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Advances In Discoveries Of Plant Phytochemicals
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Book Synopsis Phytochemicals as Lead Compounds for New Drug Discovery by : Chukwuebuka Egbuna
Download or read book Phytochemicals as Lead Compounds for New Drug Discovery written by Chukwuebuka Egbuna and published by Elsevier. This book was released on 2019-09-07 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phytochemicals as Lead Compounds for New Drug Discovery presents complete coverage of the recent advances in the discovery of phytochemicals from medicinal plants as models to the development of new drugs and chemical entities. Functional bioactive compounds of plant origin have been an invaluable source for many human therapeutic drugs and have played a major role in the treatment of diseases around the world. These compounds possess enormous structural and chemical diversity and have led to many important discoveries. This book presents fundament concepts and factors affecting the choice for plant-based products, as well as recent advances in computer-aided drug discovery and FDA drug candidacy acceptance criteria. It also details the various bioactive lead compounds and molecular targets for a range of life-threatening diseases including cancer, diabetes, and neurodegenerative diseases. Written by a global team of experts, Phytochemicals as Lead Compounds for New Drug Discovery is an ideal resource for drug developers, phytochemists, plant biochemists, food and medicinal chemists, nutritionists and toxicologists, chemical ecologists, taxonomists, analytical chemists, and other researchers in those fields. It will also be very valuable to professors, students, and researchers in this domain. - Presents fundamental concepts and factors affecting choice for plant-based products - Details the FDA drug candidacy acceptance criteria, including bottlenecks and way forward - Highlights recent advances in computational-based drug discovery - Focuses on the discovery of new drugs and potential druggable targets for the treatment of chronic diseases of world importance
Book Synopsis Advances in Discoveries of Plant Phytochemicals by : Rajesh Chandra Misra
Download or read book Advances in Discoveries of Plant Phytochemicals written by Rajesh Chandra Misra and published by Frontiers Media SA. This book was released on 2024-03-27 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plants are leading chemists that collectively synthesize a vast number of low molecular weight complex compounds called “phytochemicals” or “phytonutrients” which are the valuable source of bioactive compounds that have numerous health benefits and pharmaceutical and industrial uses. Moreover, they have been shown to possess diverse biological activities, for instance, antiviral, antiproliferative, antioxidant, larvicidal, anti-inflammatory, antibacterial, anti-parasitic, analgesic, antifungal, hepatoprotective, immunomodulatory as well as central nervous system depressant.
Book Synopsis Poisonous Plants and Phytochemicals in Drug Discovery by : Andrew G. Mtewa
Download or read book Poisonous Plants and Phytochemicals in Drug Discovery written by Andrew G. Mtewa and published by John Wiley & Sons. This book was released on 2020-12-22 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on phytochemicals and their potential for drug discovery, this book offers a comprehensive resource on poisonous plants and their applications in chemistry and in pharmacology. Provides a comprehensive resource on phytotoxins, covering historical perspectives, modern applications, and their potential in drug discovery Covers the mechanisms, benefits, risks and management protocols of phytotoxins in a scientific laboratory and the usefulness in drug discovery Presents chapters in a carefully designed, clear order, making it an ideal resource for the academic researcher or the industry professional at any stage in their career
Book Synopsis Phytochemicals, Plant Growth, and the Environment by : David Gang
Download or read book Phytochemicals, Plant Growth, and the Environment written by David Gang and published by Springer. This book was released on 2014-09-20 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the second volume since the reintroduction of the Recent Advances in Phytochemistry (RAP) series, an annual journal supported by the Phytochemical Society of North America. Topics appropriate for RAP include the biosynthesis of natural products and regulation of metabolism, the ecology of specialized metabolites and the evolution of their pathways, and the effects of natural products or plants on human health. Research appropriate for RAP involves genomics, proteomics, metabolomics, natural product structural determination and new technology development, medicinal chemistry and metabolic engineering, or any of the myriad of fields