A Novel Synergistic Diagnosis Methodology for Identifying Abnormalities in Wireless Capsule Endoscopy Videos

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Publisher :
ISBN 13 :
Total Pages : 189 pages
Book Rating : 4.:/5 (1 download)

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Book Synopsis A Novel Synergistic Diagnosis Methodology for Identifying Abnormalities in Wireless Capsule Endoscopy Videos by : Alexandros Karargyris

Download or read book A Novel Synergistic Diagnosis Methodology for Identifying Abnormalities in Wireless Capsule Endoscopy Videos written by Alexandros Karargyris and published by . This book was released on 2010 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: Wireless Capsule Endoscopy (WCE) is a new technology that allows medical personnel to view the gastrointestinal (GI) mucosa. It is a swallowable miniature capsule device the size of a pill that transmits thousands of screenshots of the digestive tract to a wearable receiver. When the procedure finishes the video is uploaded to a workstation for viewing. Capsule Endoscopy has been established as a tool to identify various gastrointestinal (GI) conditions, such as blood-based abnormalities, polyps, ulcers, Crohn's disease in the small intestine, where the classical endoscopy is not regularly used. As of 2009 the market is dominated by Given Imaging Inc. capsule (PillCam SB). More than 300,000 capsules have been sold since 2001 when it was first introduced. The company provides a software package (RAPID) to view the WCE video, offering a bleeding detector feature based on red color. It provides a position estimator of the capsule inside the digestive tract. Additionally its multi-view feature gives a simultaneous view of two or four consecutive video frames in multiple windows. Finally a library of reference images (RAPID Atlas) is provided so that the user can have easy access to on-screen case images. Although the company's software is a useful tool, the viewing of a WCE video is still a time consuming process (~ 2 hours), even for experienced gastroenterologists. In addition, the company's software has serious limitations (35% bleeding detection) and no capability of detecting polyps or ulcers according to gastroenterologists. Therefore, the need for computer aided model-methodology with robust detection performance on various conditions (blood, polyps, ulcers, etc) is clearly obvious. Thus, our research studies have been successfully carried out on: a) the automatic detection of malignant intestinal features like polyps, bleeding, and abnormal regions (tumors); b) finding the boundaries of the digestive organs; and c) reducing the viewing-examination time with a robust registra-tion methodology. These studies have led to the development of the ATRC Video Toolbox (ATRC-VT). ATRC-VT incorporates signal processing methods, color and image processing techniques, and artificial intelligence tools to detect blood-based abnormalities, polyps and ulcers in the small intestine. It is the first computer aided detection (CAD) software with multiple capabilities for WCE videos designed with a Graphics User Interface so that it is easy to use.

Endoscopy

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Publisher : BoD – Books on Demand
ISBN 13 : 1789851254
Total Pages : 152 pages
Book Rating : 4.7/5 (898 download)

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Book Synopsis Endoscopy by : Costin Teodor Streba

Download or read book Endoscopy written by Costin Teodor Streba and published by BoD – Books on Demand. This book was released on 2019-03-06 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endoscopic techniques are widely used for screening, diagnostic and therapeutic maneuvers in all groups of patients and for a large spectrum of complaints. The availability of basic iterations of endoscopic techniques made screening programs for various diseases viable in most parts of the world, while the advent of modern techniques opens new perspectives for rapid and correct diagnosis. Going beyond normal human vision, innovative techniques opened the prospect of in-situ pathology. Endoscopic ultrasound has made incredible progress in recent years. Reaching the smaller orifices by endoscopy was a major step forward in the surveillance of previously inaccessible lesions. Investigatory techniques were complemented by advances in therapy, with novel applications in many major areas of medicine.

