Advances in Listeria Research and Treatment: 2013 Edition

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Publisher : ScholarlyEditions
ISBN 13 : 1481670921
Total Pages : 110 pages
Book Rating : 4.4/5 (816 download)

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Download or read book Advances in Listeria Research and Treatment: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-06-21 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Listeria Research and Treatment: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about ZZZAdditional Research in a concise format. The editors have built Advances in Listeria Research and Treatment: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Listeria Research and Treatment: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Advances in Listeria Research and Treatment: 2012 Edition

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Publisher : ScholarlyEditions
ISBN 13 : 1464998590
Total Pages : 185 pages
Book Rating : 4.4/5 (649 download)

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Download or read book Advances in Listeria Research and Treatment: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Listeria Research and Treatment / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Listeria. The editors have built Advances in Listeria Research and Treatment / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Listeria in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Listeria Research and Treatment / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Advances in Listeria Research and Treatment: 2011 Edition

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Publisher : ScholarlyEditions
ISBN 13 : 1464933030
Total Pages : 78 pages
Book Rating : 4.4/5 (649 download)

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Download or read book Advances in Listeria Research and Treatment: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 78 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Listeria Research and Treatment: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Listeria in a concise format. The editors have built Advances in Listeria Research and Treatment: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Listeria in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Listeria Research and Treatment: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Regular Gram-Positive Asporogenous Rods—Advances in Research and Application: 2013 Edition

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Publisher : ScholarlyEditions
ISBN 13 : 1481679872
Total Pages : 101 pages
Book Rating : 4.4/5 (816 download)

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Download or read book Regular Gram-Positive Asporogenous Rods—Advances in Research and Application: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-06-21 with total page 101 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regular Gram-Positive Asporogenous Rods—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Lactobacillaceae in a concise format. The editors have built Regular Gram-Positive Asporogenous Rods—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Lactobacillaceae in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Regular Gram-Positive Asporogenous Rods—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Gram-Positive Asporogenous Rods—Advances in Research and Application: 2013 Edition

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Publisher : ScholarlyEditions
ISBN 13 : 1490100555
Total Pages : 90 pages
Book Rating : 4.4/5 (91 download)

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Book Synopsis Gram-Positive Asporogenous Rods—Advances in Research and Application: 2013 Edition by :

Download or read book Gram-Positive Asporogenous Rods—Advances in Research and Application: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-05-01 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gram-Positive Asporogenous Rods—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Regular Gram-Positive Asporogenous Rods in a concise format. The editors have built Gram-Positive Asporogenous Rods—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Regular Gram-Positive Asporogenous Rods in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Gram-Positive Asporogenous Rods—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Antigen-Presenting Cells—Advances in Research and Application: 2013 Edition

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Publisher : ScholarlyEditions
ISBN 13 : 1481685066
Total Pages : 270 pages
Book Rating : 4.4/5 (816 download)

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Book Synopsis Antigen-Presenting Cells—Advances in Research and Application: 2013 Edition by :

Download or read book Antigen-Presenting Cells—Advances in Research and Application: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-06-21 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antigen-Presenting Cells—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about ZZZAdditional Research in a concise format. The editors have built Antigen-Presenting Cells—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Antigen-Presenting Cells—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Phagocytes—Advances in Research and Application: 2013 Edition

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Publisher : ScholarlyEditions
ISBN 13 : 1481691155
Total Pages : 250 pages
Book Rating : 4.4/5 (816 download)

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Book Synopsis Phagocytes—Advances in Research and Application: 2013 Edition by :

Download or read book Phagocytes—Advances in Research and Application: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-06-21 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phagocytes—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about ZZZAdditional Research in a concise format. The editors have built Phagocytes—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Phagocytes—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Bugs as Drugs

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Publisher : John Wiley & Sons
ISBN 13 : 1555819702
Total Pages : 514 pages
Book Rating : 4.5/5 (558 download)

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Book Synopsis Bugs as Drugs by : Robert A. Britton

