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Advances In Multiple Myeloma
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Book Synopsis Advances in Multiple Myeloma by : Darell Crowder
Download or read book Advances in Multiple Myeloma written by Darell Crowder and published by . This book was released on 2015-02-20 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a compilation of detailed information on various topics in Myeloma research, diagnostic and therapeutic fields. The system of testing novel drugs for multiple myeloma treatment in clinical trials is astonishing. Scientific discoveries have unveiled complex pathogenesis of multiple myeloma; intricate reactions to treatment resulted in the creation of super cocktails. Curability of multiple myeloma is a problem that is being talked about by the complete professional myeloma world and enhancement of prognosis is a fact which is most essential from a patient's viewpoint. This book is intended for medical professionals who are specializing in hemato-oncology, students and veteran researchers.
Book Synopsis Advances in Biology and Therapy of Multiple Myeloma by : Nikhil C. Munshi
Download or read book Advances in Biology and Therapy of Multiple Myeloma written by Nikhil C. Munshi and published by Springer Science & Business Media. This book was released on 2012-12-09 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite the advances in conventional, novel agent and high dose chemotherapy multiple myeloma (MM) remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in MM focusing on the development of molecularly-based combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. Two major advances are making this goal possible. First, recent advances in genomics and proteomics in MM have allowed for increased understanding of disease pathogenesis, identified novel therapeutic targets, allowed for molecular classification, and provided the scientific rationale for combining targeted therapies to increase tumor cell cytotoxicity and abrogate drug resistance. Second, there is now an increased understanding of how adhesion of MM cells in bone marrow (BM) further impacts gene expression in MM cells, as well as in BM stromal cells (BMSCs). As a result of these advances in oncogenomics on the one hand and increased understanding of the role of the BM in the pathogenesis of MM on the other, a new treatment paradigm targeting the tumor cell and its BM microenvironment to overcome drug resistance and improve patient outcome has now been developed. Thalidomide, lenalidomide, and Bortezomib are three agents which target the tumor cell in its microenvironment in both laboratory and animal models and which have rapidly translated from the bench to the bedside. Ongoing efforts are using oncogenomics and cell signaling studies to identify next generation of therapies in MM on the one hand, and to inform the design of combination trials on the other. This new paradigm for overcoming drug resistance and improving patient outcome in MM has great promise not only to change the natural history of MM, but also to serve as a model for targeted therapeutics directed to improve outcome of patients with MM.
Book Synopsis Multiple Myeloma by : Morie A. Gertz
Download or read book Multiple Myeloma written by Morie A. Gertz and published by Springer Science & Business Media. This book was released on 2013-10-01 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a comprehensive, state-of-the-art guide to the diagnosis, treatment, and biology of multiple myeloma and related plasma disorders. Edited and written by a multidisciplinary group of recognized authorities from the Mayo Clinic, it presents clear guidelines on diagnosis and therapy and covers all aspects of multiple myeloma, from molecular classification and diagnosis, to risk stratification and therapy. Closely related plasma cell disorders such as solitary plasmacytoma, Waldenstrom macroglobulinemia, and light chain amyloidosis are discussed in detail as well. The book addresses often overlooked topics, including the role of radiation therapy, vertebral augmentation, and supportive care. Our understanding of this group of disorders is developing at an unprecedented rate, and Multiple Myeloma meets the need among oncologists and hematologists for a clear, timely, and authoritative resource on their biology, diagnosis, and treatment.
Book Synopsis Advances in Biology and Therapy of Multiple Myeloma by : Nikhil C. Munshi
Download or read book Advances in Biology and Therapy of Multiple Myeloma written by Nikhil C. Munshi and published by Springer Science & Business Media. This book was released on 2012-11-15 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite the advances in conventional, novel agent and high dose chemotherapy multiple myeloma (MM) remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in MM focusing on the development of molecularly-based combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. Two major advances are making this goal possible. First, recent advances in genomics and proteomics in MM have allowed for increased understanding of disease pathogenesis, identified novel therapeutic targets, allowed for molecular classification, and provided the scientific rationale for combining targeted therapies to increase tumor cell cytotoxicity and abrogate drug resistance. Second, there is now an increased understanding of how adhesion of MM cells in bone marrow (BM) further impacts gene expression in MM cells, as well as in BM stromal cells (BMSCs). As a result of these advances in oncogenomics on the one hand and increased understanding of the role of the BM in the pathogenesis of MM on the other, a new treatment paradigm targeting the tumor cell and its BM microenvironment to overcome drug resistance and improve patient outcome has now been developed. Thalidomide, lenalidomide, and Bortezomib are three agents which target the tumor cell in its microenvironment in both laboratory and animal models and which have rapidly translated from the bench to the bedside. Ongoing efforts are using oncogenomics and cell signaling studies to identify next generation of therapies in MM on the one hand, and to inform the design of combination trials on the other. This new paradigm for overcoming drug resistance and improving patient outcome in MM has great promise not only to change the natural history of MM, but also to serve as a model for targeted therapeutics directed to improve outcome of patients with MM.