Rapid On-site Evaluation (ROSE)

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Publisher : Springer Nature
ISBN 13 : 303021799X
Total Pages : 432 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Rapid On-site Evaluation (ROSE) by : Guoping Cai

Download or read book Rapid On-site Evaluation (ROSE) written by Guoping Cai and published by Springer Nature. This book was released on 2019-08-30 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces basic ROSE techniques and resources required to set up ROSE service. It reviews the cytomorphologic features that are recognizable during ROSE, including those important for sample adequacy, specimen triage, preliminary interpretation, and potential diagnostic pitfalls. Economic and regulatory aspects are discussed as well as the pros and cons of telecytology. The book is formatted for clinical settings, simulating the ROSE process that occurs in the ultrasound room, CT room, bronchoscopy suite, and endoscopy suite. Each chapter focuses on the cytomorphologic clues and pitfalls of the entities specific to that clinical setting. Rapid On-Site Evaluation: A Practical Guide will be a valuable resource for pathologists, cytotechnologists, physicians who perform biopsies and/or ROSE evaluation, and trainees for utilizing ROSE and improving diagnostic performance of biopsies.

Office-Based Infertility Practice

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Publisher : Springer Science & Business Media
ISBN 13 : 3642876900
Total Pages : 323 pages
Book Rating : 4.6/5 (428 download)

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Book Synopsis Office-Based Infertility Practice by : David B. Seifer

Download or read book Office-Based Infertility Practice written by David B. Seifer and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: The practice of clinical reproductive medicine has practice in the era of managed care and coordinat gradually moved from its initial 1980-90 hospital ing ancillary offsite medical personnel. base to its present (circa 2001) office site of oper The objective of this text is to assist in this ongo ation. With this transition have been improvements ing endeavor by presenting in a clear, concise man in efficiency of practice often in response to ner many of the topics relevant to contemporary increased pressure to provide the most patient sat office-based infertility practice. The initial half of isfaction. An added challenge of office-based prac this text addresses topics which focus upon general tice has been taking on many of the responsibili concepts of infertility evaluation and practice. The ties of what had been traditionally the hospital's latter half is a practical approach to the execution domain. Some of these new responsibilities have of specific office-based infertility procedures. We included the ordering of operative supplies and hope this book will assist all medical personnel who equipment, the establishment of quality control dedicate their clinical effort in achieving what is programs, construction and maintenance of special most coveted by our patients, the birth of a healthy laboratory spaces, redesigning efficient methods of newborn. DAVID B. SEIFER, M. D. UMDNJ-Robert Wood Johnson Medical School ROBERT L. COLLINS, M. D. The Reproductive Center, Youngstown, Ohio October 2001 vii Contents Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vii . . . . . . . . . . . . . . . . . Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xi . . . . . . . . . . . . . . . . . 1 Evaluation of the Female for Infertility . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Bryan D.

Artificial Intelligence: Theories, Models and Applications

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Publisher :
ISBN 13 : 9788354087885
Total Pages : 0 pages
Book Rating : 4.0/5 (878 download)

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Book Synopsis Artificial Intelligence: Theories, Models and Applications by :

Download or read book Artificial Intelligence: Theories, Models and Applications written by and published by . This book was released on 2008 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed proceedings of the 5th Hellenic Conference on Artificial Intelligence, SETN 2008, held at Syros, Greece in October 2008. The 27 revised full papers together with 17 revised short papers were carefully reviewed and selected from 76 submissions. The papers address any area of artificial intelligence; particular fields of interest include: Adaptive Systems, AI and Creativity, AI rchitectures, Artificial Life, Autonomous Systems, Data Mining and Knowledge Discovery, Hybrid Intelligent Systems & Methods, Intelligent Agents, Multi-agent Systems, Intelligent Distributed Systems, Intelligent Information Retrieval, Intelligent/Natural Interactivity, Intelligent Virtual Environments, Knowledge Representation and Reasoning, Logic Programming, Knowledge-Based Systems, Machine Learning, Neural Nets, Genetic Algorithms, Natural Language Processing, Planning and Scheduling, Problem Solving, Constraint Satisfaction, Robotics, Machine Vision, Machine Sensing.