Download or read book Bugs as Drugs written by Robert A. Britton and published by John Wiley & Sons. This book was released on 2020-07-02 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: Examining the enormous potential of microbiome manipulation to improve health Associations between the composition of the intestinal microbiome and many human diseases, including inflammatory bowel disease, cardiovascular disease, metabolic disorders, and cancer, have been elegantly described in the past decade. Now, whole-genome sequencing, bioinformatics, and precision gene-editing techniques are being combined with centuries-old therapies, such as fecal microbiota transplantation, to translate current research into new diagnostics and therapeutics to treat complex diseases. Bugs as Drugs provides a much-needed overview of microbes in therapies and will serve as an excellent resource for scientists and clinicians as they carry out research and clinical studies on investigating the roles the microbiota plays in health and disease. In Bugs as Drugs, editors Robert A. Britton and Patrice D. Cani have assembled a fascinating collection of reviews that chart the history, current efforts, and future prospects of using microorganisms to fight disease and improve health. Sections cover traditional uses of probiotics, next-generation microbial therapeutics, controlling infectious diseases, and indirect strategies for manipulating the host microbiome. Topics presented include: How well-established probiotics support and improve host health by improving the composition of the intestinal microbiota of the host and by modulating the host immune response. The use of gene editing and recombinant DNA techniques to create tailored probiotics and to characterize next-generation beneficial microbes. For example, engineering that improves the anti-inflammatory profile of probiotics can reduce the number of colonic polyps formed, and lactobacilli can be transformed into targeted delivery systems carrying therapeutic proteins or bioengineered bacteriophage. The association of specific microbiota composition with colorectal cancer, liver diseases, osteoporosis, and inflammatory bowel disease. The gut microbiota has been proposed to serve as an organ involved in regulation of inflammation, immune function, and energy homeostasis. Fecal microbiota transplantation as a promising treatment for numerous diseases beyond C. difficile infection. Practical considerations for using fecal microbiota transplantation are provided, while it is acknowledged that more high-quality evidence is needed to ascertain the importance of strain specificity in positive treatment outcomes. Because systems biology approaches and synthetic engineering of microbes are now high-throughput and cost-effective, a much wider range of therapeutic possibilities can be explored and vetted.

Conventional and Advanced Food Processing Technologies

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Publisher : John Wiley & Sons
ISBN 13 : 111840632X
Total Pages : 754 pages
Book Rating : 4.1/5 (184 download)

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Book Synopsis Conventional and Advanced Food Processing Technologies by : Suvendu Bhattacharya

Download or read book Conventional and Advanced Food Processing Technologies written by Suvendu Bhattacharya and published by John Wiley & Sons. This book was released on 2014-11-17 with total page 754 pages. Available in PDF, EPUB and Kindle. Book excerpt: Food processing technologies are an essential link in the food chain. These technologies are many and varied, changing in popularity with changing consumption patterns and product popularity. Newer process technologies are also being evolved to provide the added advantages. Conventional and Advanced Food Processing Technologies fuses the practical (application, machinery), theoretical (model, equation) and cutting-edge (recent trends), making it ideal for industrial, academic and reference use. It consists of two sections, one covering conventional or well-established existing processes and the other covering emerging or novel process technologies that are expected to be employed in the near future for the processing of foods in the commercial sector. All are examined in great detail, considering their current and future applications with added examples and the very latest data. Conventional and Advanced Food Processing Technologies is a comprehensive treatment of the current state of knowledge on food processing technology. In its extensive coverage, and the selection of reputed research scientists who have contributed to each topic, this book will be a definitive text in this field for students, food professionals and researchers.

