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An Updated View On An Emerging Target
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Book Synopsis An Updated View on an Emerging Target: Selected Papers from the 8th International Conference on Protein Kinase CK2 by : Joachim Jose
Download or read book An Updated View on an Emerging Target: Selected Papers from the 8th International Conference on Protein Kinase CK2 written by Joachim Jose and published by MDPI. This book was released on 2017-05-22 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "An Updated View on an Emerging Target: Selected Papers from the 8th International Conference on Protein Kinase CK2" that was published in Pharmaceuticals
Book Synopsis Glioblastomas: New Insights for the Healthcare Professional: 2013 Edition by :
Download or read book Glioblastomas: New Insights for the Healthcare Professional: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-07-22 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glioblastomas: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Diagnosis and Screening. The editors have built Glioblastomas: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diagnosis and Screening in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Glioblastomas: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis Improving and Accelerating Therapeutic Development for Nervous System Disorders by : Institute of Medicine
Download or read book Improving and Accelerating Therapeutic Development for Nervous System Disorders written by Institute of Medicine and published by National Academies Press. This book was released on 2014-02-06 with total page 107 pages. Available in PDF, EPUB and Kindle. Book excerpt: Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.
Book Synopsis Cancer: New Insights for the Healthcare Professional: 2012 Edition by :
Download or read book Cancer: New Insights for the Healthcare Professional: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-10 with total page 3786 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Cancer. The editors have built Cancer: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cancer in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cancer: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis New Drug Development for Known and Emerging Viruses by : Helga Rübsamen-Schaeff
Download or read book New Drug Development for Known and Emerging Viruses written by Helga Rübsamen-Schaeff and published by John Wiley & Sons. This book was released on 2022-01-31 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discusses how to fight Ebola, SARS Corona, and other known or emerging human viruses by building on the successes in antiviral therapy of the past decades Written by leading medicinal chemists from academia and industry, this book discusses the entire field of antiviral drug discovery and development from a medicinal chemistry perspective, focusing on antiviral drugs, targets, and viral disease mechanisms. It provides an outlook on emerging pathogens such as Ebola, Zika, West Nile, Lassa, and includes a chapter on SARS Coronoavirus-2 causing the present pandemic. New Drug Development for Known and Emerging Viruses describes the discovery and development process for antiviral agents for different classes of viruses and targets based on the experiences from the nine human viruses for which approved drugs are on the market (HIV, HCV, Influenza, RSV, HBV, HPV, HCMV, HSV, and VZV). It covers the properties and potential of 20 classes of currently approved antivirals, including combination drugs, and looks at novel antiviral strategies against emerging viruses. Covers the entire field of antiviral drug discovery and development Addresses the need for antiviral drugs to combat major health threats such as Ebola, Zika, West Nile, and SARS Coronavirus-2 Summarizes the successes of the past 15 years in developing ground-breaking medicines against 9 major human viruses, both from the medicinal chemistry and the pharmacological angle Discusses practical and strategic challenges in the drug discovery and development process, including screening technologies, latency, and toxicity issues New Developments in Antiviral Drugs is an important book for medicinal chemists, pharmaceutical chemists, virologists, and epidemiologists, and will be of great interest to those in the pharmaceutical industry and public health agencies.
Book Synopsis New Approaches to Drug Discovery by : Ulrich Nielsch
Download or read book New Approaches to Drug Discovery written by Ulrich Nielsch and published by Springer. This book was released on 2016-03-30 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume gives an overview of state of the art technologies and future developments in the field of preclinical pharmaceutical research. A balanced mix of experts from academia and industry give insight in selected new developments in the drug discovery pathway. The topics cover the different parts of the drug discovery process, starting with new developments in the target identification and validation area. The lead generation part as a next step focuses on the requirements and technologies to identify new small molecules as lead compounds for further optimization; in a second section the technologies to identify biologics as leads are addressed. The final part focuses on the pharmacological models and technologies to characterize new compounds and the impact of biomarkers to facilitate the transfer of drug candidates into the development phase.
