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A Short History Of The Drug Receptor Concept
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Book Synopsis A Short History of the Drug Receptor Concept by : C. Prüll
Download or read book A Short History of the Drug Receptor Concept written by C. Prüll and published by Springer. This book was released on 2009-06-25 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept of specific receptors for drugs, hormones and transmitters lies at the very heart of biomedicine. This book is the first to consider the idea from its 19th century origins in the work of John Newport Langley and Paul Ehrlich, to its development of during the 20th century and its current impact on drug discovery in the 21st century.
Book Synopsis A Short History of the Drug Receptor Concept by : Cay-Rüdiger Prüll
Download or read book A Short History of the Drug Receptor Concept written by Cay-Rüdiger Prüll and published by . This book was released on 2009 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: Humans have long used plant and animal extracts for their medicinal properties but until the end of the 19th century their actions were often explained in a speculative manner. The systematic study of drugs did not begin until the 1860s, and the concept of receptors as the target of their effects in the body only emerged at the end of the 19th century from the brilliant and independent studies of John Newport Langley (1852-1925) and Paul Ehrlich (1854-1915). This book address the people and the key discoveries that led to the development of the receptor concept and its impact on 20th-century medicine: A.J Clark in the 1930s, and later E.J Ariens and R.P Stephenson in the 1950s provided the quantitative basis of drug receptor occupancy theory. R.P Ahlquist's investigations gave rise to the proposal of receptor subtypes in 1948 and facilitated Sir James Black (and subsequently others) to apply the receptor concept to clinical therapy (beta blockers) in the mid 1960s. By the early 1980s, the first (acetylcholine) receptor had been isolated and cloned. Today, we recognize a large and diverse number of physiological receptors which can be delineated into 'receptor super-families' on the basis of their pharmacology and molecular properties. These receptors are now the focus of a multi-national, multi-billion dollar pharmaceutical industry. This book reveals that these successes were by no means foreseeable, since chance, coincidence, competition among scientists, and other factors played important roles in the history of the receptor concept.
Book Synopsis Perspectives on Twentieth-century Pharmaceuticals by : Viviane Quirke
Download or read book Perspectives on Twentieth-century Pharmaceuticals written by Viviane Quirke and published by Peter Lang. This book was released on 2010 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most striking features of the twentieth century has been the rapid growth of the pharmaceutical industry and the large increases in the use and consumption of its products. This trend began in the first half of the century, but accelerated most sharply after the Second World War, when the creation of national systems of healthcare created mass markets for drugs. The industry then assumed a major economic, social and political significance, and became one of the most highly regulated sectors of the economy, attracting the attention of industry analysts as well as academics. This volume brings together a collection of papers exploring and reflecting upon some of the significant strands in the current studies of pharmaceuticals in the twentieth century. They touch upon many of the issues that are matters of concern and debate today, and their international and multidisciplinary approaches enrich our understanding of an object, of an industry, and of a process that are at the heart of our highly medicalized contemporary societies.
Book Synopsis The Organic Chemistry of Drug Design and Drug Action by : Richard B. Silverman
Download or read book The Organic Chemistry of Drug Design and Drug Action written by Richard B. Silverman and published by Elsevier. This book was released on 2012-12-02 with total page 617 pages. Available in PDF, EPUB and Kindle. Book excerpt: Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and includes chapter problems and other elements that make the book more useful for course instruction. New edition includes new chapter problems and exercises to help students learn, plus extensive references and illustrations Clearly presents an organic chemist's perspective of how drugs are designed and function, incorporating the extensive changes in the drug industry over the past ten years Well-respected author has published over 200 articles, earned 21 patents, and invented a drug that is under consideration for commercialization
Book Synopsis Anesthetic Pharmacology by : Alex S. Evers
Download or read book Anesthetic Pharmacology written by Alex S. Evers and published by Cambridge University Press. This book was released on 2011-03-10 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years our understanding of molecular mechanisms of drug action and interindividual variability in drug response has grown enormously. Meanwhile, the practice of anesthesiology has expanded to the preoperative environment and numerous locations outside the OR. Anesthetic Pharmacology: Basic Principles and Clinical Practice, 2nd edition, is an outstanding therapeutic resource in anesthesia and critical care: Section 1 introduces the principles of drug action, Section 2 presents the molecular, cellular and integrated physiology of the target organ/functional system and Section 3 reviews the pharmacology and toxicology of anesthetic drugs. The new Section 4, Therapeutics of Clinical Practice, provides integrated and comparative pharmacology and the practical application of drugs in daily clinical practice. Edited by three highly acclaimed academic anesthetic pharmacologists, with contributions from an international team of experts, and illustrated in full colour, this is a sophisticated, user-friendly resource for all practitioners providing care in the perioperative period.
