Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Download Adenylyl Cyclase Isoforms As Potential Drug Targets full books in PDF, epub, and Kindle. Read online Adenylyl Cyclase Isoforms As Potential Drug Targets ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Author : Tarsis Brust
Publisher : Frontiers Media SA
ISBN 13 : 2832511287
Total Pages : 141 pages
Book Rating : 4.8/5 (325 download)
Download or read book Adenylyl cyclase isoforms as potential drug targets written by Tarsis Brust and published by Frontiers Media SA. This book was released on 2023-01-09 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 : 9781461464389
Total Pages : pages
Book Rating : 4.4/5 (643 download)
Download or read book Encyclopedia of Signaling Molecules written by and published by . This book was released on 19?? with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Victor R. Preedy
Publisher : Academic Press
ISBN 13 : 0128006773
Total Pages : 1106 pages
Book Rating : 4.1/5 (28 download)
Download or read book Neuropathology of Drug Addictions and Substance Misuse Volume 3 written by Victor R. Preedy and published by Academic Press. This book was released on 2016-04-25 with total page 1106 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuropathology of Drug Addictions and Substance Misuse, Volume 3: General Processes and Mechanisms, Prescription Medications, Caffeine and Areca, Polydrug Misuse, Emerging Addictions and Non-Drug Addictions is the third of three volumes in this informative series and offers a comprehensive examination of the adverse consequences of the most common drugs of abuse. Each volume serves to update the reader’s knowledge on the broader field of addiction as well as to deepen understanding of specific addictive substances. Volume 3 addresses prescription medications, caffeine, polydrug misuse, and non-drug addictions. Each section provides data on the general, molecular, cellular, structural, and functional neurological aspects of a given substance, with a focus on the adverse consequences of addictions. Research shows that the neuropathological features of one addiction are often applicable to those of others, and understanding these commonalties provides a platform for studying specific addictions in more depth and may ultimately lead researchers toward new modes of understanding, causation, prevention and treatment. However, marshalling data on the complex relationships between addictions is difficult due to the myriad of material and substances. Offers a modern approach to understanding the pathology of substances of abuse, offering an evidence-based ethos for understanding the neurology of addictions Fills an existing gap in the literature by serving as a “one-stop-shopping synopsis of everything to do with the neuropathology of drugs of addiction and substance misuse Includes in each chapter: list of abbreviations, abstract, introduction, applications to other addictions and substance misuse, mini-dictionary of terms, summary points, 6+ figures and tables, full references Offers coverage of preclinical, clinical, and population studies, from the cell to whole organs, and from the genome to whole body
Author : Colin R Martin
Publisher : Academic Press
ISBN 13 : 0128179368
Total Pages : 576 pages
Book Rating : 4.1/5 (281 download)
Download or read book The Neuroscience of Depression written by Colin R Martin and published by Academic Press. This book was released on 2021-03-05 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Neuroscience of Depression: Genetics, Cell Biology, Neurology, Behaviour and Diet is a comprehensive reference to the aspects, features and effects of depression. This book provides readers with the behavior and psychopathological effects of depression, linking anxiety, anger and PSTD to depression. Readers are provided with a detailed outline of the genetic aspects of depression including synaptic genes and the genome-wide association studies (GWAS) of depression, followed by a thorough analysis of the neurological and imaging techniques used to study depression. This book also includes three full sections on the various effects of depression, including diet, nutrition and molecular and cellular effects. The Neuroscience of Depression: Genetics, Cell Biology, Neurology, Behaviour and Diet is the only resource for researchers and practitioners studying depression. Features a section on neurological and imaging, including SPECT Neuroimaging Analyzes how diet and nutrition effect depression Examines the molecular and cellular effects of depression Covers genetics of depression Includes more than 250 illustrations and tables
Author : Sharron H. Francis
Publisher : Springer Science & Business Media
ISBN 13 : 364217969X
Total Pages : 531 pages
Book Rating : 4.6/5 (421 download)
Download or read book Phosphodiesterases as Drug Targets written by Sharron H. Francis and published by Springer Science & Business Media. This book was released on 2011-06-21 with total page 531 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors.