Geriatric Gastroenterology

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Publisher : Springer Science & Business Media
ISBN 13 : 1441916237
Total Pages : 660 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Geriatric Gastroenterology by : C. S. Pitchumoni

Download or read book Geriatric Gastroenterology written by C. S. Pitchumoni and published by Springer Science & Business Media. This book was released on 2012-07-26 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt: As aging trends in the United States and Europe in particular are strongly suggestive of increasingly older society, it would be prudent for health care providers to better prepare for such changes. By including physiology, disease, nutrition, pharmacology, pathology, radiology and other relevant associated topics, Geriatric Gastroenterology fills the void in the literature for a volume devoted specifically to gastrointestinal illness in the elderly. This unique volume includes provision of training for current and future generations of physicians to deal with the health problems of older adults. It will also serve as a comprehensive guide to practicing physicians for ease of reference. Relevant to the geriatric age group, the volume covers epidemiology, physiology of aging, gastrointestinal physiology, pharmacology, radiology, pathology, motility disorders, luminal disorders, hepato-biliary disease, systemic manifestations, neoplastic disorders, gastrointestinal bleeding, cancer and medication related interactions and adverse events, all extremely common in older adults; these are often hard to evaluate and judge, especially considering the complex aging physiology. All have become important components of modern medicine. Special emphasis is be given to nutrition and related disorders. Capsule endoscopy and its utility in the geriatric population is also covered. Presented in simple, easy to read style, the volume includes numerous tables, figures and key points enabling ease of understanding. Chapters on imaging and pathology are profusely illustrated. All chapters are written by specialists and include up to date scientific information. Geriatric Gastroenterology is of great utility to residents in internal medicine, fellows in gastroenterology and geriatric medicine as well as gastroenterologists, geriatricians and practicing physicians including primary care physicians caring for older adults.

Deep Learners and Deep Learner Descriptors for Medical Applications

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Publisher : Springer Nature
ISBN 13 : 3030427501
Total Pages : 286 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Deep Learners and Deep Learner Descriptors for Medical Applications by : Loris Nanni

Download or read book Deep Learners and Deep Learner Descriptors for Medical Applications written by Loris Nanni and published by Springer Nature. This book was released on 2020-05-15 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces readers to the current trends in using deep learners and deep learner descriptors for medical applications. It reviews the recent literature and presents a variety of medical image and sound applications to illustrate the five major ways deep learners can be utilized: 1) by training a deep learner from scratch (chapters provide tips for handling imbalances and other problems with the medical data); 2) by implementing transfer learning from a pre-trained deep learner and extracting deep features for different CNN layers that can be fed into simpler classifiers, such as the support vector machine; 3) by fine-tuning one or more pre-trained deep learners on an unrelated dataset so that they are able to identify novel medical datasets; 4) by fusing different deep learner architectures; and 5) by combining the above methods to generate a variety of more elaborate ensembles. This book is a value resource for anyone involved in engineering deep learners for medical applications as well as to those interested in learning more about the current techniques in this exciting field. A number of chapters provide source code that can be used to investigate topics further or to kick-start new projects.

Predictive Intelligence in Biomedical and Health Informatics

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Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3110676125
Total Pages : 180 pages
Book Rating : 4.1/5 (16 download)

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Book Synopsis Predictive Intelligence in Biomedical and Health Informatics by : Rajshree Srivastava

Download or read book Predictive Intelligence in Biomedical and Health Informatics written by Rajshree Srivastava and published by Walter de Gruyter GmbH & Co KG. This book was released on 2020-10-12 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Predictive Intelligence in Biomedical and Health Informatics focuses on imaging, computer-aided diagnosis and therapy as well as intelligent biomedical image processing and analysis. It develops computational models, methods and tools for biomedical engineering related to computer-aided diagnostics (CAD), computer-aided surgery (CAS), computational anatomy and bioinformatics. Large volumes of complex data are often a key feature of biomedical and engineering problems and computational intelligence helps to address such problems. Practical and validated solutions to hard biomedical and engineering problems can be developed by the applications of neural networks, support vector machines, reservoir computing, evolutionary optimization, biosignal processing, pattern recognition methods and other techniques to address complex problems of the real world.