Book Synopsis Textbook of Receptor Pharmacology by : John C. Foreman
Download or read book Textbook of Receptor Pharmacology written by John C. Foreman and published by CRC Press. This book was released on 2010-09-10 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: For the past four decades, University College London has offered a renowned course on receptor pharmacology. Originating from this course, the perennially bestselling Textbook of Receptor Pharmacology has presented in-depth coverage of this rapidly expanding area of research. This third edition continues to combine current understanding of classica
Book Synopsis Textbook of Receptor Pharmacology, Third Edition by : John C. Foreman
Download or read book Textbook of Receptor Pharmacology, Third Edition written by John C. Foreman and published by CRC Press. This book was released on 2011-06-27 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: For the past four decades, University College London has offered a renowned course on receptor pharmacology. Originating from this course, the perennially bestselling Textbook of Receptor Pharmacology has presented in-depth coverage of this rapidly expanding area of research. This third edition continues to combine current understanding of classical quantitative pharmacology and drug-receptor interactions with the basics of receptor structure and signal transduction mechanisms, providing an integrated analysis of the mechanisms of drug action at membrane receptors. The hallmark of this popular text is the uniting of four major approaches to the study of receptors: Molecular investigation of receptor structure Quantitative functional studies of agonists and antagonists Ligand binding Signal transduction at the cell membrane Maintaining the second edition’s focus on cell membrane receptors and the immediate signal transduction events at the membrane, this edition includes updated chapters on receptor structure and signal transduction by G-proteins and tyrosine kinases as well as enhancements to the quantitative treatment of drug-receptor interactions. Several chapters contain problems and worked-out solutions, giving students the ability to test their comprehension of the material. Hundreds of diagrams and figures further enhance the text. A time-saving resource and comprehensive learning tool, Textbook of Receptor Pharmacology, Third Edition carries on the tradition of providing in-depth, up-to-date coverage of this critical area that is both fundamental to the science of pharmacology and on the cutting edge of new drug development.
Download or read book Adrenaline written by Brian B. Hoffman and published by Harvard University Press. This book was released on 2013-04-15 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: Famous as the catalyst of the fight or flight response, adrenaline has also received forensic attention as a perfect, untraceable poison—and rumors persist of its power to revive the dead. True to the spirit of its topic, Adrenaline is a stimulating journey that reveals the truth behind adrenaline’s scientific importance and popular appeal.
Book Synopsis Human Drug Targets by : Edward D. Zanders
Download or read book Human Drug Targets written by Edward D. Zanders and published by John Wiley & Sons. This book was released on 2015-12-14 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: The identification of drug targets in a given disease has been central to pharmaceutical research from the latter half of the 20th century right up to the modern genomics era. Human Drug Targets provides an essential guide to one of the most important aspects of drug discovery – the identification of suitable protein and RNA targets prior to the creation of drug development candidates. The first part of the book consists of introductory chapters that provide the background to drug target discovery and highlight the way in which these targets have been organised into online databases. It also includes a user’s guide to the list of entries that forms the bulk of the book. Since this is not designed to be a compendium of drugs, the emphasis will be on the known (or speculated) biological role of the targets and not on the issues associated with pharmaceutical development. The objective is to provide just enough information to be informative and prompt further searches, while keeping the amount of text for each of the many entries to a minimum. Human Drug Targets will prove invaluable to those drug discovery professionals, in both industry and academia, who need to make some sense of the bewildering array of online information sources on current and potential human drug targets. As well as creating order out of a complex target landscape, the book will act as an ideas generator for potentially novel targets that might form the basis of future discovery projects.
Book Synopsis Drug Discovery and Development by : Ramarao Poduri
Download or read book Drug Discovery and Development written by Ramarao Poduri and published by Springer Nature. This book was released on 2021-02-15 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the processes that are involved in the development of new drugs. The authors discuss the history, role of natural products and concept of receptor interactions with regard to the initial stages of drug discovery. In a single, highly readable volume, it outlines the basics of pharmacological screening, drug target identification, and genetics involved in early drug discovery. The final chapters introduce readers to stem therapeutics, pharmacokinetics, pharmacovigilance, and toxicological testing. Given its scope, the book will enable research scholars, professionals and young scientists to understand the key fundamentals of drug discovery, including stereochemistry, pharmacokinetics, clinical trials, statistics and toxicology.
Book Synopsis The Drug Hunters by : Donald R. Kirsch
Download or read book The Drug Hunters written by Donald R. Kirsch and published by Simon and Schuster. This book was released on 2016-12-13 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: The surprising, behind-the-scenes story of how our medicines are discovered, told by a veteran drug hunter. The search to find medicines is as old as disease, which is to say as old as the human race. Through serendipity— by chewing, brewing, and snorting—some Neolithic souls discovered opium, alcohol, snakeroot, juniper, frankincense, and other helpful substances. Ötzi the Iceman, the five-thousand-year-old hunter frozen in the Italian Alps, was found to have whipworms in his intestines and Bronze-age medicine, a worm-killing birch fungus, knotted to his leggings. Nowadays, Big Pharma conglomerates spend billions of dollars on state-of the art laboratories staffed by PhDs to discover blockbuster drugs. Yet, despite our best efforts to engineer cures, luck, trial-and-error, risk, and ingenuity are still fundamental to medical discovery. The Drug Hunters is a colorful, fact-filled narrative history of the search for new medicines from our Neolithic forebears to the professionals of today, and from quinine and aspirin to Viagra, Prozac, and Lipitor. The chapters offer a lively tour of how new drugs are actually found, the discovery strategies, the mistakes, and the rare successes. Dr. Donald R. Kirsch infuses the book with his own expertise and experiences from thirty-five years of drug hunting, whether searching for life-saving molecules in mudflats by Chesapeake Bay or as a chief science officer and research group leader at major pharmaceutical companies.
