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Acta Neuropathologica Communications August 2013
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Book Synopsis Acta Neuropathologica Communications August 2013 by : Applied Research Applied Research Press
Download or read book Acta Neuropathologica Communications August 2013 written by Applied Research Applied Research Press and published by . This book was released on 2015-10-10 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains open access research articles from August of 2013 published in Acta Neuropathologica Communications: Topics include: Neuropathology of brain and spinal malformations in a case of monosomy 1p36; Establishing quantitative real-time quaking-induced conversion (qRT-QuIC) for highly sensitive detection and quantification of PrPSc in prion-infected tissues; Myelin alters the inflammatory phenotype of macrophages by activating PPARs; CSF Presenilin-1 complexes are increased in Alzheimer's disease; Disorganization of neocortical lamination in focal cortical dysplasia is brain-region dependent: evidence from layer-specific marker expression; Immune complex formation impairs the elimination of solutes from the brain: implications for immunotherapy in Alzheimer's disease; Reducing TDP-43 aggregation does not prevent its cytotoxicity; Pathological assessments for the presence of hexanucleotide repeat expansions in C9ORF72 in Alzheimer's disease; Blast overpressure induces shear-related injuries in the brain of rats exposed to a mild traumatic brain injury; Protective effects of decay-accelerating factor on blast-induced neurotrauma in rats; Simulated surgical-type cerebral biopsies from post-mortem brains allows accurate neuropathological diagnoses in the majority of neurodegenerative disease groups; Extensive deamidation at asparagine residue 279 accounts for weak immunoreactivity of tau with RD4 antibody in Alzheimer's disease brain.
Book Synopsis Acta Neuropathologica Communications July 2013 by : Applied Research Applied Research Press
Download or read book Acta Neuropathologica Communications July 2013 written by Applied Research Applied Research Press and published by . This book was released on 2015-10-10 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains open access research articles from July of 2013 published in Acta Neuropathologica Communications. Topics include: Comparative utility of LC3, p62 and TDP-43 immunohistochemistry in differentiation of inclusion body myositis from polymyositis and related inflammatory myopathies; The pathogenesis of cingulate atrophy in behavioral variant frontotemporal dementia and Alzheimer's disease; The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzheimer's disease; Endogenously regulated Dab2 worsens inflammatory injury in experimental autoimmune encephalomyelitis; Classification of FTLD-TDP cases into pathological subtypes using antibodies against phosphorylated and non-phosphorylated TDP43; Expression of TMEM106B, the frontotemporal lobar degeneration-associated protein, in normal and diseased human brain; Identification of a neuronal transcription factor network involved in medulloblastoma development; Tau pathology induces loss of GABAergic interneurons leading to altered synaptic plasticity and behavioral impairments; Calreticulin and other components of endoplasmic reticulum stress in rat and human inflammatory demyelination; Induction of CNS alpha-synuclein pathology by fibrillar and non-amyloidogenic recombinant alpha-synuclein; Differential expression of neuregulin-1 isoforms and downregulation of erbin are associated with Erb B2 receptor activation in diabetic peripheral neuropathy; Evidence of aquaporin involvement in human central pontine myelinolysis; Epilepsy: neuroinflammation, neurodegeneration, and APOE genotype; Systemic dysregulation of TDP-43 binding microRNAs in amyotrophic lateral sclerosis.
Book Synopsis Acta Neuropathologica Communications November 2013 by : Applied Research Applied Research Press
Download or read book Acta Neuropathologica Communications November 2013 written by Applied Research Applied Research Press and published by . This book was released on 2015-10-10 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains open access research articles from November of 2013 published in Acta Neuropathologica Communications. Topics include: Rapidly progressive dementia with thalamic degeneration and peculiar cortical prion protein immunoreactivity, but absence of proteinase K resistant PrP: a new disease entity?; In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer's disease pathology; Mild chronic cerebral hypoperfusion induces neurovascular dysfunction, triggering peripheral beta-amyloid brain entry and aggregation; Deciphering the pathogenesis of sporadic Creutzfeldt-Jakob disease with codon 129 M/V and type 2 abnormal prion protein; Brains from non-Alzheimer's individuals containing amyloid deposits accelerate Abeta deposition in vivo; The type of Abeta-related neuronal degeneration differs between amyloid precursor protein (APP23) and amyloid beta-peptide (APP48) transgenic mice.
