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Mechanisms And New Targets For The Treatment Of Chronic Pain
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Book Synopsis Mechanisms and New Targets for the Treatment of Chronic Pain by : Milica S. Prostran
Download or read book Mechanisms and New Targets for the Treatment of Chronic Pain written by Milica S. Prostran and published by Frontiers Media SA. This book was released on 2020-12-03 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acute pain has a physiological protective role in preventing tissue damage. However, pain can become chronic due to a multitude of pathophysiological states, such as: trauma, inflammation, neural injury, viral infection, cancer, autoimmune diseases and vascular and metabolic disorders. These pathological states can trigger alterations of the pain pathways that can lead to hypersensitivity, and in such circumstances, pain loses its protective role and instead, becomes persistent and debilitating affecting seriously to the quality of life of patients. Chronic pain is one of the most important health problems worldwide. It has been estimated that 10% of adults are diagnosed with chronic pain each year. However, despite the high prevalence of chronic pain, its management is still no fully satisfactory probably due to the variety of chronic pain conditions with different etiologies (neuropathic, visceral and musculoskeletal pain), and because their pathophysiological mechanisms are only partially known. Therefore, there is a huge need for new effective therapies for the control and/or prevention of the different types of chronic pain. Chronic pain is associated with plastic changes in pain circuits of the peripheral and central nervous system, including changes in the expression of ion channels, neurotransmitters and receptors. In addition, there is growing consensus on non-neuronal mechanisms that can amplify or resolve chronic pain, and cells traditionally thought to act just as coordinators of the inflammatory response (such as immune and glial cells) are now accepted as real modulators of pain signaling. In this regard, animal models of persistent pain, such as models of neuropathic and visceral pain and models of arthritis, are helping to elucidate our understanding of the pathogenesis of chronic pain and make it possible to test experimental treatments.
Book Synopsis Mechanisms of Vascular Disease by : Robert Fitridge
Download or read book Mechanisms of Vascular Disease written by Robert Fitridge and published by University of Adelaide Press. This book was released on 2011 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
Book Synopsis Relieving Pain in America by : Institute of Medicine
Download or read book Relieving Pain in America written by Institute of Medicine and published by National Academies Press. This book was released on 2011-10-26 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic pain costs the nation up to $635 billion each year in medical treatment and lost productivity. The 2010 Patient Protection and Affordable Care Act required the Department of Health and Human Services (HHS) to enlist the Institute of Medicine (IOM) in examining pain as a public health problem. In this report, the IOM offers a blueprint for action in transforming prevention, care, education, and research, with the goal of providing relief for people with pain in America. To reach the vast multitude of people with various types of pain, the nation must adopt a population-level prevention and management strategy. The IOM recommends that HHS develop a comprehensive plan with specific goals, actions, and timeframes. Better data are needed to help shape efforts, especially on the groups of people currently underdiagnosed and undertreated, and the IOM encourages federal and state agencies and private organizations to accelerate the collection of data on pain incidence, prevalence, and treatments. Because pain varies from patient to patient, healthcare providers should increasingly aim at tailoring pain care to each person's experience, and self-management of pain should be promoted. In addition, because there are major gaps in knowledge about pain across health care and society alike, the IOM recommends that federal agencies and other stakeholders redesign education programs to bridge these gaps. Pain is a major driver for visits to physicians, a major reason for taking medications, a major cause of disability, and a key factor in quality of life and productivity. Given the burden of pain in human lives, dollars, and social consequences, relieving pain should be a national priority.
Author :National Academies of Sciences, Engineering, and Medicine Publisher :National Academies Press ISBN 13 :0309459575 Total Pages :483 pages Book Rating :4.3/5 (94 download)
Book Synopsis Pain Management and the Opioid Epidemic by : National Academies of Sciences, Engineering, and Medicine
Download or read book Pain Management and the Opioid Epidemic written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-09-28 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.