Book Synopsis The Organic Chemistry of Drug Design and Drug Action by : Richard B. Silverman
Download or read book The Organic Chemistry of Drug Design and Drug Action written by Richard B. Silverman and published by Academic Press. This book was released on 2014-03-29 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. Updates to all chapters, including new examples and references Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry Chapter 3 (Receptors): Drug-receptor interactions, cation-p and halogen bonding; atropisomers; case history of the insomnia drug suvorexant Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates
Book Synopsis The Routledge History of Disease by : Mark Jackson
Download or read book The Routledge History of Disease written by Mark Jackson and published by Routledge. This book was released on 2016-08-05 with total page 636 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Routledge History of Disease draws on innovative scholarship in the history of medicine to explore the challenges involved in writing about health and disease throughout the past and across the globe, presenting a varied range of case studies and perspectives on the patterns, technologies and narratives of disease that can be identified in the past and that continue to influence our present. Organized thematically, chapters examine particular forms and conceptualizations of disease, covering subjects from leprosy in medieval Europe and cancer screening practices in twentieth-century USA to the ayurvedic tradition in ancient India and the pioneering studies of mental illness that took place in nineteenth-century Paris, as well as discussing the various sources and methods that can be used to understand the social and cultural contexts of disease. Chapter 24 of this book is freely available as a downloadable Open Access PDF under a Creative Commons Attribution-Non Commercial-No Derivatives 3.0 license. https://www.routledgehandbooks.com/doi/10.4324/9781315543420.ch24
Book Synopsis Explorations in Baltic Medical History, 1850-2015 by : Nils Hansson
Download or read book Explorations in Baltic Medical History, 1850-2015 written by Nils Hansson and published by Rochester Studies in Medical H. This book was released on 2019 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Examines medical history in northern Europe from 1850 to 2015 and sheds new light on the circulation of medical knowledge in that region
Book Synopsis Ways of Regulating Drugs in the 19th and 20th Centuries by : Jean-Paul Gaudillière
Download or read book Ways of Regulating Drugs in the 19th and 20th Centuries written by Jean-Paul Gaudillière and published by Springer. This book was released on 2012-12-03 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: This collection takes the perspective that the historiography of science, technology, and medicine needs a broader approach toward regulation. The authors explore the distinct social worlds involved in regulation, the forms of evidence and expertise mobilized, and means of intervention chosen to tame drugs in factories, consulting rooms and courts.
Book Synopsis Key Thinkers in Neuroscience by : Andy Wickens
Download or read book Key Thinkers in Neuroscience written by Andy Wickens and published by Routledge. This book was released on 2018-10-04 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Key Thinkers in Neuroscience provides insight into the life and work of some of the most significant minds that have shaped the field. Studies of the human brain have been varied and complex, and the field is rich in pioneers whose endeavours have broken new ground in neuroscience. Adopting a chronological and multi-disciplinary approach to each Key Thinker, the book highlights their extraordinary contributions to neuroscience. Beginning with Santiago Ramon y Cajal and finishing with the philosophers Patricia Churchland and Paul Churchland, this book provides a comprehensive look at the new ideas and discoveries that have shaped neuroscientific research and practice, and the people that have been invaluable to this field. This book will be an indispensable companion for all students of neuroscience and the history of psychology, as well as anyone interested in how we have built our knowledge of the brain.
Book Synopsis The Drug Book by : Michael C. Gerald
Download or read book The Drug Book written by Michael C. Gerald and published by Union Square + ORM. This book was released on 2013-09-03 with total page 882 pages. Available in PDF, EPUB and Kindle. Book excerpt: “A beautiful and well-researched historical guide to significant drugs” from the author of The Complete Idiot’s Guide to Prescription Drugs (Library Journal). Throughout history, humans everywhere have searched for remedies to heal our bodies and minds. Covering everything from ancient herbs to cutting-edge chemicals, this book in the hugely popular Milestones series looks at 250 of the most important moments in the development of life-altering, life-saving, and sometimes life-endangering pharmaceuticals. Illustrated entries feature ancient drugs like alcohol, opium, and hemlock; the smallpox and the polio vaccines; homeopathic cures; and controversial medical treatments like ether, amphetamines, and Xanax—while shining a light on the scientists, doctors, and companies who brought them to us. “These true tales of discovery in The Drug Book by Michael C. Gerald might change the way you think about your medicine.” —The Healthy “An excellent starting point for student researchers and is very browsable for the general reader.” —Booklist