Book Synopsis Acta Neuropathologica Communications October 2013 by : Applied Research Applied Research Press
Download or read book Acta Neuropathologica Communications October 2013 written by Applied Research Applied Research Press and published by . This book was released on 2015-10-10 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains open access research articles from October of 2013 published in Acta Neuropathologica Communications. Topics include: Human fetal inner ear involvement in congenital cytomegalovirus infection; Nerve hyperplasia: a unique feature of ketamine cystitis; Clinical and multimodal biomarker correlates of ADNI neuropathological findings; G-protein coupled receptor expression patterns delineate medulloblastoma subgroups; Focal cortical dysplasias in autism spectrum disorders; Dipeptide repeat proteins are present in the p62 positive inclusions in patients with frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9ORF72; Cerebellar hemorrhagic injury in premature infants occurs during a vulnerable developmental period and is associated with wider neuropathology; Astrocytes differentially respond to inflammatory autoimmune insults and imbalances of neural activity; Lipid accumulation, lipid oxidation, and low plasma levels of acquired antibodies against oxidized lipids associate with degeneration and rupture of the intracranial aneurysm wall.
Book Synopsis Acta Neuropathologica Communications June 2013 by : Applied Research Applied Research Press
Download or read book Acta Neuropathologica Communications June 2013 written by Applied Research Applied Research Press and published by . This book was released on 2015-10-10 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains open access research articles from June of 2013 published in Acta Neuropathologica Communications. Topics include: MCP-1/CCR2 signaling-mediated astrocytosis is accelerated in a transgenic mouse model of SOD1-mutated familial ALS; Double-labelling immunohistochemistry for MGMT and a "cocktail" of non-tumourous elements is a reliable, quick and easy technique for inferring methylation status in glioblastomas and other primary brain tumours; Alcohol-induced apoptosis of oligodendrocytes in the fetal macaque brain; Amyotrophic lateral sclerosis (ALS)-associated VAPB-P56S inclusions represent an ER quality control compartment; Friedreich ataxia: metal dysmetabolism in dorsal root ganglia; Unusual cerebral vascular prion protein amyloid distribution in scrapie-infected transgenic mice expressing anchorless prion protein; Reelin immunoreactivity in neuritic varicosities in the human hippocampal formation of non-demented subjects and Alzheimer's disease patients; Comparing metabolomic and pathologic biomarkers alone and in combination for discriminating Alzheimer's disease from normal cognitive aging.
Book Synopsis Acta Neuropathologica Communications May 2013 by : Applied Research Applied Research Press
Download or read book Acta Neuropathologica Communications May 2013 written by Applied Research Applied Research Press and published by . This book was released on 2015-10-10 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains open access articles from May of 2013 published in Acta Neuropathologica Communications. Articles include: ANC: High quality, fast publication, open access; Dysfunction of the mTOR pathway is a risk factor for Alzheimer's disease; Intrastriatal injection of interleukin-1 beta triggers the formation of neuromyelitis optica-like lesions in NMO-IgG seropositive rats; The influence of DNA repair on neurological degeneration, cachexia, skin cancer and internal neoplasms: autopsy report of four xeroderma pigmentosum patients (XP-A, XP-C and XP-D); The prion hypothesis in Parkinson's disease: Braak to the future; Do brain T2/FLAIR white matter hyperintensities correspond to myelin loss in normal aging? A radiologic-neuropathologic correlation study; ATP13A2 (PARK9) protein levels are reduced in brain tissue of cases with Lewy bodies; ALDH1 is an immunohistochemical diagnostic marker for solitary fibrous tumours and haemangiopericytomas of the meninges emerging from gene profiling study; Filamentous white matter prion protein deposition is a distinctive feature of multiple inherited prion diseases; Topography of FUS pathology distinguishes late-onset BIBD from aFTLD-U; NG2 cells, a new trail for Alzheimer's disease mechanisms?; Extensive aggregation of alpha-synuclein and tau in juvenile-onset neuroaxonal dystrophy: an autopsied individual with a novel mutation in the PLA2G6 gene-splicing site; Direct detection of alpha synuclein oligomers in vivo; Uptake of inorganic mercury by human locus ceruleus and corticomotor neurons: implications for amyotrophic lateral sclerosis; Peripheral nervous system insulin resistance in ob/ob mice; Promoter DNA methylation regulates progranulin expression and is altered in FTLD; Evidence for new targets and synergistic effect of metronomic celecoxib/fluvastatin combination in pilocytic astrocytoma; The KDM1A histone demethylase is a promising new target for the epigenetic therapy of medulloblastoma; Increased mitochondrial activity in a novel IDH1-R132H mutant human oligodendroglioma xenograft model: in situ detection of 2-HG and alpha-KG; Immunohistochemistry is highly sensitive and specific for detection of BRAF V600E mutation in pleomorphic xanthoastrocytoma.