that are now closely associated with what may be called “traditional phytochemistry” and plant biochemistry. The advent of post-genomics-based ways of thinking, of systems biology, of synthetic biology, of comparative genomics/ proteomics/ transcriptomics/ metabolomics and especially of the introduction and establishment of a mentality that leads to support of large collaborative projects, has opened up many new doors to scientists interested and versed in the (bio)chemistry of plants. The goal of RAP is to highlight these developments. Two main types of articles are printed in RAP: Perspectives and Communications. Perspectives in RAP are expected to synthesize results from the primary literature and perhaps from new/novel results and place these in perspective relative to the broader field. These articles may be similar to review articles, but also are intended to present important ideas and hypotheses, and may present proposals for interesting directions in the field. It is the hope of the Editorial Board that these articles will be of great value to a large audience. Communications are intended to represent new advances in the field that will be of interest to a large audience. Articles of both types are typically solicited from the Society membership based on the content of the annual meeting talks, but in keeping with the title “Recent Advances in Phytochemistry” the editorial board reserves the right to solicit additional Perspectives and/or Communications from non-attendees as well (e.g., where an editorial board member has knowledge of an interesting recent advancement that would be of general interest to the society membership). All submissions to RAP go through a rigorous peer review process, overseen by the Editorial Board, which includes external review. RAP is indexed with Springer published journals. All RAP papers are available not only in the published volume form, but also electronically through Springer’s online literature services. This marks a significant change from past volumes of RAP and it is the hope of the Editorial Board that this will lead to broader dissemination of the contents of and greater interest in RAP. This 42nd volume of RAP includes a total of seven articles, many, but not all, based on talks presented at the 50th annual meeting of the PSNA. As was seen in RAP volume 41, These seven Perspectives give a very good picture of the breadth of plant (bio)chemistry research in North America, which is also indicative of the state of the field worldwide. Each of these articles describes the integration of several different approaches to ask and then answer interesting questions regarding the function of interesting plant metabolites, either in the plant itself or in interactions with the environment (natural setting or human health application). Many of these Perspectives have a strong ecological focus. McCormick et al. review the discovery of the biosynthetic pathway leading to production of trichothecene mycotoxins such as the T-2 toxin in plant pathogenic and other fungi. These compounds play very important roles in plant-pathogen interaction, and are very significant from a human health perspective. In a complementary paper, Duringer et al. describe recent technological advances in monitoring mycotoxins such as ergovaline and lysergic acid in forage crops, using state of the art and highly sensitive mass spectrometric means. Gross reviews the current understanding of how infochemicals mediate interactions between plants and insects, and highlights how such knowledge can be used to mitigate crop losses by pests. Two Perspectives discuss how recent technological advances are making an impact on our understanding of the role of plant hormones in plant growth and development. Gouthu et al. outline highly sensitive methods for measurement of plant hormones in tissues such as developing grape berry. In contrast, McDowell and Gang outline how new transcriptional profiling techniques are shedding light on old questions, such as how rhizome development is regulated by different plant growth regulators. The last two Perspectives outline the role of biotechnology in modern plant biochemistry research. Makhzoum et al. review the long history of use of hairy roots and provide perspective on future utility of this tissue type in continuing to uncover mechanisms of plant natural product biosynthesis, among other apolications. Dalton et al. outline, on the other hand, recent efforts to produce non-native polymers of human interest in plants and outline many of the challenges associated with such investigations. We hope that you will find these Perspectives to be interesting, informative, and timely. It is our goal that RAP will act not only as the voice of the PSNA, but that it will serve as an authoritative, up-to-date resource that helps to set the gold standard for thought and research in fields related to plant biochemistry.