Developments in Campylobacter, Helicobacter & Related Organisms Research – CHRO 2019

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Publisher : Frontiers Media SA
ISBN 13 : 2889664805
Total Pages : 226 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Developments in Campylobacter, Helicobacter & Related Organisms Research – CHRO 2019 by : Ozan Gundogdu

Download or read book Developments in Campylobacter, Helicobacter & Related Organisms Research – CHRO 2019 written by Ozan Gundogdu and published by Frontiers Media SA. This book was released on 2021-02-11 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Advances in Food and Nutrition Research

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Publisher : Elsevier
ISBN 13 : 0443294194
Total Pages : 456 pages
Book Rating : 4.4/5 (432 download)

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Book Synopsis Advances in Food and Nutrition Research by :

Download or read book Advances in Food and Nutrition Research written by and published by Elsevier. This book was released on 2024-08-01 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Food and Nutrition Research, Volume 111 provides the latest on highly timely topics, including Understanding the Heterocyclic Aromatic Amine Research: An Overview and Recent Findings, Recent advances and challenges in the analysis of natural toxins, High Pressure Processing Plus Technologies: Enhancing the Inactivation of Vegetative Microorganisms, A discussion on A1-free milk: nuances and comments beyond implications to the health, Bioactive peptides as a novel strategy to prevent alcoholic liver injury, Hemp seed protein-derived short- and medium-chain peptides and their multifunctional properties, Condensed tannins – their content in plant foods, changes during processing, antioxidant and biological activities, and more. Contains contributions that have been carefully selected based on the vast experience and expertise of the authors on the subject Includes updated, in-depth, and critical discussions of available information, giving the reader a unique opportunity to learn Encompasses a broad view of the topics at hand

Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrés des recherches pharmaceutiques

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Publisher : Birkhäuser
ISBN 13 : 3034870949
Total Pages : 625 pages
Book Rating : 4.0/5 (348 download)

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Book Synopsis Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrés des recherches pharmaceutiques by : JUCKER

Download or read book Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrés des recherches pharmaceutiques written by JUCKER and published by Birkhäuser. This book was released on 2013-03-08 with total page 625 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Pancreatic Cancer and Periampullary Neoplasms, An Issue of Surgical Clinics of North America, E-Book

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Publisher : Elsevier Health Sciences
ISBN 13 : 0323477739
Total Pages : pages
Book Rating : 4.3/5 (234 download)

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Book Synopsis Pancreatic Cancer and Periampullary Neoplasms, An Issue of Surgical Clinics of North America, E-Book by : Jeffrey M. Hardacre

Download or read book Pancreatic Cancer and Periampullary Neoplasms, An Issue of Surgical Clinics of North America, E-Book written by Jeffrey M. Hardacre and published by Elsevier Health Sciences. This book was released on 2016-11-21 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Surgical Clinics of North America, guest edited by Dr. Jeffrey M. Hardacre, is devoted to Pancreatic Cancer and Periampullary Neoplasms. He has assembled expert authors to review the following topics: Genetics of Pancreatic Cancer and its Implication on Therapy; Familial Pancreatic Cancer and Screening of High-risk Individuals; Imaging Evaluation of Pancreatic Cancer; Endoscopic Evaluation in the Work-up of Pancreatic Cancer; Definition and Management of Borderline Resectable Pancreatic Cancer; Techniques of Vascular Resection and Reconstruction in Pancreatic Cancer Surgery; Surgical Therapy for Pancreatic and Periampullary Cancer; Post-Pancreatectomy Complications and Management; Adjuvant and Neoadjuvant Therapy for Resectable Pancreatic and Periampullary Cancer; Management of Locally Advanced Pancreatic Cancer; Management of Metastatic Pancreatic Cancer; Management of Pancreatic Neuroendocrine Tumors; Management of Intraductal Papillary Mucinous Neoplasms; Palliative Care and Surgery in Pancreatic Cancer; Enhanced Recovery Pathways in Pancreatic Cancer; and more!