Author : Rodrigo Del Rio
Publisher : Frontiers Media SA
ISBN 13 : 2889199436
Total Pages : 136 pages
Book Rating : 4.8/5 (891 download)
Download or read book Carotid Body: A New Target for Rescuing Neural Control of Cardiorespiratory Balance in Disease written by Rodrigo Del Rio and published by Frontiers Media SA. This book was released on 2016-12-12 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: The carotid body (CB) is in charge of adjusting ventilatory and cardiovascular function during changes in arterial blood gases. Regardless this essential function, the CB has been implicated in the sensing of other physiological signals such as changes in blood flow and glucose levels. More important, malfunction of the CB chemoreceptors has been associated with the progression and deterioration of several disease states such as hypertension, heart failure, renal failure, insulin resistance, diabetes and sleep apnea. Although the mechanisms involved in the alterations of the CB function in pathophysiology are currently under intense research, the development of therapeutic approaches to restore normal CB chemoreflex function remains unsolved. Recent studies showing the effect of CB denervation in pathophysiology have unveiled a key role of these arterial chemoreceptors in the development of autonomic imbalance and respiratory disturbances, and suggest that targeting the CB could represent a novel strategy to improve disease outcome. Unfortunately, classical pharmacotherapy intended to normalize CB function may be hard to establish since several cellular pathways are involved in the CB dysfunction. Augmented levels of angiotensin II, endothelin-1, cytokines and free radicals along with decreases in nitric oxide had all been related to the CB dysfunction. Moreover, changes in expression of angiotensin receptors, nitric oxide synthases and cytokines that take place within the CB tissue in pathological states also contribute to the enhanced CB chemoreflex drive. It has been shown in heart failure, hypertension and obstructive sleep apnea that the CB becomes tonically hyper-reactive. During the progression of the disease this CB chemosensory facilitation process induces central nervous system plasticity. The altered autonomic-respiratory control leads to increased cardiorespiratory distress and the deterioration of the condition. The focus of this e-book will be to cover the role of the CB in pathophysiology and to provide new evidence of the pathways involved in the maladaptive potentiation of the CB chemoreflex function. In memory of Professor Mashiko Shirahata and Professor Constancio Gonzalez.
Author : Allan Tasman
Publisher : John Wiley & Sons
ISBN 13 : 1119965403
Total Pages : 5440 pages
Book Rating : 4.1/5 (199 download)
Download or read book Psychiatry written by Allan Tasman and published by John Wiley & Sons. This book was released on 2011-10-11 with total page 5440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extensively revised and updated this edition reflects the progress and developments in the field. With 127 chapters and over 400 contributors this book is a truly comprehensive exposition of the specialty of psychiatry. Written by well-known and highly regarded experts from around the world, it takes a patient-centered approach making it an indispensable resource for all those involved in the care of patients with psychiatric disorders. For this new edition, the section on the Neuroscientific Foundations of Psychiatry has been completely revised, with a new author team recruited by Section Editors Jonathan Polan and Eric Kandel. The final section, Special Populations and Clinical Settings, features important new chapters on today’s most urgent topics, including the homeless, restraint and geriatric psychiatry. Key features include: Coverage of the entire field of psychiatry, from psychoanalysis to pharmacology and brain imaging, including family relations, cultural influence and change, epidemiology, genetics and behavioral medicine Clinical vignettes describing current clinical practice in an attractive design Numerous figures and tables that facilitate learning and comprehension appear throughout the text Clear comparisons of the DSM-IV-TR and ICD-10 criteria for easy understanding in a global context Diagnostic and treatment decision trees to help both the novice and experienced reader The chapter on Cognitive Behavioral Therapies by Edward Friedman, Michael Thase and Jesse Wright is freely available. Please click on Read Excerpt 2 above to read this superb exposition of these important therapies.
Author : Enno Klussmann
Publisher : Springer Science & Business Media
ISBN 13 : 3540728430
Total Pages : 511 pages
Book Rating : 4.5/5 (47 download)
Download or read book Protein-Protein Interactions as New Drug Targets written by Enno Klussmann and published by Springer Science & Business Media. This book was released on 2008-05-20 with total page 511 pages. Available in PDF, EPUB and Kindle. Book excerpt: Disease-relevant intracellular protein-protein interactions occurring at defined cellular sites possess great potential as drug targets. They permit highly specific pharmacological interference with defined cellular functions. Drugs targeting such interactions are likely to act with fewer side effects than conventional medication influencing whole cell functions. This book discusses therapeutically relevant protein-protein interactions with a major focus on scaffolding proteins tethering signal transduction processes to defined cellular compartments by direct protein-protein interactions. Recent advances in the development of pharmacological agents interfering with protein-protein interactions are highlighted.