Book Synopsis Phytochemistry: An in-silico and in-vitro Update by : Shashank Kumar
Download or read book Phytochemistry: An in-silico and in-vitro Update written by Shashank Kumar and published by Springer. This book was released on 2019-06-25 with total page 575 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phytochemistry is the branch of science that deals with the study of plant-derived chemicals or compounds, which are also known as phytochemicals or plant-derived secondary metabolites. Plants are known to produce phytochemicals that are essential for their growth and reproduction, as they protect them from insects, pathogens, and herbivores. Some of the major groups of plant-derived secondary metabolites are phenolics, flavonoids, terpenoids, alkaloids, tannin etc. Plant-derived phytochemicals are pharmacologically active and have the potential to cure various human diseases and disorders. Natural plant products have been known for their medicinal properties for untold years, and form the basis of several medicinal systems such as Chinese, Unani, and Ayurvedic Medicine. This book offers an essential introduction to phytochemicals and their synthetic analogues. It discusses various in silico approaches used to identify pharmacologically active phytochemicals and their biological activities, as well as in vitro and in vivo models/assays that have been utilized for the pharmacological profiling of plant-derived products to combat cancer, diabetes, cardiovascular diseases and neurological disorders. The intended audience includes upper-level undergraduate and graduate students; researchers and scientists from the pharmaceutical/food chemistry/nutrition sciences/biochemistry, and clinical biochemistry fields; and medical students. Sharing the latest findings, the book will familiarize these readers with the concepts, chemistry, and tremendous potential of phytochemistry.
Book Synopsis Bioactive Phytochemicals by : Javed Ahamad
Download or read book Bioactive Phytochemicals written by Javed Ahamad and published by . This book was released on 2020-10-28 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural bioactive compounds from medicinal plants are inexplicably diverse in chemical structure and biological properties. The unmet therapeutic requirements for various diseases serve as a guide for researchers to study natural compounds. These studies are intended to isolate, identify the structural characterization and eventually discover the pharmacological activity of natural compounds from their plant sources with the goal of treating specific diseases. Bioactive Phytochemicals: Drug Discovery to Product Development explores the scope and approaches of drug discovery from natural products. Chapters in the book cover information about the cultivation, collection and processing of medicinal plants, the methods and high throughput techniques for isolation and characterization of bioactive phytochemicals and pharmacological screening for activity, formulation and quality control. Information about the regulations specified for natural medicinal products in different region of the world is also presented, followed by a concluding chapter devoted to the role of natural herbal products for treatment of human diseases such as cancer, cardiovascular diseases, diabetes, obesity, inflammation and neurological disorders. Each chapter concludes with a general reference section, which is a bibliographic guide to more advanced texts. The contributing authors for this volume are drawn from a rich blend of experts in various areas of herbal medicine which encompass herbal drug discovery to product development. The concise and organized layout along with a broad coverage of phytochemistry and drug discovery makes this book a suitable reference for students of medicinal chemistry, researchers and industry professionals interested in herbal product development.
Book Synopsis Handbook of Research on Advanced Phytochemicals and Plant-Based Drug Discovery by : Singh, Ajeet
Download or read book Handbook of Research on Advanced Phytochemicals and Plant-Based Drug Discovery written by Singh, Ajeet and published by IGI Global. This book was released on 2022-06-24 with total page 754 pages. Available in PDF, EPUB and Kindle. Book excerpt: A great deal of interest has been generated recently in the isolation, characterization, and biological activity of phytochemicals. Phytochemicals have the potential to enhance pharmaceuticals and drug discovery. As such, there is an urgent need for current research in the global scope of phytochemicals including the chemical and physical characteristics, analytical procedures, biological activity, safety, and industrial applications. The Handbook of Research on Advanced Phytochemicals and Plant-Based Drug Discovery examines the applications of bioactive molecules from a health perspective, examining the pharmacological aspects of medicinal plants, the phytochemical and biological activities of different natural products, and ethnobotany and medicinal properties. Moreover, it presents a novel dietary approach for human disease management. Covering topics such as computer-aided drug design, government regulation, and medicinal plant taxonomy, this major reference work is beneficial to pharmacists, medical practitioners, phytologists, hospital administrators, government officials, faculty and students of higher education, librarians, researchers, and academicians.
