it comes to making decisions. The new research infrastructure proposed in this book will help the medical profession to make ethically sound and well informed decisions for their patients.
Book Synopsis Cochrane Handbook for Systematic Reviews of Interventions by : Julian P. T. Higgins
Download or read book Cochrane Handbook for Systematic Reviews of Interventions written by Julian P. T. Higgins and published by Wiley. This book was released on 2008-11-24 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: Healthcare providers, consumers, researchers and policy makers are inundated with unmanageable amounts of information, including evidence from healthcare research. It has become impossible for all to have the time and resources to find, appraise and interpret this evidence and incorporate it into healthcare decisions. Cochrane Reviews respond to this challenge by identifying, appraising and synthesizing research-based evidence and presenting it in a standardized format, published in The Cochrane Library (www.thecochranelibrary.com). The Cochrane Handbook for Systematic Reviews of Interventions contains methodological guidance for the preparation and maintenance of Cochrane intervention reviews. Written in a clear and accessible format, it is the essential manual for all those preparing, maintaining and reading Cochrane reviews. Many of the principles and methods described here are appropriate for systematic reviews applied to other types of research and to systematic reviews of interventions undertaken by others. It is hoped therefore that this book will be invaluable to all those who want to understand the role of systematic reviews, critically appraise published reviews or perform reviews themselves.
Book Synopsis Selection Bias and Covariate Imbalances in Randomized Clinical Trials by : Vance Berger
Download or read book Selection Bias and Covariate Imbalances in Randomized Clinical Trials written by Vance Berger and published by John Wiley & Sons. This book was released on 2007-10-22 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: Selection bias can, and does, occur, even in randomized clinical trials. Steps need to be taken in order to ensure that this does not compromise the integrity of clinical trials; hence “Selection Bias and Covariate Imbalances in Randomized Clinical Trials” offers a comprehensive treatment of the subject and the methodology involved. This book: Provides an overview of the hierarchy of study designs, and justifies the position of randomised trials at the top of this hierarchy. Discusses the strengths and defects of randomisation, and provides real evidence to justify concern regarding its defects. Outlays the damaging consequences that selection bias causes when it does occur. Considers courses of action that can be taken to manage/ contain the problem. Presents methods that can be used to detect selection bias in randomised trials, and methods to correct for selection bias. Concludes by providing a comprehensive plan for managing baseline imbalances and selection bias in randomised trials, and proposing open problems for future research. Illustrated with case studies, this book introduces groundbreaking ideas and research that will be invaluable to researchers and practitioners who design and analyse clinical trials. It will also be of interest to graduate students within the field of biostatistics.
Book Synopsis Logistic Regression with Missing Values in the Covariates by : Werner Vach
Download or read book Logistic Regression with Missing Values in the Covariates written by Werner Vach and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: In many areas of science a basic task is to assess the influence of several factors on a quantity of interest. If this quantity is binary logistic, regression models provide a powerful tool for this purpose. This monograph presents an account of the use of logistic regression in the case where missing values in the variables prevent the use of standard techniques. Such situations occur frequently across a wide range of statistical applications. The emphasis of this book is on methods related to the classical maximum likelihood principle. The author reviews the essentials of logistic regression and discusses the variety of mechanisms which might cause missing values while the rest of the book covers the methods which may be used to deal with missing values and their effectiveness. Researchers across a range of disciplines and graduate students in statistics and biostatistics will find this a readable account of this.
Book Synopsis Statistical Power Analysis with Missing Data by : Adam Davey
Download or read book Statistical Power Analysis with Missing Data written by Adam Davey and published by Routledge. This book was released on 2009-08-20 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Statistical power analysis has revolutionized the ways in which we conduct and evaluate research. Similar developments in the statistical analysis of incomplete (missing) data are gaining more widespread applications. This volume brings statistical power and incomplete data together under a common framework, in a way that is readily accessible to those with only an introductory familiarity with structural equation modeling. It answers many practical questions such as: How missing data affects the statistical power in a study How much power is likely with different amounts and types of missing data How to increase the power of a design in the presence of missing data, and How to identify the most powerful design in the presence of missing data. Points of Reflection encourage readers to stop and test their understanding of the material. Try Me sections test one’s ability to apply the material. Troubleshooting Tips help to prevent commonly encountered problems. Exercises reinforce content and Additional Readings provide sources for delving more deeply into selected topics. Numerous examples demonstrate the book’s application to a variety of disciplines. Each issue is accompanied by its potential strengths and shortcomings and examples using a variety of software packages (SAS, SPSS, Stata, LISREL, AMOS, and MPlus). Syntax is provided using a single software program to promote continuity but in each case, parallel syntax using the other packages is presented in appendixes. Routines, data sets, syntax files, and links to student versions of software packages are found at www.psypress.com/davey. The worked examples in Part 2 also provide results from a wider set of estimated models. These tables, and accompanying syntax, can be used to estimate statistical power or required sample size for similar problems under a wide range of conditions. Class-tested at Temple, Virginia Tech, and Miami University of Ohio, this brief text is an ideal supplement for graduate courses in applied statistics, statistics II, intermediate or advanced statistics, experimental design, structural equation modeling, power analysis, and research methods taught in departments of psychology, human development, education, sociology, nursing, social work, gerontology and other social and health sciences. The book’s applied approach will also appeal to researchers in these areas. Sections covering Fundamentals, Applications, and Extensions are designed to take readers from first steps to mastery.