Author : F. Awouters
Publisher : Elsevier
ISBN 13 : 9780080543888
Total Pages : 560 pages
Book Rating : 4.5/5 (438 download)
Download or read book XIVth International Symposium on Medicinal Chemistry written by F. Awouters and published by Elsevier. This book was released on 1997-09-12 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vaso-occlusive disorders including unstable angina, myocardial infarction, transient ischemic attacks, stroke and peripheral artery disease remain the major sources of morbidity and mortality in western civilization. Platelet activation and resulting platelet aggregation play a major role in the pathogenesis of these thromboembolic diseases. Recognition of the contribution of platelets to the pathophysiology of cardiovascular disease has provided impetus for the continued search for new antiplatelet agents. Hence, over the past two decades many strategies have been evaluated in the search for efficacious mechanisms to reduce platelet function. The medical need for more efficacious antithrombotic drugs and the growing understanding of the role of platelets in vascular injury have catalyzed the extensive evaluation of novel approaches to control platelet function. Along these lines, the volume therefore provides an in-depth assessment of ongoing clinical trials, new and clinically established agents, and other developments in this rapidly developing field.
Author : Allan Tasman
Publisher : John Wiley & Sons
ISBN 13 : 1118845471
Total Pages : 2765 pages
Book Rating : 4.1/5 (188 download)
Download or read book Psychiatry, 2 Volume Set written by Allan Tasman and published by John Wiley & Sons. This book was released on 2015-03-30 with total page 2765 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in a new Fourth Edition, Psychiatry remains the leading reference on all aspects of the current practice and latest developments in psychiatry. From an international team of recognised expert editors and contributors, Psychiatry provides a truly comprehensive overview of the entire field of psychiatry in 132 chapters across two volumes. It includes two new sections, on psychosomatic medicine and collaborative care, and on emergency psychiatry, and compares Diagnostic and Statistical Manual (DSM-5) and International Classification of Diseases (ICD10) classifications for every psychiatric disorder. Psychiatry, Fourth Edition is an essential reference for psychiatrists in clinical practice and clinical research, residents in training, and for all those involved in the treatment psychiatric disorders. Includes a a companion website at www.tasmanpsychiatry.com featuring PDFs of each chapter and downloadable images
Author : Zhe-Sheng Chen
Publisher : Frontiers Media SA
ISBN 13 : 2832530036
Total Pages : 428 pages
Book Rating : 4.8/5 (325 download)
Download or read book Targeted cancer therapies, from small molecules to antibodies, volume II written by Zhe-Sheng Chen and published by Frontiers Media SA. This book was released on 2023-07-27 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : George Fink
Publisher : Academic Press
ISBN 13 : 0123750970
Total Pages : 895 pages
Book Rating : 4.1/5 (237 download)
Download or read book Handbook of Neuroendocrinology written by George Fink and published by Academic Press. This book was released on 2012 with total page 895 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroendocrinology underpins fundamental physiological, molecular, biological, and genetic principles such as the regulation of gene transcription and translation. This handbook highlights the experimental and technical foundations of each area's major concepts and principles.
Author : John R. Geddes
Publisher : Oxford University Press, USA
ISBN 13 : 0198713002
Total Pages : 1537 pages
Book Rating : 4.1/5 (987 download)
Download or read book New Oxford Textbook of Psychiatry written by John R. Geddes and published by Oxford University Press, USA. This book was released on 2020-02-20 with total page 1537 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over its two editions, The New Oxford Textbook of Psychiatry has come to be regarded as one of the most popular and trusted standard psychiatry texts among psychiatrists and trainees. Bringing together 146 chapters from the leading figures in the discipline, it presents a comprehensive account of clinical psychiatry, with reference to its scientific basis and to the patient's perspective throughout. The New Oxford Textbook of Psychiatry, Third Edition has been extensively re-structured and streamlined to keep pace with the significant developments that have taken place in the fields of clinical psychiatry and neuroscience since publication of the second edition in 2009. The new edition has been updated throughout to include the most recent versions of the two main classification systems---the DSM-5 and the ICD-11---used throughout the world for the diagnosis of mental disorders. In the years since publication of the first edition, many new and exciting discoveries have occurred in the biological sciences, which are having a major impact on how we study and practise psychiatry. In addition, psychiatry has fostered closer ties with philosophy, and these are leading to healthy discussions about how we should diagnose and treat mental illness. This new edition recognises these and other developments. Throughout, accounts of clinical practice are linked to the underlying science, and to the evidence for the efficacy of treatments. Physical and psychological treatments, including psychodynamic approaches, are covered in depth. The history of psychiatry, ethics, public health aspects, and public attitudes to psychiatry and to patients are all given due attention.
Author : Tally Largent-Milnes
Publisher : Frontiers Media SA
ISBN 13 : 2889664422
Total Pages : 164 pages
Book Rating : 4.8/5 (896 download)
Download or read book Novel Molecular Targets for the Treatment of Pain written by Tally Largent-Milnes and published by Frontiers Media SA. This book was released on 2021-02-02 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topic Editor John Streicher is a co-founder and equity partner of Teleport Pharmaceuticals, LLC. All other Topic Editors declare no competing interests with regards to the Research Topic subject.
