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Aminopeptidases In Biology And Disease
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Book Synopsis Aminopeptidases in Biology and Disease by : Nigel M. Hooper
Download or read book Aminopeptidases in Biology and Disease written by Nigel M. Hooper and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aminopeptidases in Biology and Disease provides a comprehensive review of the emerging role of aminopeptidases in a range of biological processes and disease situations. Processes as diverse as angiogenesis, antigen presentation, neuropeptide and hormone processing, pregnancy and reproduction, protein turnover, memory, inflammation, tumour growth, cancer and metastasis, blood pressure and hypertension all critically involve one or more aminopeptidases. The individual chapters have been written by experts in the field who have provided detailed accounts of the central roles played by various aminopeptidases in biology and disease.
Book Synopsis Dipeptidyl Aminopeptidases by : Uwe Lendeckel
Download or read book Dipeptidyl Aminopeptidases written by Uwe Lendeckel and published by Springer Science & Business Media. This book was released on 2006-12-11 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first comprehensive volume on Dipeptidyl Aminopeptidases that can be marketed to a wide variety of disciplines, as well as to a variety of clinicians. Leading experts in the field contribute to this state-of-the-art view on these enzymes. This book comes at a time when our understanding of their function is growing ever more rapidly and therapeutic options have become imminent.
Download or read book Ectopeptidases written by Jürgen Langner and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: The idea to compile recent results on the ectoenzymes aminopeptidase N/CD13 and dipeptidylpeptidase IV/CD26 arose from the great interest given by readers world-wide to the two proceedings volumes edited by us in 1997 and 2000 (Ansorge and Langner, 1997; Langner and Ansorge, 2000). These volumes contained the presentations at two symposia held in Magdeburg (Germany) in 1996 and 1999 under the title "Cellular peptidases in immune functions and diseases", which was also the name of the Sonderforschungsbereich in Magdeburg, sponsored by the Deutsche Forschungsgemeinschaft between 1995 and 2001. Our groups in Magdeburg and Halle during the last two decades have provided results on these two enzymes in cells of the hematopoietic system that justify a review in an edited monograph like the present one (see the reviews by Kahne et at. , 1999; Lendeckel et at. ,1999; Riemann et at. , 1999). There are, however, many other groups in Europe, US and Japan which made important contributions to this field and particularly in topics improving the understanding of physiological and pathophysiological roles ofAPN/CD13 and DPIV/CD26. Therefore we decided to invite some of them to contribute reviews of their results to this book. Having worked for about 40 years in the field of proteolysis, for both of us to see the development of activities and knowledge from protein chemistry and enzymology to physiology and pathophysiology and even to therapy is very stimulating and fascinating. Of course, this development also reflects the dramatic improvement and refinement of methods.
Download or read book Aminopeptidases written by Allen Taylor and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes recently gathered information regarding the aminopeptidases. Nomenclature, distributions in the plant and animal kingdoms, structural and compositional information, mechanistic studies, homologies, physiological, medical and industrial uses, and molecular genetics of aminopeptidases are described.
Book Synopsis Dipeptidyl Aminopeptidases in Health and Disease by : Martin Hildebrandt
Download or read book Dipeptidyl Aminopeptidases in Health and Disease written by Martin Hildebrandt and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the International Conference on Dipeptidyl Aminopeptidases, held September 26-28, 2002, in Berlin, Germany. Dipeptidyl Aminopeptidases exert a potent modulatory role at an interface between immune mechanisms, metabolic responses and neuroendocrine pathways. Experimental models and clinical studies addressing the role of these enzymes and the effect of specific inhibitors pave the way to novel therapeutic concepts in immunology, rheumatology, oncology, reproductive medicine and diabetes. Leading experts in this field have contributed to this book which presents a state-of-the-art view on these enzymes, at a time when our understanding of their function is growing ever more rapidly and therapeutic options become imminent. The sections of the book focus on various topics: - Structure and function of dipeptidyl aminopeptidases, - DPP IV-like proteins, - Immune mechanisms and immune disorders, - Cancer and angiogenesis, - Diabetes and metabolism, - Therapeutic implications.
Book Synopsis Cell Surface Peptidases in Health and Disease by : A.J. Kenny
Download or read book Cell Surface Peptidases in Health and Disease written by A.J. Kenny and published by Taylor & Francis. This book was released on 1997-07 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cells bristle with a battery of surface enzymes, of which the peptidases form the largest and best studied group. These ectopeptidases play crucial roles in many diverse biological functions, including the termination of peptide signals in the nervous system and at peripheral sites. Some of their key physiological roles, such as those of angiotensin- and endothelin-converting enzymes in generating vasoconstrictive agents and endopeptidase-24.11 in activating natriuretic peptides, enkephalins and tachykinins, have made them prime targets for the pharmaceutical industry. Interest among immunologists and haematologists was aroused when several were shown to be identical to cell-surface markers (CD antigens) on human leukocytes. Virologists have been excited to find that some double as receptors for certain viruses.