Book Synopsis Emerging Therapies Targeting the Pathophysiology of Sickle Cell Disease, An Issue of Hematology/Oncology Clinics by : Elliot Vichinsky
Download or read book Emerging Therapies Targeting the Pathophysiology of Sickle Cell Disease, An Issue of Hematology/Oncology Clinics written by Elliot Vichinsky and published by Elsevier Health Sciences. This book was released on 2014-04-28 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Hematology/Oncology Clinics, guest edited by Dr. Elliott Vichinsky, is devoted to Sickle Cell Disease, and focuses on pathophysiology of hemoglobinopathies, therapeutic targets, and new approaches to correcting ineffective erythropoiesis and iron dysregulation. Articles in this issue include Polymerization and red cell membrane changes; Overview on reperfusion injury in the pathophysiology of SCD; Regulation of ineffective erythropoiesis in iron metabolism; Altering oxygen affinity; Cellular adhesion and the endothelium; Arginine therapy; Role of the hemostatic system on SCD pathophysiology and potential therapeutics; Adenosine signaling and novel therapies; New approaches to correcting ineffective erythropoiesis and iron dysregulation; New approaches to correcting ineffective erythropoiesis and iron dysregulation; Fetal hemoglobin induction; Gene therapy for hemoglobinopathies; and Oxidative injury and the role of antioxidant therapy.
Book Synopsis SME Internationalization Strategies by : Noémie Dominguez
Download or read book SME Internationalization Strategies written by Noémie Dominguez and published by John Wiley & Sons. This book was released on 2018-03-15 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Internationalization is a strategic issue for companies as it is today the central axis for the development of small and medium-sized enterprises (SMEs). Market expansion and the growing importance of emerging markets offer new development opportunities for SMEs to use innovative strategies - such as head-deck strategies - to effectively penetrate these markets. This book focuses on understanding these new strategies. Why do SMEs use head-of-bridge strategies in order to internationalize? How do they deploy such strategies abroad? Based on the example of five manufacturing SMEs, which are at different stages of internationalization, this book highlights the main motivations, stages of deployment but also difficulties encountered in this direction. This book is a tool for assessing potential locations and provide managers with a new alternative in terms of internationalization, enabling rapid identification of key stakeholders, adapting their international development plan and anticipating potential pitfalls.
Book Synopsis Using New Metabolic Approaches to Target and Eradicate Cancer Stem Cells by : Michael P. Lisanti
Download or read book Using New Metabolic Approaches to Target and Eradicate Cancer Stem Cells written by Michael P. Lisanti and published by Frontiers Media SA. This book was released on 2022-07-14 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topic Editors MPL and FS hold a minority interest in Lunella Biotech, Inc.
Book Synopsis Computer Vision – ECCV 2018 by : Vittorio Ferrari
Download or read book Computer Vision – ECCV 2018 written by Vittorio Ferrari and published by Springer. This book was released on 2018-10-06 with total page 855 pages. Available in PDF, EPUB and Kindle. Book excerpt: The sixteen-volume set comprising the LNCS volumes 11205-11220 constitutes the refereed proceedings of the 15th European Conference on Computer Vision, ECCV 2018, held in Munich, Germany, in September 2018.The 776 revised papers presented were carefully reviewed and selected from 2439 submissions. The papers are organized in topical sections on learning for vision; computational photography; human analysis; human sensing; stereo and reconstruction; optimization; matching and recognition; video attention; and poster sessions.
Book Synopsis Developing Programs in Adult Education by : Edgar J. Boone
Download or read book Developing Programs in Adult Education written by Edgar J. Boone and published by Waveland Press. This book was released on 2002-05-10 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second Edition of Developing Programs in Adult Education will serve as an indispensable guide for current and prospective adult educators in planning, designing/implementing, and evaluating/accounting for adult education programs. Like the successful First Edition, this revised and expanded volume presents a conceptual programming model that draws from many concepts, constructs, and theories generated by adult educators and other scholars in closely allied disciplines. The updated model, field tested and validated, enhances and elaborates on the complex contextual relationships and processual actions represented in the original. The authors offer illustrative applications within varied organizational contexts and provide a panorama of both macro- and micro-perspectives and actions of a program planning process, with examples from various fields of adult education practice. This innovative text is the definitive authority on one of the few theoretical models of the programming process based in systems theory merged with the practice ecology of adult education.
Book Synopsis Chemogenomics in Drug Discovery by : Hugo Kubinyi
Download or read book Chemogenomics in Drug Discovery written by Hugo Kubinyi and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemogenomics brings together the most powerful concepts in modern chemistry and biology, linking combinatorial chemistry with genomics and proteomics. This first reference devoted to the topic covers all stages of the early drug discovery process, from target selection to compound library and lead design. With the combined expertise of 20 research groups from academia and leading pharmaceutical companies, this is a must-have for every drug developer and medicinal chemist applying the powerful methods of chemogenomics to speed up the drug discovery process.