Author : Philip W. Harvey
Publisher : John Wiley & Sons
ISBN 13 : 9780471970866
Total Pages : 618 pages
Book Rating : 4.9/5 (78 download)
Download or read book Endocrine and Hormonal Toxicology written by Philip W. Harvey and published by John Wiley & Sons. This book was released on 1999-06-18 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endocrine and Hormonal Toxicology Edited by Philip W. Harvey, Kevin C. Rush and Andrew Cockburn AgrEvo UK Ltd, Saffron Walden, UK This is the first book to consider the integrated role of the classical endocrine system and hormones (including those from tissues outside the classical endocrine system) in toxicological responses. Although focusing on the latest knowledge on endocrine glands as target organs and the mechanistic and molecular basis for toxicity in these organs, Endocrine and Hormonal Toxicology has been written to cover toxicological responses at the whole body level mediated by endocrine or hormonal mechanisms. This whole body, multi-organ approach significantly broadens the relevance of this volume to toxicologists. Following an introductory section on the types of endocrine toxicity including primary, secondary and indirect mechanisms, the next section deals with endocrine organs as toxicological targets. International contributions focus on the pituitary, thyroid and parathyroids, adrenals, testes, ovaries and the pancreas, and comparative endocrine carcinogenesis. A third section of the book develops the whole body approach, in which chapters are devoted to hormonal mechanisms of toxicity to the immune, nervous, cardiovascular, gastrointestinal and reproductive systems, as well as to the liver, kidney and skin. The final section covers human and environmental health perspectives discussing endocrine disrupting chemicals, hormonal mechanisms in breast cancer and current regulatory trends in endocrine and hormonal toxicology. The comprehensive nature of Endocrine and Hormonal Toxicology makes it accessible to both specialist and general toxicologists, and to those within the fields of endocrinology, pharmacology and pathology.
Author : J. Larry Jameson
Publisher : Elsevier Health Sciences
ISBN 13 : 1455711268
Total Pages : 3076 pages
Book Rating : 4.4/5 (557 download)
Download or read book Endocrinology - E-Book written by J. Larry Jameson and published by Elsevier Health Sciences. This book was released on 2010-05-18 with total page 3076 pages. Available in PDF, EPUB and Kindle. Book excerpt: ENDOCRINOLOGY, edited by J. Larry Jameson, MD, PhD and Leslie J. De Groot, MD, has been considered the definitive source in its field for decades. Now this landmark reference has been exhaustively updated to bring you the latest clinical guidance on all aspects of diagnosis and treatment for the full range of endocrine and metabolism disorders, including new information on diabetes, obesity, MEN I and II, disorders of sex determination, and pituitary tumors. Entirely new chapters on Lipodystrophy Syndromes, Lipoprotein Metabolism, and Genetic Disorders of Phosphate Homeostasis keep you well informed on today’s hot topics. You’ll benefit from unique, global perspectives on adult and pediatric endocrinology prepared by an international team of renowned authorities. This reference is optimally designed to help you succeed in your demanding practice and ensure the best possible outcomes for every patient. Overcome virtually any clinical challenge with detailed, expert coverage of every area of endocrinology, authored by hundreds of leading luminaries in the field. Provide state-of-the-art care with comprehensive updates on diabetes, obesity, MEN I and II, disorders of sex determination, and pituitary tumors ... brand-new chapters on Lipodystrophy Syndromes, Lipoprotein Metabolism, and Genetic Disorders of Phosphate Homeostasis ... expanded coverage of sports performance, including testosterone, androgen research, and bone growth and deterioration ... and the newest discoveries in genetics and how they affect patient care. Make the best clinical decisions with an enhanced emphasis on evidence-based practice in conjunction with expert opinion. Rapidly consult with trusted authorities thanks to new expert-opinion treatment strategies and recommendations. Zero in on the most relevant and useful references with the aid of a more focused, concise bibliography. Locate information more quickly, while still getting the complete coverage you expect.
Author :
Publisher : Academic Press
ISBN 13 : 0080884229
Total Pages : 680 pages
Book Rating : 4.0/5 (88 download)
Download or read book G Protein Pathways, Part A: Receptors written by and published by Academic Press. This book was released on 2001-10-09 with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt: G Protein Pathways is the first of three volumes examining the nature of heterotrimeric G proteins. The text takes an integrated approach to studying common experimental questions at many different levels related to G proteins. Methods related to G proteins using molecular modeling, systems biology, protein engineering, protein biochemistry, cell biology, and physiology are all accessible in the same volume. The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today truly an essential publication for researchers in all fields of life sciences.