Endoscopy in Small Bowel Diseases

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Publisher :
ISBN 13 : 9781839687808
Total Pages : pages
Book Rating : 4.6/5 (878 download)

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Book Synopsis Endoscopy in Small Bowel Diseases by : Mahesh Goenka

Download or read book Endoscopy in Small Bowel Diseases written by Mahesh Goenka and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Innovations in Biomedical Engineering

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Publisher : Springer Nature
ISBN 13 : 3030991121
Total Pages : 341 pages
Book Rating : 4.0/5 (39 download)

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Book Synopsis Innovations in Biomedical Engineering by : Marek Gzik

Download or read book Innovations in Biomedical Engineering written by Marek Gzik and published by Springer Nature. This book was released on 2022-05-31 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the latest developments in the field of biomedical engineering and includes practical solutions and strictly scientific considerations. The development of new methods of treatment, advanced diagnostics or personalized rehabilitation requires close cooperation of experts from many fields, including, among others, medicine, biotechnology and finally biomedical engineering. The latter, combining many fields of science, such as computer science, materials science, biomechanics, electronics not only enables the development and production of modern medical equipment, but also participates in the development of new directions and methods of treatment. The presented monograph is a collection of scientific papers on the use of engineering methods in medicine. The topics of the work include both practical solutions and strictly scientific considerations expanding knowledge about the functioning of the human body. We believe that the presented works will have an impact on the development of the field of science, which is biomedical engineering, constituting a contribution to the discussion on the directions of development of cooperation between doctors, physiotherapists and engineers. We would also like to thank all the people who contributed to the creation of this monograph—both the authors of all the works and those involved in technical works.

Soft Computing Applications

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Publisher : Springer Nature
ISBN 13 : 3030521907
Total Pages : 500 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis Soft Computing Applications by : Valentina Emilia Balas

Download or read book Soft Computing Applications written by Valentina Emilia Balas and published by Springer Nature. This book was released on 2020-08-17 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the proceedings of the 8th International Workshop on Soft Computing Applications, SOFA 2018, held on 13–15 September 2018 in Arad, Romania. The workshop was organized by Aurel Vlaicu University of Arad, in conjunction with the Institute of Computer Science, Iasi Branch of the Romanian Academy, IEEE Romanian Section, Romanian Society of Control Engineering and Technical Informatics – Arad Section, General Association of Engineers in Romania – Arad Section and BTM Resources Arad. The papers included in these proceedings, published post-conference, cover the research including Knowledge-Based Technologies for Web Applications, Cloud Computing, Security Algorithms and Computer Networks, Business Process Management, Computational Intelligence in Education and Modelling and Applications in Textiles and many other areas related to the Soft Computing. The book is directed to professors, researchers, and graduate students in area of soft computing techniques and applications.

Essentials of Gastroenterology

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Publisher : John Wiley & Sons
ISBN 13 : 0470656255
Total Pages : 480 pages
Book Rating : 4.4/5 (76 download)

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Book Synopsis Essentials of Gastroenterology by : Shanthi V. Sitaraman

Download or read book Essentials of Gastroenterology written by Shanthi V. Sitaraman and published by John Wiley & Sons. This book was released on 2012-04-30 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Highly practical and concise, this hands-on guide focuses on specific common clinical scenarios. Each section covers a particular area of the GI tract and follows a regular structure of: overview of normal function, physiology, pathophysiology, clinical presentation, differential diagnosis, diagnostic tests, and treatment.