Book Synopsis Update on Multiple Myeloma by : Khalid Ahmed Al-Anazi
Download or read book Update on Multiple Myeloma written by Khalid Ahmed Al-Anazi and published by . This book was released on 2019-02 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive overview of the recent developments in the clinical and research fields of multiple myeloma. It is divided into three main sections that cover a wide range of topics, including: epidemiology and pathogenesis of the disease, genetic targets and pathways, resistance to novel therapies, angiogenesis and anti-angiogenesis, hematopoietic stem cell transplantation, role of radiology and radiotherapy in myeloma, infectious complications, and management of multiple myeloma in resource-poor countries.
Book Synopsis Treatment of Multiple Myeloma and Related Disorders by : S. Vincent Rajkumar
Download or read book Treatment of Multiple Myeloma and Related Disorders written by S. Vincent Rajkumar and published by Cambridge University Press. This book was released on 2008-10-27 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to major advances in understanding the biology and pathogenesis of the disease, the management of multiple myeloma is changing rapidly. New diagnostic and prognostic criteria have been introduced, and treatment options are multiplying with high-dose chemotherapy regimens, stem cell transplants, and the development of novel agents and immune-based strategies that target tumor cells directly. This book is aimed at the practitioner who is looking to put these advances into clinical context. It will serve as an up-to-date resource for treatment of myeloma and related disorders. Chapters are written by international authorities and contain color photos, diagrams, and algorithms outlining preferred treatment strategies. Relevant scientific information is integrated throughout, but the focus here is on providing practical therapeutic guidance for oncologists and hematologists caring for myeloma patients. The book covers all myeloma subtypes and related disorders, including amyloidosis, Waldenstrom macroglobulinemia, plasmacytoma, MGUS, and POEMS syndrome.
Book Synopsis Multiple Myeloma Cancer by : Ethan D.
Download or read book Multiple Myeloma Cancer written by Ethan D. and published by Shuttle Systems. This book was released on 2024-03-11 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Multiple Myeloma Cancer: A Comprehensive Resource for Patients and Families" is an essential guide for anyone touched by multiple myeloma. This book offers a thorough understanding of this complex cancer, from its biology to the latest in treatments and research advancements, providing invaluable support for patients and their loved ones.Deep Dive into Multiple MyelomaStart your journey with an in-depth look at multiple myeloma, including its types, epidemiology, and the historical perspective on research. Gain crucial insights into the nature of plasma cells and the genetic and molecular factors that contribute to the development of this cancer.Understanding Risk Factors and Early DetectionLearn about the risk factors associated with multiple myeloma and the importance of early detection. This book covers screening methods and the significance of early diagnosis in improving treatment outcomes.Symptoms, Diagnosis, and StagingRecognize the symptoms of multiple myeloma and understand the diagnostic process, including tests and procedures. Grasp the staging system, its role in disease progression, and its impact on treatment and prognosis.Exploring Treatment OptionsNavigate the treatment landscape of multiple myeloma, from conventional chemotherapy and stem cell transplantation to cutting-edge targeted therapies and immunotherapies. This book provides comprehensive information to help make informed decisions about care and treatment.Managing Side Effects and ComplicationsUnderstand and manage the side effects and complications of treatment, including the impact on bone health and strategies for infection management.Nutrition and LifestyleDiscover the importance of nutrition and lifestyle changes in supporting overall health during and after treatment. Get practical advice on diet, exercise, and lifestyle adjustments.Psychological and Emotional SupportFind guidance on coping with the emotional and psychological impacts of multiple myeloma. Learn about the importance of support systems, counseling, and the role of community and support groups.Living with Multiple MyelomaAddress the day-to-day challenges of living with multiple myeloma, including chronic management, quality of life issues, and survivorship care.Advances in ResearchStay informed about the latest in multiple myeloma research and emerging treatments. This section highlights the importance of clinical trials and future possibilities in myeloma care.Special ConsiderationsGain insights into how multiple myeloma affects different populations, including considerations for younger and elderly patients, and the unique aspects of the disease in men and women.Advocacy and Community EngagementUnderstand the role of patient advocacy, find community resources, and learn how to engage in raising awareness about multiple myeloma.The Future of Myeloma CareLook ahead to the innovations and evolving landscape of myeloma therapy, offering hope and a vision for the future of myeloma care."Multiple Myeloma Cancer: A Comprehensive Resource for Patients and Families" is more than just a book; it's a companion and guide through the journey of multiple myeloma. It provides the knowledge, support, and resources needed to navigate this challenging path with confidence and hope.