Advanced Technologies for Meat Processing

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Publisher : CRC Press
ISBN 13 : 1498754600
Total Pages : 722 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Advanced Technologies for Meat Processing by : Fidel Toldrá

Download or read book Advanced Technologies for Meat Processing written by Fidel Toldrá and published by CRC Press. This book was released on 2017-10-10 with total page 722 pages. Available in PDF, EPUB and Kindle. Book excerpt: As with the first edition, the main goal of Advanced Technologies for Meat Processing is to provide the reader with recent developments in new advanced technologies for the full meat- processing chain. This book is written by distinguished international contributors with recognized expertise and excellent reputations, and brings together all the advances in a wide and varied number of technologies that are applied in different stages of meat processing. This second edition contains 21 chapters, combining updated and revised versions of several chapters with entirely new chapters that deal with new online monitoring techniques like hyperspectral imaging and Raman spectroscopy, the use of nanotechnology for sensor devices or new packaging materials and the application of omics technologies like nutrigenomics and proteomics for meat quality and nutrition. The book starts with the control and traceability of genetically modified farm animals, followed by four chapters reporting the use of online non-destructive monitoring techniques like hyperspectral imaging and Raman spectroscopy, real-time PCR for pathogens detection, and nanotechnology-based sensors. Then, five chapters describe different advanced technologies for meat decontamination, such as irradiation, hydrostatic and hydrodynamic pressure processing, other non-thermal technologies, and the reduction in contaminants generation. Nutrigenomics in animal nutrition and production is the object of a chapter that is followed by five chapters dealing with nutritional-related issues like bioactive peptides, functional meats, fat and salt reduction, processing of nitrite-free products, and the use of proteomics for the improved processing of dry-cured meats. The last four chapters are reporting the latest developments in bacteriocins against meat-borne pathogens, the functionality of bacterial starters, modified atmosphere packaging and the use of new nanotechnology-based materials for intelligent and edible packaging.

Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria

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Publisher : John Wiley & Sons
ISBN 13 : 1119004829
Total Pages : 1464 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria by : Frans J. de Bruijn

Download or read book Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria written by Frans J. de Bruijn and published by John Wiley & Sons. This book was released on 2016-07-01 with total page 1464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bacteria in various habitats are subject to continuously changing environmental conditions, such as nutrient deprivation, heat and cold stress, UV radiation, oxidative stress, dessication, acid stress, nitrosative stress, cell envelope stress, heavy metal exposure, osmotic stress, and others. In order to survive, they have to respond to these conditions by adapting their physiology through sometimes drastic changes in gene expression. In addition they may adapt by changing their morphology, forming biofilms, fruiting bodies or spores, filaments, Viable But Not Culturable (VBNC) cells or moving away from stress compounds via chemotaxis. Changes in gene expression constitute the main component of the bacterial response to stress and environmental changes, and involve a myriad of different mechanisms, including (alternative) sigma factors, bi- or tri-component regulatory systems, small non-coding RNA’s, chaperones, CHRIS-Cas systems, DNA repair, toxin-antitoxin systems, the stringent response, efflux pumps, alarmones, and modulation of the cell envelope or membranes, to name a few. Many regulatory elements are conserved in different bacteria; however there are endless variations on the theme and novel elements of gene regulation in bacteria inhabiting particular environments are constantly being discovered. Especially in (pathogenic) bacteria colonizing the human body a plethora of bacterial responses to innate stresses such as pH, reactive nitrogen and oxygen species and antibiotic stress are being described. An attempt is made to not only cover model systems but give a broad overview of the stress-responsive regulatory systems in a variety of bacteria, including medically important bacteria, where elucidation of certain aspects of these systems could lead to treatment strategies of the pathogens. Many of the regulatory systems being uncovered are specific, but there is also considerable “cross-talk” between different circuits. Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria is a comprehensive two-volume work bringing together both review and original research articles on key topics in stress and environmental control of gene expression in bacteria. Volume One contains key overview chapters, as well as content on one/two/three component regulatory systems and stress responses, sigma factors and stress responses, small non-coding RNAs and stress responses, toxin-antitoxin systems and stress responses, stringent response to stress, responses to UV irradiation, SOS and double stranded systems repair systems and stress, adaptation to both oxidative and osmotic stress, and desiccation tolerance and drought stress. Volume Two covers heat shock responses, chaperonins and stress, cold shock responses, adaptation to acid stress, nitrosative stress, and envelope stress, as well as iron homeostasis, metal resistance, quorum sensing, chemotaxis and biofilm formation, and viable but not culturable (VBNC) cells. Covering the full breadth of current stress and environmental control of gene expression studies and expanding it towards future advances in the field, these two volumes are a one-stop reference for (non) medical molecular geneticists interested in gene regulation under stress.