Emerging Technologies in Surgery

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Publisher : Springer Science & Business Media
ISBN 13 : 3540396004
Total Pages : 163 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Emerging Technologies in Surgery by : Richard M. Satava

Download or read book Emerging Technologies in Surgery written by Richard M. Satava and published by Springer Science & Business Media. This book was released on 2007-08-10 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the effects of emerging technologies on surgeons and surgical practice. The book opens with an overview of disruptive technologies, and their economic, scientific, ethical and social implications. Next comes a section describing how the Internet, virtual reality and simulation technology will change training and education. A section on Robotics covers computer-guided surgery, robotics and endoluminal therapies. Innovations in surgical instruments, including MEMS and Nanotechnology are outlined, as well. Next, the book reviews tissue engineering and artificial organs, genetic engineering, stem cells, emerging transplantation technologies and the brain-machine interface. A concluding section discusses ways of adapting to future technologies.

Masterpieces of Swiss Entrepreneurship

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Publisher : Springer Nature
ISBN 13 : 3030652874
Total Pages : 579 pages
Book Rating : 4.0/5 (36 download)

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Book Synopsis Masterpieces of Swiss Entrepreneurship by : Jean-Pierre Jeannet

Download or read book Masterpieces of Swiss Entrepreneurship written by Jean-Pierre Jeannet and published by Springer Nature. This book was released on 2021-04-21 with total page 579 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book focuses on Switzerland-based medium-sized companies with a longstanding export tradition and a proven dominance in global niche markets. Based upon in-depth documentation and analysis of 36 Swiss companies over their entire history, an expert team of authors presents several parallels in the pathways and success factors which allowed these firms to become dominant and operate from a high-cost location such as Switzerland. The book enhances these insights by providing detailed company profiles documenting the company history, development, and how their relevant global niche positions were reached. Readers will benefit from these profiles as they compile a diverse selection of industries, mainly active within the B2B sector, with mostly mature companies (60 years to older than 100 years since founding) and different types of ownership structures including family firms. ‘Masterpieces of Swiss Entrepreneurship’ brings unique learning opportunities to owners and leaders of SMEs in Switzerland and elsewhere. Findings are based on detailed bottom-up research of 36 companies -- without any preconceived notions. The book is both conceptual and practical. It fosters understanding for different choices in development pathways and management practices. Matti Alahuhta, Chairman DevCo Partners, ex-CEO Kone, Board member of several global listed companies, Helsinki, Finland Start-up entrepreneurs need proven models from industry which demonstrate the various paths to success. “Masterpieces of Swiss Entrepreneurship” provides deep insights highlighting these models and the important trade-offs entrepreneurial teams must consider when choosing the path of high growth or of maximum control, as they are often mutually exclusive. Gina Domanig, Managing Partner, Emerald Technology Ventures, Zurich

The ASCRS Textbook of Colon and Rectal Surgery

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Publisher : Springer
ISBN 13 : 3319259709
Total Pages : 1269 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis The ASCRS Textbook of Colon and Rectal Surgery by : Scott R. Steele

Download or read book The ASCRS Textbook of Colon and Rectal Surgery written by Scott R. Steele and published by Springer. This book was released on 2016-03-24 with total page 1269 pages. Available in PDF, EPUB and Kindle. Book excerpt: This third edition text provides a completely revised and updated new version of this unique, modern, practical text that covers the strategic evaluation, specific approaches, and detailed management techniques utilized by expert colorectal surgeons caring for patients with complex problems–whether they result from underlying colorectal disease or from complications arising from previous surgical therapy. The format follows that of both a “how to” manual as well as an algorithm-based guide to allow the reader to understand the thought process behind the proposed treatment strategy. By making use of evidence-based recommendations, each chapter includes not only background information and diagnostic/therapeutic guidelines, but also provides a narrative by the author on his/her operative technical details and perioperative “tips and tricks” that they utilize in the management of these complex surgical challenges. Distinctive to this book, is the reliance on experts in the field including past presidents of the ASCRS, as well as multiple other national and internationally recognized surgeons, to lend their personal insight into situations where data may be more sparse, but individual and collective experience is paramount to making sound decisions and thereby optimizing patient outcomes. The text includes chapters on the assessment of risk and methods utilized to minimize perioperative complications. In addition, it incorporates sections covering the medical and surgical therapies for abdominal, pelvic and anorectal disease. Moreover, the technical challenges of managing complications resulting from the original or subsequent operations is addressed. The underlying focus throughout the text is on providing pragmatic and understandable solutions that can be readily implemented by surgeons of varying experience to successfully treat complex colorectal problems. However, it also goes beyond the technical aspects of colorectal surgery and includes special sections highlighting the essence of a surgeon; covering aspects involving the medical-legal, ethical, and economic challenges confronting surgeons. Throughout the text, each author provides an ongoing narrative of his/her individual surgical techniques along with illustrations and diagrams to “personally” take the reader through the crucial steps of the procedure, and key points of patient care inherent to that topic. Additionally, where appropriate, links to online videos give the reader an up-front look into technical aspects of colorectal surgery.