Book Synopsis Computational Phytochemistry by : Satyajit Dey Sarker
Download or read book Computational Phytochemistry written by Satyajit Dey Sarker and published by Elsevier. This book was released on 2024-03-06 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational Phytochemistry, Second Edition, explores how recent advances in computational techniques and methods have been embraced by phytochemical researchers to enhance many of their operations, refocusing and expanding the possibilities of phytochemical studies. By applying computational aids and mathematical models to extraction, isolation, structure determination, and bioactivity testing, researchers can obtain highly detailed information about phytochemicals and optimize working approaches. This book aims to support and encourage researchers currently working with or looking to incorporate computational methods into their phytochemical work. Topics in this book include computational methods for predicting medicinal properties, optimizing extraction, isolating plant secondary metabolites, and building dereplicated phytochemical libraries. The roles of high-throughput screening, spectral data for structural prediction, plant metabolomics, and biosynthesis are all reviewed before the application of computational aids for assessing bioactivities and virtual screening is discussed. Illustrated with detailed figures and supported by practical examples, this book is an indispensable guide for all those involved with the identification, extraction, and application of active agents from natural products. This new edition captures remarkable advancements in mathematical modeling and computational methods that have been incorporated in phytochemical research, addressing, e.g., extraction, isolation, structure determination, and bioactivity testing of phytochemicals. - Includes step-by-step protocols for various computational and mathematical approaches applied to phytochemical research - Features clearly illustrated chapters contributed by highly reputable researchers - Covers all key areas in phytochemical research, including virtual screening and metabolomics
Book Synopsis Functional and Preservative Properties of Phytochemicals by : Bhanu Prakash
Download or read book Functional and Preservative Properties of Phytochemicals written by Bhanu Prakash and published by Academic Press. This book was released on 2020-02-15 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional and Preservative Properties of Phytochemicals examines the potential of plant-based bioactive compounds as functional food ingredients and preservative agents against food-spoiling microbes and oxidative deterioration. The book provides a unified and systematic accounting of plant-based bioactive compounds by illustrating the connections among the different disciplines, such as food science, nutrition, pharmacology, toxicology, combinatorial chemistry, nanotechnology and biotechnological approaches. Chapters present the varied sources of raw materials, biochemical properties, metabolism, health benefits, preservative efficacy, toxicological aspect, safety and Intellectual Property Right issue of plant-based bioactive compounds. Written by authorities within the field, the individual chapters of the book are organized according to the following practical and easy to consult format: introduction, chapter topics and text, conclusions (take-home lessons), and references cited for further reading. - Provides collective information on recent advancements that increase the potential use of phytochemicals - Fosters an understanding of plant-based dietary bioactive ingredients and their physiological effects on human health at the molecular level - Thoroughly explores biotechnology, omics, and bioinformatics approaches to address the availability, cost, and mode of action of plant-based functional and preservative ingredients
Download or read book Phytochemicals written by Toshiki Asao and published by BoD – Books on Demand. This book was released on 2018-11-07 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phytochemicals provides original research work and reviews on the sources of phytochemicals, and their roles in disease prevention, supplementation, and accumulation in fruits and vegetables. The roles of anthocyanin, flavonoids, carotenoids, and taxol are presented in separate chapters. Antioxidative and free radicle scavenging activity of phytochemicals is also discussed. The medicinal properties of Opuntia, soybean, sea buckthorn, and gooseberry are presented in a number of chapters. Supplementation of plant extract with phytochemical properties in broiler meals is discussed in one chapter. The final two chapters include the impact of agricultural practices and novel processing technologies on the accumulation of phytochemicals in fruits and vegetables. This book mainly focuses on medicinal plants and the disease-preventing properties of phytochemicals, which will be a useful resource to the reader.