Recent Advancements in Microbial Diversity

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Publisher : Academic Press
ISBN 13 : 0128223693
Total Pages : 489 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Recent Advancements in Microbial Diversity by : Jae Youl Cho

Download or read book Recent Advancements in Microbial Diversity written by Jae Youl Cho and published by Academic Press. This book was released on 2022-03-18 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, researchers around the globe have deep dived into the fascination world of the Macrophage and its diverse role in tissue development, angiogenesis, and wound healing, and above all the untapped mystery of the wondering immune system within our body. Macrophages and their role in inflammation includes all the latest information of macrophages and inflammation as well as it provides an in-depth understanding of this complex and rapidly progressing field of study. - Outlines the role of macrophages in inflammation - Contains chapters by leading authors on the basic and translational aspects of macrophage biology - Deals with internal and external treats

Recent Advances in γδ T Cell Biology: New Ligands, New Functions, and New Translational Perspectives

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Publisher : Frontiers Media SA
ISBN 13 : 2889197840
Total Pages : 271 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Recent Advances in γδ T Cell Biology: New Ligands, New Functions, and New Translational Perspectives by : Dieter Kabelitz

Download or read book Recent Advances in γδ T Cell Biology: New Ligands, New Functions, and New Translational Perspectives written by Dieter Kabelitz and published by Frontiers Media SA. This book was released on 2016-02-16 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gamma/delta (γδ) T-cells are a small subset of T-lymphocytes in the peripheral circulation but constitute a major T-cell population at other anatomical localizations such as the epithelial tissues. In contrast to conventional α/β T-cells, the available number of germline genes coding for T-cell receptor (TCR) variable elements of γδ T-cells is very small. Moreover, there is a prefential localization of γδ T-cells expressing given Vgamma and Vdelta genes in certain tissues. In humans, γδ T-cells expressing the Vg9Vd2-encoded TCR account for anywhere between 50 and >95% of peripheral blood γδ T-cells, whereas cells expressing non-Vd2 genes dominate in mucosal tissues. In mice, there is an ordered appearance of γδ T-cell „waves“ during embryonic development, resulting in preferential localization of γδ T-cells expressing distinct VgammaVdelta genes in the skin, the reproductive organs, or gut epithelia. The major function of γδ T-cells resides in local immunosurveillance and immune defense against infection and malignancy. This is supported by the identification of ligands that are selectively recognized by the γδ TCR. As an example, human Vgamma9Vdelta2 T-cells recognize phosphorylated metabolites („phosphoantigens“) that are secreted by many pathogens but can also be overproduced by tumor cells, providing a basis for a role of these γδ T-cells in both anti-infective and anti-tumor immunity. Similarly, the recognition of endothelial protein C receptor by human non-Vdelta2 γδ T-cells has recently been identified to provide a link for the role for such γδ T-cells in immunity against epithelial tumor cells and cytomegalovirus-infected endothelial cells. In addition to „classical“ functions such as cytokine production and cytotoxicity, recent studies suggest that subsets of γδ T-cells can exert additional functions such as regulatory activity and – quite surpisingly – „professional“ antigen-presenting capacity. It is currently not well known how this tremendous extent of functional plasticity is regulated and what is the extent of γδ TCR ligand diversity. Due to their non-MHC-restricted recognition of unusual stress-associated ligands, γδ T-cells have raised great interest as to their potential translational application in cell-based immunotherapy. Topics of this Research Focus include: Molecular insights into the activation and differentiation requirements of γδ T-cells, role of pyrophosphates and butyrophilin molecules for the activation of human γδ T-cells, role of γδ T-cells in tumor immunity and in other infectious and non-infectious diseases, and many others. We are most grateful to all colleagues who agreed to write a manuscript. Thanks to their contributions, this E-book presents an up-to-date overview on many facets of the still exciting γδ T-cells. Dieter Kabelitz & Julie Déchanet-Merville