Book Synopsis Cellular Peptidases in Immune Functions and Diseases 2 by : Jürgen Langner
Download or read book Cellular Peptidases in Immune Functions and Diseases 2 written by Jürgen Langner and published by Springer Science & Business Media. This book was released on 2000-05-31 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of the many special roles played by proteolytic enzymes in immune reactions, this book addresses different aspects of membrane peptidases, signal transduction via ligation of membrane peptidases (especially of dipeptidyl peptidase IV/CD26 and aminopeptidase N/CD13), and regulation of membrane peptidases in vivo and in vitro. A number of newly discovered peptidases (including cathepsin F, W and X, carboxypeptidase X, attractin) are described, with special emphasis given to the role of peptidases in immune and defense reactions and in the pathogenesis of inflammatory and other diseases, including rheumatoid arthritis, pancreatitis, multiple sclerosis, Alzheimer's disease and tumours of various origins. The focus on the involvement of a selection of proteolytic enzymes in immune reactions and diseases is a unique feature of this multifaceted work , which combines biochemical, immunological and clinical research reports with literary reviews of the field.
Book Synopsis Long-lived Proteins in Human Aging and Disease by : Roger J. W. Truscott
Download or read book Long-lived Proteins in Human Aging and Disease written by Roger J. W. Truscott and published by John Wiley & Sons. This book was released on 2021-04-19 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative overview on an emerging topic in the molecular life sciences covers all aspects of the aging of (long-lived) proteins. It describes the molecular mechanisms of aging on the protein level, in particular the most common side chain modifications and includes analytical methods to study protein half-life and the accumulation of modifications. Finally, the impact of protein aging on several age-related disases in humans is dissected, and their role in limiting human lifespan is discussed.
Author :Alasdair M. Gilfillan Publisher :Springer Science & Business Media ISBN 13 :1441995331 Total Pages :312 pages Book Rating :4.4/5 (419 download)
Book Synopsis Mast Cell Biology by : Alasdair M. Gilfillan
Download or read book Mast Cell Biology written by Alasdair M. Gilfillan and published by Springer Science & Business Media. This book was released on 2011-06-28 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: The editors of Mast Cell Biology, Drs. Gilfillan and Metcalfe, have enlisted an outstanding group of investigators to discuss the emerging concepts in mast cell biology with respect to development of these cells, their homeostasis, their activation, as well as their roles in maintaining health on the one hand and on the other, their participation in disease.
Book Synopsis Handbook of Proteolytic Enzymes by : Alan J. Barrett
Download or read book Handbook of Proteolytic Enzymes written by Alan J. Barrett and published by Academic Press. This book was released on 2012-10-30 with total page 4097 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extensively revised and updated, the new edition of the highly regarded Handbook of Proteolytic Enzymes is an essential reference for biochemists, biotechnologists and molecular biologists. Edited by world-renowned experts in the field, this comprehensive work provides detailed information on all known proteolytic enzymes to date. This two-volume set unveils new developments on proteolytic enzymes which are being investigatedin pharmaceutical research for such diseases as HIV, Hepatitis C, and the common cold. Volume I covers aspartic and metallo petidases while Volume II examines peptidases of cysteine, serine, threonine and unknown catalytic type. A CD-ROM accompanies the book containing fully searchable text, specialised scissile bond searches, 3-D color structures and much more. The only comprehensive book on proteolytic enzymes Includes 671 chapters, each written by experts in their field, on proteolytic enzymes from all groups of living organisms and the viruses, including those that are currently major targets of pharmaceutical research Accompanying CD-ROM provides fully searchable text, 2D structures of peptidases in color and links directly to PubMed and MEROPS databases Each chapter describes in detail the enzyme name, its history, activity and specificity, structural chemistry, preparation, biological aspects and distinguishing features Over 1000 peptidases included
Download or read book Crocodiles written by F. W. Huchzermeyer and published by CABI. This book was released on 2003-05-08 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive reference work on the biology, management and health of crocodiles, alligators and gharials. It is applicable to both farmed and captive animals.The introductory chapter describes crocodilian anatomy, physiology, biochemistry, and behaviour. One chapter is devoted to important aspects of crocodile farming, namely nutrition; incubation of eggs; rearing; breeding; slaughter; and welfare. Subsequent chapters cover transmissible, nontransmissible and organ diseases, and diseases of eggs and hatchlings.
