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Activation Induced Changes In The Histamine Content Of Murine Mast Cells And Their Adhesion To Nih 3t3 Fibroblasts
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Book Synopsis Activation-induced Changes in the Histamine Content of Murine Mast Cells and Their Adhesion to NIH-3T3 Fibroblasts by : Lori J. Fitz
Download or read book Activation-induced Changes in the Histamine Content of Murine Mast Cells and Their Adhesion to NIH-3T3 Fibroblasts written by Lori J. Fitz and published by . This book was released on 2006 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Mast cells are immune effectors that are localized in tissues, proximal to sites of entry for allergens and other external stimuli. The mediators produced by mast cells are involved in innate immunity against bacteria and parasites, and are key effectors of allergic and asthmatic responses. Mast cell mediators also contribute to fibrosis in asthma, pulmonary fibrosis, scleroderma, and rheumatoid arthritis. The aim of this study was to test the hypothesis that mast cell interactions with fibroblasts are affected by their activation state, in a way that could contribute to the progression of fibrosis. Bone marrow mast cells (BMMC) were derived in vitro from bone marrow progenitors and connective tissue mast cells (CTMC) were harvested from mouse peritoneal cavity. An ELISA was used to measure histamine in the supernatants and cell lysates of activated BMMC and CTMC. Following activation by crosslinking the high affinity IgE receptor, histamine was released from BMMC and CTMC. Starting 24 hours after activation, the total cellular histamine concentration of BMMC was 755+/-14 ng/10 6 cells, and exceeded the amount in resting BMMC (214+/-9 ng/10 6 cells). The over-accumulation of histamine peaked 72 hours after activation (3136+/-394 ng/10 6 cells), and was transient, returning toward the amount in resting BMMC by 96 hours (1787+/-280 ng/10 6 cells). The increase in histamine was accompanied by an increase in the expression of histidine decarboxylase mRNA, and a 70 kD form of the protein encoded by this mRNA. Similar changes in histamine concentration did not occur in CTMC, indicating that histamine over-accumulation is associated with mast cell phenotype. To study changes in mast cell adhesion to fibroblasts following activation, an assay was developed to quantify adhesion between mast cells and the NIH-3T3 fibroblast cell line. Resting or activated BMMC or CTMC were cocultured with the fibroblasts for various times to allow adhesion to occur. Nonadherent cells were washed away and adherent mast cells were quantified based on recovery of histamine from the adherent cells. Following activation, adhesion of both BMMC and CTMC to fibroblasts was increased three to six fold. This increased adhesion was not due to increased integrin expression, cell proliferation, or inflammatory mediators released from the mast cells. These findings offer new insights into the role of activated mast cells in fibrotic diseases.
Book Synopsis Dissertation Abstracts International by :
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2006 with total page 860 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The FASEB Journal written by and published by . This book was released on 1991 with total page 1132 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Abridged Index Medicus written by and published by . This book was released on 1988 with total page 1544 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Journal of Immunology written by and published by . This book was released on 1990 with total page 972 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chemical Abstracts written by and published by . This book was released on 2002 with total page 2800 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1999 with total page 1860 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Biochemistry of Inflammation by : J. Whicher
Download or read book Biochemistry of Inflammation written by J. Whicher and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our understanding of inflammation has increased rapidly in recent years, due in large part to the impact of molecular biology and gene identification and cloning. This book brings together ideas from a number of different biochemical disciplines which are frequently not integrated. The first chapter gives a visual overview of the subject; the remaining chapters are organized into three themes: the affector molecules, the regulatory components and the processes of inflammation itself. This book is essential reading for the busy physician or pathologist who wants to be up-to-date with the latest developments in immunology as they affect the diagnosis and treatment of many conditions.
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 1996 with total page 834 pages. Available in PDF, EPUB and Kindle. Book excerpt: MBC online publishes papers that describe and interpret results of original research conserning the molecular aspects of cell structure and function.