Book Synopsis Pain Therapeutics by : Charlotte Allerton
Download or read book Pain Therapeutics written by Charlotte Allerton and published by Royal Society of Chemistry. This book was released on 2014 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a contemporary review of the field of pain therapeutics, including the historical medicines which still dominate standard of care treatments, as well as the new mechanisms and combinations/reformulations that have dominated the regulatory approvals over the last decade. In addition this book provides a deep review of the key biological mechanisms currently under investigation for their utility into the treatment of pain, such as ion channels, opiates and others. Additional discussion highlights the current challenges of pain research, covering a range of topics from difficulties in identifying new targets and pre-clinical models to the current regulatory and commercial challenges. This background sets the scene for recent scientific developments in pain research, such as the drive for genetic validation of targets and the derivation of human cell platforms from stem cells. Finally, the book covers the discovery and development stories of two pain products approved in the last decade. These case studies for Lyrica and the Butrans patch, will give insight into the discovery and development challenges and successes for both an oral and non-oral product.
Book Synopsis Pain Care Essentials and Innovations by : Sanjog Pangarkar
Download or read book Pain Care Essentials and Innovations written by Sanjog Pangarkar and published by Elsevier Health Sciences. This book was released on 2020-06-30 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering the newest trends and treatments in pain care, as well as the pain treatment strategies that have been successfully employed in the past, Pain Care Essentials and Innovations brings you fully up to date with effective treatments for acute and chronic pain. It offers expert guidance on both interventional and non-interventional strategies, provided by respected academic physiatrists who practice evidence-based medicine at UCLA and an ACGME-accredited rehabilitation and pain program. Covers cannabinoids in pain care, novel therapeutics in pain medicine, and integrative care in pain management. Discusses relevant basic science, psychological aspects of pain care, opioids and practice guidelines, geriatric pain management, and future research in the field. Consolidates today’s available information and guidance into a single, convenient resource.
Book Synopsis Chronic Pain: New Molecular Insights Into Pain And Treatment by : Min Zhuo
Download or read book Chronic Pain: New Molecular Insights Into Pain And Treatment written by Min Zhuo and published by World Scientific. This book was released on 2023-09-22 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book successfully explores cellular and molecular mechanisms of chronic pain based on recent basic neurobiological investigations. By focusing on major breakthroughs in basic neurosciences, it is believed to contain the promise for future new pain drug discovery.Instead of repeating extensive reviews of basic animal and clinical observations, the book provides a novel neuronal model that is believed to be the key target for treating chronic pain. In addition, it reviews and validates animal models developed for studying basic mechanisms of pain and chronic pain, and the current medicine used to treat chronic pain as well as alternative pain treatment. The final few chapters also cover how pain may interfere with other high brain functions, such as fear, anxiety, sleep, memory, etc.
Book Synopsis Novel Molecular Targets for the Treatment of Pain by : Tally Largent-Milnes
Download or read book Novel Molecular Targets for the Treatment of Pain written by Tally Largent-Milnes and published by Frontiers Media SA. This book was released on 2021-02-02 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topic Editor John Streicher is a co-founder and equity partner of Teleport Pharmaceuticals, LLC. All other Topic Editors declare no competing interests with regards to the Research Topic subject.
Book Synopsis Advances in Pain Research: Mechanisms and Modulation of Chronic Pain by : Bai-Chuang Shyu
Download or read book Advances in Pain Research: Mechanisms and Modulation of Chronic Pain written by Bai-Chuang Shyu and published by Springer. This book was released on 2018-10-10 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes the latest advances in pain research. All the chapters were contributed by speakers from Asian Pain Symposium (APS) on Acute and Chronic Pain, which was held in Taipei in 2017. Founded in Kyoto, Japan in 2000, the APS serves as a platform for scientists to present recent findings in pain research and discuss research orientation in this field. APS 2017 focused on novel strategies for pain treatment. Written by experts from various disciplines, from molecular to functional, and from basic to clinic studies, this book is composed of 18 review articles on the physiology and pathology of pain in these research fields. Specific topics include circuitry, neurotransmitter, physiology, behavior, neuropathology, pharmacology, and the treatments for neuropathic pain disorders. The book is a valuable resource for researchers and graduate students in pain medicine and neuroscience.
Book Synopsis Mechanisms and Management of Pain for the Physical Therapist by : Kathleen A. Sluka
Download or read book Mechanisms and Management of Pain for the Physical Therapist written by Kathleen A. Sluka and published by Lippincott Williams & Wilkins. This book was released on 2015-06-01 with total page 619 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the basics of pain neurobiology and reviews evidence on the mechanisms of action of physical therapy treatments, as well as their clinical effectiveness in specific pain syndromes. The book is a comprehensive textbook for the management of pain for the physical therapy student and the practicing physical therapist.