Book Synopsis Multiple Myeloma by : Paul G. Richardson
Download or read book Multiple Myeloma written by Paul G. Richardson and published by Remedica. This book was released on 2004 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple myeloma is the second most common hematologic malignancy, affecting 15,000 patients per year in the United States. Despite the advent of high-dose chemotherapy with stem cell transplantation, multiple myeloma remains incurable, with approximately 12,000 deaths per annum recorded in the US from the disease. Over the last 10 years, there has been a dramatic increase in our understanding of the biology of multiple myeloma, which has provided insights into mechanisms of cytotoxic resistance, both as inherent characteristics of the myeloma cell and the protective interaction between the tumor and its bone marrow microenvironment. Moreover, advances in our understanding of multiple myeloma pathogenesis have helped further define the intricacies of this complex disease. This book provides a concise overview of the state-of-the-art in multiple myeloma and should be of primary interest to clinicians as well as scientists and related caregivers alike in this rapidly changing f.
Book Synopsis Biology of Multiple Myeloma by : P. Leif Bergsagel
Download or read book Biology of Multiple Myeloma written by P. Leif Bergsagel and published by . This book was released on 2005-11 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: discusses the advances in molecular and cellular biology that have affected all fields of biology and have had a tremendous impact on the understanding of the biology of myeloma;reviews the dramatic clinical response to novel agents that has prompted a re-evaluation of important signaling pathways in myeloma;covers bone marrow microenvionments, molecular genetics, and other various genetic changes.
Book Synopsis Multiple Myeloma - A New Era of Treatment Strategies by : Klaus Podar
Download or read book Multiple Myeloma - A New Era of Treatment Strategies written by Klaus Podar and published by Bentham Science Publishers. This book was released on 2012-01-03 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Multiple Myeloma (MM), the second most common blood cancer in adults, is a clonal plasma cell malignancy within the bone marrow characterized by osteolytic bone lesions, renal disease, and immunodeficiency. It is now well established that MM cell- induced"
Book Synopsis New Developments in Myeloma, an Issue of Hematology/Oncology Clinics of North America by : P. Leif Bergsagel
Download or read book New Developments in Myeloma, an Issue of Hematology/Oncology Clinics of North America written by P. Leif Bergsagel and published by Elsevier. This book was released on 2024-04-28 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue of Hematology/Oncology Clinics, guest editor Dr. P. Leif Bergsagel brings his considerable expertise to the topic of New Developments in Myeloma. With the advent of next generation sequencing and immune profiling technologies, marked advances have been made recently in the understanding of the molecular and immune pathogenesis of multiple myeloma. Yet even with these advances, there is a continual search for new therapeutic approaches. In this issue, top experts discuss a full range of clinically relevant topics in this complex and fast-changing field. Contains 16 relevant, practice-oriented topics including molecular pathogenesis of multiple myeloma; monoclonal antibodies in the treatment of multiple myeloma; CAR-T cells in the treatment of multiple myeloma; management of newly diagnosed multiple myeloma today, and in the future; approach to high-risk multiple myeloma; new therapies on the horizon for relapsed refractory multiple myeloma; and more. Provides in-depth clinical reviews on new developments in myeloma, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Book Synopsis Advanced Drug Delivery Systems in the Management of Cancer by : Kamal Dua