Book Synopsis Acta Neuropathologica Communications December 2013 by : Applied Research Applied Research Press
Download or read book Acta Neuropathologica Communications December 2013 written by Applied Research Applied Research Press and published by . This book was released on 2015-10-10 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains open access research articles from December of 2013 published in Acta Neuropathologica Communications. Topics include: Myositis facilitates preclinical accumulation of pathological prion protein in muscle; Molecular chaperones and protein folding as therapeutic targets in Parkinson's disease and other synucleinopathies; Genetic CJD with a novel E200G mutation in the prion protein gene and comparison with E200K mutation cases; Heavy metals in locus ceruleus and motor neurons in motor neuron disease; Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice; A central role for dityrosine crosslinking of Amyloid-beta in Alzheimer's disease; Neurodegeneration progresses despite complete elimination of clinical relapses in a mouse model of multiple sclerosis; T cell-activation in neuromyelitis optica lesions plays a role in their formation.
Book Synopsis Acta Neuropathologica Communications September 2013 by : Applied Research Applied Research Press
Download or read book Acta Neuropathologica Communications September 2013 written by Applied Research Applied Research Press and published by . This book was released on 2015-10-10 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains open access research articles from September of 2013 published in Acta Neuropathologica Communications. Topics include: The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer's disease; Glial scaffold required for cerebellar granule cell migration is dependent on dystroglycan function as a receptor for basement membrane proteins; Decreased neuroinflammation and increased brain energy homeostasis following environmental enrichment after mild traumatic brain injury is associated with improvement in cognitive function; N-truncated Abeta starting with position four: early intraneuronal accumulation and rescue of toxicity using NT4X-167, a novel monoclonal antibody; Excitotoxin-induced caspase-3 activation and microtubule disintegration in axons is inhibited by taxol; The Arctic AbetaPP mutation leads to Alzheimer's disease pathology with highly variable topographic deposition of differentially truncated Abeta; The link between intraneuronal N-truncated amyloid-beta peptide and oxidatively modified lipids in idiopathic autism and dup(15q11.2-q13)/autism; The airbag problem-a potential culprit for bench-to-bedside translational efforts: relevance for Alzheimer's disease.
Book Synopsis Neuroanatomy and Pathology of Sporadic Alzheimer's Disease by : Heiko Braak
Download or read book Neuroanatomy and Pathology of Sporadic Alzheimer's Disease written by Heiko Braak and published by Springer. This book was released on 2014-12-11 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: As indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD-associated pathology is illustrated from its beginnings (sometimes even in childhood) to its final form, which is reached late in life. The AD process commences much earlier than the clinically recognizable phase of the disorder, and its timeline includes an extended preclinical phase. The further the pendulum swings away from the symptomatic final stages towards the early pathology, the more obvious the lesions become, although from a standpoint of severity they are more unremarkable and thus frequently overlooked during routine neuropathological assessment. For this reason, the authors deal with the hallmark lesions in the early phases of the AD process in considerable detail
Book Synopsis Molecular Neuropathology by : Gareth W. Roberts
Download or read book Molecular Neuropathology written by Gareth W. Roberts and published by Cambridge University Press. This book was released on 1995-06-08 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides an introduction to the essential techniques required for studying the molecular biology of brain disease. The approaches and strategies for investigations of gene structure and regulation are described with reference to the molecular genetics of prion and Alzheimer's disease. The effects of aberrant gene regulation can also be examined at the protein level by immunocytochemistry and autoradiography. Improved understanding of basic biology has resulted in new approaches to animal models using transgenic techniques and new therapeutic approaches. The volume is structured to illustrate all these approaches and demonstrate the practice and promise of molecular neuropathology.
Book Synopsis Alzheimer's Dementia Recognition Through Spontaneous Speech by : Fasih Haider
Download or read book Alzheimer's Dementia Recognition Through Spontaneous Speech written by Fasih Haider and published by Frontiers Media SA. This book was released on 2021-12-22 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Neurodegeneration by : Dennis Dickson
Download or read book Neurodegeneration written by Dennis Dickson and published by John Wiley & Sons. This book was released on 2011-09-09 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells (e.g. tau, α-synuclein and TDP-43) and in the extracellular compartments (e.g. β-amyloid and prion proteins) or according to a shared pathogenetic mechanism, such as trinucleotide repeats, that are a feature of specific genetic disorders. Chapters throughout the book conform to a standard lay-out for ease of access by the reader and are written by a panel of International Experts Since the first edition of this book, major advances have been made in the discovery of common molecular mechanisms between many neurodegenerative diseases most notably in the frontotemporal lobar degenerations (FTLD) and motor neuron disease or amyotrophic lateral sclerosis. This book will be essential reading for clinicians, neuropathologists and basic neuroscientists who require the firm up-to-date knowledge of mechanisms, diagnostic pathology and genetics of Neurodegenerative diseases that is required for progress in therapy and management.