Book Synopsis Meter-Wave Synthetic Aperture Radar for Concealed Object Detection by : Hans Hellsten
Download or read book Meter-Wave Synthetic Aperture Radar for Concealed Object Detection written by Hans Hellsten and published by Artech House. This book was released on 2017-05-31 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique resource presents the principles of meter wave ground imaging radar focusing on foliage penetration. Scattering of VHF/UHF radar signals are presented including the basic laws of electromagnetism, homogeneous media, media discontinuities/non-flat media discontinuities, and ground reflectivity. The book introduces meter wavelength synthetic aperture radar, bandwidth, and SAR imaging principles, including moving objects and also compares collected SAR data. Meter wavelength SAR system design and processing is explored, highlighting low frequency SAR design aspects, characterization of additive noise, antenna system basics, waveforms and emission adaptation which is critical material to the advancement in sensors and signal processing for below ground imaging by the energy industry and governments worldwide. The FFBP method of processing, explicit treatment of base 2 FFBP is explained along with motion errors sensitivity and motion estimation methods. The book also explains the Bayesian change detection, covariance moving target extraction and polarimetric subsurface imaging.
Book Synopsis Antibodies Applications and New Developments by : Eline P. Meulenberg
Download or read book Antibodies Applications and New Developments written by Eline P. Meulenberg and published by Bentham Science Publishers. This book was released on 2012-05-16 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antibodies Applications and New Developments is an overview of the current developments of techniques and methods relating to immunodiagnostics and immunoanalysis. This eBook also deals with specialties in the fields of drug, pesticide, antigen and food contaminant detection. The volume is useful for professional immunologists and biotechnologists interested in antibody research and development.
Book Synopsis New Insights in the Landscape of Rare Tumors: Translational and Clinical Research Perspective by : Toni Ibrahim
Download or read book New Insights in the Landscape of Rare Tumors: Translational and Clinical Research Perspective written by Toni Ibrahim and published by Frontiers Media SA. This book was released on 2020-12-22 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: TI has received honoraria from Eisai as a consultant and grants or funding to his institution from Novartis. TI participated in congress for which travel and accommodations were paid by Ipsen, Pharmamar, and Novartis.
Book Synopsis Schizophrenia: New Insights for the Healthcare Professional: 2012 Edition by :
Download or read book Schizophrenia: New Insights for the Healthcare Professional: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-10 with total page 565 pages. Available in PDF, EPUB and Kindle. Book excerpt: Schizophrenia: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Schizophrenia. The editors have built Schizophrenia: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Schizophrenia in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Schizophrenia: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis Mechanisms and New Targets for the Treatment of Chronic Pain by : Milica S. Prostran
Download or read book Mechanisms and New Targets for the Treatment of Chronic Pain written by Milica S. Prostran and published by Frontiers Media SA. This book was released on 2020-12-03 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acute pain has a physiological protective role in preventing tissue damage. However, pain can become chronic due to a multitude of pathophysiological states, such as: trauma, inflammation, neural injury, viral infection, cancer, autoimmune diseases and vascular and metabolic disorders. These pathological states can trigger alterations of the pain pathways that can lead to hypersensitivity, and in such circumstances, pain loses its protective role and instead, becomes persistent and debilitating affecting seriously to the quality of life of patients. Chronic pain is one of the most important health problems worldwide. It has been estimated that 10% of adults are diagnosed with chronic pain each year. However, despite the high prevalence of chronic pain, its management is still no fully satisfactory probably due to the variety of chronic pain conditions with different etiologies (neuropathic, visceral and musculoskeletal pain), and because their pathophysiological mechanisms are only partially known. Therefore, there is a huge need for new effective therapies for the control and/or prevention of the different types of chronic pain. Chronic pain is associated with plastic changes in pain circuits of the peripheral and central nervous system, including changes in the expression of ion channels, neurotransmitters and receptors. In addition, there is growing consensus on non-neuronal mechanisms that can amplify or resolve chronic pain, and cells traditionally thought to act just as coordinators of the inflammatory response (such as immune and glial cells) are now accepted as real modulators of pain signaling. In this regard, animal models of persistent pain, such as models of neuropathic and visceral pain and models of arthritis, are helping to elucidate our understanding of the pathogenesis of chronic pain and make it possible to test experimental treatments.