Book Synopsis Malaria: Drugs, Disease and Post-genomic Biology by : David Sullivan
Download or read book Malaria: Drugs, Disease and Post-genomic Biology written by David Sullivan and published by Springer Science & Business Media. This book was released on 2006-01-09 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite rapid increases in knowledge, malaria continues to kill more than a million people each year and causes symptomatic disease in a further 300 million individuals. This volume brings some of the world's best investigators to describe recent advances in both the scientific and clinical aspects of malaria, and bridges between the two.
Book Synopsis Viral Proteases and Antiviral Protease Inhibitor Therapy by : Uwe Lendeckel
Download or read book Viral Proteases and Antiviral Protease Inhibitor Therapy written by Uwe Lendeckel and published by Springer Science & Business Media. This book was released on 2009-06-19 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 8th volume in the Proteases in Biology and Disease series focuses on the role of proteases in virus function and their potential as anti-viral targets. Viral infections are still difficult to threat and some remained life-threatening diseases in spite of antiviral drug research over decades. Proteases are still regarded as an Achilles’ heel of the pathogens and, thus, protease inhibitors may help to handle the known and the emerging viral threads. The book discusses viral proteases of the most important pathogenic viruses, responsible for severe diseases: AIDS, SARS, Hepatitis, Cytomegalovirus, T-cell lymphotropic virus, Picornavirus. This book focuses specifically on the viral proteases, crucial prerequisites for viral entry into cells and viral replication. Viral proteases represent an important pharmaceutical target. The current stage of protease inhibitor development and therapy are summarised and discussed by experts in the field. This volume represents a timely and valuable continuation of the Proteases in Biology and Disease series. The reader will learn the potential for proteases as targets for effective anti-virals. This book will be a valuable source of information on viral proteases and provoke further research in this important field.
Book Synopsis Immunobiology of Osteoarticular Diseases by : Erminia Mariani
Download or read book Immunobiology of Osteoarticular Diseases written by Erminia Mariani and published by Frontiers Media SA. This book was released on 2021-07-02 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Amino Acids in Nutrition and Health by : Guoyao Wu
Download or read book Amino Acids in Nutrition and Health written by Guoyao Wu and published by Springer Nature. This book was released on 2021-03-26 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Amino acids (AAs) are not only building blocks of protein, but are also signalling molecules as well as regulators of gene expression and the protein phosphorylation cascade. Additionally, AAs are key precursors for syntheses of hormones and low-molecular weight nitrogenous substances with each having enormous biological importance. For example, physiological concentrations of AA metabolites (e.g., nitric oxide, polyamines, glutathione, taurine, thyroid hormones, and serotonin) are required for cell functions. Growing evidence shows that humans and animals have dietary requirements for all proteinogenic AAs. Mammals, birds and fish also have species- and age-dependent needs for some AA-related substances. However, elevated levels of other products (e.g., ammonia, homocysteine, H2S, and asymmetric dimethylarginine) are pathogenic factors for neurological disorders, oxidative stress, and cardiovascular disease. Thus, optimal amounts of AAs and their ratios in diets and circulation are crucial for whole body homeostasis and health. Adequate provision of one or a mixture of functional AAs or metabolites may be beneficial for ameliorating health problems at various stages of the life cycle (e.g., fetal growth restriction, neonatal morbidity and mortality, weaning-associated intestinal dysfunction and wasting syndrome, obesity, diabetes, cardiovascular disease, the metabolic syndrome, and infertility). Dietary supplementation of these nutrients can also optimize the efficiency of metabolic transformations to enhance muscle growth, milk production, and athletic performance, while preventing excess fat deposition and reducing adiposity. Therefore, functional AAs hold great promise in improving the growth, health and well-being of individuals. Chapter 7 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Book Synopsis High Yield Orthopaedics by : Javad Parvizi
Download or read book High Yield Orthopaedics written by Javad Parvizi and published by Elsevier Health Sciences. This book was released on 2010 with total page 529 pages. Available in PDF, EPUB and Kindle. Book excerpt: Get your hands on this concise, visual guide to orthopaedics packed with the absolutely essential facts!. --Book Jacket.
Book Synopsis Zebrafish at the Interface of Development and Disease Research by :
Download or read book Zebrafish at the Interface of Development and Disease Research written by and published by Academic Press. This book was released on 2017-03-21 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are many shared pathways that govern development and also can contribute to disease. Zebrafish have traditionally been used to study vertebrate development, and from decades of work in this system, we have learned details about developmental processes, genes and pathways that are implicated in disease. In each chapter of this book, we interweave how studying zebrafish development has informed our understanding of diseases from the immune system, to the kidney, liver, heart and others. The subject matter is unique - no single volume has pulled together the theme of development and disease with zebrafish as a centerpiece Leading experts in the field - all of them running zebrafish focused labs for each chapter