Book Synopsis Advances in Phytonanotechnology by : Mansour Ghorbanpour
Download or read book Advances in Phytonanotechnology written by Mansour Ghorbanpour and published by Academic Press. This book was released on 2019-05-21 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Phytonanotechnology: From Synthesis to Application guides readers through various applications of nanomaterials on plants by presenting the latest research related to nanotechnology and nanomaterials on plant systems. The book focuses on the effects of these applications on plant morphology, physiology, biochemistry, ecology and genetics. Sections cover the impact on plant yield, techniques, a review of positive and negative impacts, and an overview of current policies regarding the use of nanotechnology on plants. Additionally, the book offers insights into the appropriate application of nanoscience to plants and crops for improved outcome and an exploration of their bioavailability and toxicity in the environment. - Discusses the morphological, physiological and biochemical responses of plants to nanomaterials and the ability of the nanomaterials in modifying the genetic constitution of plants - Emphasizes new applications of nanomaterials, including nanosensors technology and nanomaterials as nanocarriers based antimicrobial phytochemicals - Presents the role of nanotechnology as a novel technique for the remediation of heavy metals by plants
Book Synopsis Handbook of Plant Food Phytochemicals by : Brijesh K. Tiwari
Download or read book Handbook of Plant Food Phytochemicals written by Brijesh K. Tiwari and published by John Wiley & Sons. This book was released on 2013-01-02 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phytochemicals are plant derived chemicals which may bestow health benefits when consumed, whether medicinally or as part of a balanced diet. Given that plant foods are a major component of most diets worldwide, it is unsurprising that these foods represent the greatest source of phytochemicals for most people. Yet it is only relatively recently that due recognition has been given to the importance of phytochemicals in maintaining our health. New evidence for the role of specific plant food phytochemicals in protecting against the onset of diseases such as cancers and heart disease is continually being put forward. The increasing awareness of consumers of the link between diet and health has exponentially increased the number of scientific studies into the biological effects of these substances. The Handbook of Plant Food Phytochemicals provides a comprehensive overview of the occurrence, significance and factors effecting phytochemicals in plant foods. A key of objective of the book is to critically evaluate these aspects. Evaluation of the evidence for and against the quantifiable health benefits being imparted as expressed in terms of the reduction in the risk of disease conferred through the consumption of foods that are rich in phytochemicals. With world-leading editors and contributors, the Handbook of Plant Food Phytochemicals is an invaluable, cutting-edge resource for food scientists, nutritionists and plant biochemists. It covers the processing techniques aimed at the production of phytochemical-rich foods which can have a role in disease-prevention, making it ideal for both the food industry and those who are researching the health benefits of particular foods. Lecturers and advanced students will find it a helpful and readable guide to a constantly expanding subject area.
Book Synopsis Therapeutic Use of Medicinal Plants and their Extracts: Volume 2 by : A.N.M. Alamgir
Download or read book Therapeutic Use of Medicinal Plants and their Extracts: Volume 2 written by A.N.M. Alamgir and published by Springer. This book was released on 2019-02-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book starts with a general introduction to phytochemistry, followed by chapters on plant constituents, their origins and chemistry, but also discussing animal-, microorganism- and mineral-based drugs. Further chapters cover vitamins, food additives and excipients as well as xenobiotics and poisons. The book also explores the herbal approach to disease management and molecular pharmacognosy and introduces methods of qualitative and quantitative analysis of plant constituents. Phytochemicals are classified as primary (e.g. carbohydrates, lipids, amino acid derivations, etc.) or secondary (e.g. alkaloids, terpenes and terpenoids, phenolic compounds, glycosides, etc.) metabolites according to their metabolic route of origin, chemical structure and function. A wide variety of primary and secondary phytochemicals are present in medicinal plants, some of which are active phytomedicines and some of which are pharmaceutical excipients.
Book Synopsis Biological Activities of Alkaloids by : Sabino Aurelio Bufo
Download or read book Biological Activities of Alkaloids written by Sabino Aurelio Bufo and published by MDPI. This book was released on 2020-05-13 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural products are increasingly attracting attention from both basic and applied science. Plant secondary metabolites, especially alkaloids, are receiving interest from a wide range of researchers due to their biological activity. They are produced to protect plants from diseases and herbivores. Therefore, they reveal a toxic activity that affects organisms at various levels of biological organization. A growing amount of research is proving their antimicrobial, antifungal, insecticidal, and anticancer activities. That makes them applicable in various fields from medicine, to pharmacology, veterinary, and toxicology, to crop protection. This Special Issue of Toxins, “Biological Activities of Alkaloids: From Toxicology to Pharmacology", collects 15 manuscripts describing the ecological, biological, pharmacological, and toxicological effects as well as structural and analytical aspects of plant alkaloids, their mode of action, and possible application in veterinary, medicine, and plant protection. These studies prove the potential for alkaloid application in various areas of science.