Book Synopsis Clinical Pain Management by : Mary E. Lynch
Download or read book Clinical Pain Management written by Mary E. Lynch and published by John Wiley & Sons. This book was released on 2022-04-11 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Pain Management Pain has many dimensions; biological, psychological and social. All of these warrant attention in clinical management and research. Despite advances in pain management and understanding, chronic pain in particular continues to be a major health concern. Many challenging problems persist in our efforts to understand and manage chronic pain. This revised and updated second edition of Clinical Pain Management: A Practical Guide draws attention to the challenges that exist for people living with chronic pain conditions, for the clinician trying to provide effective management of the patient’s pain, for the scientist seeking to unravel the mechanisms underlying pain, and for society as a whole. This book offers the opportunity for clinicians to improve their knowledge about pain and apply that knowledge for the benefit of their patients. This second edition has built upon the first edition, which was distinctive in its integration of the clinical, psychosocial and basic science topics related to the different types of pain and their management. With up-to-date information throughout the 44 chapters of this second edition, this book provides a valuable resource about pain from a variety of perspectives. Clinical Pain Management: A Practical Guide, Second Edition, will be particularly valuable not only for clinicians to help them assist with their patients experiencing an acute pain or suffering from chronic pain, but also for scientists who wish to gain more insights into these pain conditions and their underlying processes.
Book Synopsis Practical Management of Pain by : Honorio Benzon
Download or read book Practical Management of Pain written by Honorio Benzon and published by Elsevier Health Sciences. This book was released on 2022-02-10 with total page 1520 pages. Available in PDF, EPUB and Kindle. Book excerpt: For more than 30 years, Practical Management of Pain has offered expert guidance to both clinicians and trainees, covering every aspect of acute and chronic pain medicine for adult and pediatric patients. The fully revised 6th Edition brings you fully up to date with new developments in patient evaluation, diagnosis of pain syndromes, rationales for management, treatment modalities, and much more. Edited by a team of renowned pain clinicians led by Dr. Honorio Benzon, this authoritative reference is a comprehensive, practical resource for pain diagnosis and treatment using a variety of pharmacologic and physical modalities. Presents a wealth of information in a clearly written, easily accessible manner, enabling you to effectively assess and draw up an optimal treatment plan for patients with acute or chronic pain. Takes a practical, multidisciplinary approach, making key concepts and techniques easier to apply to everyday practice. Shares the knowledge and expertise of global contributors on all facets of pain management, from general principles to specific management techniques. Discusses the latest, best management techniques, including joint injections, ultrasound-guided therapies, and new pharmacologic agents such as topical analgesics. Covers recent global developments regarding opioid induced hyperalgesia, neuromodulation and pain management, and identification of specific targets for molecular based pain. Includes current information on the use of cannabinoids in pain management and related regulatory, professional, and legal considerations. Includes the latest guidelines on facet injections and safety of contrast agents. Provides new, evidence-based critical analysis on treatment modality outcomes and the latest information on chronic pain as a result of surgical interventions.
Book Synopsis Behavioral and Psychopharmacologic Pain Management by : Michael H. Ebert
Download or read book Behavioral and Psychopharmacologic Pain Management written by Michael H. Ebert and published by Cambridge University Press. This book was released on 2010-11-25 with total page 507 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pain is the most common symptom bringing a patient to a physician's attention. Physicians training in pain medicine may originate from different disciplines and approach the field with varying backgrounds and experience. This book captures the theory and evidence-based practice of behavioral, psychotherapeutic and psychopharmacological treatments in modern pain medicine. The book's contributors span the fields of psychiatry, psychology, anesthesia, neurology, physical medicine and rehabilitation, and nursing. Thus the structure and content of the book convey the interdisciplinary approach that is the current standard for the successful practice of pain management. The book is designed to be used as a text for training fellowships in pain medicine, as well as graduate courses in psychology, nursing, and other health professions.