Download or read book Advanced Drug Delivery Systems in the Management of Cancer written by Kamal Dua and published by Elsevier. This book was released on 2021-06-24 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Drug Delivery Systems in the Management of Cancer discusses recent developments in nanomedicine and nano-based drug delivery systems used in the treatment of cancers affecting the blood, lungs, brain, and kidneys. The research presented in this book includes international collaborations in the area of novel drug delivery for the treatment of cancer. Cancer therapy remains one of the greatest challenges in modern medicine, as successful treatment requires the elimination of malignant cells that are closely related to normal cells within the body. Advanced drug delivery systems are carriers for a wide range of pharmacotherapies used in many applications, including cancer treatment. The use of such carrier systems in cancer treatment is growing rapidly as they help overcome the limitations associated with conventional drug delivery systems. Some of the conventional limitations that these advanced drug delivery systems help overcome include nonspecific targeting, systemic toxicity, poor oral bioavailability, reduced efficacy, and low therapeutic index. This book begins with a brief introduction to cancer biology. This is followed by an overview of the current landscape in pharmacotherapy for the cancer management. The need for advanced drug delivery systems in oncology and cancer treatment is established, and the systems that can be used for several specific cancers are discussed. Several chapters of the book are devoted to discussing the latest technologies and advances in nanotechnology. These include practical solutions on how to design a more effective nanocarrier for the drugs used in cancer therapeutics. Each chapter is written with the goal of informing readers about the latest advancements in drug delivery system technologies while reinforcing understanding through various detailed tables, figures, and illustrations. Advanced Drug Delivery Systems in the Management of Cancer is a valuable resource for anyone working in the fields of cancer biology and drug delivery, whether in academia, research, or industry. The book will be especially useful for researchers in drug formulation and drug delivery as well as for biological and translational researchers working in the field of cancer. Presents an overview of the recent perspectives and challenges within the management and diagnosis of cancer Provides insights into how advanced drug delivery systems can effectively be used in the management of a wide range of cancers Includes up-to-date information on diagnostic methods and treatment strategies using controlled drug delivery systems
Book Synopsis Recent Advances in the Treatment of Multiple Myeloma by : H. Grant Prentice
Download or read book Recent Advances in the Treatment of Multiple Myeloma written by H. Grant Prentice and published by S. Karger AG (Switzerland). This book was released on 2005 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Contemporary Management of Multiple Myeloma by : Ravi Vij
Download or read book Contemporary Management of Multiple Myeloma written by Ravi Vij and published by JAYPEE BROTHERS MEDICAL PUBLISHERS PVT. LTD.. This book was released on 2012-12-15 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book "Contemporary Management of Multiple Myeloma" discusses in detail about the management of multiple myeloma. Multiple Myeloma is the second most common hematological malignancy in the United States. This book highlights the interplay between the malignant plasma cell and the microenvironment, and the role of genetic alterations, adhesion molecules and critical cytokines in this complex milieu. The first chapter of this book discusses epidemiology, etiology and pathogenesis of multiple myeloma. The clinical presentation of the common plasma cell dyscrasias and discuss the diagnostic and prognostic work-up with a highlighting on recent advances in chapters 3 and 4. Chapters from 5 to 9 focus on the therapeutic evolution that has occurred, and accumulate the landmark clinical trials that have changed clinical practice for up-front treatment of both transplant eligible and ineligible patients and for those with relapsed and refractory disease. These chapters also highlights on the important role of clinical research with stem cell transplantation, proteasome-inhibition and immunomodulatory drugs that form the backbone of our present day therapeutic armamentarium. Recommendations for response assessment and current understanding of the value of maximizing the depth of response in personalized therapy and patient segmentation are briefly explained in chapters 10 and 11. Chapter 12 and 13 discussed about adjunctive treatment modalities and novel therapeutic compounds in clinical trial and targets for future drug development. This book provides complete information about current landscape for multiple myeloma which is helpful in future aspects.