Book Synopsis Analysis of Experiments with Missing Data by : Yadolah Dodge
Download or read book Analysis of Experiments with Missing Data written by Yadolah Dodge and published by . This book was released on 1985-09-11 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: ONE FACTOR EXPERIMENTS; TWO WAY CLASSIFICATION MODELS; ONE WAY CLASSIFICATION MODEL; 2N FACTORIAL EXPERIMENTS; THREE WAY CLASSIFICATION MODELS; MINIMALLY CONNECTED DESIGNS; LEAST SQUARES GENERALIZED INVERSES; COMPUTER PROGRAMS.
Book Synopsis Statistical Issues in Drug Development by : Stephen S. Senn
Download or read book Statistical Issues in Drug Development written by Stephen S. Senn and published by John Wiley & Sons. This book was released on 2008-02-28 with total page 523 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug development is the process of finding and producingtherapeutically useful pharmaceuticals, turning them into safe andeffective medicine, and producing reliable information regardingthe appropriate dosage and dosing intervals. With regulatoryauthorities demanding increasingly higher standards in suchdevelopments, statistics has become an intrinsic and criticalelement in the design and conduct of drug development programmes. Statistical Issues in Drug Development presents anessential and thought provoking guide to the statistical issues andcontroversies involved in drug development. This highly readable second edition has been updated toinclude: Comprehensive coverage of the design and interpretation ofclinical trials. Expanded sections on missing data, equivalence, meta-analysisand dose finding. An examination of both Bayesian and frequentist methods. A new chapter on pharmacogenomics and expanded coverage ofpharmaco-epidemiology and pharmaco-economics. Coverage of the ICH guidelines, in particular ICH E9,Statistical Principles for Clinical Trials. It is hoped that the book will stimulate dialogue betweenstatisticians and life scientists working within the pharmaceuticalindustry. The accessible and wide-ranging coverage make itessential reading for both statisticians and non-statisticiansworking in the pharmaceutical industry, regulatory bodies andmedical research institutes. There is also much to benefitundergraduate and postgraduate students whose courses include amedical statistics component.
Book Synopsis Power Analysis for Anticipated Non-Response in Randomized Block Designs by : James E. Pustejovsky
Download or read book Power Analysis for Anticipated Non-Response in Randomized Block Designs written by James E. Pustejovsky and published by . This book was released on 2011 with total page 7 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent guidance on the treatment of missing data in experiments advocates the use of sensitivity analysis and worst-case bounds analysis for addressing non-ignorable missing data mechanisms; moreover, plans for the analysis of missing data should be specified prior to data collection (Puma et al., 2009). While these authors recommend only that missing data should be anticipated in the analysis plan of an experiment, it is logically consistent that anticipation of missing data should be incorporated into another important step in the planning process for a randomized control trial (RCT): power analysis. The paper develops power analysis formulas for the worst-case lower bound and sensitivity lower bound and compares power for these estimands to the power to detect treatment effects assuming missingness at random (MAR). The methods described provide a valid and principled approach for researchers to study the consequences of anticipated levels of missing data for planned experimental designs. The paper also illustrates how these methods can be used for cost-benefit analysis, weighing measurement approaches that are less expensive but yield lower response rates against approaches that are more expensive but yield higher response rates.
Book Synopsis Design and Analysis of Group-randomized Trials by : David M. Murray
Download or read book Design and Analysis of Group-randomized Trials written by David M. Murray and published by Monographs in Epidemiology and. This book was released on 1998 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: Community or group-randomized trials, which are usually done to evaluate the effect of health promotion effors. It reviews the underlying issues, describes the most widely used research design, and presents the many approaches to analysis that are now available.