Book Synopsis The Human Brain During the Second Trimester by : Shirley A. Bayer
Download or read book The Human Brain During the Second Trimester written by Shirley A. Bayer and published by CRC Press. This book was released on 2005-05-09 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain in the second trimester, the subject of Volume 3, is nearing anatomical maturity throughout the brainstem. In contrast, the neurogenesis and neuronal migration are still in progress in the cerebral cortex and cerebellum. Consequently, the authors chose to focus on the migration, sojourning, and settling of the neuronal populations belo
Book Synopsis Etiology of Parkinson's Disease by : Jonas H. Ellenberg
Download or read book Etiology of Parkinson's Disease written by Jonas H. Ellenberg and published by CRC Press. This book was released on 1995-03-01 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.
Book Synopsis Biocomputing 2017 - Proceedings Of The Pacific Symposium by : Russ B Altman
Download or read book Biocomputing 2017 - Proceedings Of The Pacific Symposium written by Russ B Altman and published by World Scientific. This book was released on 2016-11-23 with total page 668 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Pacific Symposium on Biocomputing (PSB) 2017 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2017 will be held on January 4 - 8, 2017 in Kohala Coast, Hawaii. Tutorials and workshops will be offered prior to the start of the conference.PSB 2017 will bring together top researchers from the US, the Asian Pacific nations, and around the world to exchange research results and address open issues in all aspects of computational biology. It is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology.The PSB has been designed to be responsive to the need for critical mass in sub-disciplines within biocomputing. For that reason, it is the only meeting whose sessions are defined dynamically each year in response to specific proposals. PSB sessions are organized by leaders of research in biocomputing's 'hot topics.' In this way, the meeting provides an early forum for serious examination of emerging methods and approaches in this rapidly changing field.
Book Synopsis Neurodegenerative Diseases by : Shamim I. Ahmad
Download or read book Neurodegenerative Diseases written by Shamim I. Ahmad and published by Springer Science & Business Media. This book was released on 2012-03-12 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: The editor of this volume, having research interests in the field of ROS production and the damage to cellular systems, has identified a number of enzymes showing ·OH scavenging activities details of which are anticipated to be published in the near future as confirmatory experiments are awaited. It is hoped that the information presented in this book on NDs will stimulate both expert and novice researchers in the field with excellent overviews of the current status of research and pointers to future research goals. Clinicians, nurses as well as families and caregivers should also benefit from the material presented in handling and treating their specialised cases. Also the insights gained should be valuable for further understanding of the diseases at molecular levels and should lead to development of new biomarkers, novel diagnostic tools and more effective therapeutic drugs to treat the clinical problems raised by these devastating diseases.
Book Synopsis Membrane Biogenesis by : Jos A.F. Op den Kamp
Download or read book Membrane Biogenesis written by Jos A.F. Op den Kamp and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many individual aspects of the dynamics and assembly of biological membranes have been studied in great detail. Cell biological approaches, advanced genetics, biophysics and biochemistry have greatly contributed to an increase in our knowledge in this field.lt is obvious however, that the three major membrane constituents - lipids, proteins and carbohydrates- are studied, in most cases separately and that a coherent overview of the various aspects of membrane biogenesis is not readily available. The NATO Advanced Study Institute on "New Perspectives in the Dynamics of Assembly of Biomembranes" intended to provide such an overview: it was set up to teach students and specialists the achievements obtained in the various research areas and to try and integrate the numerous aspects of membrane assembly into a coherent framework. The articles in here reflect this. Statting with detailed contributions on phospholipid structure, dynamics, organization and biogenesis, an up to date overview of the basic, lipidic backbone of biomembranes is given. Extensive progress is made in the research on membrane protein biosynthesis. In particular the post- and co-translational modification processes of proteins, the mechanisms of protein translocation and the sorting mechanisms which are necessary to direct proteins to their final, intra - or extracellular destination have been characterized in detail. Modern genetic approaches were indispensable in this research area: gene cloning, hybrid protein construction, site directed mutagenesis and sequencing techniques elucidated many functional aspects of specific nucleic acid and amino acid sequences.