Book Synopsis Non-melanoma Skin Cancer of the Head and Neck by : Faruque Riffat
Download or read book Non-melanoma Skin Cancer of the Head and Neck written by Faruque Riffat and published by Springer. This book was released on 2015-09-30 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: Non-melanoma skin cancer is a global public health issue. With an ever-increasing, and ageing, world population coupled with increasing numbers of immunosuppressed individuals the number of patients continues to rise. The head and neck is overwhelmingly the most frequent location for the development of a non-melanoma skin cancer and as such challenges the clinician with its complex anatomy. The importance of maintaining the aesthetics of the face and the function of the anatomy cannot be overstated, yet ultimately it is always the aim of curing a patient with the minimum of morbidity that clinicians strive for. However, the spectrum of presentations and subsequent management varies widely, ranging from patients with the ubiquitous low-risk mid-face basal cell carcinoma to those diagnosed with relatively uncommon but potentially life-threatening high-risk squamous cell carcinomas (e.g. involving metastatic lymph nodes or with perineural invasion present) and Merkel cell carcinomas.
Book Synopsis Brigham Intensive Review of Internal Medicine by : Ajay K. Singh
Download or read book Brigham Intensive Review of Internal Medicine written by Ajay K. Singh and published by Oxford University Press. This book was released on 2014-07-25 with total page 1040 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based upon the popular review course from Harvard Medical School, The Brigham Intensive Review of Internal Medicine is a comprehensive study guide for the American Board of Internal Medicine certification or maintenance of certification examination as well as for general practice review by physicians and residents. This authoritative, thorough resource provides in-depth coverage on all specialties of internal medicine, as well as palliative care, occupational medicine, psychiatry, and geriatric medicine. Editors Ajay K. Singh and Joseph Loscalzo recruited leading authorities from Harvard as well as former chief residents at Brigham and Women's Hospital to contribute to this book. Featuring over 600 board review questions, with numerous tables and figures, chapters offer detailed discussions with emphasis on essential learning points. Over 100 chapters are organized into 10 broad sections, with one additional section dedicated to board simulation. As the required content for the American Board of Internal Medicine continues to evolve, studying can prove challenging. The Brigham Intensive Review of Internal Medicine is the ideal study guide for anyone preparing for certification or recertification.
Download or read book Multiple Myeloma written by and published by Demos Medical Publishing. This book was released on 2010-08-24 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple Myeloma: The second issue of Emerging Cancer Therapeutics focuses on multiple myelomas also known as plasma cell myeloma, KahlerÌs Disease and myelomatosis. It is estimated that over 20,000 new cases are diagnosed each year with over 10,000 people dying from these malignancies. Multiple myelomas are highly treatable but rarely curable. Thus it is crucial for the practitioner to be up-to-date on the latest insights regarding their management. Management options and outcomes for individuals with multiple myelomas improved dramatically with the introduction of chemotherapy. Even further improvements in prognosis have occurred because of the introduction of newer therapies such as pulse corticosteroids, thalidomide, bortezomib, and autologous and allogeneic stem cell transplantation. With the increased number of therapeutic options to choose from, the clinician is better placed to offer effective therapy but at the same time is challenged to keep abreast of the rapidly changing treatment landscape and the newly emerging data that is shaping the treatment options today and in the future. Multiple Myeloma provides a comprehensive and in-depth review of this group of malignancies. This volume reviews the current literature, provides critical evaluations of the data and offers evidence-based recommendations. About the Series: Emerging Cancer Therapeutics is an invited review publication providing a through analysis of key clinical research related to cancer therapeutics, including a discussion and assessment of current evidence, current clinical best practice, and likely near future developments. There is an emphasis throughout on multidisciplinary approaches to the specialty, as well as on quality and outcomes analysis. Published three times a year Emerging Cancer Therapeutics provides authoritative, thorough assessments of advances in therapeutics in all major areas of oncology, both solid and hematologic malignancies, with a focus on advances in medical and biological therapies with emerging clinical impact and encompassing new technologies with implications for management such as molecular imaging. Features of Emerging Cancer Therapeutics include: Editorial board of nationally recognized experts across the spectrum of Cancer Therapeutics In-depth, up-to-date expert reviews and analysis of major new developments in all areas of Cancer Therapeutics Issues edited by an authority in specific subject area Focuses on major topics in Cancer Therapeutics with in-depth articles covering advances in clinical and translational research developments, as well as clinical applications and experience Emphasizes multidisciplinary approaches to research and practice