Advances in Experimental Surgery

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Publisher :
ISBN 13 : 9781536127737
Total Pages : 0 pages
Book Rating : 4.1/5 (277 download)

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Book Synopsis Advances in Experimental Surgery by : Huifang Chen

Download or read book Advances in Experimental Surgery written by Huifang Chen and published by . This book was released on 2017-11 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experimental surgery is an important link for the development in clinical surgery, research and teaching. Experimental surgery was part of the most important surgical discoveries in the past century. Since 1901 nine Nobel Prizes have been awarded to the pioneers had remarkable achievements in the basic or practical surgery. In recent 20 years, experimental surgery has achieved new advances, like laparoscopic and robotic surgery, tissue engineering, and gene therapy which are widely applied in clinic surgery. The present book covers wide experimental surgery in preclinical research models subdivided in two volumes. Volume I introduces surgical basic notions, techniques, and different surgical models involved in basic experimental surgery and review the biomechanical models, ischemia/reperfusion injury models, repair and regeneration models, and organ and tissue transplantation models, respectively. Volume II introduces several specific experimental models such as laparoscopic and bariatric experimental surgical models. The second volume also introduces graft-versus-host disease, and other experimental models. Review the advances and development of recent techniques such as tissue engineering, organ preservation, wound healing and scarring, gene therapy and robotic surgery. The book documents the enormous volume of knowledge we have acquired in the field of experimental surgery. In this book, we have invited experts from the United States, Canada, France, Germany, China, Japan, Korea, UK, Sweden, Netherland, Hungary and Turkey to contribute 36 chapters in the fields of their expertise. These two volumes are the compilation of basic experimental surgery and updated advances of new development in this field that will be invaluable to surgeons, residents, graduate students, surgical researchers, physicians, immunologists, veterinarians and nurses in surgery.

Computer-integrated Surgery

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Publisher : MIT Press
ISBN 13 : 9780262200974
Total Pages : 790 pages
Book Rating : 4.2/5 (9 download)

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Book Synopsis Computer-integrated Surgery by : Russell H. Taylor

Download or read book Computer-integrated Surgery written by Russell H. Taylor and published by MIT Press. This book was released on 1996 with total page 790 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Computer-Integrated Surgery leading researchers and clinical practitioners describe the exciting new partnership that is being forged between surgeons and machines such as computers and robots, enabling them to perform certain skilled tasks better than either can do alone.The 19 chapters in part I, Technology, explore the components -- registration, basic tools for surgical planning, human-machine interfaces, robotic manipulators, safety -- that are the basis of computer-integrated surgery. These chapters provide essential background material needed to get up to speed on current work as well as a ready reference for those who are already active in the field.The 39 chapters in part II, Applications, cover eight clinical areas -- neurosurgery, orthopedics, eye surgery, dentistry, minimal access surgery, ENT surgery, craniofacial surgery, and radiotherapy -- with a concluding chapter on the high-tech operating room. Each section contains a brief introduction as well as at least one "requirements and opportunities" chapter written by a leading clinician in the area under discussion.