Book Synopsis Mast Cell Activation and Mediator Release by : K. Ishizaka
Download or read book Mast Cell Activation and Mediator Release written by K. Ishizaka and published by . This book was released on 1984 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cytokines and Pain by : L.R. Watkins
Download or read book Cytokines and Pain written by L.R. Watkins and published by Springer. This book was released on 2013-03-08 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Within the past few years, it has become recognized that the immune system communicates to the brain. Substances released from activated immune cells (cytokines) stimulate peripheral nerves, thereby signaling the brain and spinal cord that infection/inflammation has occurred. Additionally, peripheral infection/inflammation leads to de novo synthesis and release of cytokines within the brain and spinal cord. Thus, cytokines effect neural activation both peripherally and centrally. Through this communication pathway, cytokines such as interleukin-1, interleukin-6 and tumor necrosis factor markedly alter brain function, physiology and behavior. One important but underrecognized aspect of this communication is the dramatic impact that immune activation has on pain modulation. The purpose of this book is to examine, for the first time, immune-to-brain communication from the viewpoint of its effect on pain processing. It is aimed both at the basic scientist and health care providers, in order to clarify the major role that substances released by immune cells play in pain modulation. This book contains chapters contributed by all of the major laboratories focused on understanding how cytokines modulate pain. These chapters provide a unique vantage point from which to examine this question, as the summarized work ranges from evolutionary approaches across diverse species, to the basics of the immune response, to the effect of cytokines on peripheral and central nervous system sites, to therapeutic potential in humans.
Book Synopsis Polyphenols: Prevention and Treatment of Human Disease by : Ronald Ross Watson
Download or read book Polyphenols: Prevention and Treatment of Human Disease written by Ronald Ross Watson and published by Academic Press. This book was released on 2018-08-06 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polyphenols in Prevention and Treatment of Human Disease, Second Edition authoritatively covers evidence of the powerful health benefits of polyphenols, touching on cardiovascular disease, cancer, obesity, diabetes and osteoporosis. This collection represents the contributions of an international group of experts in polyphenol research who share their expertise in endocrinology, public health, cardiology, pharmacology, agriculture and veterinary science. Researchers from diverse backgrounds will gain insight into how clinical observations and practices can feed back into the research cycle, thus allowing them to develop more targeted insights into the mechanisms of disease. This reference fills a void in research where nutritionists and alternative therapies may be applicable. Describes polyphenol modulation of blood flow and oxygenation as a potential mechanism of protection against vascular atherosclerosis Describes how polyphenols and antioxidants frequently change immune defenses and actions Focuses on the most important areas of research and provides insights into their relationships and translational opportunities
Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 1666 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Download or read book Conference Papers Index written by and published by . This book was released on 1988 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: Monthly. Papers presented at recent meeting held all over the world by scientific, technical, engineering and medical groups. Sources are meeting programs and abstract publications, as well as questionnaires. Arranged under 17 subject sections, 7 of direct interest to the life scientist. Full programs of meetings listed under sections. Entry gives citation number, paper title, name, mailing address, and any ordering number assigned. Quarterly and annual indexes to subjects, authors, and programs (not available in monthly issues).
Download or read book The Journal of Cell Biology written by and published by . This book was released on 1988 with total page 1034 pages. Available in PDF, EPUB and Kindle. Book excerpt: No. 2, pt. 2 of November issue each year from v. 19-47; 1963-70 and v. 55- 1972- contain the Abstracts of papers presented at the annual meeting of the American Society for Cell Biology, 3d-10th; 1963-70 and 12th- 1972- .
Book Synopsis Signaling and the Cytoskeleton by : Kermit L. Carraway
Download or read book Signaling and the Cytoskeleton written by Kermit L. Carraway and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph explores the relationships between cell signaling and the cytoplasmic cytoskeleton in fundamental cell processes, thus bridging the gap between two very active aspects of molecular cell biology. It covers the two main - and reciprocal - questions of these relationships: How are structure and function of the cytoskeleton affected by external signals which impinge on the cell? How does the cytoskeleton influence the cellular signaling processes which determine cell behavior?
Book Synopsis Cell-based Biosensors by : Qingjun Liu
Download or read book Cell-based Biosensors written by Qingjun Liu and published by Artech House. This book was released on 2009-10 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by recognized experts the field, this leading-edge resource is the first book to systematically introduce the concept, technology, and development of cell-based biosensors. You find details on the latest cell-based biosensor models and novel micro-structure biosensor techniques. Taking an interdisciplinary approach, this unique volume presents the latest innovative applications of cell-based biosensors in a variety of biomedical fields. The book also explores future trends of cell-based biosensors, including integrated chips, nanotechnology and microfluidics. Over 140 illustrations help clarify key topics throughout the book.