Book Synopsis Translational Pain Research by : Lawrence Kruger
Download or read book Translational Pain Research written by Lawrence Kruger and published by CRC Press. This book was released on 2009-11-24 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practicality of clinical trials, Translational Pain Research: From Mouse to Man effectively bridges the gap between basic research and patient care by humanely examining rodent models for pain associated with bone cancer, osteoarthritis, fibromyalgia, and cardiac episodes. Distinguished Team of International Contributors In addition to addressing the groundbreaking technical advances in tract tracing, endocannabinoids, cannabis, gene therapy, siRNA gene studies, and the role of glia, cytokines, P2X receptors and ATP, this book also presents cutting-edge information on: Nociceptor sensitization Muscle nociceptors and metabolite detection Visceral afferents in disease Innovative rodent model for bone cancer pain Highly specific receptor cloning Modular molecular mechanisms relevant to painful neuropathies This sharply focused work also discusses unexpected discoveries derived from brain-imaging studies related to thalamic pain. Translational Pain Research covers the progress made toward bringing laboratory science (much of it at the molecular level) to our understanding of pain phenomena in humans, with the ultimate goal of reducing the suffering that often accompanies pain and its indirect consequences.
Book Synopsis Current Therapy in Pain E-Book by : Howard S. Smith
Download or read book Current Therapy in Pain E-Book written by Howard S. Smith and published by Elsevier Health Sciences. This book was released on 2008-12-21 with total page 697 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique resource focuses on the diagnosis and treatment of painful conditions—both acute and chronic—from a multi-disciplinary perspective. Joined by a team of nearly 200 international contributors representing a wide range of specialties, Dr. Smith presents the best management options within and across specialties. Succinct treatment and therapy guidelines enable you to quickly access clinically useful information, for both inpatient and outpatient pain management. Offers a cross-discipline approach to pain management for a comprehensive view of the best treatment options within and across specialties including internal medicine, gynecology, physical medicine and rehabilitation, orthopedics, and family medicine. Provides succinct treatment and therapy guidelines, enabling you to locate useful information quickly. Organizes guidance on acute and chronic therapies in a templated format, to facilitate consistent, quick-access consultation appropriate for inpatient or outpatient pain management.
Book Synopsis Challenging Neuropathic Pain Syndromes by : Mitchell Freedman
Download or read book Challenging Neuropathic Pain Syndromes written by Mitchell Freedman and published by Elsevier Health Sciences. This book was released on 2017-11-12 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Get a quick, expert overview of the many key facets of neuropathic pain syndromes with this concise, practical resource by Drs. Mitchell Freedman, Jeff Gehret, George Young, and Leonard Kamen. This easy-to-read reference presents a summary of today’s best evaluation methods and evidence-based treatment options for complex regional pain syndrome as well as other challenging syndromes. Covers key topics such as: Evidence Based Approach to Many Uncommon and Difficult Neuropathic Pain Syndromes Review of Pathophysiology of Pain Approach to Chronic Pain Syndromes Work Up and Treatments for Complex Regional Pain Syndromes Consolidates today’s available information and experience in this multifaceted area into one convenient resource.
Book Synopsis Pain Management in Small Animal Medicine by : Steven M Fox
Download or read book Pain Management in Small Animal Medicine written by Steven M Fox and published by CRC Press. This book was released on 2013-12-06 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pain Management in Small Animal Medicine describes and clearly illustrates the difficulties and choices facing veterinarians in identifying and treating pain, in addition to providing an account of the neurobiological mechanisms responsible for the pain. Expanded from the author’s previous work, Chronic Pain in Small Animal Medicine, this volume uses the original text to illustrate the core theme of "mechanism base" and expands the text considerably with the inclusion of areas beyond chronic pain. Topics include: Pain assessment in small animal medicine The functional physiology of pain The use of pharmacologics and nonsteroidal anti-inflammatory drugs Nutraceutical mechanisms and therapy Management of pain related to canine osteoarthritis, musculoskeletal disease, and cancer Pain management features unique to cats Emphasizing the latest evidence and contemporary understanding of "why" and "how" to treat pain, the book will enable veterinary healthcare professionals as well as those in training, education, and research to develop a greater depth of knowledge in mechanisms of pain and potential targets for treatment— thereby raising the standard of care for pain management.