Book Synopsis Phytochemical Methods by : Jeffrey B. Harborne
Download or read book Phytochemical Methods written by Jeffrey B. Harborne and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: While there are many books available on methods of organic and biochemical analysis, the majority are either primarily concerned with the application of a particular technique (e.g. paper chromatography) or have been written for an audience of chemists or for biochemists work ing mainly with animaltissues. Thus, no simple guide to modern metho ds of plant analysis exists and the purpose of the present volume is to fill this gap. It is primarily intended for students in the plant sciences, who have a botanical or a general biological background. It should also be of value to students in biochemistry, pharmacognosy, food science and 'natural products' organic chemistry. Most books on chromatography, while admirably covering the needs of research workers, tend to overwhelm the student with long lists of solvent systems and spray reagents that can be applied to each class of organic constituent. The intention here is to simplify the situation by listing only a few specially recommended techniques that have wide currency in phytochemical laboratories. Sufficient details are provided to allow the student to use the techniques for themselves and most sections contain some introductory practical experiments which can be used in classwork.
Book Synopsis Plant-derived Natural Products by : Anne E. Osbourn
Download or read book Plant-derived Natural Products written by Anne E. Osbourn and published by Springer Science & Business Media. This book was released on 2009-07-07 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plants produce a huge array of natural products (secondary metabolites). These compounds have important ecological functions, providing protection against attack by herbivores and microbes and serving as attractants for pollinators and seed-dispersing agents. They may also contribute to competition and invasiveness by suppressing the growth of neighboring plant species (a phenomenon known as allelopathy). Humans exploit natural products as sources of drugs, flavoring agents, fragrances and for a wide range of other applications. Rapid progress has been made in recent years in understanding natural product synthesis, regulation and function and the evolution of metabolic diversity. It is timely to bring this information together with contemporary advances in chemistry, plant biology, ecology, agronomy and human health to provide a comprehensive guide to plant-derived natural products. Plant-derived natural products: synthesis, function and application provides an informative and accessible overview of the different facets of the field, ranging from an introduction to the different classes of natural products through developments in natural product chemistry and biology to ecological interactions and the significance of plant-derived natural products for humans. In the final section of the book a series of chapters on new trends covers metabolic engineering, genome-wide approaches, the metabolic consequences of genetic modification, developments in traditional medicines and nutraceuticals, natural products as leads for drug discovery and novel non-food crops.
Book Synopsis Bioactive Phytochemicals: Drug Discovery to Product Development by : Javed Ahmad
Download or read book Bioactive Phytochemicals: Drug Discovery to Product Development written by Javed Ahmad and published by Bentham Science Publishers. This book was released on 2020-10-28 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural bioactive compounds from medicinal plants are inexplicably diverse in chemical structure and biological properties. The unmet therapeutic requirements for various diseases serve as a guide for researchers to study natural compounds. These studies are intended to isolate, identify the structural characterization and eventually discover the pharmacological activity of natural compounds from their plant sources with the goal of treating specific diseases. Bioactive Phytochemicals: Drug Discovery to Product Development explores the scope and approaches of drug discovery from natural products. Chapters in the book cover information about the cultivation, collection and processing of medicinal plants, the methods and high throughput techniques for isolation and characterization of bioactive phytochemicals and pharmacological screening for activity, formulation and quality control. Information about the regulations specified for natural medicinal products in different region of the world is also presented, followed by a concluding chapter devoted to the role of natural herbal products for treatment of human diseases such as cancer, cardiovascular diseases, diabetes, obesity, inflammation and neurological disorders. Each chapter concludes with a general reference section, which is a bibliographic guide to more advanced texts. The contributing authors for this volume are drawn from a rich blend of experts in various areas of herbal medicine which encompass herbal drug discovery to product development. The concise and organized layout along with a broad coverage of phytochemistry and drug discovery makes this book a suitable reference for students of medicinal chemistry, researchers and industry professionals interested in herbal product development.
